BOC Sciences aims at powering drug delivery through bioconjugation. Relying on our comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with homing peptides. We have the capability and confidence to meet your needs for any customized conjugates.
Homing peptides are short peptide sequences with natural tissue or organ specificity that selectively bind to receptors, proteins or other molecular targets expressed or present in a specific tissue or organ. Homing peptides are available from a variety of sources, including phage display libraries, combinatorial peptide libraries, or naturally occurring peptides. Peptides that exhibit preferential binding or accumulation in specific tissues or organs generally need to be obtained through an iterative screening process.
Figure 1. Schematic diagram of a tumor homing peptide.(Jinqiang, W; et al, 2019)
Homing peptide-oligonucleotide conjugation has a wide range of applications and clear advantages in biomedical research. They primarily act as targeted drug delivery systems or tissue-specific imaging agents, thus enabling selective delivery of therapeutic agents or imaging probes to specific tissues or organs. The presence of homing peptides can improve therapeutic efficacy and specificity by minimizing off-target effects and improving drug accumulation at the desired site.
| Service | Homing Peptide-Oligonucleotide Conjugation |
| Customer provides | Oligonucleotide sequence |
| Purification | QC analysis by MS, HPLC, or PAGE |
| Delivery | Typical delivery is lyophilized samples in individual vials that are fully labeled |
| Request a Quote | Inquiry |
1. Oligonucleotide Synthesis & Modification: BOC Sciences offers custom oligonucleotide synthesis and modification services while you only need to request the sequence.
2. Selection of Suitable Conjugated Homing Peptides : BOC Sciences provides options including the following homing peptides.
3. Conjugation Method Selection: BOC Sciences will advise you on the appropriate conjugation strategy for your needs.
4. Conjugation Purification & Identification: BOC Sciences has optimized purification and evaluation methods to ensure the quality of the conjugates.
Figure 2. Service flow of homing peptide-oligonucleotide conjugation.
Homing peptide-oligonucleotide conjugation involves linking oligonucleotides with homing peptides, which are peptides that selectively target specific tissues or organs. This conjugation enables precise targeting and enhances the delivery of oligonucleotides to the desired location.
Homing peptides are short sequences that bind selectively to specific receptors on tissues or organs. When conjugated with oligonucleotides, they improve the specificity and efficiency of delivery by ensuring that the oligonucleotide reaches its target site, reducing off-target effects.
Common homing peptides include RGD (for targeting integrins on cancer cells), NGR (for targeting tumor vasculature), iRGD (for crossing the blood-brain barrier), and peptides for bone and lymphatic targeting, each designed for different therapeutic and research applications.
These conjugates are primarily used for targeted drug delivery, where the homing peptide directs the oligonucleotide to specific tissues. They can also serve as tissue-specific imaging agents, helping to visualize molecular interactions in targeted areas.
The process involves synthesizing and modifying oligonucleotides, selecting an appropriate homing peptide, and using optimized conjugation methods. The conjugates are then purified and characterized for quality and effectiveness.
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