mRNA vaccines represent a promising alternative to conventional vaccines. Due to its strong development potential, low-cost manufacturing and safety management capabilities, it is developing rapidly. With the advanced technology platform and years of experience in the field of RNA drug development and delivery, BOC RNA provides professional support in the design, production, and evaluation of mRNA vaccines.
mRNA, or messenger RNA, messenger ribonucleic acid, developed based on DNA. mRNA uses the gene in the cell as a template, and after being transcribed and generated according to the principle of complementary base pairing, it contains base sequences corresponding to certain functional fragments in DNA molecules, which can be used as a direct template for protein biosynthesis. mRNA accounts for only 2% to 5% of total RNA, but is diverse, very actively metabolized and has an extremely short half-life, even being broken down within minutes of synthesis.
We can design and synthezise mRNA sequences from DNA templates and produce lab-scale or GMP-grade mRNA vaccines for your applications from research to clinical trials.
We can customize and synthesize nucleic acid sequences with a wide range of modifications for a variety of different antigens from micrograms to milligrams. mRNA can be generated from DNA templates supplied by our customers or synthesized from scratch. Please contact us if you have special requirements.
We are experts in the field of in vivo delivery of nucleic acid drugs. With our established drug delivery technology platform, we can provide the best mRNA vaccine delivery service for your needs.
| Nano-Delivery Systems | Description |
| Lipid nanoparticles (LNPs) | Lipid nanoparticles (LNP) are nanoparticles formed using lipids and structured as vesicles consisting of phospholipid bilayers. By loading nucleic acid drugs into LNPs, the encapsulated nucleic acid drugs are protected from degradation and clearance and their transport across the cell membrane to the target site is facilitated. |
| Liposomes | We offer liposome-based mRNA delivery solutions ranging from customized liposome production and characterization to applications. We can support the encapsulation of mRNA into liposomes to ensure safe and effective delivery. Cationic liposome formulations have been shown to greatly facilitate the functional delivery of negatively charged nucleic acids to cells. |
| Polymer complexes | Polymeric materials (including PEGs, polyamines, dendrimers and copolymers) are functional materials capable of delivering mRNA vaccines, protecting RNA from RNase-mediated degradation and facilitating intracellular delivery. mRNA-polymer coupling services are available on a custom basis from BOC RNA. We also support the polymerization of various types of materials and various modifications (incorporation of lipid chains, hyperbranched groups, biodegradable subunits, etc.). |
| Cationic polypeptides | Cationic polypeptides are positively charged peptides that can interact with negatively charged nucleic acids, facilitating their applications as delivery vehicles in mRNA vaccine development. |
Global Supplier of High-Quality RNA / DNA Products & Services.
