Phosphoramidites - RNA / BOC Sciences

Trebler phosphoramidite

Description: Trebler Phosphoramidite is another specialized reagent utilized in oligonucleotide synthesis. It is designed to incorporate modifications into oligonucleotide sequences with triple repeats. This capability facilitates the synthesis of sequences with repeated motifs or specific structural features, offering researchers greater flexibility in designing custom oligonucleotides for various applications. The Trebler Phosphoramidite plays a crucial role in molecular biology research, allowing for the creation of oligonucleotides tailored to specific experimental needs, including gene expression studies, structural analysis, and therapeutic RNA-based treatments.

CAT: BRP-00536

CAS: 202193-93-9

MF: C86H101N2O14P

MF: 1417.70

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InChIKey: IOJWATJVGOQEOD-UHFFFAOYSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC(COCCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)(COCCCOC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)COCCCOC(C7=CC=CC=C7)(C8=CC=C(C=C8)OC)C9=CC=C(C=C9)OC

IUPAC Name: 3-[[3-[3-[bis(4-methoxyphenyl)-phenylmethoxy]propoxy]-2,2-bis[3-[bis(4-methoxyphenyl)-phenylmethoxy]propoxymethyl]propoxy]-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C86H101N2O14P/c1-66(2)88(67(3)4)103(101-61-20-54-87)102-65-83(62-95-55-21-58-98-84(68-24-14-11-15-25-68,71-30-42-77(89-5)43-31-71)72-32-44-78(90-6)45-33-72,63-96-56-22-59-99-85(69-26-16-12-17-27-69,73-34-46-79(91-7)47-35-73)74-36-48-80(92-8)49-37-74)64-97-57-23-60-100-86(70-28-18-13-19-29-70,75-38-50-81(93-9)51-39-75)76-40-52-82(94-10)53-41-76/h11-19,24-53,66-67H,20-23,55-65H2,1-10H3

Synonyms: Tris-2,2,2-[3-(4,4'-dimethoxytrityloxy)propyloxymethyl]ethyl-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 3-[3-[bis(4-methoxyphenyl)phenylmethoxy]propoxy]-2,2-bis[[3-[bis(4-methoxyphenyl)phenylmethoxy]propoxy]methyl]propyl 2-cyanoethyl ester; 3-[3-[Bis(4-methoxyphenyl)phenylmethoxy]propoxy]-2,2-bis[[3-[bis(4-methoxyphenyl)phenylmethoxy]propoxy]methyl]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 3-[3-[bis(4-methoxyphenyl)phenylmethoxy]propoxy]-2,2-bis[[3-[bis(4-methoxyphenyl)phenylmethoxy]propoxy]methyl]propyl 2-cyanoethyl ester

5'-Carboxy-Modifier C10

Description: 5'-Carboxy-Modifier C10 is used in oligonucleotide synthesis to introduce a carboxylic acid functional group at the 5'-end of the oligonucleotide sequence. The C10 designation indicates a specific linker length or chemical structure associated with the modifier. The carboxylic acid group allows for conjugation with other molecules or surfaces, making it useful for various applications such as immobilization, coupling with other biomolecules, or attachment to solid supports in diagnostic assays or biomaterial development.

CAT: BRP-00537

CAS: 374540-37-1

MF: C23H40N3O6P

MF: 485.55

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InChIKey: JGUCYBGKYZNDOD-UHFFFAOYSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCCCCC(=O)ON1C(=O)CCC1=O)OCCC#N

IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 10-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxydecanoate

InChI: InChI=1S/C23H40N3O6P/c1-19(2)26(20(3)4)33(31-18-12-16-24)30-17-11-9-7-5-6-8-10-13-23(29)32-25-21(27)14-15-22(25)28/h19-20H,5-15,17-18H2,1-4H3

Synonyms: 10-Carboxy-decyl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite, N-hydroxysuccinimide ester; Decanoic acid, 10-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]-, 2,5-dioxo-1-pyrrolidinyl ester; 2,5-Dioxo-1-pyrrolidinyl 10-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]decanoate; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 10-[(2,5-dioxo-1-pyrrolidinyl)oxy]-10-oxodecyl ester

5'-Maleimide-Modifier Phosphoramidite

Description: 5'-Maleimide-Modifier Phosphoramidite incorporates a maleimide functional group at the 5'-end of the oligonucleotide during synthesis. Maleimide is reactive towards thiols, enabling site-specific conjugation with thiol-containing molecules such as proteins or peptides. This modification is widely used in bioconjugation strategies, including protein labeling, antibody-drug conjugates, and surface functionalization for biosensor applications.

CAT: BRP-00538

CAS: 1316303-83-9

MF: C21H32N3O5P

MF: 437.47

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InChIKey: KXZQPWBQCGKFLY-DBRQCPGENA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OCCN1C(=O)C2C(C1=O)C3(OC2(C=C3)C)C)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl (2-((3aR,4S,7R,7aS)-4,7-dimethyl-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-epoxyisoindol-2-yl)ethyl) diisopropylphosphoramidite

InChI: InChI=1/C21H32N3O5P/c1-14(2)24(15(3)4)30(27-12-7-10-22)28-13-11-23-18(25)16-17(19(23)26)21(6)9-8-20(16,5)29-21/h8-9,14-17H,7,11-13H2,1-6H3/t16-,17+,20-,21+,30?

Synonyms: 2-(1,7-Dimethyl-3,5-dioxo-10-oxa-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl)-ethyl-1-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-4,7-dimethyl-1,3-dioxo-4,7-epoxy-2H-isoindol-2-yl]ethyl ester, rel-; rel-2-Cyanoethyl 2-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-4,7-dimethyl-1,3-dioxo-4,7-epoxy-2H-isoindol-2-yl]ethyl N,N-bis(1-methylethyl)phosphoramidite

5'-Carboxy-Modifier C5

Description: 5'-Carboxy-Modifier C5 is similar to 5'-Carboxy-Modifier C10, this reagent introduces a carboxylic acid functional group at the 5'-end of the oligonucleotide, but with a different linker length or structure designated as C5. The carboxylic acid moiety enables conjugation with other molecules or surfaces for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-00539

CAS: 486449-23-4

MF: C33H40ClN2O4P

MF: 595.11

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InChIKey: DZNODIUCNCVIMZ-UHFFFAOYSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(C)CCC(=O)OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3Cl

IUPAC Name: [(2-chlorophenyl)-diphenylmethyl] 4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypentanoate

InChI: InChI=1S/C33H40ClN2O4P/c1-25(2)36(26(3)4)41(38-24-14-23-35)40-27(5)21-22-32(37)39-33(28-15-8-6-9-16-28,29-17-10-7-11-18-29)30-19-12-13-20-31(30)34/h6-13,15-20,25-27H,14,21-22,24H2,1-5H3

Synonyms: 2-chlorotrityl 4-[(2-cyanoethyl)-(N,N-diisopropyl)phosphoramidityl]pentanoate; Pentanoic acid, 4-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]-, (2-chlorophenyl)diphenylmethyl ester; (2-Chlorophenyl)diphenylmethyl 4-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]pentanoate; 5'-Carboxy Amidite; 5'-Carboxylate Modifier CE-Phosphoramidite; 5'-Carboxy-Modifier C5 phosphoramidite

5'-Amino-Modifier C12-PDA

Description: 5'-Amino-Modifier C12-PDA introduces an amino group at the 5'-end of the oligonucleotide sequence, utilizing a C12 linker structure and a phosphoramidite backbone. The amino group can participate in conjugation reactions with various reactive functional groups, allowing for the attachment of labels, probes, or other molecules to the oligonucleotide. The C12 linker provides sufficient length to minimize steric hindrance and enhance accessibility for conjugation reactions.

CAT: BRP-00540

CAS: 1445745-27-6

MF: C30H51N4O4P

MF: 562.72

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InChIKey: YGDXDTSDRWZZDL-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCCCCCCCNC(=O)C1=CC=CC=C1C(=O)NC)OCCC#N

IUPAC Name: 2-N-[12-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxydodecyl]-1-N-methylbenzene-1,2-dicarboxamide

InChI: InChI=1S/C30H51N4O4P/c1-25(2)34(26(3)4)39(38-24-18-21-31)37-23-17-13-11-9-7-6-8-10-12-16-22-33-30(36)28-20-15-14-19-27(28)29(35)32-5/h14-15,19-20,25-26H,6-13,16-18,22-24H2,1-5H3,(H,32,35)(H,33,36)

Synonyms: 12-(N2-methyl-N1-phthalimidyl)-dodecyl-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 12-[[2-[(methylamino)carbonyl]benzoyl]amino]dodecyl ester; 2-Cyanoethyl 12-[[2-[(methylamino)carbonyl]benzoyl]amino]dodecyl N,N-bis(1-methylethyl)phosphoramidite

5'-Amino-Modifier TEG PDA

Description: 5'-Amino-Modifier TEG PDA introduces an amino group at the 5'-end of the oligonucleotide sequence, using a phosphoramidite backbone and a triethylene glycol (TEG) linker structure. The amino group allows for conjugation with other molecules or surfaces, while the TEG linker provides flexibility and solubility, reducing potential steric hindrance and improving accessibility for conjugation reactions. This modification is commonly used in applications such as nucleic acid labeling, surface functionalization, and bioconjugation strategies in molecular biology and biotechnology.

CAT: BRP-00541

CAS: 1445745-28-7

MF: C26H43N4O7P

MF: 554.62

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InChIKey: BXAGTOOYWXHIHA-UHFFFAOYSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCCOCCOCCOCCNC(=O)C1=CC=CC=C1C(=O)NC

IUPAC Name: 2-N-[2-[2-[2-[2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyethoxy]ethoxy]ethoxy]ethyl]-1-N-methylbenzene-1,2-dicarboxamide

InChI: InChI=1S/C26H43N4O7P/c1-21(2)30(22(3)4)38(36-13-8-11-27)37-20-19-35-18-17-34-16-15-33-14-12-29-26(32)24-10-7-6-9-23(24)25(31)28-5/h6-7,9-10,21-22H,8,12-20H2,1-5H3,(H,28,31)(H,29,32)

Synonyms: 10-(N2-methylphthalimidyl-N1-ethyl)-triethyleneglycol-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 13-[2-[(methylamino)carbonyl]phenyl]-13-oxo-3,6,9-trioxa-12-azatridec-1-yl ester

5'-Biotin II Phosphoramidite

Description: 5'-Biotin II Phosphoramidite is a reagent used in oligonucleotide synthesis to attach biotin at the 5'-end of the oligonucleotide sequence. Biotin is a small molecule known for its strong binding affinity to streptavidin or avidin proteins, enabling applications such as nucleic acid detection, protein purification, and surface functionalization. This modification allows specific and versatile binding to streptavidin or avidin-conjugated molecules, facilitating various molecular biology and biotechnology applications.

CAT: BRP-00542

MF: C44H60N5O7PS

MF: 834.03

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InChIKey: HGIPHLWGZYGYEZ-IILKRBAMSA-N

Solubility: Soluble in Anhydrous Acetonitrile

IUPAC Name: 2-(2-(5-((3aS,4S,6aR)-1-(bis(4-methoxyphenyl)(phenyl)methyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethyl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C44H60N5O7PS/c1-32(2)49(33(3)4)57(55-27-12-25-45)56-30-29-54-28-26-46-41(50)16-11-10-15-40-42-39(31-58-40)48(43(51)47-42)44(34-13-8-7-9-14-34,35-17-21-37(52-5)22-18-35)36-19-23-38(53-6)24-20-36/h7-9,13-14,17-24,32-33,39-40,42H,10-12,15-16,26-31H2,1-6H3,(H,46,50)(H,47,51)/t39-,40-,42-,57?/m0/s1

Synonyms: [1-N-(4,4'-Dimethoxytrityl)-biotinyl-6-aminoethoxyethyl]-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite

Acridine Phosphoramidite

Description: Acridine Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce acridine moieties into the oligonucleotide sequence. Acridine derivatives are known for their unique fluorescence properties, making them valuable for applications such as nucleic acid labeling, detection, and imaging. By incorporating acridine moieties into oligonucleotides, researchers can develop probes and molecular tools for studying DNA/RNA structure, dynamics, and interactions. This modification enables sensitive detection and visualization of nucleic acids in various biological assays and techniques, including fluorescence microscopy, in situ hybridization, and nucleic acid-based sensors.

CAT: BRP-00543

CAS: 402829-33-8

MF: C51H60ClN4O6P

MF: 891.47

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InChIKey: IVSKHMOVPUZDIM-UHFFFAOYSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC(CCCCNC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: 3-[[2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-[(6-chloro-2-methoxyacridin-9-yl)amino]hexoxy]-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C51H60ClN4O6P/c1-36(2)56(37(3)4)63(61-31-13-29-53)62-35-38(14-11-12-30-54-50-46-27-21-42(52)32-49(46)55-48-28-26-45(59-7)33-47(48)50)34-60-51(39-15-9-8-10-16-39,40-17-22-43(57-5)23-18-40)41-19-24-44(58-6)25-20-41/h8-10,15-28,32-33,36-38H,11-14,30-31,34-35H2,1-7H3,(H,54,55)

Synonyms: 1-Dimethoxytrityloxy-2-(N-acridinyl-4-aminobutyl)-propyl-3-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[(6-chloro-2-methoxy-9-acridinyl)amino]hexyl 2-cyanoethyl ester; 2-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[(6-chloro-2-methoxy-9-acridinyl)amino]hexyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-[(6-chloro-2-methoxy-9-acridinyl)amino]hexyl 2-cyanoethyl ester

5'-GalNAc C3 Phosphoramidite

Description: 5'-GalNAc C3 Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce N-acetylgalactosamine (GalNAc) at the 5'-end of the oligonucleotide sequence. GalNAc is a carbohydrate moiety commonly found in glycoproteins and glycolipids and is involved in various biological processes, including cell signaling and immune response modulation. By attaching GalNAc to oligonucleotides, researchers can develop molecular probes and therapeutics targeting specific carbohydrate-binding proteins, such as lectins and receptors. This modification enables the study of carbohydrate-protein interactions and the development of oligonucleotide-based drugs for therapeutic applications, including gene regulation, RNA interference, and targeted delivery.

CAT: BRP-00544

CAS: 2437303-51-8

MF: C62H88N5O17P

MF: 1206.36

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InChIKey: CBVYXTMIYQCOPE-KDYLSCEUSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC1(CCN(CC1)C(=O)CCCCCNC(=O)CCCOC2C(C(C(C(O2)COC(=O)C)OC(=O)C)OC(=O)C)NC(=O)C)COC(C3=CC=C(C=C3)OC)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: [(2R,3R,4R,5R,6R)-5-acetamido-3,4-diacetyloxy-6-[4-[[6-[4-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-4-[tris(4-methoxyphenyl)methoxymethyl]piperidin-1-yl]-6-oxohexyl]amino]-4-oxobutoxy]oxan-2-yl]methyl acetate

InChI: InChI=1S/C62H88N5O17P/c1-42(2)67(43(3)4)85(80-38-16-33-63)81-41-61(40-79-62(48-19-25-51(74-9)26-20-48,49-21-27-52(75-10)28-22-49)50-23-29-53(76-11)30-24-50)31-35-66(36-32-61)56(73)18-13-12-14-34-64-55(72)17-15-37-77-60-57(65-44(5)68)59(83-47(8)71)58(82-46(7)70)54(84-60)39-78-45(6)69/h19-30,42-43,54,57-60H,12-18,31-32,34-41H2,1-11H3,(H,64,72)(H,65,68)/t54-,57-,58+,59-,60-,85?/m1/s1

Synonyms: (4-(Trimethoxytrityloxymethyl)-1-(6-(4-(3,4,6-O-triacetyl-2-acetylamino-2-deoxy-β-D-galactopyranosyl)butanamido)hexanoyl)piperidin-4-yl)methyl-O-[(2-cyanoethyl)-(N,N-diisopropyl)] phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl [1-[1-oxo-6-[[1-oxo-4-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]butyl]amino]hexyl]-4-[[tris(4-methoxyphenyl)methoxy]methyl]-4-piperidinyl]methyl ester

α-Tocopherol-TEG Phosphoramidite

Description: α-Tocopherol-TEG Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce α-tocopherol (vitamin E) molecules into the oligonucleotide sequence. α-Tocopherol is a potent antioxidant known for its protective effects against oxidative stress and its potential health benefits. The addition of α-tocopherol to oligonucleotides imparts antioxidant properties to the resulting conjugates, making them suitable for applications such as protecting nucleic acids from degradation during storage or amplification processes. Additionally, the presence of a triethylene glycol (TEG) linker enhances solubility and flexibility, facilitating conjugation and improving the stability of the oligonucleotide conjugates. This modification enables the development of oligonucleotide-based therapeutics and diagnostic probes with enhanced stability and bioactivity.

CAT: BRP-00545

CAS: 1621330-39-9

MF: C68H103N2O10P

MF: 1139.53

Purity: ≥97%

Appearance: Colorless to light yellow oily matter

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InChIKey: CVFFLEDYEBZJDX-HSRHINSZSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OC(COCCOCCOCCOC=1C(=C(C=2OC(C)(CCC2C1C)CCCC(C)CCCC(C)CCCC(C)C)C)C)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: 1,1-bis(4-methoxyphenyl)-1-phenyl-14-(((R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-yl)oxy)-2,6,9,12-tetraoxatetradecan-4-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C68H103N2O10P/c1-50(2)22-18-23-53(7)24-19-25-54(8)26-20-38-67(12)39-37-64-57(11)65(55(9)56(10)66(64)79-67)76-47-46-74-43-42-73-44-45-75-48-63(80-81(78-41-21-40-69)70(51(3)4)52(5)6)49-77-68(58-27-16-15-17-28-58,59-29-33-61(71-13)34-30-59)60-31-35-62(72-14)36-32-60/h15-17,27-36,50-54,63H,18-26,37-39,41-49H2,1-14H3/t53-,54-,63?,67-,81?/m1/s1

Synonyms: 1-Dimethoxytrityloxy-3-O-[(9-DL-α-tocopheryl)-triethyleneglycol-1-yl]-glyceryl-2-O-[(2-cyanoethyl)-(N,N,-diisopropyl)]-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[bis(4-methoxyphenyl)phenylmethoxy]-1-[[2-[2-[2-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]ethoxy]ethoxy]ethoxy]methyl]ethyl 2-cyanoethyl ester; 2-[Bis(4-methoxyphenyl)phenylmethoxy]-1-[[2-[2-[2-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]ethoxy]ethoxy]ethoxy]methyl]ethyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; α-Tocopherol TEG phosphoramidite; Tocopherol TEG Phosphoramidite

Palmitate Phosphoramidite

Description: Palmitate Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce palmitic acid moieties into the oligonucleotide sequence. Palmitic acid is a saturated fatty acid commonly found in biological membranes and is known for its amphipathic properties. By attaching palmitic acid to oligonucleotides, researchers can modify the properties of the resulting conjugates, such as enhancing membrane permeability or promoting lipid bilayer interactions. This modification enables the development of oligonucleotide-based therapeutics, drug delivery systems, and molecular probes with improved cellular uptake and stability.

CAT: BRP-00546

CAS: 1772522-18-5

MF: C31H62N3O3P

MF: 555.82

Purity: ≥90% by HPLC

Appearance: White to off-white solid

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InChIKey: BFUDAHSNZSPONN-UHFFFAOYSA-N

CanonicalSMILES: CCCCCCCCCCCCCCCC(=O)NCCCCCCOP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexyl]hexadecanamide

InChI: InChI=1S/C31H62N3O3P/c1-6-7-8-9-10-11-12-13-14-15-16-17-20-24-31(35)33-26-21-18-19-22-27-36-38(37-28-23-25-32)34(29(2)3)30(4)5/h29-30H,6-24,26-28H2,1-5H3,(H,33,35)

Synonyms: Palmityl-6-aminohexyl [(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 6-[(1-oxohexadecyl)amino]hexyl ester; 2-Cyanoethyl 6-[(1-oxohexadecyl)amino]hexyl N,N-bis(1-methylethyl)phosphoramidite; Palmitic Aminohexanol Amidite; 2-cyanoethyl (6-palmitamidohexyl) diisopropylphosphoramidite; Palmitic Aminohexanol Phosphoramidite

Stearyl Phosphoramidite

Description: Stearyl Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce a stearyl group (octadecyl chain) at the 5'-end of the oligonucleotide sequence. Stearyl groups are long-chain fatty acids that enhance the hydrophobicity and lipophilicity of the oligonucleotide, improving its ability to interact with lipid membranes. This modification is beneficial for developing oligonucleotide-based therapeutics and delivery systems, as it can enhance cellular uptake and stability. Stearyl-modified oligonucleotides are often used in gene silencing, antisense therapies, and other applications requiring efficient delivery and cellular internalization.

CAT: BRP-00547

CAS: 207273-84-5

MF: C27H55N2O2P

MF: 470.71

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InChIKey: KZQNEBQNUQNMRG-UHFFFAOYSA-N

CanonicalSMILES: CCCCCCCCCCCCCCCCCCOP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[[di(propan-2-yl)amino]-octadecoxyphosphanyl]oxypropanenitrile

InChI: InChI=1S/C27H55N2O2P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-24-30-32(31-25-22-23-28)29(26(2)3)27(4)5/h26-27H,6-22,24-25H2,1-5H3

Synonyms: 1-Octadecanol CEP; C18-linker amidite; Octadecyl-1-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl octadecyl ester; 5'-Stearyl phosphoramidite

Asymmetric Doubler (Lev) Phosphoramidite

Description: Asymmetric Doubler (Lev) Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce an asymmetric doubler modification into the oligonucleotide sequence. This modification features a levulinyl (Lev) protecting group, which provides additional control during the synthesis process. The asymmetric doubler facilitates the incorporation of two nucleotides in a single coupling step, improving synthesis efficiency and allowing for the introduction of unique structural or functional properties. This reagent is valuable for creating complex oligonucleotide structures and is used in various applications, including the development of therapeutic oligonucleotides, advanced molecular probes, and functional nucleic acids for research and diagnostic purposes.

CAT: BRP-00548

CAS: 2195357-46-9

MF: C48H67N4O10P

MF: 891.04

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InChIKey: QREZMNJRLYXRTD-UHFFFAOYSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC(CNC(=O)CCCCOC(=O)CCC(=O)C)CNC(=O)CCCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC

IUPAC Name: [5-[[3-[5-[bis(4-methoxyphenyl)-phenylmethoxy]pentanoylamino]-2-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropyl]amino]-5-oxopentyl] 4-oxopentanoate

InChI: InChI=1S/C48H67N4O10P/c1-36(2)52(37(3)4)63(61-33-15-30-49)62-44(34-50-45(54)18-11-13-31-59-47(56)29-20-38(5)53)35-51-46(55)19-12-14-32-60-48(39-16-9-8-10-17-39,40-21-25-42(57-6)26-22-40)41-23-27-43(58-7)28-24-41/h8-10,16-17,21-28,36-37,44H,11-15,18-20,29,31-35H2,1-7H3,(H,50,54)(H,51,55)

Synonyms: 1-[5-(4,4'-dimethoxytrityloxy)pentylamido]-3-[5-levulinyloxypentylamido]-propyl-2-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Pentanoic acid, 4-oxo-, 8-[[[5-[bis(4-methoxyphenyl)phenylmethoxy]-1-oxopentyl]amino]methyl]-10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-5-oxo-9-oxa-6,11-diaza-10-phosphatridec-1-yl ester; 8-[[[5-[Bis(4-methoxyphenyl)phenylmethoxy]-1-oxopentyl]amino]methyl]-10-(2-cyanoethoxy)-12-methyl-11-(1-methylethyl)-5-oxo-9-oxa-6,11-diaza-10-phosphatridec-1-yl 4-oxopentanoate

Universal-CE Phosphoramidite

Description: Universal-CE Phosphoramidite is a versatile reagent used in oligonucleotide synthesis. It is designed to be incorporated at any position within the oligonucleotide sequence, providing a universal solution for a variety of modifications. This phosphoramidite enables the attachment of different functional groups or linkers to the oligonucleotide, facilitating applications such as labeling, conjugation, and immobilization. Its flexibility makes it particularly useful in research and diagnostic applications where customization of the oligonucleotide sequence is required. The Universal-CE Phosphoramidite enhances the efficiency and adaptability of the oligonucleotide synthesis process, supporting the development of tailored nucleic acid-based tools and therapeutics.

CAT: BRP-00549

CAS: 730963-37-8

MF: C23H36N3O8P

MF: 513.52

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InChIKey: CBZZWACFDATALS-LTPKXJDNNA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OCCCN1C(=O)C2C3OC(C4OC(OC)(OC43)C)C2C1=O)N(C(C)C)C(C)C

IUPAC Name: 2-cyanoethyl (3-((2r,3aR,4R,4aR,7aS,8S,8aS)-2-methoxy-2-methyl-5,7-dioxooctahydro-6H-4,8-epoxy[1,3]dioxolo[4,5-f]isoindol-6-yl)propyl) diisopropylphosphoramidite

InChI: InChI=1/C23H36N3O8P/c1-13(2)26(14(3)4)35(30-11-7-9-24)31-12-8-10-25-21(27)15-16(22(25)28)18-20-19(17(15)32-18)33-23(5,29-6)34-20/h13-20H,7-8,10-12H2,1-6H3/t15-,16+,17-,18+,19-,20+,23+,35?

Synonyms: 3-[(3aR,4R,5R,6S,7S)-6-(4,4'-dimethoxytrityloxy)-5-acetoxy-1-,3-dioxooctahydro-1H-4,7-epoxyisoindol-2-yl]propyl-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 3-[(2α,3aα,4β,4aα,7aα,8β,8aα)-octahydro-2-methoxy-2-methyl-5,7-dioxo-4,8-epoxy-6H-1,3-dioxolo[4,5-f]isoindol-6-yl]propyl ester

DMTr-2'-O-TBDMS-rA(Bz)-3'-(L)-PSM-Phosphoramidite

Description: DMTr-2'-O-TBDMS-rA(Bz)-3'-(L)-PSM-Phosphoramidite is a compound used in oligonucleotide synthesis. It protects adenine (rA) at the 5'-position with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it attaches a benzoyl (Bz) group to the adenine base and introduces a 3'-(L)-PSM modifier at the 3'-end. This compound enables precise synthesis of oligonucleotides with specific modifications for various applications.

CAT: BRP-00555

MF: C56H63N6O10PSSi

MF: 1071.27

Purity: ≥98%

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InChIKey: JEWOWPFMMHAFMF-KDYSEBNISA-N

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((1S,3S,3aS)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C56H63N6O10PSSi/c1-55(2,3)75(6,7)72-50-49(71-73-62-33-17-24-45(62)47(70-73)35-74(64,65)44-22-15-10-16-23-44)46(69-54(50)61-37-59-48-51(57-36-58-52(48)61)60-53(63)38-18-11-8-12-19-38)34-68-56(39-20-13-9-14-21-39,40-25-29-42(66-4)30-26-40)41-27-31-43(67-5)32-28-41/h8-16,18-23,25-32,36-37,45-47,49-50,54H,17,24,33-35H2,1-7H3,(H,57,58,60,63)/t45-,46+,47+,49+,50+,54+,73+/m0/s1

DMTr-2'-O-TBDMS-rA(Bz)-3'-(D)-PSM-Phosphoramidite

Description: DMTr-2'-O-TBDMS-rA(Bz)-3'-(D)-PSM-Phosphoramidite is a chemical compound used in oligonucleotide synthesis. It protects adenine (rA) at the 5'-position with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it attaches a benzoyl (Bz) group to the adenine base. The 3'-(D)-PSM modifier introduces a functional group at the 3'-end of the oligonucleotide. This compound allows for controlled synthesis of customized oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-00556

MF: C56H63N6O10PSSi

MF: 1071.27

Purity: ≥98%

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InChIKey: JEWOWPFMMHAFMF-OPURRIEGSA-N

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-(((1R,3R,3aR)-3-((phenylsulfonyl)methyl)tetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaphosphol-1-yl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

DMTr-2'-O-TBDMS-8-azanebularine-3'-CE-Phosphoramidite

Description: DMTr-2'-O-TBDMS-8-azanebularine-3'-CE-Phosphoramidite is a chemical compound used in oligonucleotide synthesis. It protects the 5'-hydroxyl group with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it incorporates 8-azanebularine as a modified nucleoside. The 3'-CE phosphoramidite facilitates nucleotide addition during synthesis. This compound allows for the controlled synthesis of oligonucleotides with specific modifications, important for various applications in molecular biology and biotechnology.

CAT: BRP-00557

CAS: 771494-03-2

MF: C45H60N7O7PSi

MF: 870.08

Purity: ≥98%

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InChIKey: QEYQVSAEEYPGQB-IEXCOMMKSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(N2N=NC=3C=NC=NC32)C1O[Si](C)(C)C(C)(C)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4R,5R)-5-(3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C45H60N7O7PSi/c1-31(2)52(32(3)4)60(56-27-15-26-46)58-40-39(57-43(41(40)59-61(10,11)44(5,6)7)51-42-38(49-50-51)28-47-30-48-42)29-55-45(33-16-13-12-14-17-33,34-18-22-36(53-8)23-19-34)35-20-24-37(54-9)25-21-35/h12-14,16-25,28,30-32,39-41,43H,15,27,29H2,1-11H3/t39-,40-,41-,43-,60?/m1/s1

Synonyms: 3H-1,2,3-Triazolo[4,5-d]pyrimidine, 3-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-; 3-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-3H-1,2,3-triazolo[4,5-d]pyrimidine; 8-Azanebularine CE-Phosphoramidite

DMTr-2'-O-TBDMS-5-Cl-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-TBDMS-5-Cl-rU-3'-CE-Phosphoramidite is a chemical compound used in oligonucleotide synthesis. It protects the 5'-hydroxyl group with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it incorporates 5-chloro-uridine as a modified nucleoside. The 3'-CE phosphoramidite facilitates nucleotide addition during synthesis. This compound allows for the controlled synthesis of oligonucleotides with specific modifications, important for various applications in molecular biology and biotechnology.

CAT: BRP-00558

MF: C45H60ClN4O9PSi

MF: 895.50

Purity: ≥98%

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InChIKey: RRACSVOLQAOFCZ-IPXQPGKOSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=C(C(=O)NC2=O)Cl)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(5-chloro-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C45H60ClN4O9PSi/c1-30(2)50(31(3)4)60(56-27-15-26-47)58-39-38(57-42(40(39)59-61(10,11)44(5,6)7)49-28-37(46)41(51)48-43(49)52)29-55-45(32-16-13-12-14-17-32,33-18-22-35(53-8)23-19-33)34-20-24-36(54-9)25-21-34/h12-14,16-25,28,30-31,38-40,42H,15,27,29H2,1-11H3,(H,48,51,52)/t38-,39-,40-,42-,60?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-chloro-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

DMTr-2'-O-TBDMS-5-F-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-TBDMS-5-F-rU-3'-CE-Phosphoramidite is a chemical compound utilized in oligonucleotide synthesis. It safeguards the 5'-hydroxyl group with a DMTr group and stabilizes the ribose sugar with a 2'-O-TBDMS modification. Additionally, it incorporates 5-fluoro-uridine as a modified nucleoside. The 3'-CE phosphoramidite facilitates nucleotide addition during synthesis. This compound enables precise control over oligonucleotide synthesis, essential for various applications in molecular biology and biotechnology.

CAT: BRP-00559

CAS: 173241-78-6

MF: C45H60FN4O9PSi

MF: 879.05

Purity: ≥98%

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InChIKey: MKGOHNKOHNRJLF-IPXQPGKOSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=C(C(=O)NC2=O)F)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C45H60FN4O9PSi/c1-30(2)50(31(3)4)60(56-27-15-26-47)58-39-38(57-42(40(39)59-61(10,11)44(5,6)7)49-28-37(46)41(51)48-43(49)52)29-55-45(32-16-13-12-14-17-32,33-18-22-35(53-8)23-19-33)34-20-24-36(54-9)25-21-34/h12-14,16-25,28,30-31,38-40,42H,15,27,29H2,1-11H3,(H,48,51,52)/t38-,39-,40-,42-,60?/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-fluoro-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5-Fluoro Uridine CED phosphoramidite

DMTr-2'-O-TBDMS-5-OMe-rU-3'-CE-Phosphoramidite

Description: DMTr-2'-O-TBDMS-5-OMe-rU-3'-CE-Phosphoramidite is employed in oligonucleotide synthesis and features a TBDMS (tert-butyldimethylsilyl) group at the 2'-O position, and a methoxy (OMe) group on the uracil (rU) nucleoside. The 3'-end is functionalized with a cyanoethyl (CE) group, facilitating efficient coupling reactions during solid-phase synthesis. It is used to introduce modified uracil residues with increased stability and altered base pairing properties into nucleic acid sequences, suitable for various research applications including RNA structural studies, aptamer development, and gene regulation research.

CAT: BRP-00560

MF: C46H63N4O10PSi

MF: 891.09

Purity: ≥98%

Appearance: White, off-white to faint yellow powder

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InChIKey: OWTUZLAYUDYRNE-ACYYXZCMSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=C(C(=O)NC2=O)OC)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(5-methoxy-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C46H63N4O10PSi/c1-31(2)50(32(3)4)61(57-28-16-27-47)59-40-39(58-43(41(40)60-62(11,12)45(5,6)7)49-29-38(55-10)42(51)48-44(49)52)30-56-46(33-17-14-13-15-18-33,34-19-23-36(53-8)24-20-34)35-21-25-37(54-9)26-22-35/h13-15,17-26,29,31-32,39-41,43H,16,28,30H2,1-12H3,(H,48,51,52)/t39-,40-,41-,43-,61?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-TBDMS-5-methoxyuridine-3'-(cyanoethyl-N,N-diisopropyl)phosphoramidite; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-methoxy-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; 5'-O-DMT-2'-O-TBDMS-5-OMe-Ur Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-5-O-methyl-Uridine 3'-cyanoethyl Phosphoramidite