BOC RNA provides long oligonucleotide synthesis services. Based on our oligonucleotide synthesis platform, we provide our customers with efficient long oligonucleotides for cloning, mutagenesis, gene expression and other applications.
For additional information regarding custom long oligonucleotides synthesis, please feel free to contact us.
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The emergence of gene synthesis and targeted mutagenesis has driven the need to synthesize long oligonucleotides (>75 nucleotides). While there is a high demand for long oligonucleotides (150 mer and more), the yields and associated side reactions of conventional DNA synthesis previously limited the availability of oligonucleotides to<150 nucleotides. The longer the oligonucleotide, the more difficult it is to isolate the pure bioactive product. No chemical reaction can be completed with 100% efficiency. In oligonucleotide synthesis reactions, conjugation, capping, oxidation and deblocking, any of these defects can lead to faulty sequences. The more the accumulation of failed sequences, the lower the possibility of obtaining pure oligonucleotides. This resulted in a mixture of n-1 deletion mutations. BOC RNA's expertise in oligonucleotide synthesis enables us to obtain high-quality DNA long oligonucleotides using the best available synthetic reagents, optimized synthetic protocols, and stringent quality assurance and quality control standards.