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Our drug discovery and development efforts have revolved around developing drug delivery system based on siRNA.
siRNA is a class of small (20-30 nucleotides), double stranded, non-coding RNA molecules. siRNA regulates eukaryotic gene expression at the most important levels of genome function, including chromosome segregation, chromatin structure, RNA processing, RNA stability, transcription, and translation. However, naked siRNA will degrade rapidly as there are a large number of RNases in the blood, it will affect the drug efficacy of RNAi. Therefore, it’s very important to improve the stability of naked siRNA. Nowadays, drug delivery system is becoming an important tool for delivering the candidate siRNA drugs to target cells.
Our siRNA drug delivery platform includes:
- siRNA-loaded exosomes
- siRNA-loaded liposomes
- siRNA-peptide conjugates
- siRNA-cholesterol conjugates
- siRNA-antibody conjugates
- siRNA-GalNAc conjugates
- siRNA-aptamer conjugates
- siRNA-folic acid conjugates
- siRNA-CpG Conjugates
- Dynamic Polyconjugates (DPC)
- siRNA- nanoparticle conjugates
- siRNA- polymer conjugates
We believe that our advanced technology in drug delivery will open the door for the research of more and more siRNA drug delivery systems, and be enabling for targeted therapeutics.
* Only for research. Not suitable for any diagnostic or therapeutic use.
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GMP Oligonucleotide Manufacturing Service
For more than 15 years, BOC Sciences has been manufacturing oligonucleotides for pre-clinical, pharmaceutical, food safety, and animal health industries. We provide customized and flexible oligonucleotide GMP or non-GMP production services to meet different production needs.
Lipid Nanoparticle(LNP) for RNA Delivery
BOC Sciences offers comprehensive LNP- mRNA delivery services tailored to meet the specific needs of mRNA vaccine development. Our expertise in nanoparticle formulation and mRNA chemistry enables us to design custom LNP formulations optimized for stability, efficacy, and safety.
BOC Sciences promises to offer you with GalNAc-siRNA conjugation services to help you conduct further research on GalNAc-siRNA conjugates and explore their mores omnics capabilities, the working mechanism as well as their potential therapeutic profiles.
BOC Sciences offers aptamer customization services to generate high-quality aptamers tailored to your goals, delivering excellent results even for the most difficult target molecules.
Peptide-Oligonucleotide Conjugation
BOC Sciences is committed to providing our customers with comprehensive modification and labeling, offering affordable custom oligonucleotides or peptide-oligonucleotide conjugates.
