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CPGs for Oligo Synthesis

Dabcyl Pro CPG

Description: Dabcyl Pro CPG is a dark quencher reagent immobilized on controlled pore glass (CPG) support for oligonucleotide synthesis. The CPG solid support enables incorporation of the Dabcyl quencher at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. It efficiently quenches fluorescence across a broad range of wavelengths via Förster resonance energy transfer (FRET), making it a classic choice for dual-labeled probe synthesis such as molecular beacons and other real-time PCR applications.
CAT: BRP-02885
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Synonyms: Dabcyl CPG; Dabcyl (hydroxyprolinol) CPG

Alkyne-modified CPG

Description: Alkyne-modified CPG is a functionalized controlled pore glass (CPG) support used in oligonucleotide synthesis. It contains a terminal alkyne group immobilized on the CPG surface, enabling incorporation of an alkyne functionality at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. The terminal alkyne allows subsequent bioorthogonal click chemistry reactions, particularly copper-catalyzed or strain-promoted azide-alkyne cycloaddition, for post-synthetic labeling and bioconjugation applications.
CAT: BRP-02886
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Synonyms: Alkyne-modified Pro CPG; Alkyne-modified (hydroxyprolinol) CPG

Alkyne doubler CPG

Description: Alkyne Doubler CPG is a functionalized controlled pore glass (CPG) support used in oligonucleotide synthesis. It contains a doubler alkyne structure immobilized on the CPG surface, enabling incorporation of multiple alkyne functionalities at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. The doubler architecture facilitates bifurcate branching, while the alkyne groups allow subsequent bioorthogonal click chemistry reactions for post-synthetic labeling and bioconjugation applications.
CAT: BRP-02887
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Synonyms: Alkyne doubler Suc CPG

Alkyne trebler Pro CPG

Description: Alkyne trebler Pro CPG is a functionalized controlled pore glass (CPG) support used in oligonucleotide synthesis. It contains a trebler alkyne structure immobilized on the CPG surface, enabling incorporation of multiple alkyne functionalities at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. The trebler architecture facilitates trifurcate branching, while the alkyne groups allow subsequent bioorthogonal click chemistry reactions for post-synthetic labeling and bioconjugation applications.
CAT: BRP-02888
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Synonyms: Alkyne trebler CPG; Alkyne trebler (hydroxyprolinol) CPG

Amino-modified CPG

Description: Amino-modified CPG is a functionalized controlled pore glass (CPG) support used in oligonucleotide synthesis. It contains a primary amine group immobilized on the CPG surface, enabling incorporation of an amino functionality at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. The amino group allows subsequent post-synthetic conjugation with NHS esters, isothiocyanates, or other amine-reactive groups for labeling and bioconjugation applications.
CAT: BRP-02889
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Synonyms: Amino-modified Pro CPG; Amino-modified (hydroxyprolinol) CPG; TFA-Amino-modified Pro CPG

Azide CPG

Description: Azide CPG is a functionalized controlled pore glass (CPG) support used in oligonucleotide synthesis. It contains an azide group immobilized on the CPG surface, enabling incorporation of an azide functionality at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. The azide group allows subsequent bioorthogonal click chemistry reactions, particularly copper-catalyzed or strain-promoted azide-alkyne cycloaddition, for post-synthetic labeling and bioconjugation applications.
CAT: BRP-02890
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Synonyms: Azide Pro CPG; Azide (hydroxyprolinol) CPG

BCN CPG

Description: BCN CPG is a functionalized controlled pore glass (CPG) support used in oligonucleotide synthesis. It contains a bicyclo[6.1.0]nonyne (BCN) functional group immobilized on the CPG surface, enabling incorporation of a BCN moiety at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. The BCN group enables highly efficient and completely orthogonal bioconjugation with various azide molecules via strain-promoted azide-alkyne cycloaddition (SPAAC) without copper catalyst, allowing bioorthogonal modification of oligonucleotides under mild conditions.
CAT: BRP-02891
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Synonyms: BCN Pro CPG; BCN (hydroxyprolinol) CPG

Behenic CPG

Description: Behenic CPG is a functionalized controlled pore glass (CPG) support used in oligonucleotide synthesis. It contains a behenic acid (docosanoic acid, C22:0) moiety immobilized on the CPG surface, enabling incorporation of a long-chain fatty acid at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. The behenic acid modification enhances cellular uptake, improves nuclease resistance, and facilitates in vivo delivery and membrane association of oligonucleotides.
CAT: BRP-02892
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Synonyms: Behenic DMT Suc CPG

Biotin Pro CPG

Description: Biotin Pro CPG is a functionalized controlled pore glass (CPG) support used in oligonucleotide synthesis. It contains a biotin moiety attached to a hydroxyprolinol-based linker, immobilized on the CPG surface. The CPG solid support enables incorporation of the biotin label at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. Biotin enables high-affinity binding to streptavidin or avidin, facilitating oligonucleotide purification, detection, and immobilization applications.
CAT: BRP-02893
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Synonyms: Biotin (hydroxyprolinol) CPG

Cholesterol Pro CPG

Description: Cholesterol Pro CPG is a functionalized controlled pore glass (CPG) support used in oligonucleotide synthesis. It contains a cholesterol moiety attached to a hydroxyprolinol-based linker, immobilized on the CPG surface. The CPG solid support enables incorporation of the cholesterol label at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. Cholesterol conjugation enhances cellular uptake, improves nuclease resistance, and facilitates in vivo delivery of oligonucleotides.
CAT: BRP-02894
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Synonyms: Cholesterol (hydroxyprolinol) CPG

Tris-GalNAc Pro CPG

Description: Tris-GalNAc Pro CPG is a functionalized controlled pore glass (CPG) support used in oligonucleotide synthesis. It contains three N-acetylgalactosamine (GalNAc) moieties attached to a hydroxyprolinol-based linker, immobilized on the CPG surface. The CPG solid support enables incorporation of the Tris-GalNAc label at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. The trivalent GalNAc ligand enables high-affinity binding to the asialoglycoprotein receptor (ASGPR) on hepatocytes, facilitating targeted delivery of oligonucleotides to the liver.
CAT: BRP-02895
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Synonyms: Tris-GalNAc CPG; Tris-GalNAc (hydroxyprolinol) CPG

Mono GalNAc TEG CPG

Description: Mono GalNAc TEG CPG is a functionalized controlled pore glass (CPG) support used in oligonucleotide synthesis. It contains a single N-acetylgalactosamine (GalNAc) moiety attached to a triethylene glycol (TEG) linker composed of three PEG units, immobilized on the CPG surface. The CPG solid support enables incorporation of the Mono GalNAc label at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. The monovalent GalNAc ligand enables binding to the asialoglycoprotein receptor (ASGPR) on hepatocytes, facilitating targeted delivery of oligonucleotides to the liver.
CAT: BRP-02896
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Synonyms: Mono GalNAc TEG DMT Suc CPG

Lipoic CPG

Description: Lipoic CPG is a functionalized controlled pore glass (CPG) support used in oligonucleotide synthesis. It contains a lipoic acid moiety immobilized on the CPG surface, enabling incorporation of a lipoic acid functionality at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. The lipoic acid group, with its reactive disulfide bond, allows post-synthetic conjugation via disulfide exchange or reduction, facilitating oligonucleotide labeling, surface immobilization on gold nanoparticles, and bioconjugation applications.
CAT: BRP-02897
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Synonyms: Lipoic Pro CPG; Lipoic (hydroxyprolinol) CPG

α-Tocopherol TEG CPG

Description: α-Tocopherol TEG CPG is a functionalized controlled pore glass (CPG) support used in oligonucleotide synthesis. It contains an α-tocopherol (vitamin E) moiety attached to a triethylene glycol (TEG) linker, immobilized on the CPG surface. The CPG solid support enables incorporation of the α-tocopherol label at the 3' end of DNA or RNA sequences during automated solid-phase synthesis. α-Tocopherol conjugation enhances cellular uptake, improves nuclease resistance, and provides antioxidant protection for oligonucleotides.
CAT: BRP-02898
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Synonyms: α-Tocopherol TEG DMT CPG

Frequently Asked Questions (FAQ)

What pore size CPG is recommended for long oligonucleotide synthesis?

For long DNA or RNA sequences, 1000 Å or 2000 Å CPG is generally recommended to improve reagent diffusion and maintain coupling efficiency during extended synthesis cycles.

Loading capacity influences both yield and coupling efficiency. Controlled and reproducible loading is essential for minimizing batch-to-batch variability in long-term manufacturing programs.

Each batch is supplied with a Certificate of Analysis (COA) and full traceability to support audits and quality reviews.

Yes. We support material supply from early process development through scale-up and routine manufacturing.

CPGs should be stored in a dry, tightly sealed container at room temperature to maintain surface functionality and consistent performance.

* Only for research. Not suitable for any diagnostic or therapeutic use.

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