Quantum Dot-Oligonucleotide Conjugation

BOC Sciences is always focusing on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides customisable conjugation services to combine oligonucleotides with quantum dots. We have the capability and confidence to meet your needs for novel conjugates.

What is Quantum Dot-Oligonucleotide Conjugation?

Attaching or linking oligonucleotides to quantum dots can form quantum dot-oligonucleotide conjugations. Quantum dots are semiconductor nanocrystals with unique optical and electronic properties that have a wide range of applications in bioimaging and sensing. The introduction of quantum dots into oligonucleotides allows them to be used for a wide range of biological imaging and sensing applications by providing both specific recognition of nucleic acids and the unique optical properties of quantum dots.

Figure 1. Conformational models for dsDNA on the surface of an MAA-capped QD. (Algar, W; et al, 2006)

• How to Get Quantum Dot-Oligonucleotide Conjugation

The conjugation of oligonucleotides to quantum dots can be achieved by a variety of methods, allowing different surface functionalisations of quantum dots or oligonucleotides depending on your needs, and finally by covalent linking to obtain different quantum dot-oligonucleotide conjugations.

• High-profile Applications of Quantum Dot-Oligonucleotide Conjugation

1. Fluorescence in situ Hybridisation (FISH)

Quantum dot-oligonucleotide conjugations can be used as fluorescent probes in FISH assays, specifically binding to complementary DNA or RNA sequences in cells or tissues, allowing the visualisation and localisation of specific genetic material. The bright and stable fluorescence of quantum dots enhances the sensitivity and accuracy of FISH analysis.

2. Nucleic Acid Detection

Quantum dot-oligonucleotide conjugations can be applied to nucleic acid detection analysis by identifying and binding specific target sequences in the sample, allowing sensitive and specific detection of genetic material. And the fluorescent properties of quantum dots facilitate the quantification of target molecules.

3. Biosensing & Diagnostics

Quantum dot-oligonucleotide conjugations enable specific molecular targets to be labelled and imaged in biological samples, allowing high resolution visualisation of cellular processes, protein interactions and disease-related biomarkers.

4. Drug Delivery

Oligonucleotides can carry specific therapeutic sequences (e.g. siRNA or antisense oligonucleotides), while quantum dots can be used as delivery vehicles. Quantum dot-oligonucleotide conjugations can also enhance the cellular uptake and release of therapeutic agents, thus improving the therapeutic effect.

Introduction of Quantum Dot-Oligonucleotide Conjugation Services

• What Are Our Quantum Dot-Oligonucleotide Conjugation Services?

1. Oligonucleotide Synthesis: BOC Sciences offers oligonucleotide synthesis services for the preparation of oligonucleotides of different lengths and sequences according to customer requirements.
2. Oligonucleotide Modification: BOC Sciences offers a range of oligonucleotide modification services including phosphorylation, amidation and fluorescent labelling.
3. Dot-Oligonucleotide Conjugation: BOC Sciences offers dot-oligonucleotide conjugation services for specific tracer or therapeutic purposes.
4. Purification & characterisation: BOC Sciences offers purification and characterisation services to ensure the purity, stability and activity of the synthesised dot-oligonucleotide conjugation.
5. Delivery of Detailed Analytical Reports: Ultimately customers will receive both the synthesised product and a detailed characterisation report from BOC Sciences.

Figure 2. Service flow of quantum dot-oligonucleotide conjugation.

• Why Choose Our Quantum Dot-Oligonucleotide Conjugation Services?

1. Unique Isolation & Purification Technology: BOC Sciences' unique and efficient isolation and purification technology ensures high quality and purity of quantum dot-oligonucleotide conjugations.
2. Strict Quality Control Standards: BOC Sciences maintains strict quality control throughout the service to ensure high quality delivery of quantum dot-oligonucleotide conjugation.
3. Wide Range of Applications: BOC Sciences' high quality quantum dot-oligonucleotide conjugation products are used in a wide range of biological research and pharmaceutical applications.
4. Customisable Services: BOC Sciences offers personalised quantum dot-oligonucleotide conjugation customisation and is committed to meeting the needs of different applications.

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Quantum Dot-Oligonucleotide Conjugation

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