BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with metal chelates. We have the capability and confidence to meet your needs for novel conjugates.
Metal chelate-oligonucleotide conjugation is a complex formed by combining a metal ion with an oligonucleotide molecule. Among them, metal ions can be common metal ions such as Fe, Cu, Zn, etc., while oligonucleotides are oligomers composed of multiple nucleotide units. Metal chelate-oligonucleotide conjugates have good biocompatibility and biodegradability, and therefore have a wide range of applications in the biomedical field.
There are two main methods to prepare metal chelate-oligonucleotide conjugates, one is by chemical synthesis and the other is by biosynthesis. Among them, the chemical synthesis method has the advantages of short preparation cycle and simple operation, but also has the risk of environmental impact and possible toxicity of chemical synthesis agent to human. In contrast, the biosynthetic method can reduce the environmental impact, and also has good biocompatibility and biodegradability.
Metal chelate-oligonucleotide conjugation has a wide range of promising applications in the biomedical field. Among them, their applications in cancer treatment and diagnosis have received a lot of attention. By combining metal chelate-oligonucleotide conjugation with tumor cell-specific markers, efficient targeting of tumor cells can be achieved. Meanwhile, metal chelate-oligonucleotide conjugation can also be used as a highly sensitive tumor diagnostic tool for early tumor diagnosis and treatment through the detection of tumor cells.
Service | Metal Chelates-Oligonucleotide Conjugation |
Customer provides | Oligonucleotide sequence |
Metal Chelates |
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Purification | QC analysis by MS, HPLC, or PAGE |
Delivery | Typical delivery is lyophilized samples in individual vials that are fully labeled |
Request a Quote | Inquiry |
1. Synthesis of metal chelate - oligonucleotide conjugates: BOC Sciences' expert team will synthesize metal chelates and oligonucleotides and link them to form metal chelate - oligonucleotide conjugates according to customer requirements.
2. Optimize the synthesis protocol: BOC Sciences' expert team will optimize the synthesis protocol to ensure high purity and high yield of the product.
3. Characterization of the product: BOC Sciences' expert team will analyze the product using various characterization techniques such as mass spectrometry and nuclear magnetic resonance to ensure the correct purity and structure of the product.
4. Customized services: BOC Sciences' team of experts will provide customized services to ensure customer satisfaction based on their specific needs.
5. High quality assurance: BOC Sciences' team of experts will ensure that all synthesis and characterization work is performed to high quality standards to ensure customer satisfaction.
GMP Oligonucleotide Manufacturing Service
For more than 15 years, BOC Sciences has been manufacturing oligonucleotides for pre-clinical, pharmaceutical, food safety, and animal health industries. We provide customized and flexible oligonucleotide GMP or non-GMP production services to meet different production needs.
Lipid Nanoparticle(LNP) for RNA Delivery
BOC Sciences offers comprehensive LNP- mRNA delivery services tailored to meet the specific needs of mRNA vaccine development. Our expertise in nanoparticle formulation and mRNA chemistry enables us to design custom LNP formulations optimized for stability, efficacy, and safety.
BOC Sciences promises to offer you with GalNAc-siRNA conjugation services to help you conduct further research on GalNAc-siRNA conjugates and explore their mores omnics capabilities, the working mechanism as well as their potential therapeutic profiles.
BOC Sciences offers aptamer customization services to generate high-quality aptamers tailored to your goals, delivering excellent results even for the most difficult target molecules.
Peptide-Oligonucleotide Conjugation
BOC Sciences is committed to providing our customers with comprehensive modification and labeling, offering affordable custom oligonucleotides or peptide-oligonucleotide conjugates.