Description: 3'-amino-Modifier CPG contains an amino group and is protected by the base-vulnerable Fmoc group, designed to functionalize the 3'-terminal of the target oligonucleotide by introducing a primary amine.
Description: 3'-CPR II CPG, a vital tool in molecular biology, is renowned for unraveling the elusive role of Toll-like receptor 9 (TLR9) in shaping the immune system. In the domain of immunotherapy, the adjuvant supplements DNA vaccines and jumpstarts immune responses to eradicate cancer and infections. Dive into the intriguing world of 3'-CPR II CPG as its therapeutic potential has undergone rigorous scrutiny in pre-clinical and clinical trials.
Synonyms: 3'-CPR II CPG 1000; 3-(4,4'-Dimethoxytrityloxy)-2,2-(dicarboxymethylamido)propyl-1-O-succinoyl-long chain alkylamino-CPG; 3'-CPR II CPG 1000Å
3'-PT-Amino-Modifier C6 CPG
Description: 3'-PT-Amino-Modifier C6 CPG, a specialized product that plays an essential role in the biomedical industry, facilitates the efficient and specific synthesis of oligonucleotides by serving as a solid support throughout the synthesis procedure. Its exceptional utility in the development of antisense drugs targeting an array of diseases, such as cancer, viral infections, and genetic disorders, underscores its criticality in biomedicine. With its high yield and purity, this product empowers researchers to create custom oligonucleotides, thereby rendering it an indispensable tool in the field of biomedicine.
Description: 3'-Cholesteryl-TEG CPG is a bioactive and indispensable chemical used in biomedical research for drug discovery and development. Renowned for its exceptional capacity in oligonucleotide synthesis, where cholesterol conjugation is absolutely indispensable, it holds great promise in the fight against cholesterol-dependent diseases such as atherosclerosis and hypercholesterolemia. Its prowess in the arena is unchallenged and highly sought after.
Description: AquaPhluor® 593 CPG is a fluorescent dye used to analyze RNA and DNA sequences in the biomedical industry. It is often used in conjunction with oligonucleotides to detect and quantify the expression levels of genes associated with diseases such as cancer or viral infections. Its unique water-soluble nature allows for easy use in aqueous environments.
Description: Cyanine 3 CPG, a premium fluorophore widely employed in biomedical research, serves as an indispensable tool for the precise detection of nucleic acids. Specifically, it presents a remarkable ability to label and detect targeted DNA and RNA sequences, guaranteeing higher sensitivity in analyses like microarray analysis and sequencing. Furthermore, its excellent fluorescent properties allow for the traceability of these sequences with great accuracy.
Description: Cyanine 5 CPG is a fluorescent labeling reagent used for DNA synthesis, DNA fragment detection, sequencing and genotyping. The product is commonly used in biomedicine to visualize and identify DNA in microarrays, hybridization analysis, and gene expression analysis. Through its sophisticated design, CPG enables an unprecedented level of precision in DNA analysis.
Description: 3'-BHQ-1 CPG is a high-quality and specialized phosphoramidite that is crucial in the synthesis of oligonucleotides used in biomedical research for applications such as DNA sequencing, gene expression analysis, and antiviral drug development. Its unique black-hole-quencher (BHQ) design allows for the detection of specific genetic mutations and gene expression patterns, making it an essential tool in the study and treatment of diseases such as cancer and viral infections.
Description: 3'-BHQ-2 CPG is a strategically-crafted synthetic phosphorothioate oligonucleotide, masterfully adorned with a 3'-Black Hole Quencher (BHQ-2) and 5'-dimethoxytrityl protected group. This illustrious product is pivotal in the oligonucleotide synthesis movement which looks towards the development of revolutionary oligonucleotide-based therapeutics to regulate gene expression, with exceeding ability. The medical industry envisages it to be the solution in the fight against malignant diseases, such as cancer and viral infections that pose a significant threat to human existence.
Description: 3'-BHQ-3 CPG, a modified nucleotide, is a vital component of oligonucleotide synthesis for scientific research. The merging of black hole quencher (BHQ) and 3' cytosine (C) modification endows it with magnified quenching capacity for fluorescent probes and enhanced nuclease stability that is imperative in the domain of diagnostics and therapeutics for addressing viral, cancerous, and immune disorders.
Description: 3'-Thiol-Modifier S-S CPG is used to introduce a 3'-Thiol junction with 3 and 6 atomic intervals in oligonucleotides. 3'-Dithiol Serinol CPG is used to introduce a Dithiol group at the 3' -terminus, and in combination with Dithiol Serinol Phosphoramidite, oligonucleotides with multiple thiol groups at the 3' terminus can be simply produced, which is well suited for conjugation to gold surfaces.
Description: MGB Eclipse® CPG is a cutting-edge biomedical breakthrough designed for utilization in diverse disease research, encapsulating a distinctive form of DNA alteration, denoted as MGB (Minor Groove Binder) Eclipse® CPG. This unparalleled composition manifests remarkable avidity when binding to precise DNA sequences.
Description: 3'-Uaq Cap CPG is an exquisite biomolecular entity found within the biomedical realm, unveiling its prominence as a revolutionary instrument. This specialized compound predominantly caters to the research and development of nucleotide sequences and oligonucleotides, infiltrating the dynamic spheres of drug development and genetic explorations encompassing ailments of formidable nature, including cancer, viral infections is and intricate genetic mutations.
Synonyms: 5'-Dimethoxytrityl-Uridine, 2'-(anthraquinone-2-yl-carboxamido)-3'-succinoyl-long chain alkylamino-CPG; 3'-Uaq Cap CPG 1000Å
CDPI3 MGB™ CPG
Description: CDPI3 MGB™ CPG is an exquisitely tailored and purposeful compound that garners marked proficiency within the realm of biomedicine, and has demonstrated efficacy in addressing diverse manifestations of cancer. Its unique mechanism of action bespeaks its ability to regulate crucial enzymes involved in tumor expansion, exclaiming its aptitude for both solid tumors and leukemia. Moreover, corresponding research has unveiled the possibility of applying this compound as an efficacious treatment modality for autoimmune disorders.
Description: 3'-Phosphate CPG, a widely employed constituent in the realm of biomedicine, serves as a crucial building block in the creation of oligonucleotides and a plethora of therapeutic agents, namely antiviral and anticancer drugs, as well as gene therapy. With its capacity to stimulate RNA and DNA amplification, this product occupies a prominent place in genetic disease research, illustrating its indispensability and utility.
Description: 3'-Glyceryl CPG is a biomolecular tool that has revolutionized the biomedical industry, enabling the synthesis and modification of oligonucleotides with unrivaled efficiency and precision. Its application in antisense therapy, where targeted mRNA sequences are identified and treated with specific oligonucleotides, has led to groundbreaking advancements in the realm of cancer and genetic disorder treatment. The expansive potential of this tool is limitless, holding promise for the development of novel therapeutics that could remedy even the most complex viral infections.
Description: 3'-Thiol-Modifier C3 S-S CPG is an indispensable entity within the biomedical sector assuming a pivotal function delineating the alteration of DNA. Its significance is paramount, particularly in the realm of nucleic acid research and development, with a specific focus on oligonucleotide construction. The utilization of this prodigious entity holds immense value in the field of drug discovery, where targeted therapeutics endeavor to combat multifarious maladies by honing in on precise genes and genetic sequences.
Description: 3'-Thiol-Modifier 6 S-S CPG, a chemical compound widely utilized in DNA synthesis and modification within the biomedical industry, functions as a support solid phase for the production of thiolated DNA molecules. These molecules have potential applications in diagnostics and therapeutics for diseases which include cancer and genetic disorders.
Description: DesthiobiotinTEG-CPG, a popular chemical compound, is frequently employed to extract biotin-binding proteins. Its application has extended to biomedicine, where it is employed to investigate and grasp the intricate biological pathways concerning biotin and its binding proteins. Employing DesthiobiotinTEG-CPG has propelled the progress of developing new therapeutic drugs for targeted diseases.
Description: 3'-PT-Amino-Modifier C3 CPG, a chemical utilized within the biomedical sector for the synthesis of nucleic acids, has the distinctive role of serving as a solid support in oligonucleotide synthesis. This molecular tool therefore has the capacity to produce modified DNA fragments augmented with exceptional capabilities. Significantly, this product plays an instrumental role in the advancement of drug discovery imperative for gene therapy and the treatment of complex diseases including cancer and genetic disorders.
Controlled Pore Glasses (CPGs) are made of silica and are widely used in solid phase synthesis reactions of oligonucleotides. CPG spheres have many irregular pore channels and are pore size stable. For spatial reasons, large pore sizes are suitable for the synthesis of long fragments, and short pore sizes are suitable for the synthesis of short fragments. BOC Sciences offers a wide range of CPGs for oligonucleotide synthesis to choose from, with pore sizes ranging from 300 Å-5000 Å. Groups linked to CPGs include TAMRA, DMT-Phosphate, Fluorescein, Aminopropyl, etc.
Different pore size CPGs can be used to synthesize oligonucleotide products with different loadings:
(1) 500 Å/600 Å pore size CPG products are suitable for oligonucleotide synthesis of < 35 mers. For example, therapeutic oligonucleotides can be synthesized at loads up to 100 μmol/g.
(2) 1000 Å pore size CPG products for >35 mers or highly modified oligonucleotide synthesis.
(3) 2000 Å/3000 Å pore size CPG products, suitable for oligonucleotide synthesis on a scale of 80 mers or more, with synthetic loads typically ranging from 10 to 20 μmol/g.
Examples of CPGs
TAMRA CPG
Because tetramethylrhodamine (TAMRA) is not base-stable, procedures for cleaving and deprotecting labeled oligonucleotides must be carefully considered. For example, to simplify the preparation of TAMRA oligonucleotides, 3'-TAMRA CPG for 3' labeling and TAMRA-dT for in-sequence labeling are available.
Fluorescein CPG
Fluorescein CPG is traditionally used to add fluorescein labeling to the 3'-end. For example, 3'-(6-FAM) CPG effectively blocks polymerase extension and exonuclease digestion at the 3'-end.
DMT-Phosphate-CPG
The phosphate functional group on the surface of DMT-Phosphate-CPG usually carries a DMT protecting group. DMT is a commonly used protecting group that protects the phosphate group from non-specific reactions during nucleotide synthesis. The DMT protecting group can be easily removed at the end of the synthesis to expose the phosphate group for further modification. CPGs have a pore size and pore structure that can be tuned similar to that of conventional CPGs. This controllable pore size facilitates efficient solid-phase synthesis of oligonucleotides and ensures good attachment and stability of the phosphate functional groups.
Aminopropyl-CPG
Aminopropyl-CPG is a CPG modified by an aminopropyl functional group, and we can provide products with pore sizes ranging from 300 Å-2000 Å. The products can be used for the amination modification of nucleotides, and by introducing an amino functional group, the chemistry and reactivity of nucleotides can be extended.
Features of CPGs
Adjustable Pore Size and Pore Structure
The pore size and pore structure of CPGs can be tuned as needed, typically in the range of 3-30 nanometers. This controllable pore size and pore structure helps ensure efficient solid phase synthesis of oligonucleotides.
Surface-active
CPGs have a large amount of surface activity, providing enough binding sites to allow nucleotide immobilization and chemical reactions to take place during the synthesis process.
Chemical Stability
CPGs have good chemical stability and can be used under common nucleotide synthesis reaction conditions. They can tolerate synthesis conditions such as alkaline conditions, organic solvents, and high temperatures, thus ensuring high-quality oligonucleotide synthesis.
Tunable Synthesis Scale
CPGs can be scaled and adjusted as needed for both small-scale research and large-scale industrial production.
After years of development, BOC Sciences has the expertise and experience to help you synthesize high-quality CPGs for oligo synthesis and accelerate the achievement of your research goals.
If you have any special requirements for CPGs products, please feel free to contact us. We look forward to working with you on attractive projects.
* Only for research. Not suitable for any diagnostic or therapeutic use.
Our Products
BOC Sciences is a leading provider of DNA and RNA products and services that meet the needs of
researchers and pharmaceutical companies worldwide. Its broad product portfolio includes various types of
oligonucleotides, DNA/RNA synthesis feedstocks, RNA interference tools, and advanced drug delivery systems, among
others. Designed to promote cutting-edge research and innovative therapeutic solutions, at BOC Sciences you are sure
to find the right product for you.
