Custom Morpholino Oligo

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Based on our wide range of synthetic reagents and expertise in oligonucleotide characterization, BOC Sciences offers chemically synthesized and modified antisense oligonucleotides (ASOs) on different scales. All customized morpholino oligos we offer are produced under strict quality control standards to ensure 100% sequence identification.

What is Morpholino Oligo?

Morpholino oligo, also known as phosphorodiamidate morpholino oligo (PMO), is a short, single-stranded DNA analog containing a morpholine ring and a phosphorodiamidate backbone that replaces the 2'-deoxyribonucleoside and phosphate bonds of canonical DNA, respectively. Morpholino substitutions are six-membered rings that provide increased conformational rigidity when doped into the backbone of an oligonucleotide. Morpholino oligo has been extensively investigated as a potential spatial blocker for the treatment of a variety of hereditary disorders in oligonucleotide therapy due to its specificity, solubility, low toxicity, stability, and high efficiency.

Assembly of a Morpholino oligo containing the 5-amineFig.1 Assembly of a Morpholino oligo containing the 5'-amine. (Moulton et al., 2017)

Mechanism of Action of Morpholino Oligo

When morpholino oligo specifically binds to the target site of its choice, it can block the binding of other cellular components to the target site, thus blocking the shearing of mRNA, and thus affecting the translation of proteins.

BOC Sciences' Morpholino Oligo Synthesis Services

BOC Sciences provides custom synthesis and chemical modification services for morpholino oligo to meet customers' needs for different sizes of morpholino oligo and also provides product optimization services.

Applications of Morpholino Oligo

Reference

  1. Moulton H M, et al. Morpholino oligomers[M]. Springer Science+ Business Media LLC, 2017.
* Only for research. Not suitable for any diagnostic or therapeutic use.
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