DNA/RNA Modification

DNA/RNA Modification

BOC RNA can provide different forms, different lengths, and large quantities of chemically modified DNA/RNA. Our custom synthesis service can be flexible and diverse to fit any specifications.

We provide the following modifications (but are not limited):

Standard RNA BasesShort CodeBackbone modificationsShort Code
(A,C,G,U)A,C,G,UPhosphorothioate*
2'-Omethyl RNA BasesShort CodePhosphorylationShort Code
2'-OMe RNA Bases (A, C, G, U)mA,mC,mG,mU5'-Phosphate5'-P
Standard DNA BasesShort Code2'-ModificationsShort Code
2'-Deoxy Bases (A, C, G, T)dA,dC, dG, dT2'-Amino-butyryl-pyrene-uridine2'-P-U
Base ModificationsShort Code2'-Amino-cytidine2'-N-C
1-Methyl-guanosinem1G2'-Amino-uridine2'-N-U
2,6-DiaminopurineDAP2'-Deoxy-uridinedU
2-Methyl-adenosinem2A2'-Fluoro-adenosine2'-F-A
2-Aminopurine2AP2'-Fluoro-cytidine2'-F-C
4-Thio-uridine4-S-U2'-Fluoro-guanosine2'-F-G
5-Bromo-UridineU[5Br]2'-Fluoro-uridine2'-F-U
5-Fluoro-cytidineC[5F]2'-OMe-inosinemI
5-Fluoro-uridineU[5F]Amino ModifiersShort Code
5-Iodo-uridineU[5I]3'-Amino modifier C12N12-3'
5-Methyl-cytidine5-M-C3'-Amino modifier C6N6-3'
5-Methyl-Deoxycytidine5-M-dC3'-Amino modifier C3N3-3'
5-Methyl-uridinerT5'-Amino modifier C12N12
InosineI5'-Amino modifier C3N3
N2-Methyl-guanosinem2G5'-Amino modifier C5N5
N3-Methyl-uridine3-M-U5'-Amino modifier C6N6
N6,N6-Dimethyl-adenosineDMA5-Aminohexylacrylamino-uridine5-LC-N-U
N6-Methyl-adenosinem6AThiol ModifiersShort Code
O6-Methyl-guanosineO6mG3'-Disulfide thiol-modifierS-S-3'
Pseudouridine~U5'-Disulfide thiol-modifierS-S
Purine ribonucleosidePuSpacer ModifiersShort Code
Pyrrolo-cytidinepCC18 Spacer18S
RibavirinRBVC3 SpacerC3
Chain TerminatorsShort CodeC9 Spacer9S
3' Inverted abasicbdSpacerdab
3' Inverted deoxy-thymidineidT-3'rSpacerrab
3'-Terminal 3'-Deoxy-Guanosine3'dGDegenerate BasesShort Code
3'-Terminal dideoxy-cytidineddCdNdN
5' Inverted deoxy-thymidineidTdSdS
5' Terminal 5'-deoxy-ribo-adenosine5'dAdWdW
5' Terminal 5'-deoxy-ribo-cytidine5'dCmNmN
5' Terminal 5'-deoxy-ribo-guanosine5'dGrNrN
5' Terminal 5'-deoxy-ribo-uridine5'dUrSrS
  rWrW

Our labeling and fluorescent modifications include (but are not limited):

LabelingShort CodeCommon dyes and fluorescent modification group (color)
3-Biotin3'-Bi6-FAM (Yellow-green)
3'-Cholesterol3'-ChlFluorescein (Yellow-green)
3'-Cy3Cy3-3'TET (Yellow-green)
3'-Cy5Cy5-3'JOE (Yellow)
3'-Cy5.5Cy5.5-3'HEX (Yellow)
3'-DY547 (Cy3 Alternative)DY547-3'Cy3 (Yellow-orange)
3'-Fluorescein3'-FlTAMRA (Yellow-orange)
3'-Biotin LC3'-LCBiROX (Orange)
3'-Biotin LC LC3'-2LCBiCy3.5 (Orange-red)
3'-PuromycinPmnCy5 (Red)
3'-TAMRA3'-TAM
5'-BiotinBi
5'-CholesterolChl
5'-Cy3Cy3
5'-Cy5Cy5
5'-Cy5.5Cy5.5
5'-DabcylDabcyl
5-DY547 (Cy3 Alternative)DY547
5'-DY647 (Cy5 Alternative)DY647
5'-DY677 (Cy5.5 Alternative)DY677
5'-FluoresceinFl
5'-Pyrene5'-Pyr
5'-TAMRATAM
5'-TETTET

Services process

DNA/RNA Modification

Service advantages

  • Flexible synthesis scales: 50 nmol, 100 nmol, 200 nmol, 1 µmol, 5 µmol, and 10 µmol. Bulk orders are available upon request
  • Provide detailed pre-service guidance and after-service follow-up
  • Experienced team: scientists and staff with over 15 years of experience in oligo synthesis and modifications
  • Provide multiple purification methods
  • High quality: QC analysis by MS, HPLC, or PAGE, and comprehensive quality control reports (HPLC/MS)
  • Competitive price
  • 24 h delivery

Contact us now to get technical advice and more information. Our technical support team will review and provide a quotation as soon as possible!

* Only for research. Not suitable for any diagnostic or therapeutic use.
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