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Modified DNA or RNA oligonucleotides contribute to the understanding of the mechanistic and stereochemical aspects of many biochemical reactions and processes. BOC RNA offers a full range of high quality custom DNA/RNA oligonucleotide modification services through direct solid-phase chemical synthesis or enzyme-assisted methods.
What is RNA Chain Termination?
Chain termination refers to the process in which chain carriers die out and do not regenerate in a chain reaction, resulting in the termination of chain propagation. Natural breakage of the active chain is unavoidable in controlled growth reactions, which include chain transfer and chain termination reactions. There is an essential difference between the two:
- In chain transfer reactions, the active site is only shifted and the concentration of active centers remains unchanged
- In chain termination, the kinetic chain is irreversibly eliminated, the growth point disappears and the kinetic chain is terminated.
What is RNA Terminator?
Terminator is also known as polymerization stabilizer, chain terminator or retarder. It is the agent used in polymerization process of polymer chemical chain, which can terminate the continuing polymerization reaction. These substances can react with initiating and growing radicals, rendering them inactive, thus terminating chain growth and halting polymerization. High-quality polymer products with uniform molecular weight and stable molecular structure can be obtained by terminating polymerization in due course.
Terminators can be divided into two categories:
- Termination is achieved independent of protein cofactors
- Relies on protein cofactors to achieve termination
The following factors should be considered when selecting a terminator:
- The terminator selection should consider the adaptability to the application conditions, such as temperature, acidity and alkalinity, etc. Effectiveness should be high, adding a small amount (ppm concentration) can terminate the polymerization reaction and continue to function in subsequent processes such as monomer removal.
- It does not affect the stability of the polymerization process and the physical and chemical properties of the polymer, and does not cause the polymer to change color or smell.
- Easily soluble in water and can be stored in the form of aqueous solutions.
- After the polymer is discharged, it is easy to remove from the reactor and will not inhibit the next batch of polymerization.
- It is cheap, non-toxic or low-toxic, and safe to use.
We Provide the Following Chain Terminators
| Chain Terminators | Short Code | Price |
| 3' Inverted abasic | b | Inquiry |
| 3' Inverted deoxy-thymidine | idT-3' | Inquiry |
| 3'-Terminal 3'-Deoxy-Guanosine | 3'dG | Inquiry |
| 3'-Terminal dideoxy-cytidine | ddC | Inquiry |
| 5' Inverted deoxy-thymidine | idT | Inquiry |
| 5' Terminal 5'-deoxy-ribo-adenosine | 5'dA | Inquiry |
| 5' Terminal 5'-deoxy-ribo-cytidine | 5'dC | Inquiry |
| 5' Terminal 5'-deoxy-ribo-guanosine | 5'dG | Inquiry |
| 5' Terminal 5'-deoxy-ribo-uridine | 5'dU | Inquiry |
Application of RNA Chain Terminators
- Antisense/RNAi
- Epigenetics/DNA Damage
- Aptamer
- CRISPR
Advantages of RNA Chain Terminators from BOC Sciences
- BOC RNA's specialized technology platform is suitable for different production scales and purification strategies, providing significant cost savings through improved chemical coupling efficiency and allowing for significant scale-up in a short time.
- BOC RNA adheres to strict multiple quality controls, and highly stable oligonucleotides are available for different downstream applications and research purposes.
- BOC RNA offers a comprehensive range of modification types and flexible synthesis specifications - OD, nmol, mg, g, etc., for batch customization.
- Real-time technical guidance from a team of experienced experts.
* Only for research. Not suitable for any diagnostic or therapeutic use.
