Antibody-Oligonucleotide Conjugation

As a leading supplier of oligonucleotides, BOC Sciences is committed to providing our customers with comprehensive modification and labeling, offering affordable custom oligonucleotides or antibody-oligonucleotide conjugates.

What is Antibody-Oligonucleotide Conjugation

Antibody-oligonucleotide Conjugates (AOCs) are novel targeted drugs consisting of chemically modified antibodies and oligonucleotides, which are highly specific and selective and can precisely target cancer cells, making them one of the hot topics of research.

• Principle of Antibody-Oligonucleotide Binding

The preparation of AOCs is based on the binding principle of antibodies to oligonucleotides. Antibodies are highly specific proteins that recognize and bind to target molecules, while oligonucleotides are sequence-specific molecules that match the mRNA sequences of target molecules. By combining oligonucleotides with antibodies, antibodies can be made to target cancer cells more precisely and achieve therapeutic effects.

• Preparation Methods of AOCs

The preparation methods of AOCs mainly include two kinds: one is to modify oligonucleotides into chemical groups that can bind to antibodies and then covalently bind to antibodies; the other is to use biological techniques to non-covalently bind oligonucleotides to antibodies, such as by DNA/RNA hybridization.

• Application Prospects of AOCs

AOCs have very promising applications. They can be used to treat various types of cancers, such as breast cancer, colorectal cancer, lung cancer, etc. In addition, AOCs can be used to diagnose and predict cancer trends, providing a new means for precision medicine.

• Advantages and Challenges of AOCs

Compared with traditional chemotherapy drugs, AOCs have many advantages. First, they are highly specific and selective, and can precisely target cancer cells and reduce damage to normal cells. Second, AOCs have a long half-life, which can extend the duration of drug action. However, the research and application of AOCs still face many challenges, such as drug stability, drug metabolism and clearance, and other issues need to be further addressed.

In conclusion, AOCs are a kind of targeted drugs with great potential, and their application prospects are very broad. With the continuous development of related technologies, it is believed that AOCs will become one of the representatives of the new generation of targeted drugs.

Fig. 1 Schematic representation of AOC use in (a) antibody arrays; (b) therapeutic; and (c) pretargeting applications. (Dovgan, 2019)

Introduction to AOC Services

• What Are Our AOC Services?

1. Antibody purification and modification: BOC Sciences provides antibody purification and modification services to ensure the purity and stability of antibodies for better modification in the next step.
2. Oligonucleotide synthesis: BOC Sciences provides oligonucleotide synthesis services to synthesize oligonucleotides with different lengths and sequences according to customer requirements.
3. Oligonucleotide modification: BOC Sciences provides oligonucleotide modification services, including phosphorylation, cholinergization, biotinylation, fluorescent labeling, etc.
4. Antibody-oligonucleotide conjugation: BOC Sciences offers antibody-oligonucleotide coupling services, where synthetic oligonucleotides are coupled to antibodies for specific detection or therapeutic purposes.
5. Identification and validation: BOC Sciences provides identification and validation services to ensure the purity, stability and activity of the synthesized antibody-oligonucleotide coupling substances for accuracy and efficacy in laboratory and clinical applications.

• Why Choose Our Antibody-Oligonucleotide Conjugates

1. High quality antibodies and oligonucleotides: BOC Sciences provides high quality antibodies and oligonucleotides to ensure optimal binding.
2. Customized services: BOC Sciences offers customized services to perform specific antibody-oligonucleotide conjugation reactions based on customer needs.
3. Flexibility: BOC Sciences' antibody-oligonucleotide conjugation services are highly flexible and can be adapted to a variety of applications, such as immunostaining, ELISA, etc.
4. Efficiency: BOC Sciences' antibody-oligonucleotide conjugation services are highly efficient, allowing for increased efficiency and accuracy of experiments.
5. Professional team: BOC Sciences has a professional team, including scientists and technicians, to provide the best quality service to our customers.
6. Cost-effectiveness: BOC Sciences' antibody-oligonucleotide conjugation services are cost-effective and can help clients save on experimental costs.

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Antibody-Oligonucleotide Conjugation

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