Lipids-Oligonucleotide Conjugation

BOC Sciences focuses on powering drug delivery through bioconjugation. Relying on our state-of-the-art manufacturing facilities and comprehensive experience in conjugation technologies, BOC Sciences provides conjugation services to combine oligonucleotides with lipids. We have the capability and confidence to meet your needs for novel conjugates.

What is Lipids-Oligonucleotide Conjugation

• Basic Structure and Characteristics of LOCs

The basic structure of lipid-oligonucleotide conjugates (LOCs) is to combine lipids and oligonucleotides through chemical bonding. The lipids can be phospholipids, fatty acids, cholesterol, etc., and the oligonucleotides can be DNA, RNA, etc. LOCs are characterized by good stability, controlled release and targeting. These characteristics make LOCs have wide application prospects in biomedical field.

• Application of LOCs in Gene Therapy

Gene therapy is a new approach to treat genetic diseases and cancers, and LOCs can be used as a vehicle for gene therapy to deliver the genes to be treated into human cells. Due to the good stability and controlled release of LOCs, they can help gene delivery into cells in gene therapy and avoid gene degradation and side effects.

• Application of LOCs in Vaccine Research

Vaccines are an effective way to prevent infectious diseases, and LOCs can be used as vaccine carriers to deliver vaccine antigens to human cells and induce immune responses in the body. Because LOCs are targeted, they can deliver vaccine antigens to specific cells and enhance the effectiveness of vaccines.

• Application of LOCs in Drug Delivery

Drug delivery is a method to deliver drugs to specific cells or tissues. LOCs can be used as carriers of drugs to specific cells or tissues. Due to the targeted nature and controlled release of LOCs, it is possible to deliver drugs to specific cells or tissues, reducing side effects and improving the effectiveness of drugs.

Fig. 1 Schematic illustration of LONs (A) presynthetic-conjugation approach and (B) postsynthetic-conjugation approach (Li X, 2020)

Introduction to Lipids-Oligonucleotide Conjugation Services

• What Are Our Lipids-Oligonucleotide Conjugation Services?

1. Select the appropriate chemical conjugation method, including cross-linking agent, cross-linker activation, chemical modification, etc.
2. Provide a wide range of oligonucleotides of different lengths to meet the needs of different applications.
3. Provide a variety of different types of proteins, including enzymes, antibodies, carrier proteins, etc.
4. Separate the conjugated products from the unreacted raw materials by efficient purification technology to ensure the purity and activity of the conjugated products.
5. Provide comprehensive quality control and analytical services, including mass spectrometry analysis, high performance liquid chromatography analysis, gel electrophoresis analysis, etc.
6. Provide personalized service, custom design and preparation according to customer's needs.
7. Provide professional technical support and consulting services to assist customers in solving various problems and difficulties.

• Why Choose Our Lipids-Oligonucleotide Conjugates

1. Efficient reaction conditions and reagent selection ensure the best binding efficiency and yield.
2. Provide a variety of selectable cross-linking agents and cross-linking methods to meet the different needs of customers.
3. Professional technical team to ensure quality control and standardized operation process.
4. Flexible and reliable production capacity to ensure on-time completion of large volume, small batch and custom orders.
5. Targeted design and optimization of solutions to ensure that specific customer research requirements are met.
6. Complete analysis and validation services to ensure that the quality of the product meets the customer's requirements.
7. Fast response and good customer service to ensure timely resolution of customer problems and needs.