BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with lipids. We have the capability and confidence to meet your needs for novel conjugates.
The basic structure of lipid-oligonucleotide conjugates (LOCs) is to combine lipids and oligonucleotides through chemical bonding. The lipids can be phospholipids, fatty acids, cholesterol, etc., and the oligonucleotides can be DNA, RNA, etc. LOCs are characterized by good stability, controlled release and targeting. These characteristics make LOCs have wide application prospects in biomedical field.
Gene therapy is a new approach to treat genetic diseases and cancers, and LOCs can be used as a vehicle for gene therapy to deliver the genes to be treated into human cells. Due to the good stability and controlled release of LOCs, they can help gene delivery into cells in gene therapy and avoid gene degradation and side effects.
Vaccines are an effective way to prevent infectious diseases, and LOCs can be used as vaccine carriers to deliver vaccine antigens to human cells and induce immune responses in the body. Because LOCs are targeted, they can deliver vaccine antigens to specific cells and enhance the effectiveness of vaccines.
Drug delivery is a method to deliver drugs to specific cells or tissues. LOCs can be used as carriers of drugs to specific cells or tissues. Due to the targeted nature and controlled release of LOCs, it is possible to deliver drugs to specific cells or tissues, reducing side effects and improving the effectiveness of drugs.
Fig. 1 Schematic illustration of LONs (A) presynthetic-conjugation approach and (B) postsynthetic-conjugation approach (Li X, 2020)
| Service | Lipids-Oligonucleotide Conjugation |
| Customer provides | Oligonucleotide sequence |
| Purification | QC analysis by MS, HPLC, or PAGE |
| Delivery | Typical delivery is lyophilized samples in individual vials that are fully labeled |
| Request a Quote | Inquiry |
References
Lipids-oligonucleotide conjugation (LOC) involves chemically linking lipids (such as phospholipids, fatty acids, or cholesterol) to oligonucleotides (such as DNA or RNA). This creates stable conjugates that have applications in targeted delivery and controlled release, making them valuable in gene therapy, vaccine research, and drug delivery.
LOCs are widely used in gene therapy, vaccine research, and targeted drug delivery. They enable efficient gene delivery, enhance vaccine efficacy by targeting specific cells, and improve drug delivery to reduce side effects and increase therapeutic effectiveness.
The synthesis of LOCs typically involves chemical conjugation methods, such as using cross-linking agents or chemical modifications. The process ensures that the lipid and oligonucleotide are covalently bonded, resulting in a stable conjugate with desired properties.
In gene therapy, LOCs improve gene stability and controlled release, which helps prevent degradation and enhances the delivery of therapeutic genes into cells. This leads to more effective gene therapies with fewer side effects.
Common lipids used in LOCs include phospholipids, cholesterol, and fatty acids. These lipids are selected based on their ability to stabilize the conjugates and ensure effective delivery to targeted cells.
Purity is ensured through rigorous purification methods, including high-performance liquid chromatography (HPLC), mass spectrometry (MS), and gel electrophoresis (PAGE). These methods allow BOC Sciences to deliver high-quality conjugates with minimal impurities.
