As a leading biotechnology company, BOC Sciences provides bridging nucleic acid (BNA) oligonucleotide synthesis services to customers worldwide with its proprietary nucleic acid technology. The third-generation nucleic acid analog, BNA, has better affinity and stability, and can better meet the specific needs of customers.
|Service||Custom BNA Oligonucleotide Synthesis|
|Purification||Desalted, deprotected, PAGE, HPLC, and/or MS|
|Quality Control||All custom BNA are manufactured under strict SOP quality control processes and checked for their quality|
Bridging nucleic acid (BNA) is a novel nucleic acid analogue. The first generation BNA, LNA, is a bicyclic nucleotide analogue. LNA has good RNA-specific binding affinity. The second generation BNA, BNANC (2'-O,4'-amino ethylene bridging nucleic acid) is a six-membered bridging oligonucleotide. Oligonucleotides containing BNANC are more thermostable and water-soluble and lead to RNase H degradation of the target RNA. The new generation of BNA contains a five-membered or six-membered bridged structure with a fixed" C3'-endo sugar puckering. This bridge binds to the 2', 4' position of the ribose to obtain a 2', 4'-BNA monomer. The potential of the new generation BNA is the iteration of various BNAs. Such as, the recent synthesis of (S)-cEt-BNA, amino-BNA (AmNA), sulphonamide-BNA, guanidino-BNA and benzylidene acetal-type BNA. Compared with the previous generations of restricted nucleic acids (LNA or BNANC), the new generation of BNA exhibits a remarkably high affinity for its complementary strand. Their extraordinary levels of sensitivity and specificity for nucleic acid resistance make BNAs an excellent tool for the development of high-value detection systems and therapeutic products.
Fig. 1 The structure of BNAcoc and other 2', 4' BNANC nucleic acids. (Kim S, 2015)
Incorporation of BNA into oligonucleotides allows the production of modified synthetic oligonucleotides with the following characteristics: