BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with virus-like particles(VLPs). We have the capability and confidence to meet your needs for novel conjugates.
Virus-Like Particles (VLPs) are self-assembling structures that mimic viral shells but do not contain the genetic material required for replication, usually derived from viral proteins, and can be used as safe and effective vaccine platforms or drug delivery systems. The combination of oligonucleotides with VLPs can be used for a variety of purposes, including targeted drug delivery, immunotherapy or diagnostics. In addition, oligonucleotides can be designed to carry specific sequences that interact with cellular receptors, specific tissues or disease markers, allowing for precise targeting.
Figure 1. Virus-like particles (VLP) as scaffolds and vectors for vaccine development. (Milad, R; et al, 2023)
The splicing process usually involves oligonucleotides and VLPs that have been modified in advance to introduce functional groups that can form covalent or non-covalent bonds. Oligonucleotides can be chemically modified using a variety of reactive groups, while the VLP surface can be designed to display complementary reactive groups or specific binding motifs. When mixed together, the oligonucleotides and the reactive groups on the VLP can form a stable linkage leading to the conjugation of the oligonucleotide to the VLP.
| Service | VLP-Oligonucleotide Conjugation |
| Customer provides | Oligonucleotide sequence |
| Purification | QC analysis by MS, HPLC, or PAGE |
| Delivery | Typical delivery is lyophilized samples in individual vials that are fully labeled |
| Request a Quote | Inquiry |
1. Oligonucleotide Synthesis & Modification: BOC Sciences' specialist synthesis team can synthesise oligonucleotides to meet the needs of our clients.
2. VLP Options: There are the following common options available at BOC Sciences.
3. Optimisation of Coupling Methods: BOC Sciences takes the most optimised coupling methods to prepare VLP-oligonucleotide conjugations.
4. Purity, Stability, Storage Performance Testing: BOC Sciences offers detailed purification and representation experiments to ensure the high quality of VLP-oligonucleotide conjugation.
Figure 2. Service flow of VLP-oligonucleotide conjugation.
Virus-Like Particles (VLPs) are self-assembling structures that mimic the outer shell of viruses but lack genetic material. They are often used as platforms for drug delivery and vaccine development.
VLPs and oligonucleotides are modified with functional groups that enable covalent or non-covalent bonding. These modified molecules are then mixed to form stable conjugates.
VLP-oligonucleotide conjugates offer excellent targeted delivery, enhanced stability, and improved cellular uptake. Their structural mimicry promotes efficient interaction with target cells.
BOC Sciences offers various VLP types for conjugation, including HPV VLPs, HBV VLPs, and bacteriophage VLPs. These options allow for versatile application in biomedical research.
By conjugating oligonucleotides to VLPs, the immune system's response can be enhanced. The VLP's structure mimics viruses, promoting stronger immune activation.
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