Ferrocene Labeling Oligonucleotides is a labeling strategy that introduces a Ferrocene moiety into an oligonucleotide molecule. This labeling is achieved by synthetically attaching the Ferrocene moiety precisely to a specific position in the oligonucleotide. Ferrocene is a molecule with specific electrochemical properties, so the introduction of this moiety results in labeled nucleic acid molecules with unique electrochemical properties. This labeling strategy can be used to study the electrochemical behavior of DNA and RNA, including their redox properties under different conditions.Ferrocene Labeling Oligonucleotides can also be applied in electrochemical sensors and biosensors by monitoring the electrochemical signals of the Ferrocene to enable the detection of nucleic acid molecules. Such labeled nucleic acid molecules have potential applications in biomedical and analytical chemistry, providing powerful tools for studying biomolecular interactions and developing novel biosensors.
Figure 1. Ferrocene-labeled oligonucleotide chains end-tethered to gold electrode surfaces. (A, Agne.; et al, 2003)
As an expert in nucleic acid synthesis, BOC Sciences mentions the introduction of Ferrocene labeling into oligonucleotide molecules as a custom modification service, which imparts special electrochemical properties to nucleic acids and assists in the field of electrochemistry and sensor development. The service processes we have used for optimization include sequence design, synthesis and labeling, purification and characterization, and even biological function evaluation.
BOC Sciences offers the following ferrocene labeling services.
Based on industry-leading oligonucleotide synthesis technology platforms and state-of-the-art equipment, more tailor-made services not mentioned are available at BOC Sciences. Please relax and contact us, we always look forward to partnering with you.
Ferrocene labeling involves attaching a Ferrocene moiety to an oligonucleotide, providing the nucleic acid with unique electrochemical properties. This modification is used to study the redox behavior of DNA and RNA, and for developing electrochemical sensors and biosensors.
Ferrocene-labeled oligonucleotides are used in electrochemical analysis, biosensor development, gene therapy research, and optimizing nucleic acid drug delivery. They enable highly sensitive and selective detection of nucleic acids in various biological and chemical studies.
Ferrocene-labeled oligonucleotides are ideal for electrochemical analysis due to the unique redox properties of Ferrocene. The electrochemical signal from Ferrocene provides valuable insights into the behavior of DNA and RNA molecules under various conditions.
Ferrocene-labeled oligonucleotides can be integrated into biosensors to detect specific nucleic acid sequences. The Ferrocene tag produces an electrochemical signal that can be monitored, offering a sensitive and efficient method for nucleic acid detection.
We offer several Ferrocene labeling options, including terminal labeling (at the 5' or 3' end), internal labeling, multiple labeling, and site-specific labeling. Each option is designed for specific research needs, from electrochemical detection to biosensor applications.
Introducing multiple Ferrocene labels on an oligonucleotide enhances the sensitivity and specificity of electrochemical signals. This is particularly useful in applications requiring high sensitivity, such as detailed electrochemical studies and biosensor development.
Yes, Ferrocene-labeled oligonucleotides are valuable in gene therapy research for studying gene expression and regulation. They allow for the monitoring of nucleic acid interactions and can aid in developing more effective gene therapies.
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