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CPGs for Oligo Synthesis

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BHQ-1 CPG; Glycolate, 500 Å (BRP-02303)

Description: BHQ-1 CPG; Glycolate, 500 Å can be used to add the non-fluorescent quencher BHQ-1 dye to the 3' end of oligonucleotides.
CAT: BRP-02303
Appearance: Dark red powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: When using fast deprotecting amidites use concentrated Ammonia for 45 min at 25 °C or Ammonia/ Methylamine (AMA) (1:1) for 15 min at 25 °C; or t-butylamine/H2O (1:3) for 90 min at 25 °C (TAMRA requires deprotection with TBA). When using standard amidites (eg. C-Bz, G-iBu) use concentrated Ammonia for 45 min at 25 °C.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Absorption Maximum (Lambda Max): 534

BHQ-1 T Linker Arm, CPG; 500 Å (BRP-02304)

Description: BHQ-1 T Linker Arm, CPG is used for oligonucleotides labeled with 3-BHQ-1 dT.
CAT: BRP-02304
Appearance: Dark red powder
Size Price Stock Quantity
-- -- --
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Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: When using fast deprotecting amidites use concentrated Ammonia for 20 min at 25 °C or Ammonia/ Methylamine (AMA) (1:1) for 5 min at 25 °C; or t-butylamine/H2O (1:3) for 45 min at 25 °C (TAMRA requires deprotection with TBA). When using standard amidites (eg. C-Bz, G-iBu) use concentrated Ammonia for 20 min at 25 °C.
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Absorption Maximum (Lambda Max): 548

BHQ-2 CPG; Glycolate, 1000 Å (BRP-02305)

Description: BHQ-2 CPG; Glycolate is used to add the non-fluorescent quencher BHQ-2 to the 3' end of oligonucleotides.
CAT: BRP-02305
Appearance: Purple powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: When using fast deprotecting amidites use concentrated Ammonia for 45 min at 25 °C or Ammonia/ Methylamine (AMA) (1:1) for 15 min at 25 °C; or t-butylamine/H2O (1:3) for 90 min at 25 °C (TAMRA requires deprotection with TBA). When using standard amidites (eg. C-Bz, G-iBu) use concentrated Ammonia for 45 min at 25 °C.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Absorption Maximum (Lambda Max): 579

BHQ-2 CPG; Glycolate, 500 Å (BRP-02306)

Description: BHQ-2 CPG; Glycolate is used to add the non-fluorescent quencher BHQ-2 to the 3' end of oligonucleotides.
CAT: BRP-02306
Appearance: Purple powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: When using fast deprotecting amidites use concentrated Ammonia for 45 min at 25 °C or Ammonia/ Methylamine (AMA) (1:1) for 15 min at 25 °C; or t-butylamine/H2O (1:3) for 90 min at 25 °C (TAMRA requires deprotection with TBA). When using standard amidites (eg. C-Bz, G-iBu) use concentrated Ammonia for 45 min at 25 °C.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Absorption Maximum (Lambda Max): 579

BHQ-2 T Linker Arm, CPG; 500 Å (BRP-02307)

Description: BHQ-2 T Linker Arm, CPG is used for oligonucleotides labeled with 3-BHQ-2 dT.
CAT: BRP-02307
Appearance: Dark purple powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: When using fast deprotecting amidites use concentrated Ammonia for 20 min at 25 °C or Ammonia/ Methylamine (AMA) (1:1)for 5 min at 25 °C; or t-butylamine/H2O(1:3) for 45 min at 25 °C (TAMRA requires deprotection with TBA). When using standard amidites (eg. C-Bz, G-iBu) use concentrated Ammonia for 20 min at 25 °C.
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Absorption Maximum (Lambda Max): 592

BHQ-3 CPG; Glycolate, 1000 Å (BRP-02308)

Description: BHQ-3 CPG; Glycolate is used to add non-fluorescent quencher BHQ-3 to the 3' end of oligonucleotides.
CAT: BRP-02308
Appearance: Dark blue powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Synthesis Conditions: We recommend only using fast deprotecting amidites with this product due to the mild cleavage and deprotection conditions.
Deprotection Conditions: Cleave and deprotect in concentrated NH4OH for 1 hour at 60°C (after 1 hour at 60°C; degradation of product may occur).
Absorption Maximum (Lambda Max): 672

C16 CPG; 1000 Å (BRP-02309)

Description: C16 CPG is used to incorporate a C16 spacer at the 3' end of the oligonucleotide.
CAT: BRP-02309
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Synthesis Conditions: Standard synthesis conditions
Cleavage Conditions: Use concentrated ammonia for 45 minutes at 25 °C or 1:1 ammonia:methylamine (AMA) for 15 minutes at 25 °C.
Synonyms: C16 CPG (1-DMT-2-Hexadecyl-Glyc-CPG); 1000 Å

C2 CPG; 500 Å (BRP-02310)

Description: C2 CPG is used to add C2 spacers to the 3' end of oligonucleotides.
CAT: BRP-02310
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 45 minutes at 25 °C or 1:1 ammonia:methylamine (AMA) for 15 minutes at 25 °C.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: C2 CPG (DMT-1,2-Etheyleneglycol-Suc-CPG); 500 Å

C3 CPG; 1000 Å (BRP-02311)

Description: C3 CPG is used to add a C3 spacer at the 3' end of an oligonucleotide.
CAT: BRP-02311
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: C3 CPG (DMT-1,3-Propanediol-Suc-CPG); 1000 Å

C6 CPG; 1000 Å (BRP-02312)

Description: C6 CPG is used to add a C6 spacer at the 3' end of an oligonucleotide.
CAT: BRP-02312
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: The glycolate spacer is more readily cleaved than the usual succinyl linkage. Cleave for 30-minutes at room temperature with concentrated NH4OH or 15 minutes at 60°C.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: C6 CPG (DMT-1,6-Hexanediol-Glyc-CPG); 1000 Å

CAL Fluor Orange 560 CPG; 500 Å (BRP-02313)

Description: CAL Fluor Orange 560 CPG is a CPG for oligonucleotides labeled with 3-CAL Fluor Orange 560.
CAT: BRP-02313
Appearance: Pink powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Fluorescence Maximum: 561
Deprotection Conditions: Cleave and deprotect the CAL dye labeled oligo in 2-Methoxyethylamine and MeOH (1:3) for 6 hours at 25°C or 3 hours at 60°C.The use of strong bases; such as concentrated ammonia; causes degradation of dye and should be avoided.
Absorption Maximum (Lambda Max): 540
Synonyms: CAL Fluor Orange 560 CPG (5'-DMT-T(C6-CAL Fluor Orange 560)-Glyc-CPG); 500 Å

CAL Fluor Red 610 CPG 500 Å (BRP-02314)

Description: CAL Fluor Red 610 CPG is a CPG for oligonucleotides labeled with 3-CAL Fluor Red 610.
CAT: BRP-02314
Appearance: Purple powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Fluorescence Maximum: 610
Synthesis Conditions: Due to the mild deprotection conditions, we recommend using fast deprotecting amidites with this support.
Deprotection Conditions: Cleave and deprotect the CAL dye labeled oligo in 2-Methoxyethylamine and MeOH (1:3) for 6 hours at 25°C or 3 hours at 60°C.The use of strong bases; such as concentrated ammonia; causes degradation of dye and should be avoided.
Absorption Maximum (Lambda Max): 593
Synonyms: CAL Fluor Red 610 CPG (5'-DMT-T(C6-CAL Fluor Red 610)-Glyc-CPG); 500 Å

DABCYL-Suc-CPG; 1000 Å (BRP-02315)

Description: DABCYL-Suc-CPG is used for 3-labeling of oligonucleotides and has a dabcyl quencher molecule attached.
CAT: BRP-02315
Appearance: Orange powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 minutes at 25°C.
Absorption Maximum (Lambda Max): 472
Synonyms: DABCYL-Suc-CPG (5'-DMT-mdC(TEG-DABCYL)-Suc-CPG); 1000 Å

DABCYL-Suc-CPG; 500 Å (BRP-02316)

Description: DABCYL-Suc-CPG is used for 3-labeling of oligonucleotides and has a dabcyl quencher molecule attached.
CAT: BRP-02316
Appearance: Orange powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 minutes at 25 °C.
Absorption Maximum (Lambda Max): 472
Synonyms: DABCYL-Suc-CPG (5'-DMT-mdC(TEG-DABCYL)-Suc-CPG); 500 Å

DMT-C3(Biotin)-CPG; 1000 Å (BRP-02317)

Description: DMT-C3(Biotin)-CPG is used to attach biotin with a C3 spacer to the 3' end of an oligonucleotide.
CAT: BRP-02317
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 minutes at 25 °C or 1:1 ammonia:methylamine (AMA) for 25 minutes at 25 °C.

DMT-Phosphate-CPG; 1000 Å (BRP-02318)

Description: DMT-Phosphate-CPG is a CPG modified with a 3 phosphate on an oligonucleotide.
CAT: BRP-02318
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: DMT-Phosphate-CPG (O-DMT-2,2'-sulfonyldiethanol-Suc-CPG); 1000 Å

DMT-Phosphate-CPG; 500 Å (BRP-02319)

Description: DMT-Phosphate-CPG is a CPG modified with a 3 phosphate on an oligonucleotide.
CAT: BRP-02319
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: DMT-Phosphate-CPG (O-DMT-2,2'-sulfonyldiethanol-Suc-CPG); 500 Å

Fluorescein-C3-CPG; 1000 Å (BRP-02320)

CAT: BRP-02320
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Fluorescence Maximum: 520
Cleavage Conditions: This support may be cleaved using concentrated NH4OH or t-butylamine/H2O(1:3) (TAMRA and other rhodamine-based dyes require deprotection with t-butylamine).
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Absorption Maximum (Lambda Max): 495

Fluorescein-C3-CPG; 500 Å (BRP-02321)

CAT: BRP-02321
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Fluorescence Maximum: 520
Cleavage Conditions: This support may be cleaved using concentrated NH4OH or t-butylamine/H2O(1:3) (TAMRA and other rhodamine-based dyes require deprotection with t-butylamine).
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Absorption Maximum (Lambda Max): 495

N Mix CPG (5'-DMT-[dA(Bz), dC(Ac), dG(dmf), T]-Glyc-CPG); 1000 Å (BRP-02322)

Description: N Mix CPG (5'-DMT-[dA(Bz), dC(Ac), dG(dmf), T]-Glyc-CPG); 1000 Å is a reagent used in the solid-phase synthesis of oligonucleotides to incorporate a randomized mixture of the four nucleosides: deoxyadenosine (dA) with benzoyl (Bz) protection, deoxycytidine (dC) with acetyl (Ac) protection, deoxyguanosine (dG) with dimethylformamidine (dmf) protection, and thymidine (T). The nucleosides are attached via a glycolate (Glyc) linker to controlled pore glass (CPG) with a 1000 Å pore size. This reagent is typically used in the synthesis of random-sequence oligonucleotides, allowing for the generation of diverse sequence libraries with each position having an equal probability of being any of the four bases. The 5'-DMT group protects the 5' end during synthesis, ensuring efficient and accurate oligonucleotide construction. Mixed base supports are used to create dNTP oligos used for mutation studies.
CAT: BRP-02322
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Cold.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.

Frequently Asked Questions (FAQ)

What pore size CPG is recommended for long oligonucleotide synthesis?

For long DNA or RNA sequences, 1000 Å or 2000 Å CPG is generally recommended to improve reagent diffusion and maintain coupling efficiency during extended synthesis cycles.

How does loading capacity affect CDMO manufacturing projects?

Loading capacity influences both yield and coupling efficiency. Controlled and reproducible loading is essential for minimizing batch-to-batch variability in long-term manufacturing programs.

Do you provide COA and batch traceability?

Each batch is supplied with a Certificate of Analysis (COA) and full traceability to support audits and quality reviews.

Can you support material supply during process scale-up?

Yes. We support material supply from early process development through scale-up and routine manufacturing.

How should CPGs be stored?

CPGs should be stored in a dry, tightly sealed container at room temperature to maintain surface functionality and consistent performance.

* Only for research. Not suitable for any diagnostic or therapeutic use.

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