Phosphoramidites - RNA / BOC Sciences

5'-DBCO-TEG Phosphoramidite

Description: 5'-DBCO-TEG Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It contains a dibenzocyclooctyne (DBCO) functional group attached to a triethylene glycol (TEG) linker at the 5'-end of the oligonucleotide sequence. This modification enables bioconjugation through strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry reactions. It facilitates the conjugation of the oligonucleotide to azide-modified molecules or surfaces, allowing for various applications such as labeling, imaging, and bioconjugation studies.

CAT: BRP-00514

CAS: 1527468-08-1

MF: C38H53N4O7P

MF: 708.83

Purity: ≥95%

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InChIKey: AZZYBGFXRGQDBX-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCOCCNC(=O)CCCCC(=O)N1CC2=CC=CC=C2C#CC3=CC=CC=C31

IUPAC Name: 6-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-N-[2-[2-[2-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethoxy]ethoxy]ethyl]-6-oxohexanamide

InChI: InChI=1S/C38H53N4O7P/c1-31(2)42(32(3)4)50(48-22-11-20-39)49-29-28-47-27-26-46-25-24-45-23-21-40-37(43)16-9-10-17-38(44)41-30-35-14-6-5-12-33(35)18-19-34-13-7-8-15-36(34)41/h5-8,12-15,31-32H,9-11,16-17,21-30H2,1-4H3,(H,40,43)

Synonyms: 10-(6-oxo-6-(dibenzo[b,f]azacyclooct-4-yn-1-yl)-capramido-N-ethyl)-O-triethyleneglycol-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DBCO-PEG3-Phosphoramidite; 2-Cyanoethyl 18-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-13,18-dioxo-3,6,9-trioxa-12-azaoctadec-1-yl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 18-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-13,18-dioxo-3,6,9-trioxa-12-azaoctadec-1-yl ester

Spacer C2 phosphoramidite

Description: Spacer C2 phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It consists of a dimethoxytrityl (DMT) group attached to an ethane-diol linker, which in turn is linked to a phosphoramidite backbone. This modification allows for the controlled addition of the oligonucleotide to the growing chain during solid-phase synthesis. The DMT group serves as a protecting group for the nucleotide base, preventing unwanted reactions during synthesis. The ethane-diol linker provides flexibility and accessibility to the nucleotide, facilitating efficient coupling reactions. This reagent enables the synthesis of high-quality oligonucleotides suitable for various molecular biology and biotechnology applications, including PCR, sequencing, and gene editing.

CAT: BRP-00515

CAS: 161029-24-9

MF: C32H41N2O5P

MF: 564.65

Purity: ≥95% by HPLC

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InChIKey: FPJGNFBQHYIROJ-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC

IUPAC Name: 3-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C32H41N2O5P/c1-25(2)34(26(3)4)40(38-22-10-21-33)39-24-23-37-32(27-11-8-7-9-12-27,28-13-17-30(35-5)18-14-28)29-15-19-31(36-6)20-16-29/h7-9,11-20,25-26H,10,22-24H2,1-6H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl 2-cyanoethyl ester; 2-[Bis(4-methoxyphenyl)phenylmethoxy]ethyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl 2-cyanoethyl ester; Spacer C2 CEP; DMT-ethane-Diol phosphoramidite; C2 Spacer; C2 Spacer phosphoramidite

DDP-Amidite

Description: DDP-Amidite is a specialized reagent used in oligonucleotide synthesis. It features a 1,3-di-O-(4,4'-dimethoxytrityl)-glycerol modification attached to a controlled efficiency (CE) phosphoramidite backbone. This modification provides a coupling site for the addition of nucleotide units during solid-phase synthesis, enabling the controlled construction of oligonucleotide sequences. Overall, this reagent facilitates the efficient and precise synthesis of oligonucleotides with specific chemical properties, suitable for various molecular biology and biotechnology applications.

CAT: BRP-00516

CAS: 125922-95-4

MF: C54H61N2O8P

MF: 897.04

Purity: ≥95% by HPLC

Appearance: White, off-white to light yellow powder

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InChIKey: ATSHTKCDALIGCV-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(COC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[1,3-bis[bis(4-methoxyphenyl)-phenylmethoxy]propan-2-yloxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C54H61N2O8P/c1-40(2)56(41(3)4)65(63-37-15-36-55)64-52(38-61-53(42-16-11-9-12-17-42,44-20-28-48(57-5)29-21-44)45-22-30-49(58-6)31-23-45)39-62-54(43-18-13-10-14-19-43,46-24-32-50(59-7)33-25-46)47-26-34-51(60-8)35-27-47/h9-14,16-35,40-41,52H,15,37-39H2,1-8H3

Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[bis(4-methoxyphenyl)phenylmethoxy]-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]ethyl 2-cyanoethyl ester; 2-[Bis(4-methoxyphenyl)phenylmethoxy]-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]ethyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-[bis(4-methoxyphenyl)phenylmethoxy]-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]ethyl 2-cyanoethyl ester; Symmetrical branching CED phosphoramidite; 1,3-di-O-DMTr-glycerol-CE-Phosphoramidite; 1,3-di-O-(4,4'-dimethoxytrityl)-glycerol-CE-Phosphoramidite

5'-Trimethoxystilbene Cap Phosphoramidite

Description: 5'-Trimethoxystilbene Cap Phosphoramidite is a reagent used in oligonucleotide synthesis, featuring a trimethoxystilbene cap group at the 5'-end. This modification enhances stability and offers versatility for various molecular biology applications, including nucleic acid detection and drug delivery.

CAT: BRP-00518

CAS: 1000852-27-6

MF: C30H42N3O6P

MF: 571.65

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InChIKey: MHLTTXDABHJESN-ZHACJKMWNA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OCCCNC(=O)C1=CC=C(C=CC2=CC(OC)=C(OC)C(OC)=C2)C=C1)N(C(C)C)C(C)C

IUPAC Name: (E)-2-cyanoethyl (3-(4-(3,4,5-trimethoxystyryl)benzamido)propyl) diisopropylphosphoramidite

InChI: InChI=1/C30H42N3O6P/c1-22(2)33(23(3)4)40(38-18-8-16-31)39-19-9-17-32-30(34)26-14-12-24(13-15-26)10-11-25-20-27(35-5)29(37-7)28(21-25)36-6/h10-15,20-23H,8-9,17-19H2,1-7H3,(H,32,34)/b11-10+

Synonyms: (3,4,5-trimethoxystilbene-4'-yl)-(3-carboxamidopropyl)-1-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanomethyl 3-[[4-[(1E)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzoyl]amino]propyl ester; 2-Cyanomethyl 3-[[4-[(1E)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzoyl]amino]propyl N,N-bis(1-methylethyl)phosphoramidite

5'-Pyrene Cap Phosphoramidite

Description: 5'-Pyrene Cap Phosphoramidite is a reagent utilized in oligonucleotide synthesis. It contains a pyrene cap group at the 5'-end of the oligonucleotide sequence. This modification provides enhanced stability and fluorescence properties to the oligonucleotide. It is commonly used in applications such as fluorescence labeling, nucleic acid detection, and biomolecular interactions studies.

CAT: BRP-00519

CAS: 1131589-25-7

MF: C30H36N3O2P

MF: 501.60

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InChIKey: PWRJUVOWYFZWNG-UHFFFAOYSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1CN(CC2=CC=C3C=CC4=CC=CC=5C=CC2=C3C45)CC1)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl (1-(pyren-1-ylmethyl)pyrrolidin-3-yl) diisopropylphosphoramidite

InChI: InChI=1S/C30H36N3O2P/c1-21(2)33(22(3)4)36(34-18-6-16-31)35-27-15-17-32(20-27)19-26-12-11-25-10-9-23-7-5-8-24-13-14-28(26)30(25)29(23)24/h5,7-14,21-22,27H,6,15,17-20H2,1-4H3

Synonyms: (N-(1-pyrenylmethyl)-pyrrolidin-3-oxy)-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 1-(1-pyrenylmethyl)-3-pyrrolidinyl ester; 2-Cyanoethyl 1-(1-pyrenylmethyl)-3-pyrrolidinyl N,N-bis(1-methylethyl)phosphoramidite

2'-O-TBDMS-N6-Me-A(Pac)-CE Phosphoramidite

Description: 2'-O-TBDMS-N6-Me-A(Pac)-CE Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It contains a 2'-O-TBDMS (2'-O-tert-butyldimethylsilyl) modification at the 2' position of adenosine (A), along with a Pac group attached to the N6 position of the adenine base. Additionally, it is compatible with controlled efficiency (CE) phosphoramidite chemistry. This modification enhances stability and protects against nuclease degradation. It finds applications in various molecular biology and biotechnology studies, including RNA interference, gene expression modulation, and therapeutic RNA-based treatments.

CAT: BRP-00520

CAS: 2638447-43-3

MF: C55H70N7O9PSi

MF: 1032.25

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InChIKey: ANPUOZBXSBVTQC-IDZTWDNASA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C2=NC=NC3N(C(=O)COC=4C=CC=CC4)C)C1O[Si](C)(C)C(C)(C)C)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-(N-methyl-2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C55H70N7O9PSi/c1-38(2)62(39(3)4)72(68-33-19-32-56)70-49-46(34-67-55(40-20-15-13-16-21-40,41-24-28-43(64-9)29-25-41)42-26-30-44(65-10)31-27-42)69-53(50(49)71-73(11,12)54(5,6)7)61-37-59-48-51(57-36-58-52(48)61)60(8)47(63)35-66-45-22-17-14-18-23-45/h13-18,20-31,36-39,46,49-50,53H,19,33-35H2,1-12H3/t46-,49-,50-,53-,72?/m1/s1

Synonyms: 5'-Dimethoxytrityl-N-methyl-N-phenoxyacetyl-Adenosine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; N6-Methyl-A-CE Phosphoramidite

Pyrrolo-C-TOM-CE Phosphoramidite

Description: Pyrrolo-C-TOM-CE Phosphoramidite is a specialized reagent employed in oligonucleotide synthesis. It incorporates a pyrrolo-C modification at the cytosine (C) nucleotide, along with a TOM (triacetoxy methyl) group. This modification enhances stability and functionality, making it resistant to nuclease degradation and suitable for various molecular biology applications, including gene expression studies and therapeutic RNA-based treatments. Additionally, its compatibility with controlled-efficiency (CE) phosphoramidite chemistry ensures efficient incorporation during solid-phase synthesis.

CAT: BRP-00521

CAS: 682335-08-6

MF: C52H72N5O9PSi

MF: 970.23

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InChIKey: XHCOLZDZLVTQGU-NXSKKRKJSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC1=CC2=CN(C(=O)N=C2N1)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCO[Si](C(C)C)(C(C)C)C(C)C

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(6-methyl-2-oxo-7H-pyrrolo[2,3-d]pyrimidin-3-yl)-4-[tri(propan-2-yl)silyloxymethoxy]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C52H72N5O9PSi/c1-34(2)57(35(3)4)67(63-29-17-28-53)66-47-46(32-62-52(41-18-15-14-16-19-41,42-20-24-44(59-12)25-21-42)43-22-26-45(60-13)27-23-43)65-50(56-31-40-30-39(11)54-49(40)55-51(56)58)48(47)61-33-64-68(36(5)6,37(7)8)38(9)10/h14-16,18-27,30-31,34-38,46-48,50H,17,29,32-33H2,1-13H3,(H,54,55,58)/t46-,47-,48-,50-,67?/m1/s1

Synonyms: 5'-Dimethoxytrityl-[6-methyl-pyrrolo-[2,3-d]-pyrimidine-2(3H)-one]-2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 3-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-β-D-ribofuranosyl]-1,3-dihydro-6-methyl-2H-pyrrolo[2,3-d]pyrimidin-2-one

Amino-Modifier C6-U Phosphoramidite

Description: Amino-Modifier C6-U Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It finds applications in various molecular biology and biotechnology studies, including the labeling, immobilization, or modification of oligonucleotides for specific downstream applications such as PCR, sequencing, or hybridization assays.

CAT: BRP-00522

CAS: 2790424-76-7

MF: C60H84F3N6O12PSi

MF: 1197.40

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InChIKey: IGPFWOVCZNQRKP-ITIMBDNUSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(C=CC(=O)NCCCCCCNC(=O)C(F)(F)F)C(=O)NC2=O)C1OCO[Si](C(C)C)(C(C)C)C(C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-5-((E)-3-oxo-3-((6-(2,2,2-trifluoroacetamido)hexyl)amino)prop-1-en-1-yl)-3,4-dihydropyrimidin-1(2H)-yl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C60H84F3N6O12PSi/c1-40(2)69(41(3)4)82(78-36-20-33-64)81-53-51(38-77-59(46-21-16-15-17-22-46,47-24-28-49(74-11)29-25-47)48-26-30-50(75-12)31-27-48)80-56(54(53)76-39-79-83(42(5)6,43(7)8)44(9)10)68-37-45(55(71)67-58(68)73)23-32-52(70)65-34-18-13-14-19-35-66-57(72)60(61,62)63/h15-17,21-32,37,40-44,51,53-54,56H,13-14,18-20,34-36,38-39H2,1-12H3,(H,65,70)(H,66,72)(H,67,71,73)/b32-23+/t51-,53-,54-,56-,82?/m1/s1

Synonyms: 5'-Dimethoxytrityl-5-[N-(trifluoroacetylaminohexyl)-3-acrylimido]-Uridine, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-O-TOM Amino-Modifier C6-U Phosphoramidite

4-Thio-U-TOM-CE Phosphoramidite

Description: 4-Thio-U-TOM-CE Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It contains a 4-thio-uridine (4-Thio-U) modification at the uridine (U) nucleotide, along with a TOM (triacetoxy methyl) group, and is compatible with controlled efficiency (CE) phosphoramidite chemistry. This modification introduces a sulfur atom at the 4th position of the uracil base, offering unique chemical properties such as enhanced binding affinity or stability in certain conditions. It finds applications in various molecular biology and biotechnology studies, including nucleic acid labeling, probing, or structural studies.

CAT: BRP-00523

MF: C52H72N5O9PSSi

MF: 1002.29

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InChIKey: UAWGPBCGWPEEIG-JAPJABEQSA-N

Solubility: Soluble in Anhydrous Acetonitrile

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-((2-cyanoethyl)thio)-2-oxopyrimidin-1(2H)-yl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H72N5O9PSSi/c1-36(2)57(37(3)4)67(63-32-16-29-53)66-48-46(34-62-52(41-18-14-13-15-19-41,42-20-24-44(59-11)25-21-42)43-22-26-45(60-12)27-23-43)65-50(56-31-28-47(55-51(56)58)68-33-17-30-54)49(48)61-35-64-69(38(5)6,39(7)8)40(9)10/h13-15,18-28,31,36-40,46,48-50H,16-17,32-35H2,1-12H3/t46-,48-,49-,50-,67?/m1/s1

Synonyms: 5'-Dimethoxytrityl-4-(2-cyanoethylthio)-Uridine, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

DMTr-2'-O-TOM-N2-MeOAc-N6-iBu-rA-3'-CE-Phosphoramidite

Description: DMTr-2'-O-TOM-N2-MeOAc-N6-iBu-rA-3'-CE-Phosphoramidite is a versatile reagent for oligonucleotide synthesis. It features a 2'-O-trimethylsilyl (TOM) modification at the ribose sugar, N2-methoxyacetyl (N2-MeOAc) and N6-isobutyryl (N6-iBu) modifications at the adenine base, and a controlled-efficiency (CE) phosphoramidite backbone at the 3'-end. This complex modification pattern enhances stability and versatility, making it suitable for various molecular biology applications, including gene expression studies and therapeutic RNA-based treatments.

CAT: BRP-00524

CAS: 872548-56-6

MF: C57H81N8O11PSi

MF: 1113.38

Purity: ≥98%

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InChIKey: KRQOMVWXZSBIKA-GNYMHLNGSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=NC(=NC32)NC(=O)COC)NC(=O)C(C)C)C1OCO[Si](C(C)C)(C(C)C)C(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-isobutyramido-2-(2-methoxyacetamido)-9H-purin-9-yl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C57H81N8O11PSi/c1-36(2)54(67)61-52-49-53(63-56(62-52)60-48(66)33-68-13)64(34-59-49)55-51(71-35-74-78(39(7)8,40(9)10)41(11)12)50(76-77(73-31-19-30-58)65(37(3)4)38(5)6)47(75-55)32-72-57(42-20-17-16-18-21-42,43-22-26-45(69-14)27-23-43)44-24-28-46(70-15)29-25-44/h16-18,20-29,34,36-41,47,50-51,55H,19,31-33,35H2,1-15H3,(H2,60,61,62,63,66,67)/t47-,50-,51-,55-,77?/m1/s1

Synonyms: 5'-Dimethoxytrityl-N6-isobutyryl-N2-methoxyacetyl-2,6-diaminopurine riboside, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-N6-isobutyryl-2-[(methoxyacetyl)amino]-2'-O-{[(triisopropylsilyl)oxy]methyl}adenosine 3'-(2-cyanoethyldiisopropylphosphoramidite); Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2-[(methoxyacetyl)amino]-N-(2-methyl-1-oxopropyl)-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2,6-Diaminopurine-TOM-CE Phosphoramidite (2-amino-A)

2'-O-TBDMS-6-Thio-G(iBu)-CE Phosphoramidite

Description: 2'-O-TBDMS-6-Thio-G(iBu)-CE Phosphoramidite is a specialized reagent for oligonucleotide synthesis. It features a 2'-O-TBDMS modification at the ribose sugar, a 6-Thio-G modification at the guanosine base, and an N6-iBu modification at the guanine base, along with a controlled-efficiency phosphoramidite backbone. This modification enhances stability and functionality, suitable for diverse molecular biology applications.

CAT: BRP-00525

MF: C53H71N8O8PSSi

MF: 1039.31

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InChIKey: ASRCEKJIZKGCAT-UFCBNZGASA-N

Solubility: Soluble in Anhydrous Acetonitrile

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(6-((2-cyanoethyl)thio)-2-isobutyramido-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C53H71N8O8PSSi/c1-35(2)48(62)58-51-57-47-44(49(59-51)71-32-18-30-55)56-34-60(47)50-46(69-72(12,13)52(7,8)9)45(68-70(66-31-17-29-54)61(36(3)4)37(5)6)43(67-50)33-65-53(38-19-15-14-16-20-38,39-21-25-41(63-10)26-22-39)40-23-27-42(64-11)28-24-40/h14-16,19-28,34-37,43,45-46,50H,17-18,31-33H2,1-13H3,(H,57,58,59,62)/t43-,45-,46-,50-,70?/m1/s1

Synonyms: 5'-Dimethoxytrityl-N2-isobutyryl-6-(2-cyanoethyl)thio-Guanosine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 6-Thio-G-CE Phosphoramidite

DMTr-2'-O-TBDMS-5-I-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-TBDMS-5-I-rU-3'-CE-Phosphoramidite is a specialized reagent for oligonucleotide synthesis. It consists of a 2'-O-tert-butyldimethylsilyl (TBDMS) modification at the ribose sugar, and a 5-I (5-iodouridine) modification at the uridine base, along with a controlled-efficiency (CE) phosphoramidite backbone at the 3'-end. This modification pattern enhances stability and functionality, making it suitable for various molecular biology applications, including gene expression studies and therapeutic RNA-based treatments.

CAT: BRP-00526

CAS: 1645262-08-3

MF: C45H60N4O9PISi

MF: 986.96

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InChIKey: CRVMASQIWIEOGL-IPXQPGKOSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=C(I)C(=O)NC2=O)C1O[Si](C)(C)C(C)(C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H60IN4O9PSi/c1-30(2)50(31(3)4)60(56-27-15-26-47)58-39-38(57-42(40(39)59-61(10,11)44(5,6)7)49-28-37(46)41(51)48-43(49)52)29-55-45(32-16-13-12-14-17-32,33-18-22-35(53-8)23-19-33)34-20-24-36(54-9)25-21-34/h12-14,16-25,28,30-31,38-40,42H,15,27,29H2,1-11H3,(H,48,51,52)/t38-,39-,40-,42-,60?/m1/s1

Synonyms: 5'-Dimethoxytrityl-5-iodo-2'-Uridine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-iodo-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5-Iodo Uridine CED phosphoramidite; 5-Iodo 2'-TBDMS Uridine 3'-CE phosphoramidite; 5-I-U-CE Phosphoramidite

2'-OMe-N6-Me-A(Pac)-CE Phosphoramidite

Description: 2'-OMe-N6-Me-A(Pac)-CE Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It contains a 2'-O-methyl (2'-OMe) modification at the ribose sugar and an N6-methyladenine (N6-Me-A) modification with a pacidamycin (Pac) protecting group at the adenine base, along with a controlled-efficiency (CE) phosphoramidite backbone. This modification enhances stability and functionality, making it suitable for various molecular biology applications, including gene expression studies and therapeutic RNA-based treatments.

CAT: BRP-00527

CAS: 2690324-66-2

MF: C50H58N7O9P

MF: 357.28

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InChIKey: YHMGZARNHDHAJO-OYGOTZKFSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C2=NC=NC3N(C(=O)COC=4C=CC=CC4)C)C1OC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxy-5-(6-(N-methyl-2-phenoxyacetamido)-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C50H58N7O9P/c1-34(2)57(35(3)4)67(64-29-15-28-51)66-45-42(30-63-50(36-16-11-9-12-17-36,37-20-24-39(59-6)25-21-37)38-22-26-40(60-7)27-23-38)65-49(46(45)61-8)56-33-54-44-47(52-32-53-48(44)56)55(5)43(58)31-62-41-18-13-10-14-19-41/h9-14,16-27,32-35,42,45-46,49H,15,29-31H2,1-8H3/t42-,45-,46-,49-,67?/m1/s1

Synonyms: 5'-Dimethoxytrityl-N-methyl-N-phenoxyacetyl-Adenosine, 2'-O-methyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-OMe-N6-Me-A-CE Phosphoramidite

DMTr-2'-O-Me-N2-iBu-N6-dmf-2-amido-rA-3'-CE-Phosphoramidite

Description: DMTr-2'-O-Me-N2-iBu-N6-dmf-2-amido-rA-3'-CE-Phosphoramidite is a complex reagent used in oligonucleotide synthesis. It consists of a 2'-O-methyl (2'-OMe) modification at the ribose sugar, an N2-isobutyryl (N2-iBu) modification, an N6-dmf-2-amido modification at the adenine base, and a controlled-efficiency (CE) phosphoramidite backbone at the 3'-end. This intricate modification pattern enhances stability and functionality, making it suitable for various molecular biology applications, including gene expression studies and therapeutic RNA-based treatments.

CAT: BRP-00528

MF: C48H62N9O8P

MF: 924.05

Purity: ≥98%

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InChIKey: ZPCPUZIRRVARQL-USWYRWCRSA-N

Solubility: Soluble in Anhydrous Acetonitrile

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(6-(((dimethylamino)methylene)amino)-2-isobutyramido-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H62N9O8P/c1-31(2)45(58)54-47-52-43(51-29-55(7)8)40-44(53-47)56(30-50-40)46-42(61-11)41(65-66(63-27-15-26-49)57(32(3)4)33(5)6)39(64-46)28-62-48(34-16-13-12-14-17-34,35-18-22-37(59-9)23-19-35)36-20-24-38(60-10)25-21-36/h12-14,16-25,29-33,39,41-42,46H,15,27-28H2,1-11H3,(H,52,53,54,58)/t39-,41-,42-,46-,66?/m1/s1

Synonyms: 5'-Dimethoxytrityl-N2-isobutyryl-N6-dimethylaminomethylidene-2'-O-methyl-2,6-diaminopurineriboside, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-OMe-2,6-Diaminopurine-CE Phosphoramidite; 2'-O-Me-N2-iBu-2-amido-A(dmf)-3'-CE-Phosphoramidite

2'-OMe-5-Br-U-CE Phosphoramidite

Description: 2'-OMe-5-Br-U-CE Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It features a 2'-O-methyl (2'-OMe) modification at the ribose sugar and a 5-bromouridine (5-Br-U) modification, along with a controlled-efficiency (CE) phosphoramidite backbone. This modification pattern enhances stability and functionality, making it suitable for various molecular biology applications, including nucleic acid labeling, structural studies, and therapeutic RNA-based treatments.

CAT: BRP-00529

CAS: 1391914-08-1

MF: C40H48BrN4O9P

MF: 839.72

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InChIKey: HHIAUEWHGOYPNO-NITXCQAWSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=C(C(=O)NC2=O)Br)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-bromo-2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H48BrN4O9P/c1-26(2)45(27(3)4)55(52-23-11-22-42)54-35-34(53-38(36(35)50-7)44-24-33(41)37(46)43-39(44)47)25-51-40(28-12-9-8-10-13-28,29-14-18-31(48-5)19-15-29)30-16-20-32(49-6)21-17-30/h8-10,12-21,24,26-27,34-36,38H,11,23,25H2,1-7H3,(H,43,46,47)/t34-,35-,36-,38-,55?/m1/s1

Synonyms: 5'-Dimethoxytrityl-5-bromo-Uridine, 2'-O-methyl, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-bromo-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-OMe 5-Br-U amidite; 5-Bromo Uridine 2'-O-Methyl CED Phosphoramidite

N6-Chloroacetyl-5'-O-DMT-N1-methyl-2'-O-TBDMS-adenosine 3'-CED phosphoramidite

Description: N6-Chloroacetyl-5'-O-DMT-N1-methyl-2'-O-TBDMS-adenosine 3'-CED phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It comprises several modifications, including a chloroacetyl group at the N6 position, a dimethoxytrityl (DMT) protecting group at the 5'-end, a methyl group at the N1 position, a 2'-O-tert-butyldimethylsilyl (TBDMS) modification at the ribose sugar, and a controlled-efficiency (CED) phosphoramidite backbone at the 3'-end. This complex modification pattern enhances stability and functionality, making it suitable for various molecular biology applications, including gene expression studies and therapeutic RNA-based treatments.

CAT: BRP-00530

CAS: 434329-10-9

MF: C48H63ClN7O7PSi

MF: 944.57

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InChIKey: XICJHXGQSVCKJN-MHHUEEDASA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC3=C2N=CN(C3=NC(=O)CCl)C)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C=5C=CC=CC5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(6-((2-chloroacetyl)imino)-1-methyl-1,6-dihydro-9H-purin-9-yl)-2-(((4-methoxyphenyl)diphenylmethoxy)methyl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C48H63ClN7O7PSi/c1-33(2)56(34(3)4)64(60-28-18-27-50)62-42-39(30-59-48(35-19-14-12-15-20-35,36-21-16-13-17-22-36)37-23-25-38(58-9)26-24-37)61-46(43(42)63-65(10,11)47(5,6)7)55-32-51-41-44(55)52-31-54(8)45(41)53-40(57)29-49/h12-17,19-26,31-34,39,42-43,46H,18,28-30H2,1-11H3/t39-,42-,43-,46-,64?/m1/s1

Synonyms: 5'-Monomethoxytrityl-N6-chloroacetyl-1-methyl-Adenosine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 1-Me-A-CE Phosphoramidite

2'-OMe-PAC-A Phosphoramidite

Description: 2'-OMe-PAC-A Phosphoramidite is a specialized reagent utilized in oligonucleotide synthesis. It features a 2'-O-methyl (2'-OMe) modification at the ribose sugar and a phenoxyacetyl (PAC) group attached to the adenine (A) nucleotide. This modification enhances stability and functionality, making it suitable for various molecular biology applications, including gene expression studies and therapeutic RNA-based treatments.

CAT: BRP-00531

CAS: 128219-82-9

MF: C49H56N7O9P

MF: 917.98

Appearance: Off-white solid

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InChIKey: LHJMWCPLFQEOGK-JLZYTDEISA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=NC3=C(N=CN=C32)NC(=O)COC4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]purin-6-yl]-2-phenoxyacetamide

InChI: InChI=1S/C49H56N7O9P/c1-33(2)56(34(3)4)66(63-28-14-27-50)65-44-41(29-62-49(35-15-10-8-11-16-35,36-19-23-38(58-5)24-20-36)37-21-25-39(59-6)26-22-37)64-48(45(44)60-7)55-32-53-43-46(51-31-52-47(43)55)54-42(57)30-61-40-17-12-9-13-18-40/h8-13,15-26,31-34,41,44-45,48H,14,28-30H2,1-7H3,(H,51,52,54,57)/t41-,44-,45-,48-,66?/m1/s1

Synonyms: 2'-OMe-Pac-A-CE Phosphoramidite; 5'-Dimethoxytrityl-N-phenoxyacetyl-Adenosine, 2'-O-methyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-phenoxyacetyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(phenoxyacetyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-OMe A(pac) amidite; 2'-O-Methyl Adenosine (n-PAC) CED phosphoramidite; 5'-O-DMTr-2'-O-Methyl-A(Pac)-3'-CE-Phosphoramidite

Related CAS: 145520-30-5 (Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(phenoxyacetyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite], (R)-)

2'-OMe-iPr-Pac-G-CE Phosphoramidite

Description: 2'-OMe-iPr-Pac-G-CE Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It features a 2'-O-methyl (2'-OMe) modification at the ribose sugar and an isopropyl-phenoxyacetyl (iPr-Pac) group attached to the guanine (G) nucleotide. This modification enhances stability and functionality, making it suitable for various molecular biology applications, including gene expression studies and therapeutic RNA-based treatments.

CAT: BRP-00532

CAS: 1402072-31-4

MF: C52H62N7O10P

MF: 976.06

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InChIKey: UIKNYIJYDVFQJH-NTWXHQQMSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC1C(OC(N2C=NC=3C(=O)N=C(NC(=O)COC4=CC=C(C=C4)C(C)C)NC32)C1OC)COC(C=5C=CC=CC5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(2-(4-isopropylphenoxy)acetamido)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C52H62N7O10P/c1-33(2)36-16-22-42(23-17-36)65-31-44(60)55-51-56-48-45(49(61)57-51)54-32-58(48)50-47(64-9)46(69-70(67-29-13-28-53)59(34(3)4)35(5)6)43(68-50)30-66-52(37-14-11-10-12-15-37,38-18-24-40(62-7)25-19-38)39-20-26-41(63-8)27-21-39/h10-12,14-27,32-35,43,46-47,50H,13,29-31H2,1-9H3,(H2,55,56,57,60,61)/t43-,46-,47-,50-,70?/m1/s1

Synonyms: 2'-OMe G(iPr-pac) amidite; 2'-OMe-Pac-G-CE Phosphoramidite; 5'-Dimethoxytrityl-N2-isopropylphenoxyacetyl-Guanosine, 2'-O-methyl, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-[2-[4-(1-methylethyl)phenoxy]acetyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

5'-Amino-Modifier TEG CE-Phosphoramidite

Description: 5'-Amino-Modifier TEG CE-Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It contains a 5'-amino modifier with a triethylene glycol (TEG) spacer attached to a controlled efficiency (CE) phosphoramidite backbone. This modification introduces an amino group to the oligonucleotide, which can be used for further conjugation or labeling reactions. The TEG spacer enhances solubility and flexibility of the oligonucleotide. This reagent is commonly used in various molecular biology applications, including nucleic acid labeling, crosslinking, and immobilization.

CAT: BRP-00534

CAS: 1384068-23-8

MF: C19H35F3N3O6P

MF: 489.47

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InChIKey: NFIAUYHOGRWWBX-UHFFFAOYSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCOCCNC(=O)C(F)(F)F

IUPAC Name: N-[2-[2-[2-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethoxy]ethoxy]ethyl]-2,2,2-trifluoroacetamide

InChI: InChI=1S/C19H35F3N3O6P/c1-16(2)25(17(3)4)32(30-8-5-6-23)31-15-14-29-13-12-28-11-10-27-9-7-24-18(26)19(20,21)22/h16-17H,5,7-15H2,1-4H3,(H,24,26)

Synonyms: 10-(O-trifluoroacetamido-N-ethyl)-triethyleneglycol-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 14,14,14-trifluoro-13-oxo-3,6,9-trioxa-12-azatetradec-1-yl ester; 2-Cyanoethyl 14,14,14-trifluoro-13-oxo-3,6,9-trioxa-12-azatetradec-1-yl N,N-bis(1-methylethyl)phosphoramidite

Symmetric Doubler Phosphoramidite

Description: Symmetric Doubler Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce symmetrical modifications into nucleic acid sequences. This modification pattern allows for precise control over the modification on both strands of the DNA or RNA duplex, ensuring symmetry and uniformity in the synthesized oligonucleotide. The Symmetric Doubler Phosphoramidite enables researchers to create nucleic acid sequences with specific structural or functional properties, making it valuable for various molecular biology and biotechnology applications.

CAT: BRP-00535

CAS: 250224-60-3

MF: C64H79N4O10P

MF: 1095.31

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InChIKey: HJCSVNFLCSBVEM-UHFFFAOYSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(CNC(=O)CCCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)CNC(=O)CCCCOC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 5-[bis(4-methoxyphenyl)-phenylmethoxy]-N-[3-[5-[bis(4-methoxyphenyl)-phenylmethoxy]pentanoylamino]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropyl]pentanamide

InChI: InChI=1S/C64H79N4O10P/c1-48(2)68(49(3)4)79(77-45-19-42-65)78-60(46-66-61(69)24-15-17-43-75-63(50-20-11-9-12-21-50,52-26-34-56(71-5)35-27-52)53-28-36-57(72-6)37-29-53)47-67-62(70)25-16-18-44-76-64(51-22-13-10-14-23-51,54-30-38-58(73-7)39-31-54)55-32-40-59(74-8)41-33-55/h9-14,20-23,26-41,48-49,60H,15-19,24-25,43-47H2,1-8H3,(H,66,69)(H,67,70)

Synonyms: 1,3-bis-[5-(4,4'-dimethoxytrityloxy)pentylamido]propyl-2-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-[[5-[bis(4-methoxyphenyl)phenylmethoxy]-1-oxopentyl]amino]-1-[[[5-[bis(4-methoxyphenyl)phenylmethoxy]-1-oxopentyl]amino]methyl]ethyl 2-cyanoethyl ester; Doubler phosphoramidite