What pore size CPG is recommended for long oligonucleotide synthesis?

For long DNA or RNA sequences, 1000 Å or 2000 Å CPG is generally recommended to improve reagent diffusion and maintain coupling efficiency during extended synthesis cycles.

How does loading capacity affect CDMO manufacturing projects?

Loading capacity influences both yield and coupling efficiency. Controlled and reproducible loading is essential for minimizing batch-to-batch variability in long-term manufacturing programs.

Do you provide COA and batch traceability?

Each batch is supplied with a Certificate of Analysis (COA) and full traceability to support audits and quality reviews.

Can you support material supply during process scale-up?

Yes. We support material supply from early process development through scale-up and routine manufacturing.

How should CPGs be stored?

CPGs should be stored in a dry, tightly sealed container at room temperature to maintain surface functionality and consistent performance.

Control Pore Glass - RNA / BOC Sciences

rA (Bz) AMP CPG

Description: rA (Bz) AMP CPG is a modification reagent used in oligonucleotide synthesis. This modification enhances stability and functionality. It facilitates the production of RNA oligonucleotides with improved properties, suitable for various molecular biology and biotechnology applications, including RNA interference and gene expression studies.

CAT: BRP-00505

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rA (Bz), 2'-OAc CNA (N16) CPG

Description: rA (Bz), 2'-OAc CNA (N16) CPG is a modification reagent used in oligonucleotide synthesis. It incorporates a riboadenosine (rA) residue modified with a benzoyl (Bz) group onto a controlled pore glass (CPG) solid support. This modification enhances stability and functionality. It enables the synthesis of RNA oligonucleotides with improved properties, suitable for various molecular biology and biotechnology applications, including RNA interference and gene expression studies.

CAT: BRP-00506

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Storage: Store at -20 °C

Synonyms: Bz-A-RNA-CPG; 5'-Dimethoxytrityl-N-benzoyl-Adenosine, 2'-acetate-3'-succinoyl-long chain alkylamino-CPG; rA (Bz), 2'-OAc CNA CPG; 2'-OAc Bz-A-RNA-CPG

3'-Azido-modifier CPG

Description: 3'-Azido-modifier CPG is a specialized reagent used in oligonucleotide synthesis. It incorporates an azide group at the 3'-end of the oligonucleotide sequence. This modification allows for further functionalization through click chemistry reactions, enabling the attachment of various molecules or probes to the oligonucleotide. The azido-modified oligonucleotides find applications in bioconjugation, labeling, and imaging studies, as well as in the development of nucleic acid-based therapeutics and diagnostics.

CAT: BRP-00508

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Synonyms: 3'-Azido-modifier CPG 1000A

Native CPG

Description: Natural CPG can be functionalized with a linker and either a base or modifier for solid-supported oligonucleotide synthesis.

CAT: BRP-00511

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2'-OMe-Ac-C-RNA-CPG

Description: 2'-OMe-Ac-C-RNA-CPG is a specialized reagent used in oligonucleotide synthesis. This modification provides enhanced stability and protection against nuclease degradation. The oligonucleotide is immobilized on a controlled pore glass (CPG) solid support, allowing for solid-phase synthesis. Overall, this reagent enables the efficient synthesis of modified RNA oligonucleotides with improved properties, suitable for various molecular biology and biotechnology applications, including gene expression studies and RNA-based therapeutics.

CAT: BRP-00517

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Storage: Store at -20 °C

Synonyms: 2'-OMe-rC(Ac) CPG; 5'-Dimethoxytrityl-N-acetyl-Cytidine, 2'-O-methyl,3'-succinoyl-long chain alkylamino-CPG

2'-OMe-G(dmf)-RNA-CPG

Description: 2'-OMe-G(dmf)-RNA-CPG is a specialized reagent used in oligonucleotide synthesis. It contains a 2'-O-methyl (2'-OMe) modification at the ribose sugar and a dimethylformamide (dmf) group attached to the guanine (G) nucleotide. This modification enhances stability and functionality, making it suitable for various molecular biology applications, including gene expression studies and therapeutic RNA-based treatments. Additionally, the oligonucleotide is immobilized on a controlled pore glass (CPG) solid support, allowing for solid-phase synthesis.

CAT: BRP-00533

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Storage: Store at RT

Synonyms: 2'-OMe-G-RNA-CPG; 5'-Dimethoxytrityl-N-dimethylformamidine-Guanosine, 2'-O-methyl,3'-succinoyl-long chain alkylamino-CPG; 5'-DMT-2'-OMe-G(dmf)-CPG

Bz-A-LNA-CPG

Description: Bz-A-LNA-CPG is a specialized reagent used in the solid-phase synthesis of oligonucleotides. This reagent features a benzoyl (Bz) protecting group on the adenine base, providing stability during the synthesis process. The inclusion of Locked Nucleic Acid (LNA) enhances the binding affinity and specificity of the resulting oligonucleotides to complementary nucleic acid sequences. The reagent is immobilized on a Controlled Pore Glass (CPG) support, which facilitates the step-by-step addition of nucleotides during oligonucleotide synthesis. These oligonucleotides are valuable in various applications, including diagnostics, molecular biology research, and the development of therapeutic agents, particularly in antisense and RNA interference (RNAi) technologies.

CAT: BRP-00550

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Storage: Store at -20 °C

Synonyms: 5'-Dimethoxytrityl-N-benzoyl-(2'-O,4'-C-methylene)-Adenosine, 3'-succinoyl-long chain alkylamino-CPG; Bz-A-LA-CPG 1000Å; Bz-A-LA-CPG; Benzoyl-Adenine-Locked Nucleic Acid-Controlled Pore Glass

Bz-5-Me-C-LNA-CPG

Description: Bz-5-Me-C-LNA-CPG is a specialized reagent used in the synthesis of oligonucleotides. It features a benzoyl (Bz) protecting group on 5-methylcytosine (5-Me-C) and incorporates Locked Nucleic Acid (LNA) for enhanced binding affinity and stability. The reagent is immobilized on Controlled Pore Glass (CPG), facilitating efficient solid-phase synthesis. This combination of modifications results in high-affinity, stable oligonucleotides suitable for applications in molecular diagnostics, therapeutic development, and advanced research.

CAT: BRP-00551

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Storage: Store at -20 °C

Synonyms: 5'-Dimethoxytrityl-N-benzoyl-5-methyl-(2'-O,4'-C-methylene)-Cytidine, 3'-succinoyl-long chain alkylamino-CPG; Bz-5-Me-C-LA-CPG 1000Å; Bz-5-Me-C-LA-CPG

dmf-G-LNA-CPG

Description: dmf-G-LNA-CPG is a specialized reagent utilized in oligonucleotide synthesis. It incorporates dimethylformamidine (dmf) as a protecting group for guanine (G) and Locked Nucleic Acid (LNA) for enhanced binding affinity and stability. Additionally, it is immobilized on Controlled Pore Glass (CPG), facilitating efficient solid-phase synthesis. This combination enables the production of high-affinity, stable oligonucleotides suitable for various molecular biology applications, including diagnostics and therapeutic development.

CAT: BRP-00552

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Storage: Store at -20 °C

Synonyms: dmf-G-LA-CPG 1000Å; dmf-G-LA-CPG; 5'-Dimethoxytrityl-N-dimethylformamidine-(2'-O,4'-C-methylene)-Guanosine, 3'-succinoyl-long chain alkylamino-CPG

5-Me-U-LNA-CPG

Description: 5-Me-U-LNA-CPG is a reagent used in oligonucleotide synthesis. It features 5-methyluridine (5-Me-U) for enhanced binding affinity and stability, Locked Nucleic Acid (LNA) for improved thermal stability and hybridization, and is immobilized on Controlled Pore Glass (CPG) for efficient solid-phase synthesis. This combination produces high-affinity, stable oligonucleotides suitable for molecular diagnostics, therapeutic development, and advanced research.

CAT: BRP-00553

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Storage: Store at -20 °C

Synonyms: 5-Me-U-LA-CPG 1000Å; 5-Me-U-LA-CPG; T-LA-CPG; 5'-Dimethoxytrityl-5-methyl-(2'-O,4'-C-methylene)-Uridine, 3'-succinoyl-long chain alkylamino-CPG

3'-Azido-Modifier Serinol CPG

Description: 3'-Azido-Modifier Serinol CPG is a specialized reagent used in oligonucleotide synthesis. It includes a serinol backbone modification and an azido functional group attached to the 3'-end of the oligonucleotide sequence. This modification allows for further conjugation with other molecules or probes using click chemistry. The Controlled Pore Glass (CPG) support facilitates the solid-phase synthesis of oligonucleotides, providing a stable platform for sequential nucleotide addition. This reagent is valuable for creating customized oligonucleotides for research, diagnostic, and therapeutic applications, particularly those requiring additional functionalization or conjugation for specific downstream assays or targeting purposes.

CAT: BRP-00554

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Storage: Store at 2-8 °C

Synonyms: 3'-Azido-Modifier Serinol CPG 1000Å; 3-Dimethoxytrityloxy-2-(3-(4-azidobutyramido)propanamido)propyl-1-O-succinyl-long chain alkylamino-CPG

TEG-GalNAc Cluster Succinate CPG

Description: TEG-GalNAc Cluster Succinate CPG refers to a solid support (controlled pore glass) functionalized with a succinate linker and multiple GalNAc (N-acetylgalactosamine) units spaced with triethylene glycol (TEG) linkers. This structure is utilized in solid-phase synthesis to construct oligonucleotides or peptides, particularly those targeted for specific cellular interactions or drug delivery applications.

CAT: BRP-01101

Purity: ≥98% by HPLC

Appearance: White, off-white to light yellow powder

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Storage: Store at 2-8 °C

Synonyms: TEG-GalNAc Cluster Succinate CPG (500Å); TEG-GalNAc Cluster Succinate CPG (1000Å)

3'-Thio modifier 6 S-S-DMTr-linker CPG

Description: 3'-Thio modifier 6 S-S-DMTr-linker CPG is a solid support (CPG) modified with a 3'-thiol group and a 6-carbon atom linker terminated with a dimethoxytrityl (DMTr) protecting group. It is used in oligonucleotide synthesis to introduce a thiol modification at the 3' end, facilitating conjugation or interaction studies.

CAT: BRP-01104

Purity: ≥98% by UPLC

Appearance: White, off-white to light yellow powder

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Storage: Store at -20 °C

Synonyms: 1-O-Dimethoxytrityl-3-oxahexyl-disulfide, 1'-succinoyl-CPG 500Å; 1-O-Dimethoxytrityl-3-oxahexyl-disulfide, 1'-succinoyl-CPG 1000Å; 3'-thio modifier 6 S-S-DMTr-linker CPG (500Å); 3'-thio modifier 6 S-S-DMTr-linker CPG (1000Å)

Cholesterol-TEG CPG (plant source)

Description: Cholesterol-TEG CPG (plant source) refers to a solid support (controlled pore glass) derived from plant sources and functionalized with cholesterol linked to a triethylene glycol (TEG) spacer. This structure is used in solid-phase synthesis to attach cholesterol to nucleic acids or peptides. Cholesterol conjugation enhances cellular uptake and membrane permeability of biomolecules, making it valuable in drug delivery and targeting applications.

CAT: BRP-01109

Purity: ≥98% by HPLC

Appearance: Colorless to faint yellow oily matter

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Storage: Store at -20 °C

Synonyms: 1-Dimethoxytrityloxy-3-O-(N-cholesteryl-3-aminopropyl)-triethyleneglycol-glyceryl-2-O-succinoyl-long chain alkylamino-CPG 500Å; Cholesterol-TEG CPG 500Å (plant source); Cholesterol-TEG CPG 1000Å (plant source); 1-Dimethoxytrityloxy-3-O-(N-cholesteryl-3-aminopropyl)-triethyleneglycol-glyceryl-2-O-succinoyl-long chain alkylamino-CPG 1000Å

2'-O-butyne Adenosine (n-bz) 3'-lcaa CPG

Description: 2'-O-butyne Adenosine (n-bz) 3'-lcaa CPG is a specialized solid support used in oligonucleotide synthesis. It comprises a controlled-pore glass (CPG) matrix with a linker molecule containing a 3'-lcaa moiety and modified with a 2'-O-butyne Adenosine (n-bz) group. This support facilitates the stepwise assembly of nucleotide sequences during automated oligonucleotide synthesis. The specific functional groups on the support enable controlled chemical reactions, ensuring precise and efficient synthesis of oligonucleotides. These synthesized oligonucleotides have various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01261

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Synonyms: 2'-O-butyne Adenosine (n-bz) 3'-lcaa CPG 500Å; 2'-O-butyne Adenosine (n-bz) 3'-lcaa CPG 1000Å

2'-O-butyne Cytidine (n-bz) 3'-lcaa CPG

Description: 2'-O-butyne Cytidine (n-bz) 3'-lcaa CPG refers to a specialized solid support used in oligonucleotide synthesis. It is composed of a controlled-pore glass (CPG) matrix functionalized with a linker molecule containing a 3'-lcaa moiety and modified with a 2'-O-butyne Cytidine (n-bz) group. This support facilitates the sequential assembly of nucleotide sequences during automated oligonucleotide synthesis. The specific functional groups on the support enable controlled chemical reactions, ensuring precise and efficient synthesis of oligonucleotides. These synthesized oligonucleotides have various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01262

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Synonyms: 2'-O-butyne Cytidine (n-bz) 3'-lcaa CPG 500Å; 2'-O-butyne Cytidine (n-bz) 3'-lcaa CPG 1000Å

2'-O-butyne Guanosine (n-ibu) 3'-lcaa CPG

Description: 2'-O-butyne Guanosine (n-ibu) 3'-lcaa CPG is a specialized solid support used in oligonucleotide synthesis. It comprises a controlled-pore glass (CPG) matrix with a linker molecule containing a 3'-lcaa moiety and modified with a 2'-O-butyne Guanosine (n-ibu) group. This support facilitates the stepwise assembly of nucleotide sequences during automated oligonucleotide synthesis. The specific functional groups on the support enable controlled chemical reactions, ensuring precise and efficient synthesis of oligonucleotides. These synthesized oligonucleotides have various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01263

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Synonyms: 2'-O-butyne Guanosine (n-ibu) 3'-lcaa CPG 500Å; 2'-O-butyne Guanosine (n-ibu) 3'-lcaa CPG 1000Å

2'-O-butyne Uridine 3'-lcaa CPG

Description: 2'-O-butyne Uridine 3'-lcaa CPG is a specialized solid support used in oligonucleotide synthesis. It consists of a controlled-pore glass (CPG) matrix functionalized with a linker molecule containing a 3'-lcaa moiety and modified with a 2'-O-butyne Uridine group. This support facilitates the stepwise assembly of nucleotide sequences during automated oligonucleotide synthesis. The specific functional groups on the support enable controlled chemical reactions, ensuring precise and efficient synthesis of oligonucleotides. These synthesized oligonucleotides have various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01264

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Synonyms: 2'-O-butyne Uridine 3'-lcaa CPG 500Å; 2'-O-butyne Uridine 3'-lcaa CPG 1000Å

2'-O-Methyl Adenosine (n-PAC) 3'-lcaa CPG

Description: 2'-O-Methyl Adenosine (n-PAC) 3'-lcaa CPG is a specialized solid support used in oligonucleotide synthesis. It comprises a controlled-pore glass (CPG) matrix functionalized with a linker molecule containing a 3'-lcaa moiety and modified with a 2'-O-Methyl Adenosine (n-PAC) group. This support facilitates the stepwise assembly of nucleotide sequences during automated oligonucleotide synthesis. The specific functional groups on the support enable controlled chemical reactions, ensuring precise and efficient synthesis of oligonucleotides. These synthesized oligonucleotides have various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01266

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Synonyms: 2'-O-Methyl Adenosine (n-PAC) 3'-lcaa CPG 500Å; 2'-O-Methyl Adenosine (n-PAC) 3'-lcaa CPG 1000Å

2'-O-Methyl Cytidine (n-PAC) 3'-lcaa CPG

Description: 2'-O-Methyl Cytidine (n-PAC) 3'-lcaa CPG is a specialized solid support used in oligonucleotide synthesis. It consists of a controlled-pore glass (CPG) matrix functionalized with a linker molecule containing a 3'-lcaa moiety and modified with a 2'-O-Methyl Cytidine (n-PAC) group. This support facilitates the stepwise assembly of nucleotide sequences during automated oligonucleotide synthesis. The specific functional groups on the support enable controlled chemical reactions, ensuring precise and efficient synthesis of oligonucleotides. These synthesized oligonucleotides have various applications in molecular biology, genetics, diagnostics, and therapeutics.

CAT: BRP-01268