Modified DNA and modified RNA help to understand the mechanistic and stereochemical aspects of many biochemical reactions and processes. BOC RNA can provide standard DNA bases. Our custom synthesis services are flexible and versatile to suit any specification.
Deoxyribo Nucleic Acid (abbreviated as DNA) is a type of nucleic acid, one of the four biological macromolecules contained in living cells. DNA carries the genetic information necessary for the synthesis of RNA and proteins and is an essential biomolecule for the development and proper functioning of living organisms.
The structure of DNA is simple. The DNA molecule is composed of two very long sugar chain structures, which are joined together by base pairs, just like a ladder. The entire molecule forms a double helix around its central axis.
Bases are derivatives of purines and pyrimidines, which are components of nucleic acids, nucleosides and nucleotides.
There are four different bases in the base pairs that form the stable helix structure. They are called A (Adenine), T (Thymine), G (Guanine) and C (Cytosine) respectively.
In the molecular structure of DNA, due to the fixed number of hydrogen bonds between bases and the constant distance between the two strands of DNA, base pairing must follow certain rules - A is always paired with T, G is always paired with C Pairing, A is paired with U during transcription. (Arrange DNA molecules according to the principle of complementary base pairing.) There are two hydrogen bonds between adenine and thymine, and three hydrogen bonds between guanine and cytosine.
Fig. 1 DNA structure
| Standard DNA Bases | Short Code | Price |
| 2'-Deoxy Bases (A) | dA | Inquiry |
| 2'-Deoxy Bases (C) | dC | Inquiry |
| 2'-Deoxy Bases (G) | dG | Inquiry |
| 2'-Deoxy Bases (T) | dT | Inquiry |
Contact us now to get technical advice and more information. Our technical support team will review and provide a quotation as soon as possible!
Standard DNA bases (A, T, G, C) are the fundamental building blocks of DNA, essential for creating specific genetic sequences. They are widely used in research for DNA synthesis, PCR, and gene cloning.
Custom DNA bases allow for precise sequence control, which is crucial for producing specific gene constructs. This flexibility ensures more reliable results in genetic studies, mutations, and synthetic biology applications.
Complementary base pairing ensures that DNA strands remain stable by following the rule that A pairs with T, and G pairs with C. This principle is vital for accurate DNA replication and transcription in molecular biology.
Yes, modified DNA bases can be used to introduce mutations or create custom genes for genetic engineering projects. This allows researchers to explore novel genetic sequences with enhanced functionality.
DNA bases are crucial in PCR for amplifying target DNA sequences by forming the template needed for replication. Accurate base pairing during PCR enables specific and reliable amplification of DNA.
DNA stability is influenced by its GC content, as GC pairs are more stable due to three hydrogen bonds compared to the two bonds in AT pairs. Higher GC content generally results in more stable DNA under varying conditions.
Our DNA bases are optimized for high-throughput sequencing, ensuring accurate and consistent results across large-scale genomic studies. They are ideal for use in next-generation sequencing (NGS) applications.
