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BOC Sciences is committed to providing quality services related to CpG-siRNA conjugates. Professional and experienced scientists will work closely with you to help streamline and accelerate your research in both routine and custom services.
The advent of RNA interference (RNAi)-based therapeutic strategies has created a unique opportunity to silence any disease-related target gene. The main barriers to the clinical application of RNAi are targeted delivery of siRNA to the cell of interest and the sensitivity of the immune system to nucleic acid stimulation. However, immune cells themselves may be important therapeutic targets in cancer therapy. Ligands for intracellular receptors, such as TLR9, have been shown to serve as targeting components for cell-specific siRNA delivery. TLR9-positive cells recognize and internalize single-stranded oligodeoxyribonucleotides containing unmethylated CpG motifs (CpG ODNs). Conjugates of CpG ODNs with Dicer substrate siRNAs (CpG-siRNAs) are recognized by human and mouse TLR9 positive cells, without any transfection reagent, to target and silence genes in mouse TLR9+ immune cells, including dendritic cells (DCs), macrophages and B cells, in vitro and in vivo. Efficacy studies in mice have shown that CpG directly and/or immune-mediately targets various tumorigenic factors via siRNA, including antitumor-active STAT3, STAT5, RELA/P65, BCL2L1, or S1PR1. In summary, CpG-siRNA conjugates have several advantages:
You can submit selected siRNA sequences or use our design tools to configure siRNA sequences.
From mini-packs of 0.015 µmol scale to large orders.
From conventional modifications to fluorescent/non-fluorescent labeling and even dual and multiple labeling services are available to suit your individual needs.
Different purification methods according to individual requirements.
Thank you for choosing BOC Sciences as your preferred CpG-siRNA conjugates service.
Our scientific team is ready to provide you with a flexible synthetic analysis service. If you have any special needs or questions, please feel free to contact us for support from our experienced experts.
References
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