Small Molecule-Oligonucleotide Conjugation

BOC Sciences is always conmmitted to powering drug delivery and drug efficiency through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences offers conjugation services to combine oligonucleotides with small molecules.

What is Small Molecule-Oligonucleotide Conjugation?

Small molecules and oligonucleotides can be chemically linked to form small molecule-oligonucleotide conjugates, which are valuable tools for the study of biological processes and interactions, and are widely used in controlled drug delivery, bioimaging and diagnostics.

Figure 1. Schematic diagram of a method for the synthesis of bifunctional small molecule-oligonucleotide hybrids. (Bhattarai, U; et al, 2020)

• Types of Small Molecules Available

1. Small molecule drugs (e.g. aspirin, paracetamol, statins, antibiotics, antivirals, chemotherapy drugs, etc.)
2. Hormones and hormone-like substances (e.g. insulin, oestrogen, testosterone, adrenaline, cortisol, etc.)
3. Enzyme cofactors (e.g. NADH, FAD, ATP, coenzyme A, etc.)
4. Small molecule dyes (e.g. chlorophyll, etc.)
5. Toxins (e.g. glyphosate, neonicotinoids, etc.)
6. Metabolite molecules (e.g. glucose, lactate, citrate, acetyl coenzyme A, etc.)

• Application of Small Molecule-Oligonucleotide Conjugation

• The direction of application of small molecule-oligonucleotide conjugation generally depends mainly on the type of small molecule, while the oligonucleotide component mainly confers sequence specificity.
• Small molecule components can provide fluorescent or radioactive properties for visualisation studies. Small molecule-oligonucleotide conjugations can be used as probes or sensors to image specific cellular targets or to detect the presence of specific nucleic acids.
• Small molecule-oligonucleotide conjugation can be used to selectively regulate gene expression, inhibit protein function or detect specific molecular interactions.

Introduction of Small Molecule-Oligonucleotide Conjugation Services

• What Are Our Small Molecule-Oligonucleotide Conjugation Services?

1. BOC Sciences' expert team will synthesise the oligonucleotide and then chemically link it to obtain the small molecule-oligonucleotide conjugation according to the customer's requirements.
2. BOC Sciences has been working on optimising different types of synthesis protocols to ensure high product purity and yield.
3. BOC Sciences has specialised characterisation platforms and purification techniques to ensure the correct purity and structure of small molecule-oligonucleotide conjugation.
4. Quality Assurance: BOC Sciences adheres to high quality standards in all synthesis, characterisation and analytical processes to ensure customer satisfaction.

Figure 2. Service flow of small molecule-oligonucleotide conjugation.

• Why Choose Our Small Molecule-Oligonucleotide Conjugation Services?

1. BOC Sciences has optimised and well-tested reaction conditions and reagent selection to ensure optimum bonding efficiency and yield.
2. BOC Sciences offers a wide range of crosslinkers and crosslinking methods to meet the different needs of our customers.
3. BOC Sciences has a dedicated technical team to ensure technical support and standardised operating procedures.
4. BOC Sciences' ability to respond quickly and with excellent customer service ensures that customer problems and needs are resolved in a timely manner.