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mRNA Delivery Platform

Unlock the full potential of RNA therapeutics with our comprehensive mRNA Delivery Platform. We provide multi-modal delivery solutions—including lipid nanoparticles (LNPs), polymer-based carriers, liposomes, exosomes, viral-like particles, RNA nanostructures, and next-generation hybrid systems—engineered to achieve precise cellular uptake, high expression efficiency, and optimized biodistribution. From carrier design and formulation optimization to in-vitro testing, in-vivo validation, and scalable manufacturing support, we deliver end-to-end services that accelerate your mRNA programs with unmatched speed, scientific rigor, and technical depth.

mRNA Delivery Technology mRNA Delivery Technology

Our Multi-Modal mRNA Delivery Platform

Lipid-Based Delivery Systems

(LNPs, Liposomes, Ionizable Lipids)

Services We Provide:

  • Custom LNP formulation tailored for mRNA size, structure & modifications
  • Ionizable lipid screening to optimize encapsulation & endosomal escape
  • Lipid composition optimization (IL/HL/Chol/PEG-lipid ratios)
  • Microfluidic manufacturing for scalable and reproducible mRNA-LNP batches
  • Liposome-based formulations for membrane fusion and improved stability
  • Encapsulation efficiency enhancement for long or chemically modified mRNA
  • Buffer, pH, and N/P ratio tuning for improved in vivo performance
  • Comprehensive QC/characterization (size, PDI, charge, encapsulation, integrity)
  • In-vitro translation & potency assays (luciferase / GFP / target protein)
  • In-vivo biodistribution, PK/PD, expression profiling

Advantages:

  • High encapsulation efficiency and strong mRNA protection
  • Clinically validated—used in approved mRNA vaccines & therapies
  • Tunable particle size, charge, and composition
  • Efficient endosomal escape and robust protein expression
  • Scalable and GMP-compatible through microfluidic production
  • Suitable for systemic and local delivery routes

Polymer-Based Delivery Systems

Services We Provide:

  • Polymer materials screening (polyesters, PEIs, dendrimers, block copolymers)
  • Custom polymer synthesis for tunable degradation and charge properties
  • Polymer-mRNA complex formulation (polyplex engineering)
  • PEG-free, immunologically safe polymer design
  • Polymer surface modification for targeted tissue/cell delivery
  • Endosomal escape optimization through functional group engineering
  • Controlled-release kinetics for durable mRNA expression
  • In-vitro transfection & expression assays in multiple cell systems
  • In-vivo polymer-based delivery validation (liver, lung, tumor, muscle)
  • Safety & biocompatibility analysis

Advantages:

  • Highly tunable chemical composition and degradability
  • Lower immunogenicity and PEG-free options
  • Suitable for challenging payloads (large or modified mRNAs)
  • Extended circulation stability and controlled release
  • Enhanced endosomal escape via engineered functionalities
  • Alternative platform when lipid systems are suboptimal

Exosome / Extracellular Vesicle (EV) Delivery

Services We Provide:

  • Exosome production from natural or engineered cell lines
  • mRNA loading optimization (electroporation / chemical / passive loading)
  • EV surface engineering with ligands, peptides, antibodies
  • Exosome stability enhancement for in vivo administration
  • BBB-penetrating EV development for CNS delivery
  • In-vitro potency evaluation in neuronal, tumor, immune cells
  • In-vivo biodistribution & targeting studies
  • Scalable EV purification workflows
  • Immunogenicity, cytokine release & safety testing

Advantages:

  • Natural biocompatibility and low immunogenicity
  • Intrinsic ability to cross biological barriers (e.g., BBB)
  • Natural cell-cell communication carriers for targeted delivery
  • High payload tolerance with customizable loading strategies
  • Excellent for difficult targets: tumors, CNS, immune cells
  • Ideal for "stealth delivery" in sensitive indications

Viral-Like Particles (VLPs) & Protein Nanocages

Services We Provide:

  • VLP assembly & mRNA packaging optimization
  • Protein nanocage engineering for encapsulation and release control
  • Surface glycoprotein functionalization for targeted tissue tropism
  • Endosomal escape enhancement built into VLP architecture
  • In-vitro mRNA expression assays using VLP carriers
  • In-vivo targeting and expression profiling
  • Large-scale VLP production & purification
  • Safety, immune response & cytokine profiling

Advantages:

  • High-efficiency cellular entry and endosomal escape
  • Strong antigen presentation—ideal for vaccine applications
  • Natural tropism enables selective tissue/cell targeting
  • Excellent for delivering mRNA to immune cells (APCs)
  • Biodegradable and customizable protein-based scaffolds
  • Combines viral efficiency with non-viral safety

RNA Nanostructure Delivery

(RNA Origami, Aptamer-Directed Systems)

Services We Provide:

  • Design and modeling of RNA nanostructures for precise assembly
  • Aptamer-guided targeting to specific receptors or tumor markers
  • Hybrid RNA-only carriers (cargo + carrier both RNA-based)
  • mRNA integration into nanostructural frameworks
  • In-vitro uptake & protein expression assays
  • In-vivo targeting and expression studies
  • Sequence optimization for stability and folding performance

Advantages:

  • Fully programmable nanostructures for precision targeting
  • Minimal components—carrier and cargo are both RNA
  • High biocompatibility with reduced formulation complexity
  • Targeting via aptamers or sequence-defined structures
  • Suitable for precision oncology and molecular targeting
  • Emerging platform with strong customization potential

Hybrid Nanoparticle Systems

(Lipid-Polymer, Lipid-Protein, Polymer-Exosome)

Services We Provide:

  • Multi-material nanoparticle design combining lipid, polymer, peptide, or EV components
  • Custom hybrid formulations for improved stability & efficiency
  • Co-delivery systems (mRNA + saRNA, mRNA + adjuvant, mRNA + protein)
  • Ligand-based tissue targeting for liver, lymph node, or tumor tropism
  • Nanoengineering for size, charge, and controlled release
  • In-vitro potency & expression studies
  • In-vivo efficacy and biodistribution testing
  • Formulation optimization for challenging payloads (long mRNA, circRNA, saRNA)

Advantages:

  • Combines strengths of multiple delivery chemistries
  • Improved stability with enhanced delivery efficiency
  • Tailored release kinetics and tissue tropism
  • Greater flexibility for complex or large-format mRNAs
  • Ideal for overcoming challenges such as immunogenicity or toxicity
  • Highly versatile for oncology, vaccines, and gene editing

Physical Delivery Methods

(Electroporation, Microinjection, Needle-Free Delivery)

Services We Provide:

  • Electroporation protocol optimization for mRNA delivery into primary cells
  • Ex vivo delivery workflows for CAR-T, NK, HSC, and iPSC applications
  • Needle-free jet injection development for dermal/muscle delivery
  • Microinjection approaches for embryos or localized tissue delivery
  • Rapid screening using electroporation-based mRNA expression assays
  • Cell viability, potency, phenotype retention evaluation

Advantages:

  • Direct cytoplasmic delivery—bypasses endosomal pathways
  • High transfection efficiency for ex vivo cell engineering
  • Ideal for CAR-T/NK manufacturing and hematopoietic cells
  • Enables high-dose local administration options
  • Useful when chemical carriers are not suitable
  • Reliable for rapid proof-of-concept and screening

Emerging & Custom Delivery Technologies

(For partners seeking cutting-edge or proprietary solutions)

Services We Provide:

  • Custom ionizable lipid development
  • Novel biodegradable polymer synthesis
  • Targeted ligand discovery & conjugation
  • Biomimetic carrier engineering (membrane-coated nanoparticles)
  • Scaffold-free mRNA delivery methods
  • mRNA + gene editing component co-formulation
  • End-to-end design of new delivery modalities for your indication
  • Data-driven optimization using AI-guided formulation modeling

Advantages:

  • Custom material synthesis (lipids, polymers, peptides)
  • Novel ionizable lipid discovery & optimization
  • Biomimetic carriers tailored to specific tissues
  • Flexible integration of targeting ligands or immune modulators
  • Co-delivery of mRNA + gRNA + proteins for gene editing
  • Built precisely for your indication and payload requirements
Delivery Platform Best Use Cases Strengths Limitations Formulation Services We Provide Targeting Options In-Vitro Capabilities In-Vivo Capabilities Scalability / GMP Readiness
Lipid-Based Systems (LNPs, Liposomes) Vaccines, gene editing, systemic deliveryHigh efficiency, clinically validated, strong endosomal escapePotential inflammation, liver-biased targetingCustom LNP formulation, microfluidic production, lipid screeningLigands, peptides, antibodies, lipid tuningUptake, potency, protein expression assaysBiodistribution, PK/PD, safety studiesExcellent; industry standard
Polymer-Based Systems Tumor targeting, lung delivery, large/modified mRNAHighly tunable, low immunogenicity, PEG-freeComplex optimization, variable in vivo efficiencyPolymer synthesis, polyplex design, release control, stability optimizationReceptor ligands, peptides, aptamersTransfection, endosomal escape, expression assaysLung/tumor/muscle targeting modelsGood; chemistry scalable
Exosomes / Extracellular Vesicles (EVs) CNS delivery, oncology, immune modulationCrosses BBB, natural, low toxicityLower loading efficiency, complex purificationEV isolation, mRNA loading, surface engineering, stability optimizationEngineered ligands, glycoproteinsPotency in neuronal/tumor/immune cellsCNS/tumor targeting, tropism validationModerate; improves with bioreactor scale
Viral-Like Particles (VLPs) Immuno-oncology, APC targetingHigh uptake, strong tropism, robust mRNA expressionMore immunogenic, complex to produceVLP assembly, mRNA packaging, nanocage designViral ligands, glycoproteinsAPC-targeted assays, expression validationImmune profiling, tumor modelsGood; established VLP production workflows
RNA Nanostructures Precision oncology, receptor-specific deliveryFully programmable, biocompatibleEarly-stage, stability challengesRNA nanostructure design, aptamer targetingSequence-guided targetingUptake/expression confirmationReceptor-specific targetingEmerging scalability
Hybrid Nanoparticle Systems Complex indications, co-deliveryCombines strengths of multiple technologiesMore complex to optimizeHybrid design, co-formulation, controlled releaseLigands, peptides, multi-targetMulti-payload potency assaysBroad biodistribution profilingGood; depends on material
Peptide / CPP Delivery Local delivery, ex vivo engineeringEfficient penetration, tunable, safeLower stability in vivoPeptide–mRNA complexes, peptide screeningTargeting peptides, receptor motifsUptake, cytotoxicity, potency assaysLocal or systemic delivery validationModerate; peptide synthesis scalable
Physical Delivery (Electroporation, Microinjection) Ex vivo cell therapy, embryosHigh efficiency, bypasses endosomal escapeNot suitable for systemic useElectroporation optimization, ex vivo workflowsN/AHigh-throughput electroporation screensEx vivo CAR-T, NK, HSC mRNA deliveryN/A for GMP drug product

Integrated R&D-to-IND Services

1Delivery System Design & Consultation

We define:

  • Target tissue
  • Administration route
  • mRNA payload characteristics
  • Required expression profiles
  • Immunogenicity & safety constraints

2Custom Carrier Screening

High-throughput screening of:

  • Lipids
  • Polymers
  • Hybrid nanoparticles
  • EV / exosome candidates
  • VLP scaffolds

Optimized for efficacy, stability, and toxicity profile.

3Formulation Development

  • Carrier composition optimization
  • Charge ratio & buffer tuning
  • Nano-scale engineering for size / PDI / stability
  • Scalability assessment for GMP manufacturing

4In Vitro Functional Delivery Assays

  • Cellular uptake & transfection efficiency
  • mRNA translation potency
  • Cytotoxicity & immunogenicity
  • Endosomal escape analysis
  • High-throughput screening across multiple cell types

5 In Vivo Delivery & Biodistribution Studies

  • PK / PD profiling
  • Biodistribution imaging
  • Tumor / liver / lymph node targeting
  • Protein expression assays
  • Safety and tolerability studies

6Scale-Up & GMP-Ready Process Development

  • Microfluidics, nanoprecipitation, extrusion
  • Polymer carrier synthesis scale-up
  • EV/VLP harvesting workflow
  • Process documentation & IND-supportive reports

Our Unique Advantages

Multi-Modal Delivery Platform Beyond LNP

While most providers rely on a single delivery system (usually LNP), we offer a true multi-modality approach, including:

  • Lipid nanoparticles (LNP)
  • Polymer-based nanoparticles
  • Liposomes & hybrid lipid-polymer carriers
  • Exosome / EV delivery
  • Viral-like particles (VLPs)
  • RNA self-assembling nanostructures
  • Electroporation & physical delivery systems

You are not limited by a single technology. We help you find the system that works best for your indication.

Proprietary Lipid & Polymer Libraries

We maintain a diverse, continuously expanding library of:

  • Ionizable lipids
  • PEG-lipids
  • Biodegradable polymers
  • Amphiphilic block copolymers
  • RNA-binding monomers & dendrimers

This allows rapid screening and optimization to achieve:

  • Higher expression efficiency
  • Lower immunogenicity
  • Better organ/tissue targeting
  • Improved in vivo stability

End-to-End Delivery Development

Unlike conventional CROs or material suppliers, we offer a fully integrated, end-to-end service platform:

  • mRNA delivery system design
  • Carrier screening (lipid, polymer, exosome, VLP, hybrid)
  • Formulation development
  • Microfluidics / nanoprecipitation manufacturing
  • Analytical characterization
  • In-vitro delivery assays
  • In-vivo biodistribution & PK/PD
  • Scale-up & documentation

Expertise Across mRNA Modalities

We support:

  • Conventional mRNA
  • Self-amplifying mRNA (saRNA)
  • circRNA
  • gene editing mRNA (base editors, prime editors)
  • mRNA-encoded antibodies & cytokines

Flexible & Collaborative Engagement Model

Whether you need:

  • a complete delivery platform,
  • only lipid/polymer screening,
  • exosome engineering,
  • or formulation optimization

We provide flexible support tailored to the specific requirements of your project.

Data-Driven Development

We emphasize:

  • Quantitative delivery metrics
  • PK/PD modeling
  • Mechanistic understanding
  • Reproducible, regulatory-aligned documentation

Your delivery system is not a black box—we turn it into a scientifically validated platform.

Applications of Our mRNA Delivery Technology

Infectious Disease Vaccines

  • Our delivery systems enable the rapid development of potent and scalable prophylactic vaccines.
  • Enhance antigen expression for stronger immunogenicity
  • Enable dose sparing and multi-antigen formulations
  • Support saRNA, circRNA, and conventional mRNA vaccine formats
  • Tailor delivery to APCs and lymphoid tissues
  • Improve stability for global distribution and low-temperature logistics

Cancer Vaccines & Immuno-Oncology

  • Engineered carriers designed for precision activation of anti-tumor immune responses.
  • Deliver tumor antigens or neoantigen-encoded mRNAs
  • Facilitate in situ cancer vaccination and APC targeting
  • Support co-delivery of mRNA + immune modulators or adjuvant RNAs
  • Enable intratumoral, systemic, and lymph node-targeted delivery
  • Enhance TME penetration through advanced nanoparticle engineering

mRNA-Encoded Antibodies & Therapeutic Proteins

  • Non-viral, transient expression of complex biologics for broad therapeutic applications.
  • Support mRNA encoding monoclonal antibodies, cytokines & fusion proteins
  • Achieve prolonged expression with controlled release systems
  • Reduce manufacturing complexity vs. traditional biologics
  • Enable rapid iteration for emergent pathogens or variant threats
  • Optimize delivery for systemic or localized protein expression

Gene Editing & Gene Regulation Therapies

  • Efficient delivery of mRNA and guide RNAs for CRISPR-based editing.
  • Deliver Cas9, Cas12, base editors, or prime editors as mRNA
  • Support co-delivery of mRNA + gRNA or multiple gRNAs
  • Reduce off-target risk through transient expression
  • Enable targeted organ/cell delivery for precision correction
  • Compatible with ex vivo editing workflows (e.g., CAR-T, HSCs)

Regenerative Medicine & Tissue Repair

  • mRNA delivery enables controlled expression of growth factors and regenerative proteins.
  • Promote tissue repair through localized mRNA delivery
  • Target muscle, skin, cardiac, and neural tissues
  • Support angiogenesis-enhancing and pro-regenerative mRNAs
  • Enable minimally invasive administration options
  • Combine with biomaterial scaffolds for enhanced retention

Rare Disease & Protein Replacement Therapies

  • A non-viral alternative to gene therapy for monogenic disorders.
  • Deliver therapeutic proteins encoded by mRNA
  • Enable repeat dosing with reduced immunogenicity
  • Achieve liver-, muscle-, or CNS-targeted delivery
  • Customize carriers for long-term expression and safety
  • Support rapid prototyping & personalized therapeutics

Ex Vivo Cell Engineering

(CAR-T, NK, HSC and iPSC Programs)

  • Physical and chemical delivery systems built for high-efficiency cell manipulation.
  • High-transfection systems compatible with delicate primary cells
  • Electroporation + nanoparticle hybrid strategies
  • Support mRNA delivery for CAR expression, genome editing, and reprogramming
  • Reduce cell toxicity while improving functional expression
  • Scalable workflows for GMP cell therapy manufacturing

Autoimmune & Inflammatory Disease Modulation

  • mRNA therapeutics for immune tuning and targeted cytokine delivery.
  • Deliver tolerogenic or immune-regulatory mRNAs
  • Achieve targeted organ or immune-cell-specific delivery
  • Enable transient, controllable immune modulation
  • Combine with targeting ligands for improved biodistribution
  • Suitable for chronic or localized inflammatory conditions

Ready to accelerate your mRNA program?

Connect with our scientific team to evaluate your goals, explore tailored delivery strategies, review feasibility options, or request a detailed proposal designed around your timeline and payload requirements. Whether you are optimizing an existing formulation or building a multi-modal delivery solution from the ground up, we provide the technical insight, data-driven guidance, and flexible support needed to move your program forward with confidence. Your breakthrough deserves a delivery system engineered for precision, performance, and scalability—let us help you build it.

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