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CPGs for Oligo Synthesis

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5'-DMT-dU-Suc-CPG (deoxyUridine CPG); 1000 Å (BRP-02283)

Description: 5'-DMT-dU-Suc-CPG is used to incorporate deoxyuridine base into the 3' end of oligonucleotides.
CAT: BRP-02283
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Synonyms: 5'-DMT-dU-Suc-CPG; 1000 Å; DeoxyUridine CPG); 1000 Å; 5'-O-DMT-2'-deoxy-U-3'-O-Suc-CPG; 1000 Å

5'-DMT-G(dmf)-Suc-CPG; 1000 Å (RNA) (BRP-02284)

Description: 5'-DMT-G(dmf)-Suc-CPG is used to add unmodified nucleotide G to the 3' end of oligonucleotides.
CAT: BRP-02284
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Synonyms: 5'-O-DMT-2'-OAc-G(dmf)-3'-O-Suc-CPG; 1000 Å (RNA)

5'-DMT-G(dmf)-Suc-CPG; 500 Å (RNA) (BRP-02285)

Description: 5'-DMT-G(dmf)-Suc-CPG is used to add unmodified nucleotide G to the 3' end of oligonucleotides.
CAT: BRP-02285
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Synonyms: 5'-O-DMT-2'-OAc-G(dmf)-3'-O-Suc-CPG; 500 Å (RNA)

5'-DMT-G(PAC)-Suc-CPG; 500 Å (RNA) (BRP-02286)

Description: 5'-DMT-G(PAC)-Suc-CPG; 500 Å (RNA) is a reagent used in the solid-phase synthesis of RNA oligonucleotides for incorporating guanosine (G) residues. It features a 5'-DMT (dimethoxytrityl) protective group, a phenoxyacetyl (PAC) protecting group on the guanine base to prevent side reactions during synthesis, and a succinyl (Suc) linker that attaches the nucleoside to controlled pore glass (CPG) with a 500 Å pore size. This setup ensures efficient and accurate synthesis of RNA sequences with guanosine incorporation while maintaining stability and ease of deprotection.
CAT: BRP-02286
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Synonyms: 5'-O-DMT-2'-OAc-G(PAC)-3'-O-Suc-CPG; 500 Å (RNA)

5'-DMT-T-3'-Q Linker-CPG; 1000 Å (BRP-02287)

Description: 5'-DMT-T-3'-Q Linker-CPG; 1000 Å is a reagent used in the solid-phase synthesis of oligonucleotides for incorporating thymidine (T) residues. It features a 5'-DMT (dimethoxytrityl) protective group, a thymidine base, and a 3'-Q (quencher) linker attached to controlled pore glass (CPG) with a 1000 Å pore size. The 3'-Q linker typically includes a quencher dye or group, used for fluorescence-based assays or to create fluorescently quenched probes. The 5'-DMT group protects the 5' end during synthesis, while the large pore size of the CPG allows for high loading capacity and efficient oligonucleotide synthesis.
CAT: BRP-02287
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Synthesis Conditions: Synthesis can be performed on these supports according to standard procedures with deprotection and cleavage modifications noted.
Cleavage Conditions: Cleavage can be carried out in 2 minutes at room temperature using concentrated NH4OH.
Deprotection Conditions: If fast deprotecting amidites are used; deprotection can be carried out using concentrated NH4OH for 1 hour at 60°C.
Synonyms: 5'-DMT-dT-3'-Q Linker-CPG; 1000 Å; 5'-O-DMT-2'-deoxy-T-3'-O-Q Linker-CPG; 1000 Å

5'-DMT-T-Suc-CPG; 1000 Å (BRP-02288)

Description: 5'-DMT-T-Suc-CPG is used to add unmodified dT to the 3' end of oligonucleotides.
CAT: BRP-02288
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: 5'-DMT-dT-Suc-CPG; 1000 Å; 5'-O-DMT-2'-deoxy-T-3'-O-Suc-CPG; 1000 Å

5'-DMT-T-Suc-CPG; 1400 Å (BRP-02289)

Description: 5'-DMT-T-Suc-CPG is used to add unmodified dT to the 3' end of oligonucleotides.
CAT: BRP-02289
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: 5'-DMT-dT-Suc-CPG; 1400 Å; 5'-O-DMT-2'-deoxy-T-3'-O-Suc-CPG; 1400 Å

5'-DMT-T-Suc-CPG; 2000 Å (BRP-02290)

Description: 5'-DMT-T-Suc-CPG is used to add unmodified dT to the 3' end of oligonucleotides.
CAT: BRP-02290
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: 5'-DMT-dT-Suc-CPG; 2000 Å; 5'-O-DMT-2'-deoxy-T-3'-O-Suc-CPG; 2000 Å

5'-DMT-T-Suc-CPG; 500 Å (BRP-02291)

Description: 5'-DMT-T-Suc-CPG is used to add unmodified dT to the 3' end of oligonucleotides.
CAT: BRP-02291
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: 5'-DMT-dT-Suc-CPG; 500 Å; 5'-O-DMT-2'-deoxy-T-3'-O-Suc-CPG; 500 Å

5'-DMT-T-Suc-CPG; 500 Å (High load) (BRP-02292)

Description: 5'-DMT-T-Suc-CPG is used to add unmodified dT to the 3' end of oligonucleotides.
CAT: BRP-02292
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Synonyms: 5'-DMT-dT-Suc-CPG; 500 Å (High load); 5'-O-DMT-2'-deoxy-T-3'-O-Suc-CPG; 500 Å (High load)

5'-DMT-U-Suc-CPG; 1000 Å (RNA) (BRP-02293)

Description: 5'-DMT-U-Suc-CPG; 1000 Å (RNA) is a reagent used in the solid-phase synthesis of RNA oligonucleotides for incorporating uridine (U) residues. It features a 5'-DMT (dimethoxytrityl) protective group to protect the 5' end of the uridine base, and a succinyl (Suc) linker that attaches the nucleoside to controlled pore glass (CPG) with a 1000 Å pore size. This setup facilitates efficient incorporation of uridine into RNA sequences while ensuring effective protection and stability during synthesis.
CAT: BRP-02293
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Synonyms: 5'-O-DMT-2'-OAc-U-3'-O-Suc-CPG; 1000 Å (RNA)

5'-DMT-U-Suc-CPG; 500 Å (RNA) (BRP-02294)

Description: 5'-DMT-U-Suc-CPG; 500 Å (RNA) is a reagent used in the solid-phase synthesis of RNA oligonucleotides for incorporating uridine (U) residues. It features a 5'-DMT (dimethoxytrityl) protective group to protect the 5' end of the uridine base, and a succinyl (Suc) linker that attaches the nucleoside to controlled pore glass (CPG) with a 500 Å pore size. This setup facilitates efficient incorporation of uridine into RNA sequences while ensuring effective protection and stability during synthesis.
CAT: BRP-02294
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: 5'-O-DMT-2'-OAc-U-3'-O-Suc-CPG; 500 Å (RNA)

Aminopropyl-CPG; 1000 Å (BRP-02295)

Description: Aminopropyl CPG can be used for functionalization of base or modifier.
CAT: BRP-02295
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at RT
Shipping: Room temperature.

Aminopropyl-CPG; 1400 Å (BRP-02296)

Description: Aminopropyl CPG can be used for functionalization of base or modifier.
CAT: BRP-02296
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at RT
Shipping: Room temperature.

Aminopropyl-CPG; 2000 Å (BRP-02297)

Description: Aminopropyl CPG can be used for functionalization of base or modifier.
CAT: BRP-02297
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at RT
Shipping: Room temperature.

Aminopropyl-CPG; 300 Å (BRP-02298)

Description: Aminopropyl CPG can be used for functionalization of base or modifier.
CAT: BRP-02298
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at RT
Shipping: Room temperature.

Aminopropyl-CPG; 500 Å (BRP-02299)

Description: Aminopropyl CPG can be used for functionalization of base or modifier.
CAT: BRP-02299
Appearance: White powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at RT
Shipping: Room temperature.

BHQ-0 CPG; Glycolate, 1000 Å (BRP-02300)

Description: BHQ-0 CPG; Glycolate, 1000 Å can be used to add the non-fluorescent quencher BHQ-0 dye to the 3' end of oligonucleotides.
CAT: BRP-02300
Appearance: Orange powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: When using fast deprotecting amidites use concentrated Ammonia for 45 min at 25 °C or Ammonia/ Methylamine (AMA) (1:1) for 15 min at 25 °C. When using standard amidites (eg. C-Bz, G-iBu) use concentrated Ammonia for 45 min at 25 °C.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Absorption Maximum (Lambda Max): 493

BHQ-0 CPG; Glycolate, 500 Å (BRP-02301)

Description: BHQ-0 CPG; Glycolate, 500 Å can be used to add the non-fluorescent quencher BHQ-0 dye to the 3' end of oligonucleotides.
CAT: BRP-02301
Appearance: Orange powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: When using fast deprotecting amidites use concentrated Ammonia for 45 min at 25 °C or Ammonia/ Methylamine (AMA) (1:1) for 15 min at 25 °C. When using standard amidites (eg. C-Bz, G-iBu) use concentrated Ammonia for 45 min at 25 °C.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Absorption Maximum (Lambda Max): 493

BHQ-1 CPG; Glycolate, 1000 Å (BRP-02302)

Description: BHQ-1 CPG; Glycolate, 1000 Å can be used to add the non-fluorescent quencher BHQ-1 dye to the 3' end of oligonucleotides.
CAT: BRP-02302
Appearance: Dark red powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: When using fast deprotecting amidites use concentrated Ammonia for 45 min at 25 °C or Ammonia/ Methylamine (AMA) (1:1) for 15 min at 25 °C; or t-butylamine/H2O (1:3) for 90 min at 25 °C (TAMRA requires deprotection with TBA). When using standard amidites (eg. C-Bz, G-iBu) use concentrated Ammonia for 45 min at 25 °C.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Absorption Maximum (Lambda Max): 534

Frequently Asked Questions (FAQ)

What pore size CPG is recommended for long oligonucleotide synthesis?

For long DNA or RNA sequences, 1000 Å or 2000 Å CPG is generally recommended to improve reagent diffusion and maintain coupling efficiency during extended synthesis cycles.

How does loading capacity affect CDMO manufacturing projects?

Loading capacity influences both yield and coupling efficiency. Controlled and reproducible loading is essential for minimizing batch-to-batch variability in long-term manufacturing programs.

Do you provide COA and batch traceability?

Each batch is supplied with a Certificate of Analysis (COA) and full traceability to support audits and quality reviews.

Can you support material supply during process scale-up?

Yes. We support material supply from early process development through scale-up and routine manufacturing.

How should CPGs be stored?

CPGs should be stored in a dry, tightly sealed container at room temperature to maintain surface functionality and consistent performance.

* Only for research. Not suitable for any diagnostic or therapeutic use.

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