Modified DNA or RNA oligonucleotides contribute to the understanding of the mechanistic and stereochemical aspects of many biochemical reactions and processes. BOC RNA offers a full range of high quality custom DNA/RNA oligonucleotide modification services through direct solid-phase chemical synthesis or enzyme-assisted methods.
Chain termination refers to the process in which chain carriers die out and do not regenerate in a chain reaction, resulting in the termination of chain propagation. Natural breakage of the active chain is unavoidable in controlled growth reactions, which include chain transfer and chain termination reactions. There is an essential difference between the two:
Terminator is also known as polymerization stabilizer, chain terminator or retarder. It is the agent used in polymerization process of polymer chemical chain, which can terminate the continuing polymerization reaction. These substances can react with initiating and growing radicals, rendering them inactive, thus terminating chain growth and halting polymerization. High-quality polymer products with uniform molecular weight and stable molecular structure can be obtained by terminating polymerization in due course.
Terminators can be divided into two categories:
The following factors should be considered when selecting a terminator:
| Chain Terminators | Short Code | Price |
| 3' Inverted abasic | b | Inquiry |
| 3' Inverted deoxy-thymidine | idT-3' | Inquiry |
| 3'-Terminal 3'-Deoxy-Guanosine | 3'dG | Inquiry |
| 3'-Terminal dideoxy-cytidine | ddC | Inquiry |
| 5' Inverted deoxy-thymidine | idT | Inquiry |
| 5' Terminal 5'-deoxy-ribo-adenosine | 5'dA | Inquiry |
| 5' Terminal 5'-deoxy-ribo-cytidine | 5'dC | Inquiry |
| 5' Terminal 5'-deoxy-ribo-guanosine | 5'dG | Inquiry |
| 5' Terminal 5'-deoxy-ribo-uridine | 5'dU | Inquiry |
RNA chain termination is the process by which the elongation of an RNA strand stops, preventing further nucleotide addition. This is a critical mechanism in RNA synthesis and plays a key role in controlling gene expression and RNA functionality.
An RNA terminator is a chemical agent used to halt RNA chain elongation during transcription. It can bind to growing RNA strands, stopping further nucleotide addition and ensuring controlled, accurate RNA synthesis for research applications.
We offer a range of RNA chain terminators, including 3' Inverted abasic, 3' Inverted deoxy-thymidine, 3'-Terminal dideoxy-cytidine, and 5' Terminal 5'-deoxy-ribo-adenosine, each designed for different applications in RNA synthesis and manipulation.
RNA chain terminators are commonly used in antisense technology, RNA interference (RNAi), CRISPR, and aptamer research. They help control RNA synthesis, enabling precise experiments in gene silencing, RNA modification, and genetic editing.
In CRISPR and RNAi experiments, RNA chain terminators enable the production of precise RNA molecules by controlling the length of RNA transcripts. This ensures better targeting and efficiency in gene editing and gene silencing applications.
Selecting the appropriate RNA chain terminator depends on factors such as the specific type of RNA synthesis, the desired termination point, and compatibility with your experimental conditions. Our team offers technical guidance to help you choose the best terminator for your needs.
