Phosphoramidites

Thiol-Modifier C3 S-S CE Phosphoramidite

Description: Thiol-Modifier C3 S-S CE Phosphoramidite is a specialized reagent used in oligonucleotide synthesis for molecular biology applications. It introduces a thiol (-SH) group into synthetic oligonucleotides at the third carbon position (C3) from the 5' end, connected to a disulfide bridge for stability. This modification enables reversible conjugation reactions, facilitating various applications such as DNA-protein interactions, surface immobilization, and biosensor development.

CAT: BRP-00483

CAS: 1263065-01-5

Molecular Formula: C36H49N2O5PS2

Molecular Weight: 684.89

Appearance: Colourless oily matter

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InChIKey: CUHXVAZCAZMSBS-UHFFFAOYSA-N

CanonicalSMILES: N#CCCOP(OCCCSSCCCOC(C=1C=CC=CC1)(C2=CC=C(OC)C=C2)C3=CC=C(OC)C=C3)N(C(C)C)C(C)C

IUPAC Name: 3-((3-(bis(4-methoxyphenyl)(phenyl)methoxy)propyl)disulfaneyl)propyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C36H49N2O5PS2/c1-29(2)38(30(3)4)44(42-25-10-23-37)43-26-12-28-46-45-27-11-24-41-36(31-13-8-7-9-14-31,32-15-19-34(39-5)20-16-32)33-17-21-35(40-6)22-18-33/h7-9,13-22,29-30H,10-12,24-28H2,1-6H3

Synonyms: 3-[[3-[Bis(4-methoxyphenyl)phenylmethoxy]propyl]dithio]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 3-[[3-[bis(4-methoxyphenyl)phenylmethoxy]propyl]dithio]propyl 2-cyanoethyl ester

Spacer C6 CE Phosphoramidite

Description: Spacer phosphamides C3, C9, C12, and C18 are used to insert spacer arms in oligonucleotides, and these compounds can be added multiple times when longer spacer arms are needed.

CAT: BRP-00484

CAS: 158041-82-8

Molecular Formula: C36H49N2O5P

Molecular Weight: 620.77

Purity: ≥98%

Appearance: Colourless oily matter

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InChIKey: AEDFSPMNECTXJM-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)OCCC#N

IUPAC Name: 3-[6-[bis(4-methoxyphenyl)-phenylmethoxy]hexoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C36H49N2O5P/c1-29(2)38(30(3)4)44(43-28-14-25-37)42-27-13-8-7-12-26-41-36(31-15-10-9-11-16-31,32-17-21-34(39-5)22-18-32)33-19-23-35(40-6)24-20-33/h9-11,15-24,29-30H,7-8,12-14,26-28H2,1-6H3

Synonyms: 6-[Bis(4-methoxyphenyl)phenylmethoxy]hexyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 6-[bis(4-methoxyphenyl)phenylmethoxy]hexyl 2-cyanoethyl ester; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 6-[bis(4-methoxyphenyl)phenylmethoxy]hexyl 2-cyanoethyl ester; C6 Spacer Amidite; DMT-1,6-Hexandiol; C6 Spacer Phosphoramidite; Spacer Phosphoramidite C6; DMT-hexane-Diol phosphoramidite; 6-(4,4'-Dimethoxytrityloxy) hexyl-1-[(2-cyanoethyl)-(N,N-diisopropyl)] phosphoramidite

Spermine CE Phosphoramidite

Description: Spermine CE Phosphoramidite is used to produce oligospermine-oligonucleotide conjugate-zip Nucleic Acids (ZNA) Oligos, which are thought to use oligospermine to find and move along the oligonucleotide chain (scan). Until the probe complementary sequence is found. Oligospermine then stabilizes the formed double chains by reducing electrostatic repulsion, thereby significantly increasing the binding affinity. ZNA oligomers can be used for the following applications: multiplex PCR, AT-rich region PCR, RT qPCR, MicroRNA detection, improved SNP recognition, and antisense and antigenic effects. Spermine phosphorite is easy to use in oligonucleotide synthesis, can be added multiple times at the 3' or 5' end, and is easy to protect and separate. HPLC analysis of conjugates requires a high pH value to inhibit the ionization of spermine residues.

CAT: BRP-00485

CAS: 942054-48-0

Molecular Formula: C56H73F12N6O9P

Molecular Weight: 1233.19

Appearance: Colourless oily matter

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InChIKey: LKEZZLVCFMFJGQ-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCN(CCCN(CCCCN(CCCN(CCCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)C(=O)C(F)(F)F)C(=O)C(F)(F)F)C(=O)C(F)(F)F)C(=O)C(F)(F)F)OCCC#N

IUPAC Name: N-[3-[4-[bis(4-methoxyphenyl)-phenylmethoxy]butyl-(2,2,2-trifluoroacetyl)amino]propyl]-N-[4-[3-[4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxybutyl-(2,2,2-trifluoroacetyl)amino]propyl-(2,2,2-trifluoroacetyl)amino]butyl]-2,2,2-trifluoroacetamide

InChI: InChI=1S/C56H73F12N6O9P/c1-41(2)74(42(3)4)84(83-40-16-29-69)82-39-15-13-33-73(51(78)56(66,67)68)37-18-35-71(49(76)54(60,61)62)31-11-10-30-70(48(75)53(57,58)59)34-17-36-72(50(77)55(63,64)65)32-12-14-38-81-52(43-19-8-7-9-20-43,44-21-25-46(79-5)26-22-44)45-23-27-47(80-6)28-24-45/h7-9,19-28,41-42H,10-18,30-40H2,1-6H3

Synonyms: N1-[4-(4,4'-Dimethoxytrityloxy)butyl]-N1,N4,N9,N12-tetrakis(trifluoroacetyl)-spermine-N12-butyl-4-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Spermine Phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 24,24-bis(4-methoxyphenyl)-24-phenyl-5,9,14,18-tetrakis(2,2,2-trifluoroacetyl)-23-oxa-5,9,14,18-tetraazatetracos-1-yl 2-cyanoethyl ester; 24,24-Bis(4-methoxyphenyl)-24-phenyl-5,9,14,18-tetrakis(2,2,2-trifluoroacetyl)-23-oxa-5,9,14,18-tetraazatetracos-1-yl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

5'-Ferrocene CE Phosphoramidite

Description: 5'-Ferrocene CE Phosphoramidite is an oligonucleotide synthesis reagent that adds the electromagnetic group ferrocene to the oligonucleotide chain for application in oligonucleotide labeling. The absorption wavelength of 5'-Ferrocene CE Phosphoramidite is 438 nm and the extinction coefficient is 230M-1 cm-1.

CAT: BRP-00486

Molecular Formula: C26H40FeN3O3P

Molecular Weight: 529.44

Appearance: Yellow solid

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Synonyms: 5'-Ferrocene Amidite; N-Ferrocenoyl-6-aminohexan-1-(2-cyanoethyl-diisoproylamino phoshoramidite)

rG (iPr-Pac) CE-Phosphoramidite

Description: rG (iPr-Pac) CE-Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It incorporates a guanosine (G) residue modified with a tert-butyldimethylsilyl (TBDMS) group at the 2'-position and an isopropyl-pacidamycin (iPr-Pac) group. The TBDMS group provides stability during chemical synthesis, while the iPr-Pac group enhances functionality. The CE designation indicates its compatibility with controlled-efficiency (CE) phosphoramidite chemistry, ensuring efficient incorporation during solid-phase synthesis. This reagent facilitates the production of modified RNA oligonucleotides with improved stability and functionality, suitable for various molecular biology and biotechnology applications, including RNA interference and gene expression studies.

CAT: BRP-00495

CAS: 689283-85-0

Molecular Formula: C57H74N7O10PSi

Molecular Weight: 1076.32

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InChIKey: NLVBSBWTUJBMAJ-WYRUHZNWSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)COC4=CC=C(C=C4)C(C)C)NC32)C1O[Si](C)(C)C(C)(C)C)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H74N7O10PSi/c1-37(2)40-20-26-46(27-21-40)69-35-48(65)60-55-61-52-49(53(66)62-55)59-36-63(52)54-51(74-76(12,13)56(7,8)9)50(73-75(71-33-17-32-58)64(38(3)4)39(5)6)47(72-54)34-70-57(41-18-15-14-16-19-41,42-22-28-44(67-10)29-23-42)43-24-30-45(68-11)31-25-43/h14-16,18-31,36-39,47,50-51,54H,17,33-35H2,1-13H3,(H2,60,61,62,65,66)/t47-,50-,51-,54-,75?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-[[4-(1-methylethyl)phenoxy]acetyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-Dimethoxytrityl-N-p-isopropylphenoxyacetyl-Guanosine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; iPr-Pac-G-CE Phosphoramidite; 2'-O-TBDMS-G(iPr-Pac) 3'-CE Phosphoramidite

Quasar 570 Amidite

Description: Quasar 570 Amidite is a specialized reagent utilized in oligonucleotide synthesis. It contains a fluorescent dye molecule that emits light at a wavelength of 570 nanometers, enabling the labeling of nucleic acid sequences during synthesis. This allows for the detection and visualization of the synthesized oligonucleotides in various molecular biology and biotechnology applications, including DNA sequencing, PCR, and fluorescence in situ hybridization (FISH). The Quasar 570 Amidite facilitates the development of labeled probes and primers for sensitive and specific nucleic acid detection assays.

CAT: BRP-00507

CAS: 1207162-64-8

Molecular Formula: C44H65F6N5O4P2

Molecular Weight: 903.95

Appearance: Red solid

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InChIKey: SXRGIEQDPKCFKB-UHFFFAOYSA-O

CanonicalSMILES: N#CCCOP(OCCOCCNC(=O)CCCCCN1C=2C=CC=CC2C(C1=CC=CC3=[N+](C=4C=CC=CC4C3(C)C)CC)(C)C)N(C(C)C)C(C)C.[F-][P+5]([F-])([F-])([F-])([F-])[F-]

IUPAC Name: 2-(3-(1-(6-((2-(2-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)ethoxy)ethyl)amino)-6-oxohexyl)-3,3-dimethylindolin-2-ylidene)prop-1-en-1-yl)-1-ethyl-3,3-dimethyl-3H-indol-1-ium;hexafluorophosphate

InChI: InChI=1S/C44H64N5O4P.F6P/c1-10-47-38-22-15-13-20-36(38)43(6,7)40(47)24-18-25-41-44(8,9)37-21-14-16-23-39(37)48(41)29-17-11-12-26-42(50)46-28-31-51-32-33-53-54(52-30-19-27-45)49(34(2)3)35(4)5;1-7(2,3,4,5)6/h13-16,18,20-25,34-35H,10-12,17,19,26,28-33H2,1-9H3;/q;-1/p+1

Synonyms: 3H-Indolium, 2-[3-[1-[14-[bis(1-methylethyl)amino]-17-cyano-6-oxo-10,13,15-trioxa-7-aza-14-phosphaheptadec-1-yl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3,3-dimethyl-, hexafluorophosphate(1-) (1:1)

Related CAS: 865650-90-4 (free base)

Long trebler phosphoramidite

Description: Long trebler phosphoramidite is a highly branched or multifunctional phosphoramidite, potentially offering unique properties or applications in oligonucleotide chemistry.It likely plays a crucial role in the efficient and controlled synthesis of oligonucleotides for various research and biotechnological applications.

CAT: BRP-00509

CAS: 1516489-83-0

Molecular Formula: C89H107N2O15P

Molecular Weight: 1475.78

Purity: ≥95%

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InChIKey: GLIQPXBAWPTSHZ-UHFFFAOYSA-N

Solubility: Soluble in Acetonitrile, DCM, THF

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCOCC(COCCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)(COCCCOC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)COCCCOC(C7=CC=CC=C7)(C8=CC=C(C=C8)OC)C9=CC=C(C=C9)OC)OCCC#N

IUPAC Name: 3-[3-[3-[3-[bis(4-methoxyphenyl)-phenylmethoxy]propoxy]-2,2-bis[3-[bis(4-methoxyphenyl)-phenylmethoxy]propoxymethyl]propoxy]propoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C89H107N2O15P/c1-69(2)91(70(3)4)107(105-63-20-55-90)106-64-24-59-101-68-86(65-98-56-21-60-102-87(71-25-14-11-15-26-71,74-31-43-80(92-5)44-32-74)75-33-45-81(93-6)46-34-75,66-99-57-22-61-103-88(72-27-16-12-17-28-72,76-35-47-82(94-7)48-36-76)77-37-49-83(95-8)50-38-77)67-100-58-23-62-104-89(73-29-18-13-19-30-73,78-39-51-84(96-9)52-40-78)79-41-53-85(97-10)54-42-79/h11-19,25-54,69-70H,20-24,56-68H2,1-10H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 3-[3-[3-[bis(4-methoxyphenyl)phenylmethoxy]propoxy]-2,2-bis[[3-[bis(4-methoxyphenyl)phenylmethoxy]propoxy]methyl]propoxy]propyl 2-cyanoethyl ester; 3-[3-[3-[Bis(4-methoxyphenyl)phenylmethoxy]propoxy]-2,2-bis[[3-[bis(4-methoxyphenyl)phenylmethoxy]propoxy]methyl]propoxy]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Tris-2,2,2-[3-(4,4'-dimethoxytrityloxy)propyloxymethyl]methyleneoxypropyl-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

5'-Hexynyl CE Phosphoramidite

Description: The 5'-Hexynyl CE Phosphoramidite is a reagent used in oligonucleotide synthesis. It features a hexynyl group at the 5'-end and is compatible with controlled-efficiency phosphoramidite chemistry. This modification allows for further bioconjugation through click chemistry reactions, making it valuable for labeling, imaging, and bioconjugation studies.

CAT: BRP-00510

CAS: 1048985-37-0

Molecular Formula: C15H27N2O2P

Molecular Weight: 298.36

Purity: ≥95% by HPLC

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InChIKey: IFNKHZIJWLUIHZ-UHFFFAOYSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCC#C)OCCC#N

IUPAC Name: 3-[[di(propan-2-yl)amino]-hex-5-ynoxyphosphanyl]oxypropanenitrile

InChI: InChI=1S/C15H27N2O2P/c1-6-7-8-9-12-18-20(19-13-10-11-16)17(14(2)3)15(4)5/h1,14-15H,7-10,12-13H2,2-5H3

Synonyms: 2-Cyanoethyl hex-5-yn-1-yl diisopropylphosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 5-hexyn-1-yl ester; 2-Cyanoethyl 5-hexyn-1-yl N,N-bis(1-methylethyl)phosphoramidite; 5-Hexynyl phosphoramidite; 5-Hexyn-1-yl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; 5'-Hexynyl Phosphoramidite

2'-O-C16-rA(Bz)-Phosphoramidite

Description: 2'-O-C16-rA(Bz)-Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It contains a 2'-O-C16-rA(Bz) modification, where a C16 alkyl chain is attached to the 2'-position of riboadenosine (rA) and a benzoyl (Bz) group is attached to the adenine base. This modification enhances stability and functionality. It facilitates the production of modified RNA oligonucleotides with improved properties, suitable for various molecular biology and biotechnology applications, including RNA interference and gene expression studies.

CAT: BRP-00512

CAS: 2382942-35-8

Molecular Formula: C63H84N7O8P

Molecular Weight: 1098.38

Purity: ≥95%

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InChIKey: JEFOGZDZKKCGEJ-OSIIFERKSA-N

CanonicalSMILES: CCCCCCCCCCCCCCCCOC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-hexadecoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C63H84N7O8P/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-27-42-74-58-57(78-79(76-43-28-41-64)70(47(2)3)48(4)5)55(77-62(58)69-46-67-56-59(65-45-66-60(56)69)68-61(71)49-29-23-21-24-30-49)44-75-63(50-31-25-22-26-32-50,51-33-37-53(72-6)38-34-51)52-35-39-54(73-7)40-36-52/h21-26,29-40,45-48,55,57-58,62H,8-20,27-28,42-44H2,1-7H3,(H,65,66,68,71)/t55-,57-,58-,62-,79?/m1/s1

Synonyms: N6-Bz-5'-O-DMTr-2'-O-hexadecanyl adenosine 3'-CED phosphoramidite; DMTr-2'-O-C16-rA(Bz)-3'-CE-Phosphoramidite; 2'-O-C16-A(Bz) phosphoramidite; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-hexadecyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

6-Bromohexyl phosphoramidite

Description: 6-Bromohexyl Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It contains a 6-bromohexyl group attached to the phosphoramidite backbone. This modification allows for the introduction of a bromohexyl moiety into the oligonucleotide sequence, facilitating further functionalization or conjugation reactions. This reagent enables the synthesis of modified oligonucleotides with specific chemical properties, suitable for various molecular biology and biotechnology applications, including DNA/RNA labeling, cross-linking, and affinity purification.

CAT: BRP-00513

CAS: 956093-29-1

Molecular Formula: C15H30BrN2O2P

Molecular Weight: 381.29

Purity: ≥95%

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InChIKey: SJNZBRJYEIWFFW-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCBr)OCCC#N

IUPAC Name: 3-[6-bromohexoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C15H30BrN2O2P/c1-14(2)18(15(3)4)21(20-13-9-11-17)19-12-8-6-5-7-10-16/h14-15H,5-10,12-13H2,1-4H3

Synonyms: 5'-Bromohexyl Phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 6-bromohexyl 2-cyanoethyl ester; 6-Bromohexyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; 6-Bromo-hex-1-yl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite

5'-DBCO-TEG Phosphoramidite

Description: 5'-DBCO-TEG Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It contains a dibenzocyclooctyne (DBCO) functional group attached to a triethylene glycol (TEG) linker at the 5'-end of the oligonucleotide sequence. This modification enables bioconjugation through strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry reactions. It facilitates the conjugation of the oligonucleotide to azide-modified molecules or surfaces, allowing for various applications such as labeling, imaging, and bioconjugation studies.

CAT: BRP-00514

CAS: 1527468-08-1

Molecular Formula: C38H53N4O7P

Molecular Weight: 708.83

Purity: ≥95%

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InChIKey: AZZYBGFXRGQDBX-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCOCCNC(=O)CCCCC(=O)N1CC2=CC=CC=C2C#CC3=CC=CC=C31

IUPAC Name: 6-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-N-[2-[2-[2-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethoxy]ethoxy]ethyl]-6-oxohexanamide

InChI: InChI=1S/C38H53N4O7P/c1-31(2)42(32(3)4)50(48-22-11-20-39)49-29-28-47-27-26-46-25-24-45-23-21-40-37(43)16-9-10-17-38(44)41-30-35-14-6-5-12-33(35)18-19-34-13-7-8-15-36(34)41/h5-8,12-15,31-32H,9-11,16-17,21-30H2,1-4H3,(H,40,43)

Synonyms: 10-(6-oxo-6-(dibenzo[b,f]azacyclooct-4-yn-1-yl)-capramido-N-ethyl)-O-triethyleneglycol-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DBCO-PEG3-Phosphoramidite; 2-Cyanoethyl 18-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-13,18-dioxo-3,6,9-trioxa-12-azaoctadec-1-yl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 18-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-13,18-dioxo-3,6,9-trioxa-12-azaoctadec-1-yl ester

Spacer C2 phosphoramidite

Description: Spacer C2 phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a dimethoxytrityl (DMT) group attached to an ethane-diol linker, which in turn is linked to a phosphoramidite backbone. This modification allows for the controlled addition of the oligonucleotide to the growing chain during solid-phase synthesis. The DMT group serves as a protecting group for the nucleotide base, preventing unwanted reactions during synthesis. The ethane-diol linker provides flexibility and accessibility to the nucleotide, facilitating efficient coupling reactions. This reagent enables the synthesis of high-quality oligonucleotides suitable for various molecular biology and biotechnology applications, including PCR, sequencing, and gene editing.

CAT: BRP-00515

CAS: 161029-24-9

Molecular Formula: C32H41N2O5P

Molecular Weight: 564.65

Purity: ≥95% by HPLC

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InChIKey: FPJGNFBQHYIROJ-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC

IUPAC Name: 3-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C32H41N2O5P/c1-25(2)34(26(3)4)40(38-22-10-21-33)39-24-23-37-32(27-11-8-7-9-12-27,28-13-17-30(35-5)18-14-28)29-15-19-31(36-6)20-16-29/h7-9,11-20,25-26H,10,22-24H2,1-6H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl 2-cyanoethyl ester; 2-[Bis(4-methoxyphenyl)phenylmethoxy]ethyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl 2-cyanoethyl ester; Spacer C2 CEP; DMT-ethane-Diol phosphoramidite; C2 Spacer; C2 Spacer phosphoramidite

DDP-Amidite

Description: DDP-Amidite is a specialized reagent used in oligonucleotide synthesis. It features a 1,3-di-O-(4,4'-dimethoxytrityl)-glycerol modification attached to a controlled efficiency (CE) phosphoramidite backbone. This modification provides a coupling site for the addition of nucleotide units during solid-phase synthesis, enabling the controlled construction of oligonucleotide sequences. Overall, this reagent facilitates the efficient and precise synthesis of oligonucleotides with specific chemical properties, suitable for various molecular biology and biotechnology applications.

CAT: BRP-00516

CAS: 125922-95-4

Molecular Formula: C54H61N2O8P

Molecular Weight: 897.04

Purity: ≥95% by HPLC

Appearance: White, off-white to light yellow powder

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InChIKey: ATSHTKCDALIGCV-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(COC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[1,3-bis[bis(4-methoxyphenyl)-phenylmethoxy]propan-2-yloxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C54H61N2O8P/c1-40(2)56(41(3)4)65(63-37-15-36-55)64-52(38-61-53(42-16-11-9-12-17-42,44-20-28-48(57-5)29-21-44)45-22-30-49(58-6)31-23-45)39-62-54(43-18-13-10-14-19-43,46-24-32-50(59-7)33-25-46)47-26-34-51(60-8)35-27-47/h9-14,16-35,40-41,52H,15,37-39H2,1-8H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[bis(4-methoxyphenyl)phenylmethoxy]-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]ethyl 2-cyanoethyl ester; 2-[Bis(4-methoxyphenyl)phenylmethoxy]-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]ethyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-[bis(4-methoxyphenyl)phenylmethoxy]-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]ethyl 2-cyanoethyl ester; Symmetrical branching CED phosphoramidite; 1,3-di-O-DMTr-glycerol-CE-Phosphoramidite; 1,3-di-O-(4,4'-dimethoxytrityl)-glycerol-CE-Phosphoramidite

5'-Trimethoxystilbene Cap Phosphoramidite

Description: 5'-Trimethoxystilbene Cap Phosphoramidite is a reagent used in oligonucleotide synthesis, featuring a trimethoxystilbene cap group at the 5'-end. This modification enhances stability and offers versatility for various molecular biology applications, including nucleic acid detection and drug delivery.

CAT: BRP-00518

CAS: 1000852-27-6

Molecular Formula: C30H42N3O6P

Molecular Weight: 571.65

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InChIKey: MHLTTXDABHJESN-ZHACJKMWNA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OCCCNC(=O)C1=CC=C(C=CC2=CC(OC)=C(OC)C(OC)=C2)C=C1)N(C(C)C)C(C)C

IUPAC Name: (E)-2-cyanoethyl (3-(4-(3,4,5-trimethoxystyryl)benzamido)propyl) diisopropylphosphoramidite

InChI: InChI=1/C30H42N3O6P/c1-22(2)33(23(3)4)40(38-18-8-16-31)39-19-9-17-32-30(34)26-14-12-24(13-15-26)10-11-25-20-27(35-5)29(37-7)28(21-25)36-6/h10-15,20-23H,8-9,17-19H2,1-7H3,(H,32,34)/b11-10+

Synonyms: (3,4,5-trimethoxystilbene-4'-yl)-(3-carboxamidopropyl)-1-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanomethyl 3-[[4-[(1E)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzoyl]amino]propyl ester; 2-Cyanomethyl 3-[[4-[(1E)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzoyl]amino]propyl N,N-bis(1-methylethyl)phosphoramidite

5'-Pyrene Cap Phosphoramidite

Description: 5'-Pyrene Cap Phosphoramidite is a reagent utilized in oligonucleotide synthesis. It contains a pyrene cap group at the 5'-end of the oligonucleotide sequence. This modification provides enhanced stability and fluorescence properties to the oligonucleotide. It is commonly used in applications such as fluorescence labeling, nucleic acid detection, and biomolecular interactions studies.

CAT: BRP-00519

CAS: 1131589-25-7

Molecular Formula: C30H36N3O2P

Molecular Weight: 501.60

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InChIKey: PWRJUVOWYFZWNG-UHFFFAOYSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1CN(CC2=CC=C3C=CC4=CC=CC=5C=CC2=C3C45)CC1)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl (1-(pyren-1-ylmethyl)pyrrolidin-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C30H36N3O2P/c1-21(2)33(22(3)4)36(34-18-6-16-31)35-27-15-17-32(20-27)19-26-12-11-25-10-9-23-7-5-8-24-13-14-28(26)30(25)29(23)24/h5,7-14,21-22,27H,6,15,17-20H2,1-4H3

Synonyms: (N-(1-pyrenylmethyl)-pyrrolidin-3-oxy)-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 1-(1-pyrenylmethyl)-3-pyrrolidinyl ester; 2-Cyanoethyl 1-(1-pyrenylmethyl)-3-pyrrolidinyl N,N-bis(1-methylethyl)phosphoramidite

2'-O-TBDMS-N6-Me-A(Pac)-CE Phosphoramidite

Description: 2'-O-TBDMS-N6-Me-A(Pac)-CE Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It contains a 2'-O-TBDMS (2'-O-tert-butyldimethylsilyl) modification at the 2' position of adenosine (A), along with a Pac group attached to the N6 position of the adenine base. Additionally, it is compatible with controlled efficiency (CE) phosphoramidite chemistry. This modification enhances stability and protects against nuclease degradation. It finds applications in various molecular biology and biotechnology studies, including RNA interference, gene expression modulation, and therapeutic RNA-based treatments.

CAT: BRP-00520

CAS: 2638447-43-3

Molecular Formula: C55H70N7O9PSi

Molecular Weight: 1032.25

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InChIKey: ANPUOZBXSBVTQC-IDZTWDNASA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C2=NC=NC3N(C(=O)COC=4C=CC=CC4)C)C1O[Si](C)(C)C(C)(C)C)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-(N-methyl-2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C55H70N7O9PSi/c1-38(2)62(39(3)4)72(68-33-19-32-56)70-49-46(34-67-55(40-20-15-13-16-21-40,41-24-28-43(64-9)29-25-41)42-26-30-44(65-10)31-27-42)69-53(50(49)71-73(11,12)54(5,6)7)61-37-59-48-51(57-36-58-52(48)61)60(8)47(63)35-66-45-22-17-14-18-23-45/h13-18,20-31,36-39,46,49-50,53H,19,33-35H2,1-12H3/t46-,49-,50-,53-,72?/m1/s1

Synonyms: 5'-Dimethoxytrityl-N-methyl-N-phenoxyacetyl-Adenosine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; N6-Methyl-A-CE Phosphoramidite

Pyrrolo-C-TOM-CE Phosphoramidite

Description: Pyrrolo-C-TOM-CE Phosphoramidite is a specialized reagent employed in oligonucleotide synthesis. It incorporates a pyrrolo-C modification at the cytosine (C) nucleotide, along with a TOM (triacetoxy methyl) group. This modification enhances stability and functionality, making it resistant to nuclease degradation and suitable for various molecular biology applications, including gene expression studies and therapeutic RNA-based treatments. Additionally, its compatibility with controlled-efficiency (CE) phosphoramidite chemistry ensures efficient incorporation during solid-phase synthesis.

CAT: BRP-00521

CAS: 682335-08-6

Molecular Formula: C52H72N5O9PSi

Molecular Weight: 970.23

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InChIKey: XHCOLZDZLVTQGU-NXSKKRKJSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC1=CC2=CN(C(=O)N=C2N1)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCO[Si](C(C)C)(C(C)C)C(C)C

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(6-methyl-2-oxo-7H-pyrrolo[2,3-d]pyrimidin-3-yl)-4-[tri(propan-2-yl)silyloxymethoxy]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C52H72N5O9PSi/c1-34(2)57(35(3)4)67(63-29-17-28-53)66-47-46(32-62-52(41-18-15-14-16-19-41,42-20-24-44(59-12)25-21-42)43-22-26-45(60-13)27-23-43)65-50(56-31-40-30-39(11)54-49(40)55-51(56)58)48(47)61-33-64-68(36(5)6,37(7)8)38(9)10/h14-16,18-27,30-31,34-38,46-48,50H,17,29,32-33H2,1-13H3,(H,54,55,58)/t46-,47-,48-,50-,67?/m1/s1

Synonyms: 5'-Dimethoxytrityl-[6-methyl-pyrrolo-[2,3-d]-pyrimidine-2(3H)-one]-2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 3-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-β-D-ribofuranosyl]-1,3-dihydro-6-methyl-2H-pyrrolo[2,3-d]pyrimidin-2-one

Amino-Modifier C6-U Phosphoramidite

Description: Amino-Modifier C6-U Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It finds applications in various molecular biology and biotechnology studies, including the labeling, immobilization, or modification of oligonucleotides for specific downstream applications such as PCR, sequencing, or hybridization assays.

CAT: BRP-00522

CAS: 2790424-76-7

Molecular Formula: C60H84F3N6O12PSi

Molecular Weight: 1197.40

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InChIKey: IGPFWOVCZNQRKP-ITIMBDNUSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C=CC(=O)NCCCCCCNC(=O)C(F)(F)F)C(=O)NC2=O)C1OCO[Si](C(C)C)(C(C)C)C(C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-5-((E)-3-oxo-3-((6-(2,2,2-trifluoroacetamido)hexyl)amino)prop-1-en-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C60H84F3N6O12PSi/c1-40(2)69(41(3)4)82(78-36-20-33-64)81-53-51(38-77-59(46-21-16-15-17-22-46,47-24-28-49(74-11)29-25-47)48-26-30-50(75-12)31-27-48)80-56(54(53)76-39-79-83(42(5)6,43(7)8)44(9)10)68-37-45(55(71)67-58(68)73)23-32-52(70)65-34-18-13-14-19-35-66-57(72)60(61,62)63/h15-17,21-32,37,40-44,51,53-54,56H,13-14,18-20,34-36,38-39H2,1-12H3,(H,65,70)(H,66,72)(H,67,71,73)/b32-23+/t51-,53-,54-,56-,82?/m1/s1

Synonyms: 5'-Dimethoxytrityl-5-[N-(trifluoroacetylaminohexyl)-3-acrylimido]-Uridine, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-O-TOM Amino-Modifier C6-U Phosphoramidite

4-Thio-U-TOM-CE Phosphoramidite

Description: 4-Thio-U-TOM-CE Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It contains a 4-thio-uridine (4-Thio-U) modification at the uridine (U) nucleotide, along with a TOM (triacetoxy methyl) group, and is compatible with controlled efficiency (CE) phosphoramidite chemistry. This modification introduces a sulfur atom at the 4th position of the uracil base, offering unique chemical properties such as enhanced binding affinity or stability in certain conditions. It finds applications in various molecular biology and biotechnology studies, including nucleic acid labeling, probing, or structural studies.

CAT: BRP-00523

Molecular Formula: C52H72N5O9PSSi

Molecular Weight: 1002.29

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InChIKey: UAWGPBCGWPEEIG-JAPJABEQSA-N

Solubility: Soluble in Anhydrous Acetonitrile

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-((2-cyanoethyl)thio)-2-oxopyrimidin-1(2H)-yl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H72N5O9PSSi/c1-36(2)57(37(3)4)67(63-32-16-29-53)66-48-46(34-62-52(41-18-14-13-15-19-41,42-20-24-44(59-11)25-21-42)43-22-26-45(60-12)27-23-43)65-50(56-31-28-47(55-51(56)58)68-33-17-30-54)49(48)61-35-64-69(38(5)6,39(7)8)40(9)10/h13-15,18-28,31,36-40,46,48-50H,16-17,32-35H2,1-12H3/t46-,48-,49-,50-,67?/m1/s1

Synonyms: 5'-Dimethoxytrityl-4-(2-cyanoethylthio)-Uridine, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

DMTr-2'-O-TOM-N2-MeOAc-N6-iBu-rA-3'-CE-Phosphoramidite

Description: DMTr-2'-O-TOM-N2-MeOAc-N6-iBu-rA-3'-CE-Phosphoramidite is a versatile reagent for oligonucleotide synthesis. It features a 2'-O-trimethylsilyl (TOM) modification at the ribose sugar, N2-methoxyacetyl (N2-MeOAc) and N6-isobutyryl (N6-iBu) modifications at the adenine base, and a controlled-efficiency (CE) phosphoramidite backbone at the 3'-end. This complex modification pattern enhances stability and versatility, making it suitable for various molecular biology applications, including gene expression studies and therapeutic RNA-based treatments.

CAT: BRP-00524

CAS: 872548-56-6

Molecular Formula: C57H81N8O11PSi

Molecular Weight: 1113.38

Purity: ≥98%

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InChIKey: KRQOMVWXZSBIKA-GNYMHLNGSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC(=NC32)NC(=O)COC)NC(=O)C(C)C)C1OCO[Si](C(C)C)(C(C)C)C(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-isobutyramido-2-(2-methoxyacetamido)-9H-purin-9-yl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H81N8O11PSi/c1-36(2)54(67)61-52-49-53(63-56(62-52)60-48(66)33-68-13)64(34-59-49)55-51(71-35-74-78(39(7)8,40(9)10)41(11)12)50(76-77(73-31-19-30-58)65(37(3)4)38(5)6)47(75-55)32-72-57(42-20-17-16-18-21-42,43-22-26-45(69-14)27-23-43)44-24-28-46(70-15)29-25-44/h16-18,20-29,34,36-41,47,50-51,55H,19,31-33,35H2,1-15H3,(H2,60,61,62,63,66,67)/t47-,50-,51-,55-,77?/m1/s1

Synonyms: 5'-Dimethoxytrityl-N6-isobutyryl-N2-methoxyacetyl-2,6-diaminopurine riboside, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-N6-isobutyryl-2-[(methoxyacetyl)amino]-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine 3'-(2-cyanoethyldiisopropylphosphoramidite); Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2-[(methoxyacetyl)amino]-N-(2-methyl-1-oxopropyl)-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2,6-Diaminopurine-TOM-CE Phosphoramidite (2-amino-A)

Thiol-Modifier C3 S-S CE Phosphoramidite

Spacer C6 CE Phosphoramidite

Spermine CE Phosphoramidite

5'-Ferrocene CE Phosphoramidite

rG (iPr-Pac) CE-Phosphoramidite

Quasar 570 Amidite

Long trebler phosphoramidite

5'-Hexynyl CE Phosphoramidite

2'-O-C16-rA(Bz)-Phosphoramidite

6-Bromohexyl phosphoramidite

5'-DBCO-TEG Phosphoramidite

Spacer C2 phosphoramidite

DDP-Amidite

5'-Trimethoxystilbene Cap Phosphoramidite

5'-Pyrene Cap Phosphoramidite

2'-O-TBDMS-N6-Me-A(Pac)-CE Phosphoramidite

Pyrrolo-C-TOM-CE Phosphoramidite

Amino-Modifier C6-U Phosphoramidite

4-Thio-U-TOM-CE Phosphoramidite

DMTr-2'-O-TOM-N2-MeOAc-N6-iBu-rA-3'-CE-Phosphoramidite

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