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CPGs for Oligo Synthesis

2-Amino Purine Riboside 3'-tBDSilyl 2'-lcaa CPG 1000Å

Description: 2-Amino Purine Riboside 3'-tBDSilyl 2'-lcaa CPG 1000Å is a modified nucleoside which is used as a building block for the synthesis of oligonucleotides. It contains a 2-amino purine base, a ribose sugar, and a protecting group at the 3'-position. The 2'-lcaa CPG refers to the controlled pore glass (CPG) support with a linker attached to the 2'-position of the ribose sugar. The 1000Å designation refers to the pore size of the CPG support, indicating the size of molecules that can be efficiently synthesized on this support. This compound is commonly used in the field of molecular biology and nucleic acid research for the synthesis of modified oligonucleotides with specific properties.
CAT: BRP-01403
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Synonyms: 2-Amino Purine Riboside 3'-tBDSilyl 2'-lcaa CPG 500Å; 2-Amino Purine Riboside 3'-tBDSilyl 2'-lcaa CPG

8-methyl-rGuanosine (n-ibu) 2'-tBDSilyl-3'-lcaa CPG 1000Å

Description: 8-methyl-rGuanosine (n-ibu) 2'-tBDSilyl-3'-lcaa CPG 1000Å is a specific type of controlled-pore glass (CPG) used in solid-phase oligonucleotide synthesis. It has a 1000 Å pore size and is modified with 8-methyl-rGuanosine (n-ibu) and 2'-tBDSilyl-3'-lcaa groups, which are protective groups commonly used in oligonucleotide synthesis to protect specific reactive sites. This specific CPG is designed for the synthesis of oligonucleotides with these specific modifications.
CAT: BRP-01405
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Synonyms: 8-methyl-rGuanosine (n-ibu) 2'-tBDSilyl-3'-lcaa CPG 500Å; 8-methyl-rGuanosine (n-ibu) 2'-tBDSilyl-3'-lcaa CPG

2-Amino Adenosine 3'-tBDSilyl 2'-lcaa CPG 500Å

Description: 2-Amino Adenosine 3'-tBDSilyl 2'-lcaa CPG 500Å is a modified form of Adenosine with an amino group at the 2-position and a tert-butyldimethylsilyl group at the 3'-position. It is attached to a controlled pore glass (CPG) support with a pore size of 500 angstroms (500Å). This modified nucleoside can be used in solid-phase synthesis of oligonucleotides and has applications in molecular biology research and drug development.
CAT: BRP-01406
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Synonyms: 2-Amino Adenosine 3'-tBDSilyl 2'-lcaa CPG 1000Å; 2-Amino Adenosine 3'-tBDSilyl 2'-lcaa CPG

Purine Riboside 3'-tBDSilyl 2'-lcaa CPG 500Å

Description: Purine Riboside 3'-tBDSilyl 2'-lcaa CPG 500Å is a type of solid support used in the synthesis of oligonucleotides. It consists of a purine riboside molecule with a 3'-tBDSilyl group and a 2'-lcaa group attached to a controlled pore glass (CPG) support with a pore size of 500 Å. This solid support allows for the step-by-step assembly of nucleotides during oligonucleotide synthesis by protecting the growing chain and facilitating the attachment of new nucleotides.
CAT: BRP-01407
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Synonyms: Purine Riboside 3'-tBDSilyl 2'-lcaa CPG 1000Å; Purine Riboside 3'-tBDSilyl 2'-lcaa CPG

N3-Methyl Uridine 3'-tBDSilyl-2' lcaa CPG 500Å

Description: N3-Methyl Uridine 3'-tBDSilyl-2' lcaa CPG 500Å is a type of solid support used in oligonucleotide synthesis, specifically for the immobilization of nucleosides during the process. This support consists of a controlled pore glass (CPG) matrix with a pore size of 500Å, derivatized with a linker molecule containing a tBDMSilyl-protected 3'-hydroxyl group and a 2' lcaa group for efficient coupling of nucleosides. N3-Methyl Uridine is a modified form of the nucleoside uridine, where the nitrogen at position 3 is methylated. The tBDSilyl group is a protective group commonly used in nucleic acid synthesis to prevent unwanted side reactions. Overall, this support plays a crucial role in the efficient and selective synthesis of modified oligonucleotides for various research and diagnostic applications.
CAT: BRP-01411
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Synonyms: N3-Methyl Uridine 3'-tBDSilyl-2' lcaa CPG 1000Å; N3-Methyl Uridine 3'-tBDSilyl-2' lcaa CPG

N3-Thiobenzoylethyl Uridine 3'-tBDSilyl-2'-lcaa CPG 1000Å

Description: N3-Thiobenzoylethyl Uridine 3'-tBDSilyl-2'-lcaa CPG 1000Å is a modified nucleoside that can be used in solid-phase synthesis of oligonucleotides. It contains a thiol group on the uridine base, as well as a benzoylethyl group and a TBDMS protecting group on the ribose sugar. It is attached to a controlled pore glass (CPG) support with a pore size of 1000Å, allowing for efficient synthesis of oligonucleotides. This modified nucleotide can be used in the synthesis of oligonucleotides with specific modifications or functionalities for various research and diagnostic applications.
CAT: BRP-01412
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Synonyms: N3-Thiobenzoylethyl Uridine 3'-tBDSilyl-2'-lcaa CPG 500Å; N3-Thiobenzoylethyl Uridine 3'-tBDSilyl-2'-lcaa CPG

N6-Benzyl Adenosine-3'-tBDSilyl 2'-lcaa CPG 500Å

Description: N6-Benzyl Adenosine-3'-tBDSilyl 2'-lcaa CPG 500Å is a specialized type of solid support for the synthesis of oligonucleotides. This modification serves as a linker between the solid support and the growing oligonucleotide chain during synthesis. The CPG 500Å support allows for efficient and high-quality oligonucleotide synthesis with minimal steric hindrance and improved yields.
CAT: BRP-01415
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Synonyms: N6-Benzyl Adenosine-3'-tBDSilyl 2'-lcaa CPG 1000Å; N6-Benzyl Adenosine-3'-tBDSilyl 2'-lcaa CPG

N6-Isopentenyl Adenosine-3'-tBDSilyl 2'-lcaa CPG 500Å

Description: N6-Isopentenyl Adenosine-3'-tBDSilyl 2'-lcaa CPG 500Å is a specific type of solid support used in nucleic acid synthesis and purification. This type of solid support is commonly used in oligonucleotide synthesis, particularly for the efficient and selective coupling of nucleotides during solid-phase synthesis. The tBDSilyl and lcaa protections help to protect the reactive hydroxyl groups of the nucleotides and facilitate the synthesis of high-quality oligonucleotides. The 500Å pore size of the CPG allows for efficient binding and release of the nucleotides during the synthesis process.
CAT: BRP-01417
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Synonyms: N6-Isopentenyl Adenosine-3'-tBDSilyl 2'-lcaa CPG 1000Å; N6-Isopentenyl Adenosine-3'-tBDSilyl 2'-lcaa CPG

Adenosine (n-PAC) 2'-tBDSilyl 3'-oxalyl lcaa CPG 500Å

Description: Adenosine (n-PAC) 2'-tBDSilyl 3'-oxalyl lcaa CPG 500Å is a type of solid support used in nucleic acid synthesis. This CPG (Controlled Pore Glass) material is commonly used in the synthesis of oligonucleotides, where the adenosine base is protected with a n-PAC group and the 2' and 3' positions are modified for stability and protection during synthesis. The material has a pore size of 500Å, which allows for efficient coupling of nucleotides and proper separation of different oligonucleotide sequences. This CPG material is widely used in research and diagnostic laboratories for the synthesis of custom oligonucleotides for various applications.
CAT: BRP-01418
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Synonyms: Adenosine (n-PAC) 2'-tBDSilyl 3'-oxalyl lcaa CPG

Cytidine (n-PAC) 2'-tBDSilyl 3'-oxalyl lcaa CPG 500Å

Description: Cytidine (n-PAC) 2'-tBDSilyl 3'-oxalyl lcaa CPG 500Å is a type of solid support used in solid-phase synthesis for the synthesis of oligonucleotides. It consists of a controlled-pore glass (CPG) matrix with a spacer arm attached to a modified cytidine nucleoside (n-PAC) at the 5' position. The 2'-tBDSilyl and 3'-oxalyl groups are used as protecting groups to prevent unwanted reactions during oligonucleotide synthesis. The 500Å designation refers to the pore size of the CPG matrix, indicating the range of molecular sizes that can interact with the support. This type of CPG is commonly used in automated oligonucleotide synthesis processes for the efficient and high-quality production of nucleic acid sequences.
CAT: BRP-01419
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Synonyms: Cytidine (n-PAC) 2'-tBDSilyl 3'-oxalyl lcaa CPG

Guanosine (n-PAC) 2'-tBDSilyl 3'-oxalyl lcaa CPG 500Å

Description: Guanosine (n-PAC) 2'-tBDSilyl 3'-oxalyl lcaa CPG 500Å is a type of controlled-pore glass (CPG) support for solid-phase synthesis of oligonucleotides. It is modified with guanosine monomers carrying a napierian protecting group (n-PAC) at the 2'-position, a TBDMS group at the 3'-position, and an oxalyl linker at the phosphate anchor. The CPG has a pore size of 500 angstroms, which allows for efficient coupling and deprotection during oligonucleotide synthesis. This specific modification is used in nucleic acid research and synthesis applications.
CAT: BRP-01420
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Synonyms: Guanosine (n-PAC) 2'-tBDSilyl 3'-oxalyl lcaa CPG

Uridine 2'-tBDSilyl 3'-oxalyl lcaa CPG 500Å

Description: Uridine 2'-tBDSilyl 3'-oxalyl lcaa CPG 500Å is used for solid-phase synthesis of nucleic acids. The CPG stands for Controlled Pore Glass, which is the solid support used for synthesis. The 500Å refers to the pore size of the CPG, indicating its ability to separate molecules based on size. The uridine monomer has protective groups (tBDSilyl and oxalyl) attached to the 2' and 3' positions, respectively, which help to control the synthesis and protect the nucleotide during the reaction steps. Overall, this modified uridine monomer is used in automated solid-phase synthesis of nucleic acids, such as DNA or RNA, in research and biotechnology applications.
CAT: BRP-01421
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Synonyms: Uridine 2'-tBDSilyl 3'-oxalyl lcaa CPG

3'-Phosphate-ON lcaa CPG 1000Å

Description: 3'-Phosphate-ON lcaa CPG 1000Å is a type of solid support used in oligonucleotide synthesis. This support has a long-chain alkylamine (lcaa) linker with a 3'-phosphate group attached to it, allowing for the synthesis of oligonucleotides with a phosphate group at the 3' end. This type of solid support is used in the synthesis of phosphate-modified oligonucleotides for various research and diagnostic applications.
CAT: BRP-01422
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Synonyms: 3'-Phosphate-ON lcaa CPG 500Å; 3'-Phosphate-ON lcaa CPG

Adenosine (n-bz) 3'-tBDSilyl succinyl Polystyrene 300Å

Description: Adenosine (N-Bz) 3'-tBDSilyl succinyl Polystyrene 300Å is a modified adenosine nucleotide used in oligonucleotide synthesis. It features a 3'-t-butyldimethylsilyl (tBDMS) protected hydroxyl group and an N6-benzoyl (N-Bz) protected exocyclic amino group, attached to a 300Å polystyrene support. This configuration aids in the efficient and precise synthesis of RNA and DNA sequences.
CAT: BRP-01432
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Synonyms: Adenosine (n-bz) 3'-tBDSilyl succinyl Polystyrene

Cytidine (n-bz) 3'-tBDSilyl succinyl Polystyrene 300Å

Description: Cytidine (N-Bz) 3'-tBDSilyl succinyl Polystyrene 300Å is a modified cytidine nucleotide used in oligonucleotide synthesis. It features a 3'-t-butyldimethylsilyl (tBDMS) protected hydroxyl group and an N4-benzoyl (N-Bz) protected amino group, attached to a 300Å polystyrene support. This setup is designed to facilitate the precise and efficient synthesis of RNA and DNA sequences.
CAT: BRP-01433
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Synonyms: Cytidine (n-bz) 3'-tBDSilyl succinyl Polystyrene

Guanosine (n-ibu) 3'-tBDSilyl succinyl Polystyrene 300Å

Description: Guanosine (N-ibu) 3'-tBDSilyl succinyl Polystyrene 300Å is a modified guanosine nucleotide employed in oligonucleotide synthesis. It is characterized by a 3'-t-butyldimethylsilyl (tBDMS) protected hydroxyl group and an N2-isobutyryl (N-ibu) protected exocyclic amino group. This nucleotide is attached to a 300Å polystyrene support, facilitating the efficient and precise construction of RNA and DNA sequences.
CAT: BRP-01434
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Synonyms: Guanosine (n-ibu) 3'-tBDSilyl succinyl Polystyrene

Uridine 3'-tBDSilyl succinyl Polystyrene 300Å

Description: Uridine 3'-tBDSilyl succinyl Polystyrene 300Å is a modified uridine nucleotide utilized in oligonucleotide synthesis. It is affixed to a 300Å polystyrene support and incorporates a 3'-t-butyldimethylsilyl (tBDMS) guarded hydroxyl group. This configuration enables the controlled and accurate assembly of RNA and DNA sequences.
CAT: BRP-01435
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Synonyms: Cytidine (n-acetyl) 3'-tBDSilyl succinyl Polystyrene

Cytidine (n-acetyl) 3'-tBDSilyl succinyl Polystyrene 300Å

Description: Cytidine (N-acetyl) 3'-tBDSilyl succinyl Polystyrene 300Å is a modified cytidine nucleotide used in oligonucleotide synthesis. It is attached to a 300Å polystyrene support and features a 3'-t-butyldimethylsilyl (tBDMS) protected hydroxyl group. Additionally, the amino group at the 4-position of cytidine is protected by an acetyl (N-acetyl) group. This configuration allows for precise and efficient synthesis of RNA and DNA sequences.
CAT: BRP-01436
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Synonyms: Cytidine (n-acetyl) 3'-tBDSilyl succinyl Polystyrene

Psoralen Support 500Å

Description: Psoralen Support 500Å refers to a solid support used in nucleic acid synthesis, specifically in the context of molecular biology and genetic research. This support is typically a resin or matrix with a pore size of 500 angstroms (Å), providing a solid framework for the attachment of psoralen molecules. Psoralen is a natural compound known for its ability to crosslink with nucleic acids under ultraviolet (UV) light. By immobilizing psoralen molecules onto the support, researchers can perform controlled modifications of nucleic acids, facilitating studies on DNA-protein interactions, nucleic acid structure, and various molecular biology techniques.
CAT: BRP-01440
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Synonyms: Psoralen Support

IQ2 CPG 1000Å

Description: IQ2 CPG 1000Å is a Controlled Pore Glass (CPG) utilized in oligonucleotide synthesis, with a 1000 angstrom pore size. The ''IQ2'' designation signifies its incorporation of a quencher, making it particularly suited for applications requiring efficient and precise suppression of fluorescence signals, such as in the synthesis of molecular probes and diagnostics. This specialized CPG is valuable in molecular biology and genetic research, facilitating the development of sensitive and specific nucleic acid detection assays.
CAT: BRP-01441
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Synonyms: IQ2 CPG 500Å; IQ2 CPG

Frequently Asked Questions (FAQ)

What pore size CPG is recommended for long oligonucleotide synthesis?

For long DNA or RNA sequences, 1000 Å or 2000 Å CPG is generally recommended to improve reagent diffusion and maintain coupling efficiency during extended synthesis cycles.

How does loading capacity affect CDMO manufacturing projects?

Loading capacity influences both yield and coupling efficiency. Controlled and reproducible loading is essential for minimizing batch-to-batch variability in long-term manufacturing programs.

Do you provide COA and batch traceability?

Each batch is supplied with a Certificate of Analysis (COA) and full traceability to support audits and quality reviews.

Can you support material supply during process scale-up?

Yes. We support material supply from early process development through scale-up and routine manufacturing.

How should CPGs be stored?

CPGs should be stored in a dry, tightly sealed container at room temperature to maintain surface functionality and consistent performance.

* Only for research. Not suitable for any diagnostic or therapeutic use.

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