BOC Sciences is always focusing on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides customisable conjugation services to combine oligonucleotides with quantum dots. We have the capability and confidence to meet your needs for novel conjugates.
Attaching or linking oligonucleotides to quantum dots can form quantum dot-oligonucleotide conjugations. Quantum dots are semiconductor nanocrystals with unique optical and electronic properties that have a wide range of applications in bioimaging and sensing. The introduction of quantum dots into oligonucleotides allows them to be used for a wide range of biological imaging and sensing applications by providing both specific recognition of nucleic acids and the unique optical properties of quantum dots.
Figure 1. Conformational models for dsDNA on the surface of an MAA-capped QD. (Algar, W; et al, 2006)
The conjugation of oligonucleotides to quantum dots can be achieved by a variety of methods, allowing different surface functionalisations of quantum dots or oligonucleotides depending on your needs, and finally by covalent linking to obtain different quantum dot-oligonucleotide conjugations.
Quantum dot-oligonucleotide conjugations can be used as fluorescent probes in FISH assays, specifically binding to complementary DNA or RNA sequences in cells or tissues, allowing the visualisation and localisation of specific genetic material. The bright and stable fluorescence of quantum dots enhances the sensitivity and accuracy of FISH analysis.
Quantum dot-oligonucleotide conjugations can be applied to nucleic acid detection analysis by identifying and binding specific target sequences in the sample, allowing sensitive and specific detection of genetic material. And the fluorescent properties of quantum dots facilitate the quantification of target molecules.
Quantum dot-oligonucleotide conjugations enable specific molecular targets to be labelled and imaged in biological samples, allowing high resolution visualisation of cellular processes, protein interactions and disease-related biomarkers.
Oligonucleotides can carry specific therapeutic sequences (e.g. siRNA or antisense oligonucleotides), while quantum dots can be used as delivery vehicles. Quantum dot-oligonucleotide conjugations can also enhance the cellular uptake and release of therapeutic agents, thus improving the therapeutic effect.
| Service | Quantum dot-oligonucleotide Conjugation |
| Customer provides | Oligonucleotide sequence |
| Purification | QC analysis by MS, HPLC, or PAGE |
| Delivery | Typical delivery is lyophilized samples in individual vials that are fully labeled |
| Request a Quote | Inquiry |
Figure 2. Service flow of quantum dot-oligonucleotide conjugation.
Reference
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