Phosphoramidites

2'-O-Propargyl G(iBu)-3'-phosphoramidite (BRP-00321)

Description: 2'-O-Propargyl G(iBu)-3'-phosphoramidite is a vital compound extensively used in the field of biomedicine. This compound acting as a versatile building block for the synthesis of modified nucleosides and oligonucleotides. It finding applications in the development of therapeutic compounds, particularly for the reserch of viral infections and genetic diseases.

CAT: BRP-00321

CAS: 171486-61-6

Molecular Formula: C47H56N7O9P

Molecular Weight: 893.96

Purity: ≥95%

Appearance: White, off-white to faint yellow powder

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InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCC#C

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-prop-2-ynoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C47H56N7O9P/c1-10-26-59-41-40(63-64(61-27-14-25-48)54(31(4)5)32(6)7)38(62-45(41)53-29-49-39-42(53)50-46(52-44(39)56)51-43(55)30(2)3)28-60-47(33-15-12-11-13-16-33,34-17-21-36(57-8)22-18-34)35-19-23-37(58-9)24-20-35/h1,11-13,15-24,29-32,38,40-41,45H,14,26-28H2,2-9H3,(H2,50,51,52,55,56)/t38-,40-,41-,45-,64?/m1/s1

Synonyms: N2-iBu-5'-O-DMTr-2'-O-propargylguanosine-3'-CED-phosphoramidite; N2-iso-Butyroyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl guanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 5'-O-DMT-N2-isobutyryl-2'-O-propynylguanosine 3'-CE phosphoramidite; 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-2'-O-2-propynyl-guanosine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-N-isobutyryl-2'-O-2-propyn-1-ylguanosine; DMTr-2'-O-propargyl-rG(iBu)-3'-CE-Phosphoramidite; 5'-O-DMT-2'-O-Propargyl-N2-isobutyryl-Guanosine 3'-CE phosphoramidite; N2-iBu-DMT-2'-O-propargyl-G-CE-Phosphoramidite; 2'-O-propargyl Guanosine (n-ibu) CED phosphoramidite

N4-Acetyl-5'-O-DMT-2'-O-propynylcytidine 3'-CE phosphoramidite

Description: N4-Acetyl-5'-O-DMT-2'-O-propynylcytidine 3'-CE phosphoramidite is a key reagent widely used in the biomedical industry for nucleic acid synthesis. It enables the efficient introduction of N4-acetyl-5'-O-DMT-2'-O-propynylcytidine into oligonucleotides during solid-phase synthesis. This phosphoramidite plays a crucial role in drug development and research related to diseases such as cancer, viral infections, and genetic disorders.

CAT: BRP-00322

CAS: 1498305-51-3

Molecular Formula: C44H52N5O9P

Molecular Weight: 825.89

Purity: ≥98%

Appearance: White, off-white to faint yellow powder

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InChIKey: JIMYWWYYWAHJAD-ZMHKPELYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCC#C)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-prop-2-ynoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C44H52N5O9P/c1-9-27-54-41-40(58-59(56-28-13-25-45)49(30(2)3)31(4)5)38(57-42(41)48-26-24-39(46-32(6)50)47-43(48)51)29-55-44(33-14-11-10-12-15-33,34-16-20-36(52-7)21-17-34)35-18-22-37(53-8)23-19-35/h1,10-12,14-24,26,30-31,38,40-42H,13,27-29H2,2-8H3,(H,46,47,50,51)/t38-,40-,41-,42-,59?/m1/s1

Synonyms: DMTr-2'-O-propargyl-rC(Ac)-3'-CE-Phosphoramidite; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propyn-1-yl-cytidine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; DMT-2'-O-propargyl-C(Ac)-CE-Phosphoramidite; Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propyn-1-yl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N4-Ac-DMT-2'-O-propargyl-C-CE-Phosphoramidite; [N4-acetyl--5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-cytidine]-3'-[(2-cyanoethyl)-N,N-diisopropyl]phosphoramidite

2'-O-Acetyl-N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)arabinocytidine 3'-O-phosphoramidite

Description: 2'-O-Acetyl-N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)arabinocytidine 3'-O-phosphoramidite, a fundamental compound in oligonucleotide synthesis, plays a vital role in the advancement of diagnostic tools and therapeutic drugs within the biomedical field.

CAT: BRP-00324

CAS: 675573-97-4

Molecular Formula: C48H54N5O10P

Molecular Weight: 891.94

Purity: ≥95%

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InChIKey: QZCUPWVSXYRPJB-UIRYRFQFSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC(=O)C)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: [(2R,3S,4R,5R)-2-(4-benzamido-2-oxopyrimidin-1-yl)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-3-yl] acetate

InChI: InChI=1S/C48H54N5O10P/c1-32(2)53(33(3)4)64(60-30-14-28-49)63-43-41(62-46(44(43)61-34(5)54)52-29-27-42(51-47(52)56)50-45(55)35-15-10-8-11-16-35)31-59-48(36-17-12-9-13-18-36,37-19-23-39(57-6)24-20-37)38-21-25-40(58-7)26-22-38/h8-13,15-27,29,32-33,41,43-44,46H,14,30-31H2,1-7H3,(H,50,51,55,56)/t41-,43-,44+,46-,64?/m1/s1

Synonyms: DMTr-2'-ara-OAc-C(Bz)-3'-CE-Phosphoramidite; N-[1-[2-O-Acetyl-5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-β-D-arabinofuranosyl]-1,2-dihydro-2-oxo-4-pyrimidinyl]benzamide; (2R,3S,4R,5R)-2-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-3-yl acetate; N4-benzoyl-(5'-O-(4,4'-dimethoxytrityl)-2'-O-acetyl-arabinocytidine-3'-[(2-cyanoethyl)-(N,N-diisopropropyl)]-Phosphoramidite; 5'-O-DMTr-2'-ara-OAc-C(Bz)-3'-CE-Phosphoramidite; Cytosine Arabinoside

Morpholino O6-(p-nitrophenethyl) G monomer

Description: Morpholino O6-(p-nitrophenethyl) G monomer is an essential component within the biomedicine industry, providing researchers with an invaluable tool for designing versatile oligonucleotides capable of inhibiting the expression of various target genes implicated in important pathologies like cancer. Its unique molecular structure allows for improved stability and specificity when compared to traditional nucleotide analogs, whilst simultaneously providing a new level of sophistication. Incorporating this monomer into various DNA or RNA molecules allows for the effective attainment of specific gene knockdown, hence the reason for its introduction in numerous preclinical studies.

CAT: BRP-00325

CAS: 2504201-88-9

Molecular Formula: C43H46ClN8O7P

Molecular Weight: 853.30

Purity: 98%

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Density: 1.36±0.1 g/cm3

InChIKey: WAHZVPMCAUKPIH-UHFFFAOYSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=N1)OCCC3=CC=C(C=C3)[N+](=O)[O-])N=CN2C4CN(CC(O4)COP(=O)(N(C)C)Cl)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7

IUPAC Name: N-[9-[6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]-6-[2-(4-nitrophenyl)ethoxy]purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C43H46ClN8O7P/c1-30(2)40(53)47-42-46-39-38(41(48-42)57-25-24-31-20-22-35(23-21-31)52(54)55)45-29-51(39)37-27-50(26-36(59-37)28-58-60(44,56)49(3)4)43(32-14-8-5-9-15-32,33-16-10-6-11-17-33)34-18-12-7-13-19-34/h5-23,29-30,36-37H,24-28H2,1-4H3,(H,46,47,48,53)

Synonyms: Morpholino o6-(p-nitrophenethyl) g monomer; O6-NPE-N2-iBu protected G PMO Monomer; (6-(2-isobutyramido-6-(4-nitrophenethoxy)-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate

Related CAS: 2756846-27-0 ((2S,6R)-isomer)

O6-NPE-N2-iBu protected G PMO Monomer

Description: Nucleoside Analog Development Synthetic Compound (NADSC) is a highly sophisticated and chemically intricate substance that is extensively employed in the design and production of antiviral nucleoside analogues, particularly for HIV and hepatitis B. The exceptional configuration of NADSC enables precise nucleoside modification, generating superior antiviral efficacy and reducing toxicity. Prominently utilized in scientific laboratories, NADSC facilitates cutting-edge nucleoside analogue synthesis practices that revolutionize antiviral therapy.

CAT: BRP-00326

CAS: 2756846-27-0

Molecular Formula: C43H46ClN8O7P

Molecular Weight: 853.31

Purity: ≥98%

Appearance: White to off-white powder

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Density: 1.36±0.1 g/cm3

InChIKey: WAHZVPMCAUKPIH-BZIXDFOGSA-N

CanonicalSMILES: O=C(NC=1N=C(OCCC2=CC=C(C=C2)N(=O)=O)C=3N=CN(C3N1)C4OC(COP(=O)(Cl)N(C)C)CN(C4)C(C=5C=CC=CC5)(C=6C=CC=CC6)C=7C=CC=CC7)C(C)C

IUPAC Name: N-[9-[(2R,6S)-6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]-6-[2-(4-nitrophenyl)ethoxy]purin-2-yl]-2-methylpropanamide

Synonyms: PMO G; Morpholino G subunit; ((2S,6R)-6-(2-Isobutyramido-6-(4-nitrophenethoxy)-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate; O(6)-NPE-N(2)-iBu protected G PMO Monomer; (2S,6R)-N2-isobutyryl-O6-p-nitrophenethyl-9-(4'-trityl-6'-methoxy-(dimethylamino)(chloro)phosphate)-morpholin-2'-yl)-guanine

Related CAS: 2708274-72-8 (rel-isomer)

N-(6-Hydroxy-9-(6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-9H-purin-2-yl) isobutyramide

Description: N2-Isobutyryl-N-trityl-morpholino guanine is a modified form of guanine, typically utilized in oligonucleotide synthesis and related molecular biology applications. It features an isobutyryl (Isobutyryl) group and a trityl (Trityl) group attached to the guanine base, along with a morpholino moiety. These modifications serve to protect the guanine base during oligonucleotide synthesis, enabling controlled nucleotide incorporation and facilitating downstream reactions. This compound is commonly used in the synthesis of modified nucleic acids for various research and diagnostic purposes.

CAT: BRP-00376

CAS: 722458-03-9

Molecular Formula: C33H34N6O4

Molecular Weight: 578.66

Purity: >98%

Appearance: White to yellow powder

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Density: 1.33±0.1 g/cm3

InChIKey: LNQQABQFAZWVNX-UHFFFAOYSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3CN(CC(O3)CO)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

IUPAC Name: N-[9-[6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C33H34N6O4/c1-22(2)30(41)36-32-35-29-28(31(42)37-32)34-21-39(29)27-19-38(18-26(20-40)43-27)33(23-12-6-3-7-13-23,24-14-8-4-9-15-24)25-16-10-5-11-17-25/h3-17,21-22,26-27,40H,18-20H2,1-2H3,(H2,35,36,37,41,42)

Synonyms: 4-Trityl-6-[2-(isobutyrylamino)-6-oxo-1,6-dihydro-9H-purine-9-yl]morpholine-2-methanol; N-(9-(6-(Hydroxymethyl)-4-tritylmorpholin-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide; N2-Isobutyryl-N-trityl-morpholino guanine; N-[6,9-Dihydro-9-[6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

Related CAS: 956139-24-5 (N-[6,9-Dihydro-9-[(2R,6S)-6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide)

N2-Isobutyryl-N-trityl-morpholinoguanosine

Description: N2-Isobutyryl-N-trityl-morpholinoguanosine is a modified form of guanosine, a nucleoside commonly used in oligonucleotide synthesis and related molecular biology applications. In this compound, the guanosine base is modified with an isobutyryl (Isobutyryl) group and a trityl (Trityl) group. Additionally, a morpholino moiety is present in the structure. These modifications serve to protect the guanosine base during oligonucleotide synthesis, allowing for controlled nucleotide incorporation and facilitating subsequent reactions. This compound finds utility in the synthesis of modified nucleic acids for research and diagnostic purposes.

CAT: BRP-00377

CAS: 956139-24-5

Molecular Formula: C33H34N6O4

Molecular Weight: 578.66

Purity: ≥95%

Appearance: White to yellow powder

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Storage: Store at 2-8°C

Density: 1.3±0.1 g/cm3

Melting Point: 198°C

InChIKey: LNQQABQFAZWVNX-RRPNLBNLSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3CN(CC(O3)CO)C(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

IUPAC Name: N-[9-[(2R,6S)-6-(hydroxymethyl)-4-tritylmorpholin-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

Synonyms: N-[6,9-Dihydro-9-[(2R,6S)-6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide; N-isobutyryl-7-hydroxy-N-trityl morpholinoguanosine; N2-isobutyryl-7'-OH-N-trityl morpholino guanosine; N-(9-((2R,6S)-6-(Hydroxymethyl)-4-tritylmorpholin-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide; N-{9-[(2R,6S)-6-(Hydroxymethyl)-4-trityl-2-morpholinyl]-6-oxo-6,9-dihydro-3H-purin-2-yl}-2-methylpropanamide

Related CAS: 722458-03-9 (N-(6-Hydroxy-9-(6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-9H-purin-2-yl) isobutyramide)

5-Me-DMT-2'-O-Me-C(Ac)-CE Phosphoramidite

Description: 5-Me-DMT-2'-O-Me-C(Ac)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a 5-methylcytosine base, a dimethoxytrityl (DMT) protecting group on the 3' hydroxyl, and a 2'-O-methyl modification on the ribose sugar. Additionally, the cytosine base is acetylated (Ac). The 5'-cyanoethyl (CE) phosphoramidite functionality enables controlled addition during synthesis. This compound is used to enhance the stability and modify the properties of synthetic oligonucleotides for various molecular biology research applications, including gene regulation studies and the development of therapeutic nucleic acids.

CAT: BRP-00384

Molecular Formula: C43H54N5O9P

Molecular Weight: 815.90

Purity: ≥98%

Appearance: White to off-white powder

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InChIKey: OGKXPQMWAXJVBW-KZQAAKLLSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C43H54N5O9P/c1-28(2)48(29(3)4)58(55-25-13-24-44)57-38-37(56-41(39(38)53-9)47-26-30(5)40(45-31(6)49)46-42(47)50)27-54-43(32-14-11-10-12-15-32,33-16-20-35(51-7)21-17-33)34-18-22-36(52-8)23-19-34/h10-12,14-23,26,28-29,37-39,41H,13,25,27H2,1-9H3,(H,45,46,49,50)/t37-,38-,39-,41-,58?/m1/s1

Synonyms: N4-Acetyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-cyanoethyl phosphoramidite; 2'-OMe-5-Me-C-CE Phosphoramidite; 5'-Dimethoxytrityl-N-acetyl-5-methyl-Cytidine, 2'-O-methyl, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 5-Me-DMT-2'-O-Me-C(Ac)-CE-Phosphoramidite; 5-Me-5'-DMT-2'-O-Me-C(Ac)-CE-Phosphoramidite

5-Me-DMT-2'-O-Me-C(dmf)-CE Phosphoramidite

Description: 5-Me-DMT-2'-O-Me-C(dmf)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a 5-methylcytosine base with a dimethylformamide (dmf) protecting group on the cytosine. The compound includes a dimethoxytrityl (DMT) protecting group on the 3' hydroxyl and a 2'-O-methyl modification on the ribose sugar. The 5'-cyanoethyl (CE) phosphoramidite functionality allows for controlled addition during synthesis. This phosphoramidite is used to create stable and precisely modified oligonucleotides for molecular biology research, including applications in gene regulation and the development of therapeutic nucleic acids.

CAT: BRP-00385

Molecular Formula: C44H57N6O8P

Molecular Weight: 828.95

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: IFBAEFQLIMLQSD-IROHRKTHSA-N

IUPAC Name: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(4-(((dimethylamino)methylene)amino)-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C44H57N6O8P/c1-30(2)50(31(3)4)59(56-26-14-25-45)58-39-38(57-42(40(39)54-10)49-27-32(5)41(47-43(49)51)46-29-48(6)7)28-55-44(33-15-12-11-13-16-33,34-17-21-36(52-8)22-18-34)35-19-23-37(53-9)24-20-35/h11-13,15-24,27,29-31,38-40,42H,14,26,28H2,1-10H3/t38-,39-,40-,42-,59?/m1/s1

Synonyms: N4-Dimethylformamide-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-cyanoethyl phosphoramidite; 2'-OMe 5-Me-C(dmf) amidite; 2'-OMe MeC(dmf) amidite; N4-dimethylformamidine-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-cyanoethyl Phosphoramidite; 5-Methyl Cytidine (n,n-dmf) 2'-O-Methyl CED phosphoramidite

LNA-5-Me-C(Bz)-CE Phosphoramidite

Description: LNA-5-Me-C(Bz)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a locked nucleic acid (LNA) backbone with a 5-methylcytosine base modified with a benzoyl (Bz) group. Additionally, it includes a 5'-cyanoethyl (CE) phosphoramidite functionality, allowing for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, making this phosphoramidite useful for applications requiring high-affinity binding and specificity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays in molecular biology research.

CAT: BRP-00387

CAS: 206055-82-5

Molecular Formula: C48H54N5O9P

Molecular Weight: 875.96

Purity: ≥95%

Appearance: Off-white to yellow powder

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InChIKey: XHILZPWJJJDDDY-HXAWEXODSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C4C(C(O3)(CO4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[1-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C48H54N5O9P/c1-32(2)53(33(3)4)63(60-28-14-27-49)62-42-41-45(52-29-34(5)43(51-46(52)55)50-44(54)35-15-10-8-11-16-35)61-47(42,30-58-41)31-59-48(36-17-12-9-13-18-36,37-19-23-39(56-6)24-20-37)38-21-25-40(57-7)26-22-38/h8-13,15-26,29,32-33,41-42,45H,14,28,30-31H2,1-7H3,(H,50,51,54,55)/t41-,42+,45-,47-,63?/m1/s1

Synonyms: 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-C(Bz) Phosphoramidite; DMT-locMeC(bz)Amidite; DMT-locMeC(bz) phosphoramidite; N-[1-[2,5-Anhydro-5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-1,2-dihydro-5-methyl-2-oxo-4-pyrimidinyl]benzamide; DMTr-LNA-5MeC(Bz)-3-CED-phosphoramidite; N4-benzoyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-cytidine-3'-cyanoethyl Phosphoramidite; LNA-5MeC(Bz)-3-CED-phosphoramidite; Bz-5-Me-C-LA-CE Phosphoramidite; DMT-2'-O-4'-C-Locked-5-Me-C(Bz)-CE; LNA-5mC(Bz) phosphoramidite; N4-Bz-2'-O-4'-C-Locked-5-Me-Cr-CE-Phosphoramidite

LNA-5-Me-C(Ac)-CE Phosphoramidite

Description: LNA-5-Me-C(Ac)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It comprises a locked nucleic acid (LNA) backbone with a 5-methylcytosine base modified with an acetyl (Ac) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, and the 5-methyl modification further enhances these characteristics. This phosphoramidite is valuable in molecular biology research for applications requiring high specificity and affinity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays.

CAT: BRP-00388

Molecular Formula: C43H52N5O9P

Molecular Weight: 813.89

Purity: ≥95%

Appearance: Off-white to yellow powder

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InChIKey: UUPGQIYQTKJJKS-GKGIDAFMSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C)C2C3C(C(O2)(CO3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N

InChI: InChI=1S/C43H52N5O9P/c1-28(2)48(29(3)4)58(55-24-12-23-44)57-38-37-40(47-25-30(5)39(45-31(6)49)46-41(47)50)56-42(38,26-53-37)27-54-43(32-13-10-9-11-14-32,33-15-19-35(51-7)20-16-33)34-17-21-36(52-8)22-18-34/h9-11,13-22,25,28-29,37-38,40H,12,24,26-27H2,1-8H3,(H,45,46,49,50)/t37-,38+,40-,42-,58?/m1/s1

Synonyms: N6-Acetyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-LNA-cytidine-3'-cyanoethyl phosphoramidite; 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-C(Ac) Phosphoramidite; DMT-locMeC(Ac)Amidite; DMT-locMeC(Ac) phosphoramidite; DMTr-LNA-5MeC(Ac)-3-CED-phosphoramidite; N6-Acetyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-cytidine-3'-cyanoethyl Phosphoramidite; LNA-5MeC(Ac)-3-CED-phosphoramidite; Ac-5-Me-C-LA-CE Phosphoramidite; DMTr-2'-O-4'-C-Locked-5-Me-rC(Ac)-3'-CE-Phosphoramidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-5-Methyl-Cytidine-3'-cyanoethyl Phosphoramidite; LNA MeC(Ac) amidite

LNA-C(Ac)-CE Phosphoramidite

Description: LNA-C(Ac)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a locked nucleic acid (LNA) backbone with a cytosine base modified with an acetyl (Ac) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, and the acetyl modification further enhances these characteristics. This phosphoramidite is valuable in molecular biology research for applications requiring high specificity and affinity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays.

CAT: BRP-00389

Molecular Formula: C42H50N5O9P

Molecular Weight: 799.86

Purity: ≥95%

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InChIKey: VLHUEAKCEPSXIL-WFNFTXKBSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=CC(=NC6=O)NC(=O)C

InChI: InChI=1S/C42H50N5O9P/c1-28(2)47(29(3)4)57(54-25-11-23-43)56-38-37-39(46-24-22-36(44-30(5)48)45-40(46)49)55-41(38,26-52-37)27-53-42(31-12-9-8-10-13-31,32-14-18-34(50-6)19-15-32)33-16-20-35(51-7)21-17-33/h8-10,12-22,24,28-29,37-39H,11,25-27H2,1-7H3,(H,44,45,48,49)/t37-,38+,39-,41-,57?/m1/s1

Synonyms: N6-Acetyl-5'-O-(4,4'-dimethoxytrityl)-LNA-cytidine-3'-cyanoethyl phosphoramidite; 5'-O-DMTr-2'-O-4'-C-Locked-C(Ac) Phosphoramidite; DMT-locC(Ac)Amidite; DMT-locC(Ac) phosphoramidite; DMTr-LNA-C(Ac)-3-CED-phosphoramidite; N6-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-cytidine-3'-cyanoethyl Phosphoramidite; LNA-C(Ac)-3-CED-phosphoramidite; Ac-C-LA-CE Phosphoramidite; DMTr-2'-O-4'-C-Locked-rC(Ac)-3'-CE-Phosphoramidite; N4-Acetyl-5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-4'-C-Locked-cytidine-3'-CE Phosphoramidite; N4-Ac-2'-O-4'-C-Locked-Cr-CE-Phosphoramidite

LNA-G(dmf)-CE Phosphoramidite

Description: LNA-G(dmf)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a locked nucleic acid (LNA) backbone with a guanine base modified with a dimethylformamide (dmf) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, and the dmf modification further enhances these characteristics. This phosphoramidite is valuable in molecular biology research for applications requiring high specificity and affinity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays.

CAT: BRP-00390

CAS: 709641-79-2

Molecular Formula: C44H53N8O8P

Molecular Weight: 852.91

Purity: ≥95%

Appearance: Off-white to yellow powder

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InChIKey: ACJXYPZQPQPGNE-KPKUBJDASA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C6N=C(NC7=O)N=CN(C)C

IUPAC Name: N'-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C44H53N8O8P/c1-29(2)52(30(3)4)61(58-24-12-23-45)60-38-37-41(51-28-46-36-39(51)48-42(49-40(36)53)47-27-50(5)6)59-43(38,25-56-37)26-57-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,37-38,41H,12,24-26H2,1-8H3,(H,48,49,53)/t37-,38+,41-,43-,61?/m1/s1

Synonyms: 2'-O-4'-C-Locked-rG(dmf) Phosphoramidite; 5'-Dimethoxytrityl-N-dimethylformamidine-(2'-O,4'-C-methylene)-Guanosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; dmf-G-LA-CE Phosphoramidite; 5'-DMT-LNA-Guanosine(N-dmf) CE Phosphoramidite; DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite; N'-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide; DMT-2'-O-4'-C-Locked-G(dmf)-CE; LNA-G(dmf) phosphoramidite; N2-Dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-Guanosine-3'-cyanoethyl Phosphoramidite; N2-dmf-2'-O-4'-C-Locked-Gr-CE-Phosphoramidite

LNA-U-CE Phosphoramidite

Description: LNA-U-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It comprises a locked nucleic acid (LNA) backbone with a uracil base and includes a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced stability and affinity for complementary sequences, making them valuable in molecular biology research for applications such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays. This phosphoramidite variant specifically provides increased stability and specificity in oligonucleotide design, contributing to more effective molecular tools for diverse research needs.

CAT: BRP-00391

CAS: 206055-76-7

Molecular Formula: C40H47N4O9P

Molecular Weight: 758.81

Purity: ≥95%

Appearance: White to off-white solid

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InChIKey: ROCIJWWVBQZMMI-PUIMFIDCSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=CC(=O)NC6=O

IUPAC Name: 3-[[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-(2,4-dioxopyrimidin-1-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H47N4O9P/c1-27(2)44(28(3)4)54(51-24-10-22-41)53-36-35-37(43-23-21-34(45)42-38(43)46)52-39(36,25-49-35)26-50-40(29-11-8-7-9-12-29,30-13-17-32(47-5)18-14-30)31-15-19-33(48-6)20-16-31/h7-9,11-21,23,27-28,35-37H,10,24-26H2,1-6H3,(H,42,45,46)/t35-,36+,37-,39-,54?/m1/s1

Synonyms: DMTr-LNA-U-3-CED-phosphoramidite; 1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-2,4(1H,3H)-pyrimidinedione; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O,4'-C-methylene-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; DMTr-2'-O-4'-C-Locked-rU-3'-CE-Phosphoramidite; 5'-O-DMTr-2'-O,4'-C-methyleneuridine 3'-CE-phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-4'-C-Locked-uridine-3'-CE Phosphoramidite; 2'-O-4'-C-Locked-Ur-CE-Phosphoramidite

DMT-2'-O-4'-C Locked-Tr-CE Phosphoramidite

Description: DMT-2'-O-4'-C Locked-Tr-CE Phosphoramidite is a phosphoramidite compound used for the synthesis of locked nucleic acids (LNAs). This molecule is derived from a nucleoside and features several key modifications: a dimethoxytrityl (DMT) group at the 5' position, a 2'-O-4'-C methylene bridge (creating a locked ribose conformation), and a cyanoethyl (CE) phosphoramidite group for incorporation into oligonucleotides. DMT-2'-O-4'-C Locked-Tr-CE Phosphoramidite is valuable in various applications, including antisense therapy, siRNA, miRNA research, and diagnostic assays. The enhanced stability and binding properties of LNA-modified oligonucleotides make them powerful tools in molecular biology and medical research, providing greater specificity and efficacy in targeting RNA or DNA sequences.

CAT: BRP-00393

CAS: 206055-75-6

Molecular Formula: C41H49N4O9P

Molecular Weight: 772.84

Purity: ≥98% by HPLC

Appearance: White to off-white solid

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InChIKey: STPXOEPMLLHUDQ-ZRCIEBSPSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C3C(C(O2)(CO3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: 3-[[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-(5-methyl-2,4-dioxopyrimidin-1-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H49N4O9P/c1-27(2)45(28(3)4)55(52-23-11-22-42)54-36-35-38(44-24-29(5)37(46)43-39(44)47)53-40(36,25-50-35)26-51-41(30-12-9-8-10-13-30,31-14-18-33(48-6)19-15-31)32-16-20-34(49-7)21-17-32/h8-10,12-21,24,27-28,35-36,38H,11,23,25-26H2,1-7H3,(H,43,46,47)/t35-,36+,38-,40-,55?/m1/s1

Synonyms: DMTr-LNA-5MeU-3-CED-phosphoramidite; 5'-O-DMT-2'-O,4'-C-methylene-5-methyluridine 3'-CE-phosphoramidite; 5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-thymidine-3'-cyanoethyl Phosphoramidite; 1-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 5'-O-(4,4'-Dimethoxytrityl)-LNA-thymidine-3'-cyanoethyl phosphoramidite; DMT-locT Amidite; LNA-T phosphoramidite

DMTr-LNA-A(Bz)-3-CED-phosphoramidite

Description: DMTr-LNA-A(Bz)-3'-CED-phosphoramidite is a chemically modified nucleotide used in the synthesis of oligonucleotides. It features an adenine base (A) with a benzoyl (Bz) protecting group, incorporated into a locked nucleic acid (LNA) structure. The nucleotide has a dimethoxytrityl (DMTr) protecting group at the 5' position and a cyanoethyl diisopropylamino (CED) phosphoramidite group at the 3' position. This modification enhances the stability and binding affinity of oligonucleotides, making it useful for advanced genetic and molecular biology research, as well as for the development of therapeutic nucleic acids. It can be used for the synthesis of ASOs (antisense oligonucleotides).

CAT: BRP-00394

CAS: 206055-79-0

Molecular Formula: C48H52N7O8P

Molecular Weight: 885.96

Purity: ≥95%

Appearance: White to off-white solid

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InChIKey: HPIDKMAOZZZGOP-LIUGLABVSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C(N=CN=C76)NC(=O)C8=CC=CC=C8

IUPAC Name: N-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]purin-6-yl]benzamide

InChI: InChI=1S/C48H52N7O8P/c1-32(2)55(33(3)4)64(61-27-13-26-49)63-42-41-46(54-31-52-40-43(50-30-51-44(40)54)53-45(56)34-14-9-7-10-15-34)62-47(42,28-59-41)29-60-48(35-16-11-8-12-17-35,36-18-22-38(57-5)23-19-36)37-20-24-39(58-6)25-21-37/h7-12,14-25,30-33,41-42,46H,13,27-29H2,1-6H3,(H,50,51,53,56)/t41-,42+,46-,47-,64?/m1/s1

Synonyms: N-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-9H-purin-6-yl]benzamide; N6-Bz-2'-O-4'-A-Locked-Ar-CE-Phosphoramidite; DMT-locA(bz)Amidite; LNA-A(Bz) amidite; N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-adenosine-3'-cyanoethyl Phosphoramidite; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-LNA-adenosine-3'-cyanoethyl phosphoramidite; LNA-A(Bz)-CE Phosphoramidite; Bz-A-LA-CE Phosphoramidite

6-ROX-Phosphoramidite

Description: 6-ROX-Phosphoramidite is a fluorescent dye phosphoramidite used in the synthesis of labeled oligonucleotides. The 6-ROX (6-carboxy-X-rhodamine) dye is known for its strong fluorescence and is often used in molecular biology applications, such as real-time PCR, DNA sequencing, and fluorescence in situ hybridization (FISH). Incorporating 6-ROX into oligonucleotides allows for the visualization and tracking of nucleic acids in various research and diagnostic applications.

CAT: BRP-00400

Molecular Formula: C48H60N5O6P

Molecular Weight: 834.01

Purity: ≥97%

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InChIKey: OVEHZTATEJWCCS-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC(=C(C=C1)C(=O)[O-])C2=C3C=C4CCC[N+]5=C4C(=C3OC6=C2C=C7CCCN8C7=C6CCC8)CCC5)OCCC#N

IUPAC Name: 4-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylcarbamoyl]-2-(3-oxa-23-aza-9-azoniaheptacyclo[17.7.1.15,9.02,17.04,15.023,27.013,28]octacosa-1(27),2(17),4,9(28),13,15,18-heptaen-16-yl)benzoate

InChI: InChI=1S/C48H60N5O6P/c1-31(2)53(32(3)4)60(58-27-13-20-49)57-26-8-6-5-7-21-50-47(54)35-18-19-36(48(55)56)39(30-35)42-40-28-33-14-9-22-51-24-11-16-37(43(33)51)45(40)59-46-38-17-12-25-52-23-10-15-34(44(38)52)29-41(42)46/h18-19,28-32H,5-17,21-27H2,1-4H3,(H-,50,54,55,56)

Synonyms: 6-ROX Phosphoramidite

DMT-2'-O-TBDMS-G(dmf)-CE Phosphoramidite

Description: DMT-2'-O-TBDMS-G(dmf)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group on the 3' hydroxyl, a tert-butyldimethylsilyl (TBDMS) protecting group on the 2' hydroxyl, and a guanine base modified with a dimethylformamide (dmf) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. This compound enables stable and precise synthesis of oligonucleotides for various molecular biology research applications, including gene silencing, antisense therapy, and diagnostics.

CAT: BRP-00402

CAS: 149559-87-5

Molecular Formula: C49H67N8O8PSi

Molecular Weight: 955.18

Purity: ≥95%

Appearance: White to light yellow powder

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InChIKey: RQXRLANMGPTUJP-UTESLAMRSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C2N=C(NC3=O)N=CN(C)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C49H67N8O8PSi/c1-33(2)57(34(3)4)66(62-29-17-28-50)64-42-40(30-61-49(35-18-15-14-16-19-35,36-20-24-38(59-10)25-21-36)37-22-26-39(60-11)27-23-37)63-46(43(42)65-67(12,13)48(5,6)7)56-32-51-41-44(56)53-47(54-45(41)58)52-31-55(8)9/h14-16,18-27,31-34,40,42-43,46H,17,29-30H2,1-13H3,(H,53,54,58)/t40-,42-,43-,46-,66?/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N2-Dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite; 5'-O-DMT-2'-O-TBDMS-N2-DMF-Guanosine 3'-CE phosphoramidite; rG (dmf) CE-Phosphoramidite

5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite is a specialized nucleotide compound utilized in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and an adenine base modified with a benzoyl (Bz) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite enables controlled addition during synthesis and offers enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It finds applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00403

Molecular Formula: C52H53N6O8PS2

Molecular Weight: 985.12

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: CLDYJLPUISOESS-LTMMGAFGSA-N

CanonicalSMILES: COC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N8CCCC8)SCCSC(=O)C9=CC=CC=C9

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C52H53N6O8PS2/c1-61-41-25-21-39(22-26-41)52(38-19-11-6-12-20-38,40-23-27-42(62-2)28-24-40)64-33-43-45(66-67(57-29-13-14-30-57)69-32-31-68-51(60)37-17-9-5-10-18-37)46(63-3)50(65-43)58-35-55-44-47(53-34-54-48(44)58)56-49(59)36-15-7-4-8-16-36/h4-12,15-28,34-35,43,45-46,50H,13-14,29-33H2,1-3H3,(H,53,54,56,59)/t43-,45-,46-,50-,67?/m1/s1

Synonyms: S-(2-(((((2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate; DMT-2'-OMe-A(Bz)-3'-PS; [N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-adenosine]-3'-[S-(β-(Benzoylmercapto)ethyl) Pyrrolidino Thiophosphoroamidite]; 2'-OMe-A-Thiophosphoramidite; 5'-Dimethoxytrityl-N-benzoyl-Adenosine, 2'-O-methyl, 3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite

5'-DMT-2'-OMe-G(iBu)-3'-PS-Phosphoramidite

Description: 5'-DMT-2'-OMe-G(iBu)-3'-PS-Phosphoramidite is a specialized nucleotide compound employed in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and a guanine base modified with an isobutyl (iBu) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite enables controlled addition during synthesis and offers enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It finds applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

CAT: BRP-00404

Molecular Formula: C49H55N6O9PS2

Molecular Weight: 967.11

Purity: ≥90% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C

InChIKey: HZMNPGZRUUSWOU-VKFKYRIUSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N7CCCC7)SCCSC(=O)C8=CC=CC=C8)OC

IUPAC Name: S-[2-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-pyrrolidin-1-ylphosphanyl]sulfanylethyl] benzenecarbothioate

InChI: InChI=1S/C49H55N6O9PS2/c1-32(2)44(56)52-48-51-43-40(45(57)53-48)50-31-55(43)46-42(61-5)41(64-65(54-26-12-13-27-54)67-29-28-66-47(58)33-14-8-6-9-15-33)39(63-46)30-62-49(34-16-10-7-11-17-34,35-18-22-37(59-3)23-19-35)36-20-24-38(60-4)25-21-36/h6-11,14-25,31-32,39,41-42,46H,12-13,26-30H2,1-5H3,(H2,51,52,53,56,57)/t39-,41-,42-,46-,65?/m1/s1

Synonyms: DMT-2'-OMe-G(iBu)-3'-PS; [N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine]-3'-[S-(β-(Benzoylmercapto)ethyl)pyrrolidino Thiophosphoroamidite]; S-(2-(((((2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1H-purin-9(6H)-yl)-4-methoxytetrahydrofuran-3-yl)oxy)(pyrrolidin-1-yl)phosphino)thio)ethyl) benzothioate; 2'-OMe-G-Thiophosphoramidite; 5'-Dimethoxytrityl-N-isobutyryl-Guanosine, 2'-O-methyl,3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite

2'-O-Propargyl G(iBu)-3'-phosphoramidite (BRP-00321)

N4-Acetyl-5'-O-DMT-2'-O-propynylcytidine 3'-CE phosphoramidite

2'-O-Acetyl-N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)arabinocytidine 3'-O-phosphoramidite

Morpholino O6-(p-nitrophenethyl) G monomer

O6-NPE-N2-iBu protected G PMO Monomer

N-(6-Hydroxy-9-(6-(hydroxymethyl)-4-tritylmorpholin-2-yl)-9H-purin-2-yl) isobutyramide

N2-Isobutyryl-N-trityl-morpholinoguanosine

5-Me-DMT-2'-O-Me-C(Ac)-CE Phosphoramidite

5-Me-DMT-2'-O-Me-C(dmf)-CE Phosphoramidite

LNA-5-Me-C(Bz)-CE Phosphoramidite

LNA-5-Me-C(Ac)-CE Phosphoramidite

LNA-C(Ac)-CE Phosphoramidite

LNA-G(dmf)-CE Phosphoramidite

LNA-U-CE Phosphoramidite

DMT-2'-O-4'-C Locked-Tr-CE Phosphoramidite

DMTr-LNA-A(Bz)-3-CED-phosphoramidite

6-ROX-Phosphoramidite

DMT-2'-O-TBDMS-G(dmf)-CE Phosphoramidite

5'-DMT-2'-OMe-A(Bz)-3'-PS-Phosphoramidite

5'-DMT-2'-OMe-G(iBu)-3'-PS-Phosphoramidite

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