Protein-Oligonucleotide Conjugation

BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with proteins. We have the capability and confidence to meet your needs for novel conjugates.

An Overview of Protein-Oligonucleotide Conjugation

• What is Protein-Oligonucleotide Conjugation

Protein-oligonucleotide conjugation is a process of attaching a short, single-stranded DNA molecule (oligonucleotide) to a protein molecule (such as an antibody or enzyme).

• Protein-Oligonucleotide Conjugation Approach

Protein-oligonucleotide conjugation can be accomplished through various methods, such as chemical, enzymatic, and hybridization-based approaches. Chemical conjugation entails employing reactive chemicals to establish a covalent linkage between the protein and oligonucleotide, while enzymatic conjugation employs enzymes to catalyze the bond formation. Meanwhile, hybridization-based conjugation relies on the complementary base pairing between a specific region of the oligonucleotide and the protein.

• Applications of Protein-Oligonucleotide Conjugation

The conjugation of proteins and oligonucleotides has a broad spectrum of uses, such as drug delivery, diagnostics, and therapeutics. In drug delivery, these conjugates can be utilized to enhance the effectiveness of drugs and minimize adverse reactions by targeting particular cells or tissues. In diagnostics, they can detect specific biomolecules, for example, proteins or nucleic acids, in biological specimens. In therapy, they can control gene expression or hinder specific disease-causing proteins.

• Challenges of Protein-Oligonucleotide Conjugation

Despite its many applications, protein-oligonucleotide conjugation poses some challenges. One of the main challenges is achieving site-specific binding, which involves linking the oligonucleotide to a specific site on the protein. Another challenge is to maintain the stability and activity of the protein-oligonucleotide conjugate, as the conjugation process affects the structure and function of both molecules. In addition, the synthesis and purification of protein-oligonucleotide conjugates can be complex and time-consuming.

Introduction to Protein-Oligonucleotide Conjugation Services

• What Are Our Protein-Oligonucleotide Conjugation Services?

1.Design and synthesis of suitable oligonucleotide sequences

2.Select and prepare suitable proteins

3.Chemically modify oligonucleotides to bind to proteins

4. Covalently bind the modified oligonucleotide to the protein

5.Purify and characterize the product

6. Provide high quality products with detailed analytical reports

7. Provide customized services to meet specific customer needs

8. Provide fast, reliable and economical services to ensure customer satisfaction.

• Why Choose Our Protein-Oligonucleotide Conjugates

1. High Purity: BOC Sciences' protein-oligonucleotide conjugation service is able to provide high purity products to ensure the accuracy and reliability of experimental results.
2. Customization: BOC Sciences' protein-oligonucleotide conjugation service can be customized to meet the specific needs of customers for different experimental requirements.
3. Multiple Labeling Methods: BOC Sciences' protein-oligonucleotide conjugation service offers multiple labeling methods, including fluorescent labeling, enzyme labeling, etc., to meet the needs of different experiments.
4. Professional Team: BOC Sciences has an experienced and professional team to provide high-quality protein-oligonucleotide conjugation services.
5. Fast Delivery: BOC Sciences' protein-oligonucleotide conjugation services are able to provide fast delivery to meet the urgent needs of customers.
6. Competitive Pricing: BOC Sciences' protein-oligonucleotide conjugation services offer competitive pricing to help clients save money in their experiments.