Folic acid–siRNA Conjugates

What are Folic Acid–siRNA Conjugates?

RNA interference (RNAi) is an endogenous pathway that uses double-stranded RNA to suppress the expression of a target mRNA, resulting in sequence-specific gene silencing. Delivering siRNA to target cells or tissues has been one of the major challenges in RNAi research. Due to their large size and polyanionic backbone, bare siRNAs cannot diffuse across cell membranes. Therefore, receptor-targeted ligands can be used to deliver siRNAs to target cells and tissues. For example, vitamin folic acid, which has been widely used as a drug delivery system to target folate receptors (FRs) in tumor cells, is a cell surface glycoprotein that binds folate with high affinity. These receptors are expressed at low levels in most tissues because their expression is restricted to cells important for folate uptake and embryonic development, but they are highly overexpressed on the surface of many cancers. This includes about 90% of ovarian cancers as well as breast, endometrial, brain and kidney cancers. Once bound to FR, folate enters the cell via receptor-mediated endocytosis. Remarkably, folate binding retains the ability to bind to and be internalized by this receptor, making FR an attractive molecular target for cancer research.

Key Advantages of Folic Acid for siRNA Delivery

• Folic acid binds with high affinity to the cell surface folate receptor
• Enhanced gene silencing activity and low cytotoxicity
• Potent dose-dependent knockdown of the anti-apoptotic gene

BOC Sciences has expert technical support to provide accurate and affordable folic acid–siRNA conjugates services.

Custom Folic Acid–siRNA Conjugates Services

• Free design of siRNA sequences (four siRNA oligonucleotides)
• siRNA oligonucleotide synthesis
• Modification of siRNA
• Oligonucleotide deprotection and purification
• Synthesis and purification of folic acid–siRNA conjugates
• Copolymer Characterization

Highlights of Folic Acid-siRNA Conjugates Services

• Can be started at any stage of this scope of services upon request.
• Deliverables: The experimental report includes information on experimental methods, purification results, processing reports, etc.
• Top technology supports and experienced experts.
• 1 on 1 customer service, competitive price, and fast delivery.

Applications of Folic Acid-siRNA Conjugates

• Basic Research
• Drug discovery and development
• Clinical Practice

Quotation and Ordering

We can tailor this service to your research interest. Please feel free to contact us or send us an inquiry directly and we will be happy to assist you.

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Folic acid–siRNA Conjugates

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