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Custom siRNA

Browse our siRNA Products

BOC RNA specializes in siRNA synthesis according to your special requirements, and our siRNA services have competitive prices and high quality. We provide a variety of modification and purification methods. Each siRNA is produced in accordance with strict ISO standards during the synthesis process and is controlled in accordance with BOC RNA's strict quality assurance and quality control standards. The quality control of all customized siRNA oligonucleotides is performed by analytical HPLC, mass spectrometry, annealing in RNase-free water, and double-stranded analysis by analytical gel. Large-scale sterile, endotoxin-free siRNA can be used for therapeutic applications.

BOC Sciences' Competitive Advantages for siRNA Synthesis

From conventional modification to fluorescent/non-fluorescent labeling, even dual and multiple labeling.

Two of the three custom siRNAs will produce 80% siRNA knockdown.

0.015 µmol, 50 nmol, 100 nmol, 200 nmol, 1 µmol, 5 µmol, 10 µmol, and > 10 µmol. Mass production can be provided upon request.

You can submit selected siRNA sequences, or use our design tools to configure siRNA sequences.

Scientists and employees with more than 15 years of experience in oligonucleotide synthesis and modification.

Competitive price and excellent value for money.

All of our custom siRNAs are purified by HPLC. If you have special requirements, please contact us. The quantity we can provide ranges from 2 OD to 250 OD

Cat. No.ProductQuantityPurificationPrice
BRC-001Custom siRNA2 OD-250 ODHPLCInquiry

Custom siRNA Services

BOC RNA provides flexible siRNA synthesis scale to meet your individual research needs. The 0.015 µmol scale mini package is designed to avoid tight budgets. Large quantities of orders are also available on request.

 DesaltedHPLCIn vivoIn vivo HPLC
nmolnmolnmolnmol
0.015 µmol scale10---
0.025 µmol scale20---
0.05 µmol scale50-25-
0.2 µmol scale1506510050
0.4 µmol scale300180200100
1.0 µmol scale750375500250
2.0 µmol scale15007501000500
5.0 µmol scale3750187525001250
10.0 µmol scale7500375050002500
> 10.0 µmol    

To learn more, please refer to our chemical modification services and fluorescent labeling services. If necessary, special modifications can be made.

For unmodified siRNA strands, we usually achieve purity of 80-85% without purification.

However, when the chemically synthesized siRNA is chemical modification at the 3'end or inside, double modified on the same chain, or designed for highly sensitive assays or in vivo applications, the options listed below are frequently used:

Processing TypesSingle StrandsDesaltedHPLCIn vivoIn vivo HPLC
Desalted 
Deprotected 
Duplexed 
Purified   
Endotoxin tested   
Sodium counter-ion   
Recommended for modified RNA   
Recommended for in vivo use   
2'ACE protected single-strands    


We also provide siRNAs purified according to your needs by choosing different methods. Please contact technical support for more information on purification recommendations or estimation of the purity of unpurified substances.

Note: All siRNA oligonucleotides are supplied in the form of lyophilized powder to ensure stability during delivery.

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* Only for research. Not suitable for any diagnostic or therapeutic use.
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