Homing Peptide-Oligonucleotide Conjugation

BOC Sciences aims at powering drug delivery through bioconjugation. Relying on our comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with homing peptides. We have the capability and confidence to meet your needs for any customized conjugates.

What is Homing Peptide-Oligonucleotide Conjugation?

• Overview of Homing Peptide

Homing peptides are short peptide sequences with natural tissue or organ specificity that selectively bind to receptors, proteins or other molecular targets expressed or present in a specific tissue or organ. Homing peptides are available from a variety of sources, including phage display libraries, combinatorial peptide libraries, or naturally occurring peptides. Peptides that exhibit preferential binding or accumulation in specific tissues or organs generally need to be obtained through an iterative screening process.

Figure 1. Schematic diagram of a tumor homing peptide.(Jinqiang, W; et al, 2019)

• Application of Homing Peptide-Oligonucleotide Conjugation

Homing peptide-oligonucleotide conjugation has a wide range of applications and clear advantages in biomedical research. They primarily act as targeted drug delivery systems or tissue-specific imaging agents, thus enabling selective delivery of therapeutic agents or imaging probes to specific tissues or organs. The presence of homing peptides can improve therapeutic efficacy and specificity by minimizing off-target effects and improving drug accumulation at the desired site.

Introduction of Homing Peptide-Oligonucleotide Conjugation Services

• What Are Our Homing Peptide-Oligonucleotide Conjugation Services?

1. Oligonucleotide Synthesis & Modification: BOC Sciences offers custom oligonucleotide synthesis and modification services while you only need to request the sequence.

2. Selection of Suitable Conjugated Homing Peptides : BOC Sciences provides options including the following homing peptides.

• RGD (Arg-Gly-Asp) peptides are extracellular matrix proteins that bind specifically to integrin receptors, which are overexpressed in various types of cancer cells.
• NGR (Asn-Gly-Arg) peptide is selective for aminopeptidase N(CD13), which is highly expressed in tumor vessels and certain tumor cells.
• Internalized RGD (iRGD) is a brain-penetrating peptide with the ability to cross the blood-brain barrier (BBB) and deliver therapeutic agents to the brain.
• Bone targeting peptides specifically target bone tissue with the ability to deliver therapeutic agents to bone tissue to promote bone tissue regeneration.
• Lymphatic targeting peptides bind exclusively to lymphatic vessels and play a key role in the immune response.

3. Conjugation Method Selection: BOC Sciences will advise you on the appropriate conjugation strategy for your needs.

4. Conjugation Purification & Identification: BOC Sciences has optimized purification and evaluation methods to ensure the quality of the conjugates.

Figure 2. Service flow of homing peptide-oligonucleotide conjugation.

• Why Choose Our Homing Peptide-Oligonucleotide Conjugation Services?

1. BOC Sciences has extensive experience and know-how in peptide synthesis, oligonucleotide synthesis, chemical modification, purification and preparation.
2. BOC Sciences provides customized design services according to customer needs and experimental purposes to ensure the best experimental results.
3. BOC Sciences uses top-end raw materials with optimal reaction conditions and purification steps to ensure high purity and stability of the products.
4. BOC Sciences not only offers reasonable and competitive pricing to customers, but also guarantees high quality services and products.

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Homing Peptide-Oligonucleotide Conjugation

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