BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with glycomimetics. We have the capability and confidence to meet your needs for novel conjugates.
Glycomimetics are synthetic molecules that mimic the structure and function of carbohydrates. The combination of glycomimetics with oligonucleotides allows the combination of their respective properties, thus enabling the development of hybrid molecules with both the targeting ability of glycomimetics and the gene regulation or gene silencing properties of oligonucleotides.
Figure 1. Examples of glycomimetics.(Tamburrini, A; et al, 2019)
Achieving glycomimetic-oligonucleotide binding involves a series of chemical reactions and strategies to covalently link the glycomimetic molecule to the oligonucleotide. The specific methods used to prepare sugar mimics and oligonucleotides can vary depending on the desired application and the chemistry of the molecules involved. There are a number of binding strategies that can be employed, including reactive ester or acid-base reactions, click chemistry, peptide coupling, and solid-phase synthesis to obtain the desired sugar mimetic-oligonucleotide conjugates.
Glycomimetic-oligonucleotide conjugation has a wide range of applications in biotechnology and medicine, such as targeted gene modulation, drug delivery systems, vaccine development, immunotherapy, diagnostic tools, biomaterials and tissue engineering scaffolds. The development and optimization of specific coupling strategies and applications are currently a hot research area.
| Service | Glycomimetic-Oligonucleotide Conjugation |
| Customer provides | Oligonucleotide sequence |
| Purification | QC analysis by MS, HPLC, or PAGE |
| Delivery | Typical delivery is lyophilized samples in individual vials that are fully labeled |
| Request a Quote | Inquiry |
Figure 2. Service flow of glycomimetic-oligonucleotide conjugation.
Glycomimetics mimic carbohydrates and can be conjugated to oligonucleotides to enable targeted gene regulation. This combination enhances both targeting ability and gene modulation.
Conjugates are made by chemically linking glycomimetics to oligonucleotides using methods like ester reactions or click chemistry. The approach depends on the specific application and molecule properties.
These conjugates are used in gene modulation, targeted drug delivery, vaccine development, and diagnostic tools. They enable precise targeting of cells or tissues for various biotechnological applications.
Common glycomimetics mimic sugars like sialic acid, mannose, or fucose. The choice depends on the receptor target and desired biological activity.
Yes, BOC Sciences offers custom conjugation based on your oligonucleotide sequence and glycomimetic selection. We tailor the conjugates to your specific research needs.
We use HPLC, mass spectrometry, and PAGE to ensure high purity. These methods guarantee the quality of the conjugates for your research applications.
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