Cell-penetrating peptide, or CPP for short, is a short peptide that can penetrate through the cell membranes and directly enter the cytosol to facilitate intracellular. CPPs can deliver the cargo into the cells, which can be a very promising tool for drug delivery system to deliver the candidate drugs as the sequence and function diversity of the peptides. There are many internalization pathways for CPPs, such as direct penetration through the cellular membrane, endocytosis-mediated cell entry followed by endosomolysis, and receptor-mediated uptake.
Figure 1. peptide 3D illustration
Examples: Tat, Arginine oligomer
Examples: MPG-8, BPrPp, Pep-1, Penetratin, CADY
Examples: mAb-R9, A1-Tat, RVG-R9
Examples: ACPP
CPPs can deliver siRNA into the cells by conjugation with siRNA. Up to now, more than 100 CPPs have been identified, and they are different in 3D conformations, polarity, hydrophilicity, hydrophobicity, electric charges, and length of amino acids. T hey display different functions including siRNA binding, membrane penetration, endosome disruption, and targeting.
The 5'-internal or 3'-terminus of a siRNA can be linked to N-internal or C-terminus of a peptide using preactivated small molecules with functional groups residing in peptides to form peptide-siRNA conjugates.
We provide peptide-siRNA conjugates with high quality. We can design and synthesis the siRNA based on the target gene, and our parent company BOC Sciences can provide high quality peptides, we can conjugate them to form peptide-siRNA conjugates.
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GMP Oligonucleotide Manufacturing Service
For more than 15 years, BOC Sciences has been manufacturing oligonucleotides for pre-clinical, pharmaceutical, food safety, and animal health industries. We provide customized and flexible oligonucleotide GMP or non-GMP production services to meet different production needs.
Lipid Nanoparticle(LNP) for RNA Delivery
BOC Sciences offers comprehensive LNP- mRNA delivery services tailored to meet the specific needs of mRNA vaccine development. Our expertise in nanoparticle formulation and mRNA chemistry enables us to design custom LNP formulations optimized for stability, efficacy, and safety.
BOC Sciences promises to offer you with GalNAc-siRNA conjugation services to help you conduct further research on GalNAc-siRNA conjugates and explore their mores omnics capabilities, the working mechanism as well as their potential therapeutic profiles.
BOC Sciences offers aptamer customization services to generate high-quality aptamers tailored to your goals, delivering excellent results even for the most difficult target molecules.
Peptide-Oligonucleotide Conjugation
BOC Sciences is committed to providing our customers with comprehensive modification and labeling, offering affordable custom oligonucleotides or peptide-oligonucleotide conjugates.
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