CPGs for Oligo Synthesis

Description: DMT-dT-LCAA-CPG; 500 Å is a reagent used in the solid-phase synthesis of oligonucleotides for incorporating thymidine (dT) residues. It features a 5'-DMT (dimethoxytrityl) protective group, which safeguards the 5' end during synthesis, and is attached to a long-chain alkylamine (LCAA) linker bound to controlled pore glass (CPG) with a 500 Å pore size. This setup is designed for efficient synthesis of DNA sequences, particularly shorter oligonucleotides, allowing for precise thymidine incorporation with stable protection throughout the synthesis process.

CAT: BRP-02343

Description: CPG column for incorporation of unmodified U at the 3' end of an oligonucleotide.

CAT: BRP-02344

Description: CPG column for incorporation of unmodified U at the 3' end of an oligonucleotide.

CAT: BRP-02345

Description: GalNAc CPG allows the synthesis of siRNA-GalNAc conjugate.

CAT: BRP-02362

Description: 3'-6-Fluorescein Serinol CPG is a key constituent in the realm of biomedical science, holding immense significance for the research and development of biocompatible oligonucleotides. Serving as an indispensable companion, it orchestrates the solid-phase research and development process owing to its inherent nature as a controlled pore glass support. By facilitating seamless labeling and detection of fluorescence, this remarkable entity empowers researchers to fashion nucleotide probes instrumental in unraveling the intricacies of gene expression analysis, genetic sequencing, and the diagnosis of maladies like cancer and infectious disorders.

CAT: BRP-02363

Description: It is a diamine-scaffold-based GalNAc CPG that plays a key role in the synthesis of N-acetylgalactosamine (GalNAc)-siRNA conjugate as a solid support to facilitate the step-up synthesis of amide-phosphorus. This method guarantees the high purity and yield of the final product, while improving the stability of the synthesized siRNA molecule. In addition, it allows for improved liver-targeted delivery of siRNA by attaching GalNAc, thereby increasing cellular uptake efficiency and thus improving therapeutic efficacy.

CAT: BRP-02500

Description: 3'-Amino(TFA)-Modifier C7 CPG is a solid support reagent designed for the incorporation of a 3'-terminal amino group into oligonucleotides during solid-phase synthesis. The amino group is protected by a trifluoroacetyl (TFA) group, which can be selectively removed post-synthesis to enable conjugation with labels, such as fluorophores or biotin, via amide bond formation. The C7 spacer arm provides a seven-carbon linker between the amino group and the oligonucleotide backbone, optimizing the accessibility of the amino group for subsequent reactions and minimizing steric hindrance.

CAT: BRP-02670

Appearance: Off-white solid

Description: 3'-Cholesteryl CPG is a solid support reagent designed for the synthesis of cholesterol-conjugated oligonucleotides, enabling the site-specific incorporation of a cholesterol moiety at the 3'-terminus of DNA or RNA strands. The cholesterol group enhances the lipophilicity and cellular uptake of oligonucleotides, making it particularly useful for applications in drug delivery and therapeutics. The reagent is compatible with standard solid-phase oligonucleotide synthesis protocols and is typically supplied as a controlled pore glass (CPG) support. It is commonly used in the development of targeted delivery systems, where the cholesterol moiety facilitates the interaction with cell membranes, thereby improving the cellular uptake and stability of the oligonucleotides.

CAT: BRP-02672

Appearance: Off-white solid

Description: 3'-Spacer C6 CPG is a solid support reagent designed for the incorporation of a 6-carbon spacer at the 3'-terminus of oligonucleotides during solid-phase synthesis. This hydrophobic spacer serves as an alternative to a 3'-phosphate group, effectively blocking enzymatic activity (e.g., exonucleases and polymerases) at the 3'-end while maintaining structural integrity. It is particularly useful for applications requiring nuclease resistance or enhanced stability, such as in antisense oligonucleotides or diagnostic probes. The C6 spacer also provides flexibility for conjugation or labeling reactions by creating distance between the oligonucleotide and functional moieties, minimizing steric hindrance and potential interference with hybridization or enzymatic processes.

CAT: BRP-02673

Appearance: Off-white solid

Description: Morpholino PS is a solid support reagent designed for synthesizing morpholino-modified oligonucleotides. It enables the incorporation of morpholino rings (replacing ribose sugars) during solid-phase synthesis, enhancing nuclease resistance and binding affinity. It is ideal for producing therapeutic antisense oligonucleotides or research tools requiring high stability and target specificity.

CAT: BRP-02688

Appearance: Light yellow solid