Polymer-Oligonucleotide Conjugation

Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technology, BOC Sciences is committed to providing high quality conjugation services to combine oligonucleotides with polymers. BOC Sciences aims to power drug delivery and enhance drug efficacy through bioconjugation technology.

Introduction of Polymer-Oligonucleotide Conjugation

Polymer-oligonucleotide conjugation consists of covalently linked polymers and oligonucleotides. Such conjugates can greatly broaden the range of applications for polymers and oligonucleotides respectively by combining the unique properties of polymers and oligonucleotides to create novel hybrid molecules with enhanced functionality.

• Procedure for the Preparation of Polymer-Oligonucleotide Conjugation

The initial stage of preparing polymer-oligonucleotide conjugates requires the preparation of a modified polymer and a modified oligonucleotide, respectively.

1. Synthesis of the polymer using appropriate polymerisation techniques or modification of an existing polymer to introduce reactive groups for conjugation to give it the desired biocompatibility, stability or targeting ability.
2. Incorporating or introducing a reactive functional group onto an oligonucleotide during synthesis or by post-synthetic modification to make it fit the need. Common reactive groups include amino groups (e.g., primary amines), thiol groups (e.g., sulfhydryl groups) or reactive phosphoramidites.

The most important thing is to mix the oligonucleotide with the polymer under conditions suitable for the affixation reaction according to the requirements. After the corresponding chemical reactions and purification, the target polymer-oligonucleotide conjugation is obtained.

• Application of Polymer-Oligonucleotide Conjugation

Polymer-oligonucleotide conjugation hybridizes the unique properties of each polymer and oligonucleotide to exhibit higher cycling stability, enhanced cellular uptake, better target specificity and controlled drug release. Polymer-oligonucleotide conjugation serves as an important tool for a wide range of applications in drug delivery, gene therapy, biosensing and other fields.

Introduction of Polymer-Oligonucleotide Conjugation Services

• What Are Our Polymer-Oligonucleotide Conjugation Services?

1. A team of experts work together to assist in the selection of the appropriate chemical coupling method, including cross-linking agents, cross-linker activation and chemical modifications.
2. A wide range of different types of oligonucleotide synthesis services are available in BOC Sciences to meet the needs of different research areas.
3. A variety of different types of polymers are available in BOC Sciences, including polyethylene glycol (PEG), poly(lactic-co-glycolic acid) (PLGA), polyamidoamine (PAMAM), polylysine, polymeric micelles, chitosan, etc.
4. Comprehensive quality control, purification analysis and characterisation services, including mass spectrometry, high performance liquid chromatography, gel electrophoresis analysis, etc.
5. Professional technical support and consultancy services to assist customers in solving various problems and difficulties.

Figure 1. Service flow of polymer-oligonucleotide conjugation.

• Why Choose Our Polymer-Oligonucleotide Conjugation Services?

1. High Purity: BOC Sciences' proprietary and efficient separation and purification technology ensures high purity and quality polymer-oligonucleotide conjugation products.
2. Professional Support: BOC Sciences' dedicated team can provide a full range of technical advice and support services to ensure that customers are able to run their projects smoothly with custom polymer-oligonucleotide conjugation products.
3. Customisable Service: BOC Sciences specialises in developing customised polymer-oligonucleotide conjugation products to meet the specific requirements of our customers.
4. Reasonable Pricing: BOC Sciences really offers competitive prices in the bio-market, but at the same time ensures high quality products.

Frequently Asked Questions (FAQ)

What is polymer-oligonucleotide conjugation used for?

Polymer-oligonucleotide conjugation combines the properties of polymers and oligonucleotides, enhancing stability, targeting, and drug release. This technology is widely used in drug delivery, gene therapy, and biosensing.

How is polymer-oligonucleotide conjugation prepared?

The conjugation is achieved by modifying both the polymer and oligonucleotide to introduce reactive functional groups. These groups are then chemically bonded under optimized conditions to form the conjugate.

Can polymer-oligonucleotide conjugates be used for RNA delivery?

Yes, polymer-oligonucleotide conjugates are excellent for RNA delivery, as they enhance stability and promote efficient cellular uptake, crucial for RNA-based therapies.