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CPGs for Oligo Synthesis

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BHQ-1 CPG; Glycolate, 500 Å (BRP-02303)

Description: BHQ-1 CPG; Glycolate, 500 Å can be used to add the non-fluorescent quencher BHQ-1 dye to the 3' end of oligonucleotides.
CAT: BRP-02303
Appearance: Dark red powder
Size Price Stock Quantity
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Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: When using fast deprotecting amidites use concentrated Ammonia for 45 min at 25 °C or Ammonia/ Methylamine (AMA) (1:1) for 15 min at 25 °C; or t-butylamine/H2O (1:3) for 90 min at 25 °C (TAMRA requires deprotection with TBA). When using standard amidites (eg. C-Bz, G-iBu) use concentrated Ammonia for 45 min at 25 °C.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Absorption Maximum (Lambda Max): 534

BHQ-1 T Linker Arm, CPG; 500 Å (BRP-02304)

Description: BHQ-1 T Linker Arm, CPG is used for oligonucleotides labeled with 3-BHQ-1 dT.
CAT: BRP-02304
Appearance: Dark red powder
Size Price Stock Quantity
-- -- --
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Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: When using fast deprotecting amidites use concentrated Ammonia for 20 min at 25 °C or Ammonia/ Methylamine (AMA) (1:1) for 5 min at 25 °C; or t-butylamine/H2O (1:3) for 45 min at 25 °C (TAMRA requires deprotection with TBA). When using standard amidites (eg. C-Bz, G-iBu) use concentrated Ammonia for 20 min at 25 °C.
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Absorption Maximum (Lambda Max): 548

BHQ-2 CPG; Glycolate, 1000 Å (BRP-02305)

Description: BHQ-2 CPG; Glycolate is used to add the non-fluorescent quencher BHQ-2 to the 3' end of oligonucleotides.
CAT: BRP-02305
Appearance: Purple powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: When using fast deprotecting amidites use concentrated Ammonia for 45 min at 25 °C or Ammonia/ Methylamine (AMA) (1:1) for 15 min at 25 °C; or t-butylamine/H2O (1:3) for 90 min at 25 °C (TAMRA requires deprotection with TBA). When using standard amidites (eg. C-Bz, G-iBu) use concentrated Ammonia for 45 min at 25 °C.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Absorption Maximum (Lambda Max): 579

BHQ-2 CPG; Glycolate, 500 Å (BRP-02306)

Description: BHQ-2 CPG; Glycolate is used to add the non-fluorescent quencher BHQ-2 to the 3' end of oligonucleotides.
CAT: BRP-02306
Appearance: Purple powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: When using fast deprotecting amidites use concentrated Ammonia for 45 min at 25 °C or Ammonia/ Methylamine (AMA) (1:1) for 15 min at 25 °C; or t-butylamine/H2O (1:3) for 90 min at 25 °C (TAMRA requires deprotection with TBA). When using standard amidites (eg. C-Bz, G-iBu) use concentrated Ammonia for 45 min at 25 °C.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Absorption Maximum (Lambda Max): 579

BHQ-2 T Linker Arm, CPG; 500 Å (BRP-02307)

Description: BHQ-2 T Linker Arm, CPG is used for oligonucleotides labeled with 3-BHQ-2 dT.
CAT: BRP-02307
Appearance: Dark purple powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: When using fast deprotecting amidites use concentrated Ammonia for 20 min at 25 °C or Ammonia/ Methylamine (AMA) (1:1)for 5 min at 25 °C; or t-butylamine/H2O(1:3) for 45 min at 25 °C (TAMRA requires deprotection with TBA). When using standard amidites (eg. C-Bz, G-iBu) use concentrated Ammonia for 20 min at 25 °C.
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Absorption Maximum (Lambda Max): 592

BHQ-3 CPG; Glycolate, 1000 Å (BRP-02308)

Description: BHQ-3 CPG; Glycolate is used to add non-fluorescent quencher BHQ-3 to the 3' end of oligonucleotides.
CAT: BRP-02308
Appearance: Dark blue powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Synthesis Conditions: We recommend only using fast deprotecting amidites with this product due to the mild cleavage and deprotection conditions.
Deprotection Conditions: Cleave and deprotect in concentrated NH4OH for 1 hour at 60°C (after 1 hour at 60°C; degradation of product may occur).
Absorption Maximum (Lambda Max): 672

C16 CPG; 1000 Å (BRP-02309)

Description: C16 CPG is used to incorporate a C16 spacer at the 3' end of the oligonucleotide.
CAT: BRP-02309
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Synthesis Conditions: Standard synthesis conditions
Cleavage Conditions: Use concentrated ammonia for 45 minutes at 25 °C or 1:1 ammonia:methylamine (AMA) for 15 minutes at 25 °C.
Synonyms: C16 CPG (1-DMT-2-Hexadecyl-Glyc-CPG); 1000 Å

C2 CPG; 500 Å (BRP-02310)

Description: C2 CPG is used to add C2 spacers to the 3' end of oligonucleotides.
CAT: BRP-02310
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 45 minutes at 25 °C or 1:1 ammonia:methylamine (AMA) for 15 minutes at 25 °C.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: C2 CPG (DMT-1,2-Etheyleneglycol-Suc-CPG); 500 Å

C3 CPG; 1000 Å (BRP-02311)

Description: C3 CPG is used to add a C3 spacer at the 3' end of an oligonucleotide.
CAT: BRP-02311
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: C3 CPG (DMT-1,3-Propanediol-Suc-CPG); 1000 Å

C6 CPG; 1000 Å (BRP-02312)

Description: C6 CPG is used to add a C6 spacer at the 3' end of an oligonucleotide.
CAT: BRP-02312
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: The glycolate spacer is more readily cleaved than the usual succinyl linkage. Cleave for 30-minutes at room temperature with concentrated NH4OH or 15 minutes at 60°C.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: C6 CPG (DMT-1,6-Hexanediol-Glyc-CPG); 1000 Å

CAL Fluor Orange 560 CPG; 500 Å (BRP-02313)

Description: CAL Fluor Orange 560 CPG is a CPG for oligonucleotides labeled with 3-CAL Fluor Orange 560.
CAT: BRP-02313
Appearance: Pink powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Fluorescence Maximum: 561
Deprotection Conditions: Cleave and deprotect the CAL dye labeled oligo in 2-Methoxyethylamine and MeOH (1:3) for 6 hours at 25°C or 3 hours at 60°C.The use of strong bases; such as concentrated ammonia; causes degradation of dye and should be avoided.
Absorption Maximum (Lambda Max): 540
Synonyms: CAL Fluor Orange 560 CPG (5'-DMT-T(C6-CAL Fluor Orange 560)-Glyc-CPG); 500 Å

CAL Fluor Red 610 CPG 500 Å (BRP-02314)

Description: CAL Fluor Red 610 CPG is a CPG for oligonucleotides labeled with 3-CAL Fluor Red 610.
CAT: BRP-02314
Appearance: Purple powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Fluorescence Maximum: 610
Synthesis Conditions: Due to the mild deprotection conditions, we recommend using fast deprotecting amidites with this support.
Deprotection Conditions: Cleave and deprotect the CAL dye labeled oligo in 2-Methoxyethylamine and MeOH (1:3) for 6 hours at 25°C or 3 hours at 60°C.The use of strong bases; such as concentrated ammonia; causes degradation of dye and should be avoided.
Absorption Maximum (Lambda Max): 593
Synonyms: CAL Fluor Red 610 CPG (5'-DMT-T(C6-CAL Fluor Red 610)-Glyc-CPG); 500 Å

DABCYL-Suc-CPG; 1000 Å (BRP-02315)

Description: DABCYL-Suc-CPG is used for 3-labeling of oligonucleotides and has a dabcyl quencher molecule attached.
CAT: BRP-02315
Appearance: Orange powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 minutes at 25°C.
Absorption Maximum (Lambda Max): 472
Synonyms: DABCYL-Suc-CPG (5'-DMT-mdC(TEG-DABCYL)-Suc-CPG); 1000 Å

DABCYL-Suc-CPG; 500 Å (BRP-02316)

Description: DABCYL-Suc-CPG is used for 3-labeling of oligonucleotides and has a dabcyl quencher molecule attached.
CAT: BRP-02316
Appearance: Orange powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 minutes at 25 °C.
Absorption Maximum (Lambda Max): 472
Synonyms: DABCYL-Suc-CPG (5'-DMT-mdC(TEG-DABCYL)-Suc-CPG); 500 Å

DMT-C3(Biotin)-CPG; 1000 Å (BRP-02317)

Description: DMT-C3(Biotin)-CPG is used to attach biotin with a C3 spacer to the 3' end of an oligonucleotide.
CAT: BRP-02317
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 minutes at 25 °C or 1:1 ammonia:methylamine (AMA) for 25 minutes at 25 °C.

DMT-Phosphate-CPG; 1000 Å (BRP-02318)

Description: DMT-Phosphate-CPG is a CPG modified with a 3 phosphate on an oligonucleotide.
CAT: BRP-02318
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at 2-8 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: DMT-Phosphate-CPG (O-DMT-2,2'-sulfonyldiethanol-Suc-CPG); 1000 Å

DMT-Phosphate-CPG; 500 Å (BRP-02319)

Description: DMT-Phosphate-CPG is a CPG modified with a 3 phosphate on an oligonucleotide.
CAT: BRP-02319
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Synonyms: DMT-Phosphate-CPG (O-DMT-2,2'-sulfonyldiethanol-Suc-CPG); 500 Å

Fluorescein-C3-CPG; 1000 Å (BRP-02320)

CAT: BRP-02320
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Fluorescence Maximum: 520
Cleavage Conditions: This support may be cleaved using concentrated NH4OH or t-butylamine/H2O(1:3) (TAMRA and other rhodamine-based dyes require deprotection with t-butylamine).
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Absorption Maximum (Lambda Max): 495

Fluorescein-C3-CPG; 500 Å (BRP-02321)

CAT: BRP-02321
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Room temperature.
Fluorescence Maximum: 520
Cleavage Conditions: This support may be cleaved using concentrated NH4OH or t-butylamine/H2O(1:3) (TAMRA and other rhodamine-based dyes require deprotection with t-butylamine).
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
Absorption Maximum (Lambda Max): 495

N Mix CPG (5'-DMT-[dA(Bz), dC(Ac), dG(dmf), T]-Glyc-CPG); 1000 Å (BRP-02322)

Description: N Mix CPG (5'-DMT-[dA(Bz), dC(Ac), dG(dmf), T]-Glyc-CPG); 1000 Å is a reagent used in the solid-phase synthesis of oligonucleotides to incorporate a randomized mixture of the four nucleosides: deoxyadenosine (dA) with benzoyl (Bz) protection, deoxycytidine (dC) with acetyl (Ac) protection, deoxyguanosine (dG) with dimethylformamidine (dmf) protection, and thymidine (T). The nucleosides are attached via a glycolate (Glyc) linker to controlled pore glass (CPG) with a 1000 Å pore size. This reagent is typically used in the synthesis of random-sequence oligonucleotides, allowing for the generation of diverse sequence libraries with each position having an equal probability of being any of the four bases. The 5'-DMT group protects the 5' end during synthesis, ensuring efficient and accurate oligonucleotide construction. Mixed base supports are used to create dNTP oligos used for mutation studies.
CAT: BRP-02322
Appearance: White to off-white powder
Size Price Stock Quantity
-- -- --
Inquiry   
Storage: Store at -20 °C
Shipping: Cold.
Cleavage Conditions: Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions: When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1h or AMA for 30 min. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5h.
* Only for research. Not suitable for any diagnostic or therapeutic use.

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