Base-modified siRNA

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In vitro optimization and in vivo regulation of the properties of siRNAs are often inseparable from chemical modifications. Chemically modified siRNAs exhibit better stability, specificity and cellular uptake, and furthermore will yield better gene silencing effects. BOC Sciences is dedicated to provide you with professional base-modified siRNA, and also includes custom modified siRNA on demand.

Base Modifications in siRNA

Modified bases, also known as rare bases, are derivatives of bases other than the major base (ATCGU). tRNAs tend to contain a high number of rare bases, with some tRNAs containing up to 10% rare bases. Similar to the functions of other chemical modifications, base modifications have an important role in tuning and optimizing siRNA properties, including stability, nuclease resistance, cellular uptake, targeting, cytotoxicity, immunogenicity and gene silencing efficiency. For example, pseudouridine modification is a hot and very critical step in RNA vaccine development today, and is important in determining the efficiency of vaccine action.

Base modifications of siRNA. - BOC SciencesFigure 1. Base modifications of siRNA.

More new ideas for base modifications are also being developed to meet various scientific research needs, and the diversity of nucleic acid molecule structures and functions meet this need exactly. Customers have full access to custom properties and functions of siRNAs at BOC Sciences based on the different modifications explored by our expert team.

Phosphate backbone-modified siRNA from BOC Sciences

ModificationShort CodePurificationDetailsPrice
1-Methyl-guanosinem1GHPLC1-methyl-guanosine is guanosine substituted with a methyl group at position N-1.Inquiry
2,6-DiaminopurineDAPHPLCIt is a purine nucleobase, structurally similar to adenine, but with two amino groups (-NH2).Inquiry
2-Methyl-adenosinem2AHPLCA modified nucleoside derived from adenosine with the methyl(-CH3) attached to the nitrogen atom at the 2-position of the adenine base.Inquiry
2-Aminopurine2APHPLCModified base derivative derived from adenine, which has an amino group (-NH2) located at the 2-position of the purine ring, replacing the ketone group in adenine.Inquiry
4-Thio-uridine4-S-UHPLCA modified nucleoside obtained from uridine in which the sulfur atom (-S) replaces the oxygen atom at the 4-position of the uracil base.Inquiry
5-Bromo-UridineU[5Br]HPLC5-Bromouridine is a modified nucleoside of uridine in which a bromine atom (-Br) replaces the hydrogen atom at the 5-position of the uracil base.Inquiry
5-Fluoro-cytidineC[5F]HPLCA fluorine atom (-F) is substituted for the hydrogen atom at the 5-position of the cytidine base.Inquiry
5-Fluoro-uridineU[5F]HPLCA fluorine atom (-F) is substituted for the hydrogen atom at the 5-position of the uracil base.Inquiry
5-Iodo-uridineU[5I]HPLCAn iodine atom (-I) is substituted for the hydrogen atom at position 5 of the uracil base.Inquiry
5-Methyl-cytidine5-M-CHPLCA methyl group (-CH3) replaces the H atom at the 5-position of the cytidine base.Inquiry
5-Methyl-Deoxycytidine5-M-dCHPLCA methyl group (-CH3) replaces the H atom at the 5-position of the cytosine base.Inquiry
5-Methyl-uridinerTHPLCA methyl group (-CH3) is attached to the 5-position of the uracil base.Inquiry
InosineIHPLCInosine is a naturally occurring adenine nucleoside that does not require artificial modification.Inquiry
N2-Methyl-guanosinem2GHPLCA methyl group (-CH3) is attached to the nitrogen atom at the 2 position of the guanine base.Inquiry
N3-Methyl-uridine3-M-UHPLCIn N3-methyluridine, a methyl group (-CH3) is affixed to the nitrogen atom at the 3-position of the uracil base.Inquiry
N6,N6-Dimethyl-adenosineDMAHPLCTwo methyl groups (-CH3) are attached to the nitrogen atom at the 6 position of the adenine base.Inquiry
N6-Methyl-adenosinem6AHPLCA methyl group (-CH3) is linked to the nitrogen atom at the 6-position of the adenine base.Inquiry
O6-Methyl-guanosineO6mGHPLCMethyl (-CH3) is attached to the oxygen atom at the 6 position of the guanine base.Inquiry
PseudouridineΨHPLCUridines are isomerized to form pseudouridine.Inquiry
Purine ribonucleosidePuHPLCA group of nucleosides consisting of a purine base attached to a ribose molecule.Inquiry
Pyrrolo-cytidinepCHPLCModified RNA base.Inquiry
RibavirinRBVHPLCRibavirin is a 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide.Inquiry

BOC Sciences has a team of experts with a decade of experience in RNA synthesis and advanced equipment to ensure high quality and competitive price for base modified siRNA. For more custom base modified siRNA, please feel free to contact us.

* Only for research. Not suitable for any diagnostic or therapeutic use.
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