Name: 5'-DMT-U-Suc-CPG; 500 Å (RNA)
Brand: BOC Sciences
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5'-DMT-U-Suc-CPG; 500 Å (RNA)

5'-DMT-U-Suc-CPG; 500 Å (RNA) is a reagent used in the solid-phase synthesis of RNA oligonucleotides for incorporating uridine (U) residues. It features a 5'-DMT (dimethoxytrityl) protective group to protect the 5' end of the uridine base, and a succinyl (Suc) linker that attaches the nucleoside to controlled pore glass (CPG) with a 500 Å pore size. This setup facilitates efficient incorporation of uridine into RNA sequences while ensuring effective protection and stability during synthesis.

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Catalog

BRP-02294

Synonyms

5'-O-DMT-2'-OAc-U-3'-O-Suc-CPG; 500 Å (RNA)

Appearance

White powder

Storage

Store at -20 °C

Shipping

Room temperature.

Cleavage Conditions

Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.

Deprotection Conditions

When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.

Chemical Structure: