We specialize in designing and manufacturing custom oligonucleotide probe pools tailored for advanced genomic applications. Whether your project involves targeted sequencing, gene expression profiling, CRISPR screening, or rare variant detection, our high-fidelity synthesis technology ensures maximum specificity, sensitivity, and reproducibility. With end-to-end customization-from probe design to synthesis and quality validation-we deliver solutions that accelerate research breakthroughs while meeting the highest industry standards.
Oligonucleotide probe pools (oligo pools) are high-complexity, synthetic DNA libraries designed for diverse applications in genomics, synthetic biology, and molecular diagnostics. These pools consist of thousands to millions of unique oligonucleotides synthesized in parallel, enabling cost-effective and scalable solutions for gene synthesis, CRISPR guide RNA libraries, fluorescence in situ hybridization (FISH), and targeted sequencing. Our custom oligo pools are manufactured using high-fidelity chip-based synthesis and next-generation quality control, ensuring high accuracy and uniformity. With flexible design options, researchers can tailor oligo pools for gene assembly, pathway engineering, or high-resolution genomic imaging.
Low Sensitivity in Rare Variant Detection: Detecting low-frequency genetic variants is often hindered by inadequate probe design and synthesis quality. Our optimized custom oligonucleotide probe pools enhance hybridization efficiency, enabling precise detection of rare alleles even in complex genomic backgrounds.
Off-Target Hybridization and Background Noise: Non-specific binding can compromise sequencing accuracy and inflate data noise. We employ advanced bioinformatics and stringent sequence filtering to minimize off-target interactions, ensuring high specificity and reliable results.
Time-Consuming Probe Development: Traditional probe development workflows can delay research timelines. With streamlined design-to-delivery processes and automated synthesis platforms, we significantly reduce turnaround time without sacrificing quality.
Batch-to-Batch Inconsistency: Variability in probe performance between production batches can lead to irreproducible results. Our manufacturing protocols maintain strict quality control, delivering consistent performance across every batch.
Scalability Challenges for Large Genomic Panels: Expanding from small-scale to large-scale projects often increases cost and complexity. Our scalable synthesis capabilities support both small pilot studies and high-throughput genomic applications cost-effectively.
Tailored sequence design using bioinformatics analysis to ensure optimal coverage and target specificity.
Scalable manufacturing for small pilot studies or large-scale genomic programs.
Options for labeling, chemical modifications, or specialized chemistries to meet assay requirements.
QC via mass spectrometry, HPLC, and NGS-based validation to ensure sequence accuracy and purity.
apid production cycles without compromising quality.
Reliable delivery to research institutions and companies worldwide.
We start by discussing your project's goals, target regions, and performance requirements. Our technical experts evaluate your needs and recommend the most suitable probe design strategy.
Using advanced design algorithms, we create oligonucleotide sequences with optimal coverage, GC content, and minimal off-target potential.
We synthesize the custom probe pools with your chosen modifications—such as fluorophores, biotin labels, or chemical backbones—tailored to your assay.
Every batch undergoes stringent QC processes, including mass spectrometry, HPLC, and sequencing validation to ensure purity and accuracy.
Probes are carefully packaged under controlled conditions and shipped worldwide with complete documentation and performance reports.
Our team provides ongoing technical assistance for troubleshooting, optimization, and scaling up to meet evolving research demands.
Oligo pools serve as affordable DNA sources for constructing gene libraries, metabolic pathways, and engineered strains [1, 3].
Designed for high-resolution fluorescence in situ hybridization (FISH), enabling visualization of chromosomal loci and structural variants [2, 6].
Custom sgRNA libraries for genome-wide screening and targeted gene editing [4, 5].
Multiplexed probe sets for enriching and sequencing small genomic regions or rare variants.
We can accommodate both small-scale research projects and large-scale commercial orders, with flexible minimums to fit your needs.
We offer multiple chemistries and labels, including fluorescent dyes, biotin, phosphate groups, LNA modifications, and more, tailored to your application.
All probes undergo mass spectrometry, HPLC, and sequence validation before shipping, ensuring high purity, accuracy, and batch-to-batch consistency.
Absolutely. Our scientific support team is available to help with protocol optimization, troubleshooting, and project scaling.
Unlock the full potential of your research with our Custom Oligonucleotide Probe Pools—engineered for precision, scalability, and reliability in advanced genomic applications. Whether you're working on targeted sequencing, gene expression profiling, or rare variant detection, our expert team is here to deliver probe solutions tailored to your exact needs.
Contact us today to discuss your project and get a free consultation—because in genomics, precision isn't optional, it's everything.
References
Global Supplier of High-Quality RNA / DNA Products & Services.
