mRNA vaccines represent a promising alternative to conventional vaccines. Due to its strong development potential, low-cost manufacturing and safety management capabilities, it is developing rapidly. With the advanced technology platform and years of experience in the field of RNA drug development and delivery, BOC RNA provides professional support in the design, production, and evaluation of mRNA vaccines.
Competitive Advantages:
From mRNA design & synthesis, in vivo delivery solution, to mRNA vaccine production.
Scientists and employees with more than 15 years of experience in oligonucleotide synthesis and drug delivery.
Competitive price and excellent value for money.
- High quality raw materials
- Free design
- Strict QA and QC
- Advanced analytical equipments
- Professional technical support
- 1 on 1 customer service
- Fast delivery
Services
We can design and synthesis the mRNA sequence from a DNA template, and produce mRNA vaccines in laboratory scales or GMP grade to match your applications from research to clinical trial.
We can customize and synthesize nucleic acid sequences with a variety of modifications, which are applicable to a variety of different antigens, ranging from micrograms to milligrams. mRNA can be generated from the DNA template provided by our customers, or synthesized from scratch. If you have special requirements, please contact us.
- mRNA vaccine delivery technology solution
We are experts in the field of nucleic acid drugs in vivo delivery. With the aid of the established drug delivery technology platform, we can provide the best mRNA vaccine delivery service according to your needs.
We provide liposome-based mRNA delivery solutions ranging from custom liposome production, characterization to application. We can support the encapsulation of mRNA into liposomes and ensure the safety and effectiveness of delivery. It has been demonstrated that cationic liposome formulations greatly promote the functional delivery of negatively charged nucleic acids to cells.
Protamine is a cationic peptide used in many early studies to deliver mRNA vaccines. Our scientists can help couple the target mRNA sequence to protamine to help achieve the efficient delivery of mRNA vaccines.
Polymeric materials (including PEG, polyamines, dendrimers, and copolymers) are functional materials capable of delivering mRNA vaccine, protecting RNA from RNase-mediated degradation, and promoting intracellular delivery. BOC RNA provides customized mRNA-polymer conjugate services. We also support various types of material polymerization and various modifications (incorporation of lipid chains, hyperbranched groups, and biodegradable subunits, etc.).
Advantages of mRNA drugs
- Low risk of gene mutation
- Easy to design
- Faster and cheaper to produce
- Can express multi kinds of proteins at a time
- Broad applications
The mechanism of mRNA
- Protein replacement therapy\
The mRNA encoding a specific protein is delivered to the body, and it replaces a protein in patients in whom that particular protein is deficient or absent.
The mRNA encoding a disease specific antigen is delivered to the body, the protein is synthesized and the antigen is expressed by the antigen-presenting cell, the antigen is recognized by the immune system, thus realizing the prevention and treatment of the disease.
The advantages of mRNA vaccines compared to protein replacement therapy
- Relatively low protein expression.
- Immune response of mRNA is beneficial for the effects of vaccines.
- Antigen-presenting cells are naturally good at absorbing molecules, which is beneficial for absorbing drugs.
We are committed to providing customers with the most reliable and effective research services to meet your research goals. Want to know more? Please feel free to contact us.
