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mRNA vaccines represent a promising alternative to conventional vaccines. Due to its strong development potential, low-cost manufacturing and safety management capabilities, it is developing rapidly. With the advanced technology platform and years of experience in the field of RNA drug development and delivery, BOC RNA provides professional support in the design, production, and evaluation of mRNA vaccines.
What are mRNA Drugs?
Definition of mRNA
mRNA, or messenger RNA, messenger ribonucleic acid, developed based on DNA. mRNA uses the gene in the cell as a template, and after being transcribed and generated according to the principle of complementary base pairing, it contains base sequences corresponding to certain functional fragments in DNA molecules, which can be used as a direct template for protein biosynthesis. mRNA accounts for only 2% to 5% of total RNA, but is diverse, very actively metabolized and has an extremely short half-life, even being broken down within minutes of synthesis.
Mechanism of mRNA
- Protein replacement therapy - The mRNA, which encodes a specific protein, is delivered to the body and replaces that protein in patients who are deficient or absent of the particular protein.
- mRNA vaccines - The mRNA, which encodes the disease-specific antigen, is delivered to the body, and the protein is synthesized by the antigen-presenting cell and the antigen is expressed, and the antigen is recognized by the immune system, thereby realizing the prevention and treatment of the disease.
Advantages of mRNA
- According to the central dogma, mRNA is synthesized by in vitro transcription, which is relatively simple, and mRNA can theoretically express any protein and has the potential to treat many diseases.
- As the core of genetics, DNA can only be transcribed into mRNA when it enters the nucleus. However, mRNA can initiate protein translation in the cytoplasm without entering the nucleus, and its efficiency is much higher than that of DNA.
- mRNA will not be inserted into the genome to affect genetic information like DNA and viral vectors. The mRNA-encoded protein will only be expressed instantaneously and then degraded soon. There is no risk of gene integration and high safety.
- Compared with proteins and viruses, mRNA can quickly translate the required protein in the cell, and the effect is faster. Moreover, the production is simple, the cost is low, and industrial production is easy.
Advantages of mRNA Drugs
- Low risk of genetic mutations
- Easy to design
- Faster and cheaper production
- Multiple proteins can be expressed simultaneously
- Wide range of applications
Advantages of mRNA Vaccines Over Protein Replacement Therapies
- Relatively low protein expression
- Immune response to mRNA favors vaccine efficacy
- Antigen-presenting cells are naturally good at absorbing molecules, which is conducive to the absorption of drugs
BOC Sciences' Custom mRNA Synthesis Service
We can design and synthezise mRNA sequences from DNA templates and produce lab-scale or GMP-grade mRNA vaccines for your applications from research to clinical trials.
We can customize and synthesize nucleic acid sequences with a wide range of modifications for a variety of different antigens from micrograms to milligrams. mRNA can be generated from DNA templates supplied by our customers or synthesized from scratch. Please contact us if you have special requirements.
mRNA vaccine delivery technology solutions
We are experts in the field of in vivo delivery of nucleic acid drugs. With our established drug delivery technology platform, we can provide the best mRNA vaccine delivery service for your needs.
| Nano-Delivery Systems | Description |
| Lipid nanoparticles (LNPs) | Lipid nanoparticles (LNP) are nanoparticles formed using lipids and structured as vesicles consisting of phospholipid bilayers. By loading nucleic acid drugs into LNPs, the encapsulated nucleic acid drugs are protected from degradation and clearance and their transport across the cell membrane to the target site is facilitated. |
| Liposomes | We offer liposome-based mRNA delivery solutions ranging from customized liposome production and characterization to applications. We can support the encapsulation of mRNA into liposomes to ensure safe and effective delivery. Cationic liposome formulations have been shown to greatly facilitate the functional delivery of negatively charged nucleic acids to cells. |
| Polymer complexes | Polymeric materials (including PEGs, polyamines, dendrimers and copolymers) are functional materials capable of delivering mRNA vaccines, protecting RNA from RNase-mediated degradation and facilitating intracellular delivery. mRNA-polymer coupling services are available on a custom basis from BOC RNA. We also support the polymerization of various types of materials and various modifications (incorporation of lipid chains, hyperbranched groups, biodegradable subunits, etc.). |
| Cationic polypeptides | Cationic polypeptides are positively charged peptides that can interact with negatively charged nucleic acids, facilitating their applications as delivery vehicles in mRNA vaccine development. |
Production of mRNA vaccines at laboratory scale or GMP level
BOC Sciences' Competitive Advantages
- From mRNA design and synthesis, in vivo delivery solutions to mRNA vaccine production
- Scientists and staff with over 15 years of experience in oligonucleotide synthesis and drug delivery
- Competitive pricing and excellent value for money
- High quality raw materials
- Strict QA and QC
- State-of-the-art analytical equipment
- Professional technical support
- 1-to-1 customer service
- Fast delivery
* Only for research. Not suitable for any diagnostic or therapeutic use.
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GMP Oligonucleotide Manufacturing Service
For more than 15 years, BOC Sciences has been manufacturing oligonucleotides for pre-clinical, pharmaceutical, food safety, and animal health industries. We provide customized and flexible oligonucleotide GMP or non-GMP production services to meet different production needs.
Lipid Nanoparticle(LNP) for RNA Delivery
BOC Sciences offers comprehensive LNP- mRNA delivery services tailored to meet the specific needs of mRNA vaccine development. Our expertise in nanoparticle formulation and mRNA chemistry enables us to design custom LNP formulations optimized for stability, efficacy, and safety.
BOC Sciences promises to offer you with GalNAc-siRNA conjugation services to help you conduct further research on GalNAc-siRNA conjugates and explore their mores omnics capabilities, the working mechanism as well as their potential therapeutic profiles.
BOC Sciences offers aptamer customization services to generate high-quality aptamers tailored to your goals, delivering excellent results even for the most difficult target molecules.
Peptide-Oligonucleotide Conjugation
BOC Sciences is committed to providing our customers with comprehensive modification and labeling, offering affordable custom oligonucleotides or peptide-oligonucleotide conjugates.
