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Ferrocene Labeling of Oligonucleotides

What is Ferrocene Labeling Oligonucleotides?

Ferrocene Labeling Oligonucleotides is a labeling strategy that introduces a Ferrocene moiety into an oligonucleotide molecule. This labeling is achieved by synthetically attaching the Ferrocene moiety precisely to a specific position in the oligonucleotide. Ferrocene is a molecule with specific electrochemical properties, so the introduction of this moiety results in labeled nucleic acid molecules with unique electrochemical properties. This labeling strategy can be used to study the electrochemical behavior of DNA and RNA, including their redox properties under different conditions.Ferrocene Labeling Oligonucleotides can also be applied in electrochemical sensors and biosensors by monitoring the electrochemical signals of the Ferrocene to enable the detection of nucleic acid molecules. Such labeled nucleic acid molecules have potential applications in biomedical and analytical chemistry, providing powerful tools for studying biomolecular interactions and developing novel biosensors.

Ferrocene-labeled oligonucleotide chains end-tethered to gold electrode surfaces.Figure 1. Ferrocene-labeled oligonucleotide chains end-tethered to gold electrode surfaces. (A, Agne.; et al, 2003)

Applications of Ferrocene Labeling Oligonucleotides

BOC Sciences Offers Ferrocene Oligonucleotides

As an expert in nucleic acid synthesis, BOC Sciences mentions the introduction of Ferrocene labeling into oligonucleotide molecules as a custom modification service, which imparts special electrochemical properties to nucleic acids and assists in the field of electrochemistry and sensor development. The service processes we have used for optimization include sequence design, synthesis and labeling, purification and characterization, and even biological function evaluation.

BOC Sciences offers the following ferrocene labeling services.

Based on industry-leading oligonucleotide synthesis technology platforms and state-of-the-art equipment, more tailor-made services not mentioned are available at BOC Sciences. Please relax and contact us, we always look forward to partnering with you.

Reference

  1. A, Agne.; et al. 3'-Ferrocene-Labeled Oligonucleotide Chains End-Tethered to Gold Electrode Surfaces: Novel Model Systems for Exploring Flexibility of Short DNA Using Cyclic Voltammetry.J. AM. CHEM. SOC.2003, 125: 1112-1113.
* Only for research. Not suitable for any diagnostic or therapeutic use.
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