RNA has been an important tool for gene function analysis and development of new treatment strategies and is widely used in biomedical research applications. BOC RNA can customized high-quality, cost-effective RNA oligonucleotides with flexible scales, which can be used for various labeling, modification, scale, and purity.
Customized RNA oligonucleotide synthesis service
BOC RNA can provide unmodified RNA, modified RNA, chimeric oligonucleotides with mixed DNA and RNA bases, 2'-OMe-RNA, 2'-F-RNA, and others according to specific requirements.
We provide RNA synthesis of long RNA oligonucleotides up to 300 bases in length. To ensure the highest quality of RNA oligonucleotides, they are synthesized using the latest nucleic acid technology and identified by mass spectrometry to determine the final sequence and purity.
Modifications/Labeling
BOC RNA provides various modifications, includes regular modification, label modification, and backbone modification.
| Classification | Phosphorothioates | Digoxin | Quenchers | Electrochemical |
| Modification | SPO3 | 3' or 5' Digoxin | 3' DABCYL | Ferrocene |
| Scale | 20 nmol, 50 nmol, 100 nmol, 200 nmol, 1 µmol, 5 µmol, and 10 µmol, or more. |
| Classification | Modified Bases | Phosphorylation | Disulfide Linkers | |
| Modification | dI
dU | 5' PO4
3' PO4 | 3' C3 S-S
5' C6 S-S | |
| Scale | 20 nmol, 50 nmol, 100 nmol, 200 nmol, 1 µmol, 5 µmol, and 10 µmol, or more. |
| Classification | Amino Linkers | Spacers | Biotin | Fluorophores |
| Modification | 3' or 5' NH2 C3
5' NH2 C6
3' NH2 C7
5' NH2 C12
NH2 C6 dT | Spacer C3
Spacer C6
Spacer 9
Spacer 18
dSpacer | 5' Biotin
3' Biotin
5' Biotin TEG
3' Biotin TEG
5' Dual Biotin
5' or Internal Biotin dT
5' PC Biotin | 5' Cy3
5' Cy5
5' FAM
3' FAM
5' HEX
3' TET
3' or 5' TAMRA
Internal TAMRA |
| Scale | 20 nmol, 50 nmol, 100 nmol, 200 nmol, 1 µmol, 5 µmol, and 10 µmol, or more. |
Applications
| Single-stranded RNA can be used for | Custom microRNA inhibitors
Aptamer
Ribozyme
Ribonucleic acid
FISH / ISH probe
FRET probe
RNA/DNA hybrid Custom RNA Duplex Dicer substrate Antisense oligonucleotide Enzyme substrate |
| Long RNA oligonucleotides can be used for | Single guide RNA for CRISPR genome editing
RNA-based diagnosis and treatment method development |
Workflow of custom RNA synthesis
Competitive advantages
- Comprehensive backbone: RNA, 2'-OMe-RNA, 2'-F-RNA, and other analogs.
- Flexible synthesis ratio: 20 nmol, 50 nmol, 100 nmol, 200 nmol, 1 µmol, 5 µmol, and 10 µmol. Bulk orders can be provided upon request.
- High-quality assurance: comprehensive quality control report (HPLC, MS).
- MS guarantees quality change<1‰
- RNase-free HPLC results ensure the purity of more than 90%
- Flexible synthesis platform: Combining solid phase and ligation technology can successfully synthesize highly complex RNA oligonucleotides.
- Experienced team: Scientists and staff with over 15 years of experience in oligo synthesis and modifications
- Cost-effective
Please contact us for purification advice or quotation.
