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Modification of the 2' position of the ribose ring is an important biotechnological experiment, and 2'-modified oligonucleotides exhibit a high binding affinity to target RNA, enhanced metabolic stability, and improved pharmacokinetic and toxicity profiles. BOC RNA has extensive experience in the chemical synthesis of oligonucleotides, with exclusive equipment, reagents, and expertise to ensure the high quality of each oligonucleotide. We specialize in offering a comprehensive range of DNA/RNA modification services, including 2'-modified oligonucleotides.
Oligonucleotides can specifically conjugate to target genes or mRNA according to the principle of base complementarity, and inhibit the expression of target genes at the level of gene replication, transcription, mRNA splicing, transport or translation, thus achieving gene regulation. Its biological function is largely dependent on its stability, bioavailability and properties of binding or reacting with target genes.
Modified oligonucleotides are considered as new research tools for selective inhibition of gene expression and the most promising new drugs for antitumor and antiviral chemotherapy. Thus methylated antisense DNA, phosphorothioate antisense DNA, phosphorodithioate antisense DNA, alpha-configuration antisense DNA and antisense DNA with various terminal chemical modifications came into being. The chemical modification of oligonucleotides is mainly to introduce various active groups through covalent linkage on oligonucleotides to artificially synthesize oligonucleotide conjugates.
Modification at the 2' position of the ribose ring is commonly used to help increase oligonucleotide stability and improve resistance to nuclease activity in vivo. 2'-Modifications can be used to alter the structure, shape, function and activity of RNA molecules. This technique may improve the sensitivity of genomics experiments, especially in transcription products that are highly stable in RNA molecules. 2'-Modifications can also be used to block the effects of RNA recognition and modification of proteins, thereby altering the expression level of RNA and activating or repressing genes. In addition, it can also be used to modify RNA splicing as well as to enhance RNA-DNA interactions.
2'-Modifications have been successfully applied to modify oligonucleotides to alter the expression of oligonucleotides, which helps to study the structure and function of proteins, and even applied to gene therapy to improve therapeutic efficiency. In addition, modifying the 2' position can be used to develop anti-infectious disease drugs, anti-tumor drugs, and anti-inflammatory drugs.
| 2'-Modifications | Short Code | Unit Molecular Weight: | Price |
| 2'-Amino-butyryl-pyrene-uridine | 2'-P-U | 575.51 | Inquiry |
| 2'-Amino-cytidine | 2'-N-C | 304.20 | Inquiry |
| 2'-Amino-uridine | 2'-N-U | 305.18 | Inquiry |
| 2'-Deoxy-uridine | dU | 290.17 | Inquiry |
| 2'-Fluoro-adenosine | 2'-F-A | 331.20 | Inquiry |
| 2'-Fluoro-cytidine | 2'-F-C | 307.17 | Inquiry |
| 2'-Fluoro-guanosine | 2'-F-G | 347.20 | Inquiry |
| 2'-Fluoro-uridine | 2'-F-U | 308.16 | Inquiry |
| 2'-OMe-inosine | mI | 344.22 | Inquiry |
BOC RNA is committed to providing end-to-end custom DNA/RNA modification services. If you have additional questions (for larger volumes, flexible packaging, custom manufacturing services), please contact us.
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