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5'-DMT-U-Suc-CPG; 1000 Å (RNA)
5'-DMT-U-Suc-CPG; 1000 Å (RNA) is a reagent used in the solid-phase synthesis of RNA oligonucleotides for incorporating uridine (U) residues. It features a 5'-DMT (dimethoxytrityl) protective group to protect the 5' end of the uridine base, and a succinyl (Suc) linker that attaches the nucleoside to controlled pore glass (CPG) with a 1000 Å pore size. This setup facilitates efficient incorporation of uridine into RNA sequences while ensuring effective protection and stability during synthesis.
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Catalog
BRP-02293
Synonyms
5'-O-DMT-2'-OAc-U-3'-O-Suc-CPG; 1000 Å (RNA)
Appearance
White powder
Storage
Store at -20 °C
Shipping
Room temperature.
Cleavage Conditions
Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions
When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Chemical Structure:
