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Base Modifications
BOC RNA has international advanced high-throughput synthesizers, professional technicians and mature synthetic purification methods to provide you with high-quality, multi-species DNA/RNA modification services, including modified base, connector, spacer, base modification, etc.
Modified Base
Modified bases, also known as rare bases, are relatively rare in nucleic acid molecules. However, they are naturally occurring and not artificially synthesized. They are formed by methylation, acetylation, hydrogenation, fluorination and sulfuration after nucleic acid transcription.
The modified bases are mostly methyl derivatives of the major bases. For example: 5-methylcytidine, 5,6-didehydrouridine, etc. In addition, there is a special nucleoside: pseudouridine nucleoside is due to the different way of base and ribose connection, that is, the C-C glycosidic bond formed by the carbon of uracil 5 position and nucleoside. tRNA contains more modified bases, and some tRNAs contain rare bases up to 10%.
Fig. 1 Structures of base-modified nucleosides known to be present at internal positions in mRNA (Harcourt EM, 2017)
We Provide the Following Base Modifications
| Base Modifications | Short Code | Description | Price |
| 1-Methyl-guanosine | m1G | 1-methyl-guanosine is guanosine substituted with a methyl group at position N-1. It has a role as a metabolite. | Inquiry |
| 2,6-Diaminopurine | DAP | One of a number of organic compounds with a purine-like structure with antiviral and antitumor properties. | Inquiry |
| 2-Methyl-adenosine | m2A | A methyl adenosine in which the methyl group is located at position 2 on the adenine ring. | Inquiry |
| 2-Aminopurine | 2AP | The parent compound of 2-aminopurine, comprising a purine core with an amino substituent at the 2-position. It has antimetabolite properties. | Inquiry |
| 4-Thio-uridine | 4-S-U | A mercapturidine and nucleoside analogue. It has an affinity label and anti-metabolite effect. | Inquiry |
| 5-Bromo-Uridine | U[5Br] | 5-Bromo-Uridine is a uridine having a bromo substituent at the 5-position. It has a role as a mutagen. | Inquiry |
| 5-Fluoro-cytidine | C[5F] | 5-Fluoro-cytidine is an organofluorine compound and a member of cytidines. | Inquiry |
| 5-Fluoro-uridine | U[5F] | 5-Fluoro-uridine is an organofluorine compound that is uridine bearing a fluoro substituent at position 5 on the uracil ring. It has a role as a mutagen. | Inquiry |
| 5-Iodo-uridine | U[5I] | An analog of iodinated thymidine. | Inquiry |
| 5-Methyl-cytidine | 5-M-C | 5-Methyl-cytidine is a methylcytidine. | Inquiry |
| 5-Methyl-Deoxycytidine | 5-M-dC | 5-Methyl-Deoxycytidine is a dinucleotide. | Inquiry |
| 5-Methyl-uridine | rT | 5-Methyl-uridine is a natural product found in Ctenodiscus crispatus, Brassica napus, and other organisms with data available. | Inquiry |
| Inosine | I | Inosine is a purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond. | Inquiry |
| N2-Methyl-guanosine | m2G | N2-Methyl-guanosine is guanosine with the hydrogen on the amine at position N-2 substituted with a methyl group. | Inquiry |
| N3-Methyl-uridine | 3-M-U | N3-Methyl-uridine is a pyrimidine nucleoside. | Inquiry |
| N6,N6-Dimethyl-adenosine | DMA | N6,N6-Dimethyl-adenosine is a methyladenosine compound with two methyl groups attached to N(6) of the adenine nucleobase. | Inquiry |
| N6-Methyl-adenosine | m6A | N6-Methyl-adenosine is an abundant modification of mRNA and DNA and is found in several viruses, and most eukaryotes. | Inquiry |
| O6-Methyl-guanosine | O6mG | O6-Methyl-guanosine is a derivative of the nucleobase guanine. | Inquiry |
| Pseudouridine | ~U | Pseudouridine is the C-glycosyl isomer of the nucleoside uridine. It has a role as an essential metabolite. | Inquiry |
| Purine ribonucleoside | Pu | Purine nucleoside is a natural product. | Inquiry |
| Pyrrolo-cytidine | pC | Modified RNA base. | Inquiry |
| Ribavirin | RBV | Ribavirin is a 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. | Inquiry |
Advantages
- Advanced technology platform
- Comprehensive range of modification types
- Flexible synthesis specifications
- Professional synthesis team
- Strict quality control
- High quality products
Reference
- Harcourt EM; et al. Chemical and structural effects of base modifications in messenger RNA. Nature. 2017 Jan 18; 541(7637): 339-346.
* Only for research. Not suitable for any diagnostic or therapeutic use.
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