BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences offers conjugation services to combine oligonucleotides with exosomes. We indeed have the capability to meet your needs for novel conjugates.
Exosomes are small extracellular vesicles released by cells and play a role in intercellular communication by transferring biomolecules such as proteins, RNA and DNA between cells. In exosome-oligonucleotide conjugation, exosomes act as carriers to protect oligonucleotides from degradation and to facilitate their transport to specific cells or tissues.
Figure 1. Exosomes. (Zipkin, M, 2019)
The process of preparing an exosome-oligonucleotide conjugation typically involves modifying the surface of the exosome or oligonucleotide to produce a reactive group that can form a covalent bond. Various chemical or bioengineering techniques, such as click chemistry, lipid-based methods or genetic engineering methods, can be utilised to achieve the attachment of oligonucleotides to the surface of exosomes or to encapsulate them inside exosomes.
Based on the specific biological status of exosomes, exosome-oligonucleotide conjugation has great potential to advance the field of nucleic acid-based therapeutics and precision medicine.
| Service | Exosome-Oligonucleotide Conjugation |
| Customer provides | Oligonucleotide sequence |
| Purification | QC analysis by MS, HPLC, or PAGE |
| Delivery | Typical delivery is lyophilized samples in individual vials that are fully labeled |
| Request a Quote | Inquiry |
BOC Sciences is committed to providing a personalised service, customising designs and fabrications to meet customer requirements.
Figure 2. Service flow of exosome-oligonucleotide conjugation.
Exosome-oligonucleotide conjugation involves attaching oligonucleotides to exosomes, which serve as carriers to protect and deliver nucleic acids to specific cells or tissues. This technique is widely used in nucleic acid-based therapies and precision medicine.
The conjugation process typically involves modifying the surface of exosomes or oligonucleotides with reactive groups, followed by chemical or bioengineering techniques like click chemistry or lipid-based methods to bind them. This results in a stable conjugate with enhanced delivery capabilities.
Exosome-oligonucleotide conjugates are used in RNA interference (RNAi) for gene silencing, precise gene editing, vaccine development, targeted drug delivery, and as biomarkers for diagnostics and prognostics.
Exosomes can be isolated from various cell types, including immune cells, stem cells, cancer cells, or specific tissue types. BOC Sciences offers a range of exosome options for custom conjugation services.
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