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5'-DMT-T-3'-Q Linker-CPG; 1000 Å
5'-DMT-T-3'-Q Linker-CPG; 1000 Å is a reagent used in the solid-phase synthesis of oligonucleotides for incorporating thymidine (T) residues. It features a 5'-DMT (dimethoxytrityl) protective group, a thymidine base, and a 3'-Q (quencher) linker attached to controlled pore glass (CPG) with a 1000 Å pore size. The 3'-Q linker typically includes a quencher dye or group, used for fluorescence-based assays or to create fluorescently quenched probes. The 5'-DMT group protects the 5' end during synthesis, while the large pore size of the CPG allows for high loading capacity and efficient oligonucleotide synthesis.
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Catalog
BRP-02287
Synonyms
5'-DMT-dT-3'-Q Linker-CPG; 1000 Å; 5'-O-DMT-2'-deoxy-T-3'-O-Q Linker-CPG; 1000 Å
Appearance
White powder
Storage
Store at 2-8 °C
Shipping
Room temperature.
Synthesis Conditions
Synthesis can be performed on these supports according to standard procedures with deprotection and cleavage modifications noted.
Cleavage Conditions
Cleavage can be carried out in 2 minutes at room temperature using concentrated NH4OH.
Deprotection Conditions
If fast deprotecting amidites are used; deprotection can be carried out using concentrated NH4OH for 1 hour at 60°C.
Chemical Structure:
