miRNA mimics are small double-stranded RNAs that can mimic endogenous mature miRNAs. BOC Sciences provides miRNA mimics synthesis services to accelerate miRNA research progress.
In genetics, microRNA (miRNA) is a class of evolutionarily conserved non-coding small molecules, typically between 21-23 nucleotides in length and function in regulating gene expression at the translational level. In the vertebrate genome, up to 1,000 different miRNAs were found and regulating at least 30% of gene expression.
miRNA mimics are the mimics of endogenous miRNA. miRNA mimics are chemically synthesized mature miRNA duplexes that enhance the function of endogenous miRNA. miRNA mimics are composed of two sequences, one consistent with the targeted mature miRNA sequence and the other complementary to the targeted mature miRNA sequence.
miRNA mimics synthesized by BOC Sciences cover roughly all human, mouse, and rat miRNA within the miRBase database. We mimic endogenous miRNAs in organisms to specifically enhance related functions. Moreover, we are capable of providing miRNA in different forms, lengths, and designs for customers worldwide (microRNA sequences are from miRBase).
Fig. 1 miRNA mimics (F Abdallah, 2019)
miRNA Mimics has become one of the effective tools capable of regulating gene expression. It has its applications in fields such as medicine and scientific research. It can be used as targeted activation of specific genes. miRNA Mimics is useful for disease treatment. For example, in cancer therapy, miRNA Mimics is used as a carrier construct to enhance the expression of specific mRNAs in animals to an order of magnitude and to carry out the cell transfection process through messenger RNA viral vectors for therapeutic purposes.
miRNA Mimics can be potential drugs for the treatment of cancer. It is an effective therapeutic tool that reduces the size of tumors and inhibits the proliferation of cancer cells. Current oncology treatments use miRNA Mimics for the treatment of disease. With the help of small molecule RNAs, the side effects of chemotherapy-dependent treatment can be reduced and a more precise and safe treatment can be achieved.
The research and development of miRNA Mimics is impacting the field of cancer treatment and basic scientific research. It has changed the idea of previous therapies and greatly improved the effectiveness of treating cancer. Meanwhile, miRNA Mimics has become a powerful tool for studying the biological functions of miRNAs in basic biological research. miRNA Mimics provides new avenues for miRNA research and development, and has important contributions to future biological research and drug development.
BOC Sciences' Custom miRNA Mimics Synthesis service is a high-quality custom manufacturing service that specializes in miRNA mimic synthesis for customers.
1. Efficient Chemical Synthesis
BOC Sciences expert team will use the most advanced chemical synthesis techniques to ensure high purity and optimal activity of miRNA mimics.
2. Design and Selection
BOC Sciences will design and select the most suitable sequences of miRNA mimics according to the customer's requirements to ensure their optimal functionality and stability.
3. Comprehensive Analysis
BOC Sciences will use different analytical techniques to identify and purify miRNA mimics, including mass spectrometry and HPLC analysis, to ensure the purity and quality of miRNA mimics.
4. Custom Production
BOC Sciences will perform custom production of miRNA mimics from small scale to large scale production according to customer requirements and volume requirements.
5. Regular Updates
BOC Sciences will regularly update the latest technologies and methods for miRNA mimics production to ensure that customers get the most effective and reliable miRNA mimics products.
| Product Name | Purification Method | Price |
| Single strand miRNA mimics | HPLC | Inquiry |
| Double strand miRNA mimics | HPLC | Inquiry |
| miRNA mimics single-stranded negative control | HPLC | Inquiry |
| miRNA mimics double-stranded negative control | HPLC | Inquiry |
| miRNA mimics FAM-labeled single-stranded negative control | HPLC | Inquiry |
| miRNA mimics FAM-labeled double-stranded negative control | HPLC | Inquiry |
miRNA mimics are synthetic double-stranded RNAs that mimic the function of endogenous microRNAs (miRNAs). These mimics are designed to enhance the activity of specific miRNAs, regulating gene expression by interacting with target mRNAs to promote gene silencing or activation.
miRNA mimics are widely used in functional genomics to study gene expression regulation. They are valuable tools for cancer research, gene modulation, and understanding miRNA functions in cellular processes. Additionally, they can be used in animal models to investigate gene activation or repression.
BOC Sciences employs advanced chemical synthesis methods to ensure high purity and activity of miRNA mimics. Each batch undergoes rigorous quality control, including HPLC and mass spectrometry analysis, to confirm the sequence integrity and purity before delivery.
Yes, BOC Sciences offers highly customizable miRNA mimic synthesis services. We can design and produce miRNA mimics in various forms, lengths, and sequences according to your specific research goals. Customization is available for both small-scale and large-scale synthesis.
Single-stranded miRNA mimics contain only one strand of RNA, while double-stranded mimics consist of two complementary strands that are more stable and function similarly to endogenous miRNAs. Double-stranded mimics are often preferred for gene silencing applications due to their enhanced stability and efficacy.
miRNA mimics can be chemically modified to enhance their stability, delivery, and function. Modifications include fluorescent labeling (e.g., FAM), chemical modifications to improve resistance to nucleases, and other stabilizing modifications that increase the mimics' half-life in biological systems.
The synthesis and delivery time for miRNA mimics depends on the complexity and scale of the order. BOC Sciences provides rapid turnaround times for both small and large-scale miRNA mimic production, ensuring timely delivery for your research projects.
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