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Peptide nucleic acids (PNAs), as a kind of synthetic nucleic acid analogs, have proved to be of powerful use in molecular biology procedures and diagnostic analyses. In this respect, peptide nucleic acid probe has attracted a lot of attention because of its high sensitivity and specificity. Here, BOC Sciences, as an expert in nucleic acids, is very good at capturing the relevant research hotspots in the field of oligonucleotides and providing custom synthesis services for customers in need of PNA probe development.
What is Peptide Nucleic Acid Probe?
What is Peptide Nucleic Acid?
Structural comparison of PNA with RNA and DNA.( Singh, K, R.; et al. 2020)
Peptide nucleic acid (PNA) is a synthetic polymer similar to DNA or RNA.The backbone of PNA is built up from repeating N-(2-aminoethyl)-glycine units through peptide bonds (amide bonds). In the PNA molecule, various purine and pyrimidine bases are fused to the N of the glycine portion of the backbone through an acetyl structure.
Peptide Nucleic Acid Probe & DNA Probe
| Peptide Nucleic Acid Probe | DNA Probe | |
| Structure | A peptide backbone made of N-(2-aminoethyl)glycine, with the same four nucleotide bases found in DNA | A sugar-phosphate backbone with four different nucleotide bases |
| Binding Affinity | PNA-DNA interactions exhibit higher binding affinities | DNA-DNA interactions show relatively weak binding affinity compared to PNA-DNA |
| Nuclease Resistance | + + + | - |
| Specificity | + + + | - |
| Sensitivity | + + + | - |
| Thermal Stability | + + + | + |
| Cell Permeability | + + + | - |
What are Nucleic Acid Probes Used for?
- Molecular Diagnostics
- Real-time Polymerase Chain Reaction (qPCR)
- Genotyping and Mutation Analysis
- Antisense Therapy
- Genomic Expression and Regulation Studies
- Bioimaging
- Drug Delivery
- Pathogen Detection
- Nanomedicine Development
BOC Sciences' Custom Peptide Nucleic Acid Probe Service
PNA Probe Design & Synthesis: With over 15 years of experience in oligonucleotide synthesis, BOC Sciences' team of experts will take into account sequence length, specificity, and customer-specific applications to provide customized PNA probes that match your specific target DNA or RNA sequence.
Labeling & Modification of PNA Probes: For visualization or detection requirements in specific applications, BOC Sciences offers you a range of reporter molecules, such as fluorophores or bursting agents, for labeling and modification.
Custom Scale & Amount: BOC Sciences can synthesize custom PNA probes at different scales and quantities depending on your project needs. In particular, for large-scale synthesis needs, BOC Sciences offers you the most competitive pricing and shortest lead times while maintaining quality and purity.
Application Support: Comprehensive after-sales service and additional technical support is available at BOC Sciences. Feel free to contact our experts for professional advice on any questions regarding the practice of our PNA probe products.
Quality Control Throughout Production: BOC Sciences has well-established quality control systems, such as MS and HPLC analysis. We ensure strict quality control standards when providing any customized service.
The process of PNA probes custom service.
Order PNA FISH Probe Here
| PNA Fish Probes | Details | Price |
| Telomere Probes | Telomere PNA probes can be used for qualitative and quantitative analysis of repetitive telomere sequences. | Inquiry |
| Centromere Probes | Centromere PNA probes can be used to identify the centromere region of each chromosome and to detect chromosomes for numerical analysis. | Inquiry |
| CAG Repeat Probes | CAG repeat PNA probes are mainly used for the detection and analysis of repeat sequences. | Inquiry |
For more custom PNA services, please feel free to contact us.
Reference
- Singh, K, R.; et al. Potential Applications of Peptide Nucleic Acid in Biomedical Domain. Engineering Reports. 2020, 2(9): e12238.
* Only for research. Not suitable for any diagnostic or therapeutic use.
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