Metal Chelates-Oligonucleotide Conjugation

Metal Chelates-Oligonucleotide Conjugation

BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with metal chelates. We have the capability and confidence to meet your needs for novel conjugates.

Introduction to Metal Chelate Oligonucleotide Conjugation

  • What is Metal Chelate Oligonucleotide Conjugation?

Metal chelate-oligonucleotide conjugation is a complex formed by combining a metal ion with an oligonucleotide molecule. Among them, metal ions can be common metal ions such as Fe, Cu, Zn, etc., while oligonucleotides are oligomers composed of multiple nucleotide units. Metal chelate-oligonucleotide conjugates have good biocompatibility and biodegradability, and therefore have a wide range of applications in the biomedical field.

  • How to Prepare Metal Chelate Oligonucleotide Conjugates

There are two main methods to prepare metal chelate-oligonucleotide conjugates, one is by chemical synthesis and the other is by biosynthesis. Among them, the chemical synthesis method has the advantages of short preparation cycle and simple operation, but also has the risk of environmental impact and possible toxicity of chemical synthesis agent to human. In contrast, the biosynthetic method can reduce the environmental impact, and also has good biocompatibility and biodegradability.

  • Application of Metal Chelate-Oligonucleotide Conjugation

Metal chelate-oligonucleotide conjugation has a wide range of promising applications in the biomedical field. Among them, their applications in cancer treatment and diagnosis have received a lot of attention. By combining metal chelate-oligonucleotide conjugation with tumor cell-specific markers, efficient targeting of tumor cells can be achieved. Meanwhile, metal chelate-oligonucleotide conjugation can also be used as a highly sensitive tumor diagnostic tool for early tumor diagnosis and treatment through the detection of tumor cells.

Introduction to Metal Chelate-Oligonucleotide Conjugation Services

ServiceMetal Chelates-Oligonucleotide Conjugation
Customer providesOligonucleotide sequence
Metal Chelates
  • 2,2'-Dipicolylamine
  • DOTA (1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid)
  • DTPA (1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetra(methylene phosphonic) acid)
  • NOTA (1,4,7- triazacyclononane-N,N,N-triacetic acid)
  • TETA (1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid tetrahydrochloride)
PurificationQC analysis by MS, HPLC, or PAGE
DeliveryTypical delivery is lyophilized samples in individual vials that are fully labeled
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  • What Are Our Metal Chelate-Oligonucleotide Conjugation Services?

1. Synthesis of metal chelate - oligonucleotide conjugates: BOC Sciences' expert team will synthesize metal chelates and oligonucleotides and link them to form metal chelate - oligonucleotide conjugates according to customer requirements.

    • 2,2'-Dipicolylamine Oligo Conjugates
    • DOTA Oligo Conjugates
    • DTPA Oligo Conjugates
    • NOTA Oligo Conjugates
    • TETA Oligo Conjugates

2. Optimize the synthesis protocol: BOC Sciences' expert team will optimize the synthesis protocol to ensure high purity and high yield of the product.

3. Characterization of the product: BOC Sciences' expert team will analyze the product using various characterization techniques such as mass spectrometry and nuclear magnetic resonance to ensure the correct purity and structure of the product.

4. Customized services: BOC Sciences' team of experts will provide customized services to ensure customer satisfaction based on their specific needs.

5. High quality assurance: BOC Sciences' team of experts will ensure that all synthesis and characterization work is performed to high quality standards to ensure customer satisfaction.

  • Why Choose Our Metal Chelate-Oligonucleotide Conjugates

  1. By utilizing top-tier metal chelators and oligonucleotides, BOC Sciences guarantees product purity for our metal chelates-oligonucleotide conjugation service.
  2. To cater to varying application needs, BOC Sciences provides flexible customization options for our metal chelates-oligonucleotide conjugation service.
  3. With a skilled and seasoned team, BOC Sciences delivers top-quality services for metal chelates-oligonucleotide conjugation.
  4. Ensuring safety is a top priority for BOC Sciences' metal chelates-oligonucleotide conjugation service, using only safe chemical reagents and processes.
  5. Thanks to efficient processes, BOC Sciences' metal chelates-oligonucleotide conjugation service offers speedy turnaround times, increasing overall efficiency.

Metal Chelates-Oligonucleotide Conjugation

* Only for research. Not suitable for any diagnostic or therapeutic use.
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