What pore size CPG is recommended for long oligonucleotide synthesis?

For long DNA or RNA sequences, 1000 Å or 2000 Å CPG is generally recommended to improve reagent diffusion and maintain coupling efficiency during extended synthesis cycles.

How does loading capacity affect CDMO manufacturing projects?

Loading capacity influences both yield and coupling efficiency. Controlled and reproducible loading is essential for minimizing batch-to-batch variability in long-term manufacturing programs.

Do you provide COA and batch traceability?

Each batch is supplied with a Certificate of Analysis (COA) and full traceability to support audits and quality reviews.

Can you support material supply during process scale-up?

Yes. We support material supply from early process development through scale-up and routine manufacturing.

How should CPGs be stored?

CPGs should be stored in a dry, tightly sealed container at room temperature to maintain surface functionality and consistent performance.

Control Pore Glass - RNA / BOC Sciences

Fluorescein Support 500Å

Description: Fluorescein Support 500Å is a controlled pore glass (CPG) with a pore size of 500 angstroms, functionalized with fluorescein. This support material is used for synthesizing oligonucleotides labeled with fluorescein at the 3' end. The 500Å pore size facilitates the synthesis of longer oligonucleotides by allowing efficient reagent diffusion. The fluorescein label is widely used in various molecular biology applications, including fluorescence-based detection, quantitative PCR (qPCR), and fluorescence resonance energy transfer (FRET) assays, due to its strong and reliable fluorescence properties.

CAT: BRP-01363

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Synonyms: Fluorescein Support CPG; Fluorescein Support CPG 500Å

6-FAM Glyceryl Support 500Å

Description: 6-FAM Glyceryl Support CPG 500Å is a controlled pore glass (CPG) with a pore size of 500 angstroms, functionalized with a glyceryl linker and 6-carboxyfluorescein (6-FAM). This support material is used for synthesizing oligonucleotides that are fluorescently labeled with 6-FAM, facilitating applications in molecular biology such as fluorescence-based detection, quantitative PCR (qPCR), and fluorescence resonance energy transfer (FRET) assays. The glyceryl linker ensures efficient attachment of the fluorophore to the oligonucleotide, providing strong and reliable fluorescence signals.

CAT: BRP-01364

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Synonyms: 6-FAM Glyceryl Support CPG; 6-FAM Glyceryl Support CPG 500Å

DMT-5-FAM lcaa CPG 500Å

Description: DMT-5-FAM lcaa CPG 500Å is a controlled pore glass (CPG) with a pore size of 500 angstroms, featuring a 5-carboxyfluorescein (5-FAM) fluorophore linked through a long chain alkylamine (lcaa) spacer and protected by a dimethoxytrityl (DMT) group. This support is designed for the synthesis of 3'-fluorescein-labeled oligonucleotides. The DMT protecting group allows for efficient incorporation and subsequent deprotection during synthesis, while the lcaa linker enhances the accessibility and performance of the fluorophore. This material is commonly used in fluorescence-based detection, quantitative PCR (qPCR), and fluorescence resonance energy transfer (FRET) assays due to its strong and reliable fluorescence signals.

CAT: BRP-01367

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Synonyms: DMT-5-FAM lcaa CPG

8-Bromo Adenosine (n,n-dibuf) 3'-tBDSilyl 2'-lcaa CPG 500Å

Description: 8-Bromo Adenosine (n,n-dibuf) 3'-tBDSilyl 2'-lcaa CPG 500Å is a specialized solid support used in the synthesis of modified oligonucleotides. It facilitates the incorporation of 8-bromo adenosine into oligonucleotides. The modifications include a 3'-tert-butyldimethylsilyl (tBDSilyl) group for protecting the 3'-hydroxyl, and an n,n-dibutylformamidine (dibuf) protection on the adenosine base. The long chain alkylamine (lcaa) linker and the controlled pore glass (CPG) with 500Å pores ensure efficient solid-phase synthesis. The resulting oligonucleotides are useful in biochemical research for studying nucleic acid interactions and for therapeutic applications requiring enhanced stability and specific binding properties.

CAT: BRP-01369

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Synonyms: 8-Bromo Adenosine (n,n-dibuf) 3'-tBDSilyl 2'-lcaa CPG 1000Å; 8-Bromo Adenosine (n,n-dibuf) 3'-tBDSilyl 2'-lcaa CPG

5-Bromo Uridine 3'-tBDSilyl 2'-lcaa CPG 500Å

Description: 5-Bromo Uridine 3'-tBDSilyl 2'-lcaa CPG 500Å is a specialized solid support used in the synthesis of modified oligonucleotides. It facilitates the incorporation of 5-Bromo uridine into oligonucleotides. It features a 3'-tert-butyldimethylsilyl (tBDSilyl) group protecting the 3'-hydroxyl, and a long chain alkylamine (lcaa) linker attached to controlled pore glass (CPG) with 500Å pores. The modification with 5-Bromo uridine provides enhanced stability and unique properties to the synthesized oligonucleotides, which are useful for various research applications, including studies of nucleic acid interactions and the development of therapeutic agents.

CAT: BRP-01370

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Synonyms: 5-Bromo Uridine 3'-tBDSilyl 2'-lcaa CPG 1000Å; 5-Bromo Uridine 3'-tBDSilyl 2'-lcaa CPG

5-Fluoro Uridine 3'-tBDSilyl 2'-lcaa CPG 1000Å

Description: 5-Fluoro Uridine 3'-tBDSilyl 2'-lcaa CPG 1000Å is a specialized solid support used in the synthesis of modified oligonucleotides. It facilitates the incorporation of 5-fluoro uridine into oligonucleotides. It features a 3'-tert-butyldimethylsilyl (tBDSilyl) group protecting the 3'-hydroxyl, and a long chain alkylamine (lcaa) linker attached to controlled pore glass (CPG) with 1000Å pores. The modification with 5-fluoro uridine provides enhanced stability and unique properties to the synthesized oligonucleotides, which are useful for various research applications, including studies of nucleic acid interactions and the development of therapeutic agents.

CAT: BRP-01371

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Synonyms: 5-Fluoro Uridine 3'-tBDSilyl 2'-lcaa CPG 500Å; 5-Fluoro Uridine 3'-tBDSilyl 2'-lcaa CPG

5-Bromo Cytidine (n-bz) 3'-tBDSilyl 2'-lcaa CPG 1000Å

Description: 5-Bromo Cytidine (n-bz) 3'-tBDSilyl 2'-lcaa CPG 1000Å is a specialized solid support used in the synthesis of modified oligonucleotides. It facilitates the incorporation of 5-bromo cytidine into oligonucleotides. It includes a 5-bromo modification on the cytidine base, a benzoyl (n-bz) protecting group on the exocyclic amino group, a 3'-tert-butyldimethylsilyl (tBDSilyl) group protecting the 3'-hydroxyl, and a long chain alkylamine (lcaa) linker attached to controlled pore glass (CPG) with 1000Å pores. This setup ensures efficient solid-phase synthesis and provides the resulting oligonucleotides with enhanced stability and unique properties for various biochemical and therapeutic research applications.

CAT: BRP-01372

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Synonyms: 5-Bromo Cytidine (n-bz) 3'-tBDSilyl 2'-lcaa CPG 500Å; 5-Bromo Cytidine (n-bz) 3'-tBDSilyl 2'-lcaa CPG

5-Iodo Cytidine (n-bz) 3'-tBDSilyl 2'-lcaa CPG 500Å

Description: 5-Iodo Cytidine (n-bz) 3'-tBDSilyl 2'-lcaa CPG 500Å is a specialized solid support used in the synthesis of modified oligonucleotides. It facilitates the incorporation of 5-iodo cytidine into oligonucleotides. It includes a 5-iodo modification on the cytidine base, a benzoyl (n-bz) protecting group on the exocyclic amino group, a 3'-tert-butyldimethylsilyl (tBDSilyl) group protecting the 3'-hydroxyl, and a long chain alkylamine (lcaa) linker attached to controlled pore glass (CPG) with 500Å pores. This setup ensures efficient solid-phase synthesis and provides the resulting oligonucleotides with enhanced stability and unique properties for various biochemical and therapeutic research applications.

CAT: BRP-01373

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Synonyms: 5-Iodo Cytidine (n-bz) 3'-tBDSilyl 2'-lcaa CPG 1000Å; 5-Iodo Cytidine (n-bz) 3'-tBDSilyl 2'-lcaa CPG

5-Iodo Uridine 3'-tBDSilyl 2'-lcaa CPG 1000Å

Description: 5-Iodo Uridine 3'-tBDSilyl 2'-lcaa CPG 1000Å is a specialized solid support used in the synthesis of modified oligonucleotides. It facilitates the incorporation of 5-Iodo uridine into oligonucleotides. It features a 3'-tert-butyldimethylsilyl (tBDSilyl) group protecting the 3'-hydroxyl, and a long chain alkylamine (lcaa) linker attached to controlled pore glass (CPG) with 1000Å pores. The modification with 5-Iodo uridine provides enhanced stability and unique properties to the synthesized oligonucleotides, which are useful for various research applications, including studies of nucleic acid interactions and the development of therapeutic agents.

CAT: BRP-01375

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Synonyms: 5-Iodo Uridine 3'-tBDSilyl 2'-lcaa CPG 500Å; 5-Iodo Uridine 3'-tBDSilyl 2'-lcaa CPG

isoGuanosine (n,n-isobudmf) 2'-lcaa CPG 1000Å

Description: isoGuanosine (n,n-isobudmf) 2'-lcaa CPG 1000Å is a specialized solid support used in oligonucleotide synthesis to incorporate modified guanosine, isoGuanosine, into nucleic acid sequences. This modification provides unique chemical properties, enabling tailored customization of oligonucleotides for diverse research and therapeutic applications.

CAT: BRP-01377

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Synonyms: isoGuanosine (n,n-isobudmf) 2'-lcaa CPG 500Å; isoGuanosine (n,n-isobudmf) 2'-lcaa CPG

IsoCytidine (n,n-diisobutylformamidine) 2'-lcaa CPG 1000Å

Description: IsoCytidine (n,n-diisobutylformamidine) 2'-lcaa CPG 1000Å is a specialized solid support used in oligonucleotide synthesis to introduce modified cytidine, IsoCytidine, into nucleic acid sequences. This modification offers unique chemical properties, allowing for customized oligonucleotide design for various research and therapeutic applications.

CAT: BRP-01379

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Synonyms: IsoCytidine (n,n-diisobutylformamidine) 2'-lcaa CPG 500Å; IsoCytidine (n,n-diisobutylformamidine) 2'-lcaa CPG

Beta-L-2'-tBDSilyl Guanosine (n-ibu) 3'-lcaa CPG 1000Å

Description: Beta-L-2'-tBDSilyl Guanosine (n-ibu) 3'-lcaa CPG 1000Å is a specialized solid support used in oligonucleotide synthesis to incorporate modified guanosine, specifically Beta-L-2'-tBDSilyl Guanosine, into nucleic acid sequences. This modification involves a Beta-L configuration at the 2'-position of the ribose sugar, a tert-butyldimethylsilyl (tBDSilyl) group at the 2'-position, and an n-ibu (n-isobutyryl) group at the nucleobase. Additionally, it features a long-chain alkylamine linker with controlled pore glass (CPG) having 1000 angstrom pores. This reagent facilitates the synthesis of oligonucleotides with unique structural and chemical properties for various research and therapeutic applications.

CAT: BRP-01380

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Synonyms: Beta-L-2'-tBDSilyl Guanosine (n-ibu) 3'-lcaa CPG 500Å; Beta-L-2'-tBDSilyl Guanosine (n-ibu) 3'-lcaa CPG

Beta-L-2'-tBDSilyl Adenosine (n-bz) 3'-lcaa CPG 1000Å

Description: Beta-L-2'-tBDSilyl Adenosine (n-bz) 3'-lcaa CPG 1000Å is a specialized solid support used in oligonucleotide synthesis to incorporate modified adenosine, specifically Beta-L-2'-tBDSilyl Adenosine, into nucleic acid sequences. This modification involves a Beta-L configuration at the 2'-position of the ribose sugar, a tert-butyldimethylsilyl (tBDSilyl) group at the 2'-position, and a benzoyl (n-bz) group at the nucleobase. Additionally, it features a long-chain alkylamine linker with controlled pore glass (CPG) having 1000 angstrom pores. This reagent facilitates the synthesis of oligonucleotides with unique structural and chemical properties for various research and therapeutic applications.

CAT: BRP-01381

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Synonyms: Beta-L-2'-tBDSilyl Adenosine (n-bz) 3'-lcaa CPG 500Å; Beta-L-2'-tBDSilyl Adenosine (n-bz) 3'-lcaa CPG

Beta-L-2'-tBDSilyl Cytidine (n-bz) 3'-lcaa CPG 500Å

Description: Beta-L-2'-tBDSilyl Cytidine (n-bz) 3'-lcaa CPG 500Å is a specialized solid support used in oligonucleotide synthesis to incorporate modified cytidine, specifically Beta-L-2'-tBDSilyl Cytidine, into nucleic acid sequences. This modification involves a Beta-L configuration at the 2'-position of the ribose sugar, a tert-butyldimethylsilyl (tBDSilyl) group at the 2'-position, and a benzoyl (n-bz) group at the nucleobase. Additionally, it features a long-chain alkylamine linker with controlled pore glass (CPG) having 500 angstrom pores. This reagent facilitates the synthesis of oligonucleotides with unique structural and chemical properties for various research and therapeutic applications.

CAT: BRP-01383

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Synonyms: Beta-L-2'-tBDSilyl Cytidine (n-bz) 3'-lcaa CPG 1000Å; Beta-L-2'-tBDSilyl Cytidine (n-bz) 3'-lcaa CPG

Beta-L-2'-tBDSilyl Uridine 3'-lcaa CPG 1000Å

Description: Beta-L-2'-tBDSilyl Uridine 3'-lcaa CPG 1000Å is a specialized solid support utilized in oligonucleotide synthesis to introduce modified uridine, specifically Beta-L-2'-tBDSilyl Uridine, into nucleic acid sequences. This modification involves a Beta-L configuration at the 2'-position of the ribose sugar, with a tert-butyldimethylsilyl (tBDSilyl) group attached. Additionally, it features a long-chain alkylamine linker with controlled pore glass (CPG) having 1000 angstrom pores. This reagent facilitates the synthesis of oligonucleotides with unique structural and chemical properties, suitable for various research and therapeutic applications.

CAT: BRP-01384

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Synonyms: Beta-L-2'-tBDSilyl Uridine 3'-lcaa CPG 500Å; Beta-L-2'-tBDSilyl Uridine 3'-lcaa CPG

Beta-L-2'-tBDSilyl Cytidine (n-acetyl) 3'-lcaa CPG 500Å

Description: Beta-L-2'-tBDSilyl Cytidine (n-acetyl) 3'-lcaa CPG 500Å is a specialized solid support used in oligonucleotide synthesis to incorporate modified cytidine, specifically Beta-L-2'-tBDSilyl Cytidine, into nucleic acid sequences. This modification includes a Beta-L configuration at the 2'-position of the ribose sugar, a tert-butyldimethylsilyl (tBDSilyl) group at the 2'-position, and an acetyl (n-acetyl) group at the nucleobase. Additionally, it features a long-chain alkylamine linker with controlled pore glass (CPG) having 500 angstrom pores. This reagent facilitates the synthesis of oligonucleotides with unique structural and chemical properties, suitable for various research and therapeutic applications.

CAT: BRP-01385

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Synonyms: Beta-L-2'-tBDSilyl Cytidine (n-acetyl) 3'-lcaa CPG 1000Å; Beta-L-2'-tBDSilyl Cytidine (n-acetyl) 3'-lcaa CPG

5-Methyl Cytidine (n,n-dmf) 2'-O-Methyl lcaa CPG 1000Å

Description: 5-Methyl Cytidine (n,n-dmf) 2'-O-Methyl lcaa CPG 1000Å is a specialized solid support used in oligonucleotide synthesis to incorporate modified cytidine, specifically 5-methyl cytidine, into nucleic acid sequences. This modification introduces a methyl group at the 5-position of the cytidine base and features a long-chain alkylamine linker with controlled pore glass (CPG) having 1000 angstrom pores. This reagent enables the tailored synthesis of oligonucleotides with enhanced stability and specific chemical properties for diverse research and therapeutic applications.

CAT: BRP-01393

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Synonyms: 5-Methyl Cytidine (n,n-dmf) 2'-O-Methyl lcaa CPG 500Å; 5-Methyl Cytidine (n,n-dmf) 2'-O-Methyl lcaa CPG

2'-O-Methyl Inosine lcaa CPG 500Å

Description: 2'-O-Methyl Inosine lcaa CPG 500Å is a solid support reagent used in oligonucleotide synthesis. It features 2'-O-methyl inosine linked to long chain alkylamine (lcaa) on Controlled Pore Glass (CPG) with a pore size of 500 angstroms. This modification enhances the stability and nuclease resistance of synthesized oligonucleotides, making it suitable for various research and therapeutic applications.

CAT: BRP-01395

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Synonyms: 2'-O-Methyl Inosine lcaa CPG 1000Å; 2'-O-Methyl Inosine lcaa CPG

5-Bromo Uridine 2'-O-Methyl lcaa CPG 500Å

Description: 5-Bromo Uridine 2'-O-Methyl lcaa CPG 500Å is a reagent utilized in oligonucleotide synthesis. It contains 5-Bromo Uridine, where a bromine atom is attached to the 5-position of the uridine nucleoside, along with a methyl group at the 2'-position of the ribose sugar. The nucleoside is linked to a solid support using a long-chain alkylamine (lcaa) linker, and the support material is Controlled Pore Glass (CPG) with a pore size of 500 angstroms. This reagent is instrumental in the creation of oligonucleotides with enhanced stability and resistance to degradation, crucial for diverse research and diagnostic applications in molecular biology.

CAT: BRP-01398

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Synonyms: 5-Bromo Uridine 2'-O-Methyl lcaa CPG 1000Å; 5-Bromo Uridine 2'-O-Methyl lcaa CPG

5-Iodo Uridine 2'-O-Methyl lcaa CPG 500Å

Description: 5-Iodo Uridine 2'-O-Methyl lcaa CPG 500Å is a reagent used in oligonucleotide synthesis. It contains 5-Iodo Uridine, where an iodine atom is attached to the 5-position of the uridine nucleoside, along with a methyl group at the 2'-position of the ribose sugar. The nucleoside is linked to a solid support using a long-chain alkylamine (lcaa) linker, and the support material is Controlled Pore Glass (CPG) with a pore size of 500 angstroms. This reagent facilitates the synthesis of oligonucleotides with enhanced stability and resistance to degradation, important for various molecular biology applications.

CAT: BRP-01399