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Antibody is an important tool in drug delivery as its high specificity and affinity to antigen. In the past, there are already many antibody drugs approved. Based on antibody, antibody-drug conjugate (ADC) is one of the strategies for drug delivery. The technology of ADC is mature now, with seven approved ADCs on the market, researchers are inspired and have already developed the antibody-based delivery technology by conjugating antibody for siRNA delivery.
Figure 1. Antibody 3D illustration
Mechanistically, antibody-siRNA conjugates (ARCs) exert their activity by
The main advantage of ARCs is high ligand binding efficiency and prolonged presence in blood due to high molecular weight (~150 kDa). However, the development of ARC is still at the early stage. Though the design principle of ARC is somewhat the same with ADC, there are still some challenges for ARC:
Thus, further optimization, including the use of humanized antibodies or Fab fragments, endosomolytic agents, and chemically-modified siRNAs, are potential strategies for the use of ARCs in the clinic.
We provide antibody-siRNA conjugates with high quality. We can design and synthesis the siRNA based on the target gene, and our parent company BOC Sciences can provide high quality antibodies, we can conjugate them to form antibody-siRNA conjugates.
Ref:
Global Supplier of High-Quality RNA / DNA Products & Services.
