What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - BOC Sciences

N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite

Description: N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite is an indispensable compound within the biomedical domain with widespread application as a phosphoramidite constituent during oligonucleotide synthesis, primarily in the research of antisense therapy and gene silencing.

CAT: BRP-01976

CAS: 142808-44-4

Molecular Formula: C46H50F2N5O8P

Molecular Weight: 869.89

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at 2-8°C

InChIKey: XLVPZSDAOMSDQP-XBADOKRKSA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1(F)F)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[1-[(2R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3,3-difluorooxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C46H50F2N5O8P/c1-31(2)53(32(3)4)62(59-29-13-27-49)61-41-39(60-43(46(41,47)48)52-28-26-40(51-44(52)55)50-42(54)33-14-9-7-10-15-33)30-58-45(34-16-11-8-12-17-34,35-18-22-37(56-5)23-19-35)36-20-24-38(57-6)25-21-36/h7-12,14-26,28,31-32,39,41,43H,13,29-30H2,1-6H3,(H,50,51,54,55)/t39-,41-,43-,62?/m1/s1

Synonyms: N4-Bz-DMT-2',2'-difluoro-dC-CE-Phosphoramidite; DMTr-2',2'-difluoro-dC(Bz)-3'-CED-phosphoramidite; Gemcitabine amidite; Gemcitabine 3'-CE phosporamidite; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',2'-difluoro-2'-deoxycytidine 3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; 5'-O-DMT-N4-Benzoyl-2',2'-difluoro-2'-deoxycytidine 3'-CE phosphoramidite; 5'-DMT-N4-Bz-2',2'-difluoro-dC 3'-CE phosphoramidite

5-Methyl-2'-Fluoro-U Phosphoramidite

Description: 5-Methyl-2'-Fluoro-U Phosphoramidite, a pivotal compound with paramount significance in the domain of biomedicine, assumes the role of a fundamental constituent within the intricate framework of synthesized nucleic acids. Its exceptional utility lies in its indispensable contribution to the progressive advancement of antisense oligonucleotide development. Notably, this phosphoramidite possesses an intrinsic capacity to effectively combat a myriad of ailments encompassing viral infections and genetic disorders, by selectively targeting specified genes or RNA sequences.

CAT: BRP-02020

CAS: 182700-06-7

Molecular Formula: C40H48FN4O8P

Molecular Weight: 762.82

Purity: 95%

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: XUCJAZSCNJHDKP-ANEPUODISA-N

SMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)F

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-fluoro-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H48FN4O8P/c1-26(2)45(27(3)4)54(51-23-11-22-42)53-36-34(52-38(35(36)41)44-24-28(5)37(46)43-39(44)47)25-50-40(29-12-9-8-10-13-29,30-14-18-32(48-6)19-15-30)31-16-20-33(49-7)21-17-31/h8-10,12-21,24,26-27,34-36,38H,11,23,25H2,1-7H3,(H,43,46,47)/t34-,35-,36-,38-,54?/m1/s1

Synonyms: 5-Me-5'-O-DMT-2'-fluoro-2'-Deoxyuridine 3'-CE phosphoramidite; 2'-F T amidite; 2'-Fluoro-dT Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoro-5-methyluridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-5-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 2'-Fluoro-5MeU-3'-phosphoramidite; DMTr-2'-F-dT-3'-CE-Phosphoramidite; DMT-5-Me-2'-F-dU-CE-Phosphoramidite

Fmoc-PNA-C(Bhoc)-OH

Description: Fmoc-PNA-C(Bhoc)-OH is a cytosine-based PNA monomer featuring Bhoc-protected nucleobase functionality and an Fmoc-protected backbone. The Bhoc group minimizes side reactions involving the cytosine exocyclic amine. This monomer supports efficient solid-phase synthesis of cytosine-containing PNA sequences. It is integrated into PNA constructs requiring controlled base chemistry.

CAT: BRP-02043

CAS: 186046-81-1

Molecular Formula: C39H35N5O8

Molecular Weight: 701.7

Purity: 98%

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Storage: -20°C for long term storage

Density: 1.34±0.1 g/cm3

InChIKey: YPTOIRLDQISSCH-UHFFFAOYSA-N

SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)OC(=O)NC3=NC(=O)N(C=C3)CC(=O)N(CCNC(=O)OCC4C5=CC=CC=C5C6=CC=CC=C46)CC(=O)O

IUPAC Name: 2-[[2-[4-(benzhydryloxycarbonylamino)-2-oxopyrimidin-1-yl]acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]acetic acid

InChI: InChI=1S/C39H35N5O8/c45-34(23-44-21-19-33(41-37(44)48)42-39(50)52-36(26-11-3-1-4-12-26)27-13-5-2-6-14-27)43(24-35(46)47)22-20-40-38(49)51-25-32-30-17-9-7-15-28(30)29-16-8-10-18-31(29)32/h1-19,21,32,36H,20,22-25H2,(H,40,49)(H,46,47)(H,41,42,48,50)

Synonyms: 2-[[2-[4-[[(diphenylmethyl)oxy-oxomethyl]amino]-2-oxo-1-pyrimidinyl]-1-oxoethyl]-[2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]ethyl]amino]acetic acid; 2-[[2-[4-(benzhydryloxycarbonylamino)-2-oxopyrimidin-1-yl]acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]acetic acid

Fmoc-PNA-A(Bhoc)-OH

Description: Fmoc-PNA-A(Bhoc)-OH is an adenine-containing PNA monomer protected with Fmoc on the backbone and Bhoc on the nucleobase amine. The protection strategy preserves base integrity during synthetic cycles. It enables accurate introduction of adenine units into PNA oligomers. This monomer is commonly used in the preparation of sequence-specific PNA strands.

CAT: BRP-02044

CAS: 186046-82-2

Molecular Formula: C40H35N7O7

Molecular Weight: 725.7

Purity: 98%

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Storage: -20°C for long term storage

Density: 1.39±0.1 g/cm3

Application:

Fmoc-PNA-A(Bhoc)-OH is an Fmoc PNA monomer containing an Fmoc (9-fluorenylmethoxycarbonyl) group for solid phase peptide synthesis and a Bhoc (benzhydryloxycarbonyl) protecting group for specific applications.

1. Solid Phase Peptide Synthesis (SPPS): The solid phase synthesis of PNA oligomers is one of the primary uses of Fmoc-PNA-A(Bhoc)-OH. Stepwise assembly of PNA sequences on a solid support is made possible by the potent approach known as SPPS, which usually makes use of Fmoc chemistry. PNA monomers can be controlled when introduced to the expanding chain while shielding reactive functional groups to avoid unwanted side reactions by using Fmoc-PNA-A(Bhoc)-OH as a building block. PNA oligomers may be synthesized efficiently with high yield and purity using this approach, which is crucial for researching PNA's interactions with other biomolecules and nucleic acids.

2. Antisense therapy: PNA oligomers have demonstrated significant promise as antisense agents for controlling gene expression, particularly those made with Fmoc-PNA-A(Bhoc)-OH. Complementary base pairing allows PNA oligomers to bind particular mRNA sequences, which in turn prevent translation and, eventually, the expression of genes. Using Fmoc-PNA-A(Bhoc)-OH to synthesize antisense PNA oligomers guarantees the stability and specificity of the targeted mRNA, making it a potentially effective molecular treatment for hereditary and other illnesses.

3. Diagnostic instruments: Fmoc-PNA-A(Bhoc)-OH can also be employed to create instruments for the detection of proteins and nucleic acids. PNA can identify target sequences in biological materials with strong binding affinity for complementary DNA/RNA sequences. Researchers can develop extremely sensitive and selective instruments to identify gene mutations, viral infections, and biomarkers linked to a variety of diseases by integrating Fmoc-PNA-A(Bhoc)-OH into probes or biosensors. This application has significant effects on tracking patient response to treatment and enhancing disease diagnosis.

4. Nanotechnology: PNA is a desirable option for nanotechnology applications due to its special qualities, which include stability and hybridization ability. Fmoc-PNA-A(Bhoc)-OH can be conjugated to nanoparticles or other nanostructures to create functional materials for gene editing, targeted drug administration, and imaging applications. The adaptability and programmability of PNA-based nanodevices are improved by the ability to accurately change PNA sequences through solid-phase synthesis techniques, creating new avenues for innovation in nanomedicine and biotechnology.

5. Pharmacogenomics: As personalized medicine continues to advance, PNA oligomers synthesized using Fmoc-PNA-A(Bhoc)-OH may play a key role in pharmacogenomics. By targeting specific genetic variants associated with drug metabolism or disease susceptibility, PNA-based therapies can be tailored to individual patients to improve efficacy and safety.

InChIKey: LVVQRXRVCLWIIO-UHFFFAOYSA-N

SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)OC(=O)NC3=NC=NC4=C3N=CN4CC(=O)N(CCNC(=O)OCC5C6=CC=CC=C6C7=CC=CC=C57)CC(=O)O

IUPAC Name: 2-[[2-[6-(benzhydryloxycarbonylamino)purin-9-yl]acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]acetic acid

InChI: InChI=1S/C40H35N7O7/c48-33(46(22-34(49)50)20-19-41-39(51)53-23-32-30-17-9-7-15-28(30)29-16-8-10-18-31(29)32)21-47-25-44-35-37(42-24-43-38(35)47)45-40(52)54-36(26-11-3-1-4-12-26)27-13-5-2-6-14-27/h1-18,24-25,32,36H,19-23H2,(H,41,51)(H,49,50)(H,42,43,45,52)

Synonyms: 2-[[2-[6-[[(diphenylmethyl)oxy-oxomethyl]amino]-9-purinyl]-1-oxoethyl]-[2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]ethyl]amino]acetic acid; 2-[[2-[6-(benzhydryloxycarbonylamino)purin-9-yl]acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]acetic acid

Fmoc-PNA-G(Bhoc)-OH

Description: Fmoc-PNA-G(Bhoc)-OH is a guanine-containing PNA monomer protected with Bhoc on the nucleobase and Fmoc on the backbone. The protection scheme ensures controlled reactivity of the guanine functional groups during assembly. It supports accurate synthesis of guanine-rich PNA sequences. This monomer is compatible with standard peptide-coupling-based PNA synthesis workflows.

CAT: BRP-02045

CAS: 186046-83-3

Molecular Formula: C40H35N7O8

Molecular Weight: 741.76

Purity: 98%

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Storage: -20°C for long term storage

Density: 1.4±0.1 g/cm³

InChIKey: ZNHVLNAONKUINW-UHFFFAOYSA-N

SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)OC(=O)NC3=NC4=C(C(=O)N3)N=CN4CC(=O)N(CCNC(=O)OCC5C6=CC=CC=C6C7=CC=CC=C57)CC(=O)O

IUPAC Name: 2-[[2-[2-(benzhydryloxycarbonylamino)-6-oxo-1H-purin-9-yl]acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]acetic acid

InChI: InChI=1S/C40H35N7O8/c48-32(46(22-33(49)50)20-19-41-39(52)54-23-31-29-17-9-7-15-27(29)28-16-8-10-18-30(28)31)21-47-24-42-34-36(47)43-38(44-37(34)51)45-40(53)55-35(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-18,24,31,35H,19-23H2,(H,41,52)(H,49,50)(H2,43,44,45,51,53)

Synonyms: 2-[N-[2-(Fmoc-amino)ethyl]-2-[2-[[(benzhydryloxy)carbonyl]amino]-6-oxo-1H-purin-9(6H)-yl]acetamido]acetic Acid

Fmoc-PNA-T-OH

Description: Fmoc-PNA-T-OH is an Fmoc-protected PNA monomer incorporating a thymine nucleobase linked to an aminoethylglycine backbone. The neutral PNA framework enables stable and sequence-specific base pairing without electrostatic repulsion. This monomer is compatible with standard solid-phase synthesis protocols for PNA oligomer assembly. It is routinely used in the construction of thymine-containing PNA sequences for nucleic acid recognition studies.

CAT: BRP-02046

CAS: 169396-92-3

Molecular Formula: C26H26N4O7

Molecular Weight: 506.5

Purity: 98%

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Storage: -20°C for long term storage

Density: 1.368±0.06 g/cm3

InChIKey: REUYSHQBEXUIRY-UHFFFAOYSA-N

SMILES: CC1=CN(C(=O)NC1=O)CC(=O)N(CCNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)CC(=O)O

IUPAC Name: 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl-[2-(5-methyl-2,4-dioxopyrimidin-1-yl)acetyl]amino]acetic acid

InChI: InChI=1S/C26H26N4O7/c1-16-12-30(25(35)28-24(16)34)13-22(31)29(14-23(32)33)11-10-27-26(36)37-15-21-19-8-4-2-6-17(19)18-7-3-5-9-20(18)21/h2-9,12,21H,10-11,13-15H2,1H3,(H,27,36)(H,32,33)(H,28,34,35)

Synonyms: Fmoc PNA T OH

Fmoc-PNA-J(BOC)-OH

Description: Fmoc-PNA-J(BOC)-OH is a protected peptide nucleic acid (PNA) monomer used in the synthesis of peptide nucleic acids, featuring the synthetic J base with BOC protection for enhanced binding properties. It provides stability against enzymatic degradation and strong hybridization properties, making it useful in genetic diagnostics, antisense therapy, and various molecular biology applications where higher binding strength and additional functionalization are advantageous.

CAT: BRP-02050

CAS: 1095275-70-9

Molecular Formula: C30H33N5O8

Molecular Weight: 591.61

Purity: ≥95%

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Density: 1.37±0.1 g/cm3

InChIKey: HKYCYPRKFVETLD-UHFFFAOYSA-N

SMILES: CC(C)(C)OC(=O)NC1=NC=C(C(=O)N1)CC(=O)N(CCNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)CC(=O)O

IUPAC Name: 2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]-6-oxo-1H-pyrimidin-5-yl]acetyl]amino]acetic acid

InChI: InChI=1S/C30H33N5O8/c1-30(2,3)43-29(41)34-27-32-15-18(26(39)33-27)14-24(36)35(16-25(37)38)13-12-31-28(40)42-17-23-21-10-6-4-8-19(21)20-9-5-7-11-22(20)23/h4-11,15,23H,12-14,16-17H2,1-3H3,(H,31,40)(H,37,38)(H2,32,33,34,39,41)

Synonyms: Fmoc-J-(BOC)-AEG-OH; N-[2-[2-[[(1,1-Dimethylethoxy)carbonyl]amino]-1,6-dihydro-6-oxo-5-pyrimidinyl]acetyl]-N-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethyl]glycine; N-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-N-(2-(2-((tert-butoxycarbonyl)amino)-6-oxo-1,6-dihydropyrimidin-5-yl)acetyl)glycine; 2-[2-(2-{[(tert-butoxy)carbonyl]amino}-6-oxo-1,6-dihydropyrimidin-5-yl)-N-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]acetamido]acetic acid

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (BRP-02153)

Description: N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is a classic protected 2-OTBDMS phosphoramidite used to incorporate nucleoside A into the synthesis of oligonucleotides.

CAT: BRP-02153

CAS: 104992-55-4

Molecular Formula: C53H66N7O8PSi

Molecular Weight: 988.22

Purity: ≥98% by HPLC

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Storage: Store at -20 °C

InChIKey: FFXHNCNNHASXCT-RFMFGJHUSA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1

Synonyms: Bz-rA Phosphoramidite; DMT-2'O-TBDMS-rA(Bz) Phosphoramidite; 5'-O-DMT-2'-O-tert-Butyldimethylsiyl-N6-Benzoyl-adenosine 3'-CE phosphoramidite; N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 3'-CE phosphoramidite; 5'-O-DMT-2'-O-TBDMS-rA(Bz) 3'-CE phosphoramidite; DMT-2'-O-TBDMS-A(Bz)-CE-Phosphoramidite; N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-adenosine-3'-cyanoethyl Phosphoramidite

5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite (BRP-02154)

Description: 5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite is a phosphoramidite reagent used to introduce 2-O-methyl modified U nucleotide into oligonucleotides.

CAT: BRP-02154

CAS: 110764-79-9

Molecular Formula: C40H49N4O9P

Molecular Weight: 760.81

Purity: ≥95%

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Storage: Store at 2-8 °C

InChIKey: UVUOJOLPNDCIHL-XKZJCBTISA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C40H49N4O9P/c1-27(2)44(28(3)4)54(51-25-11-23-41)53-36-34(52-38(37(36)49-7)43-24-22-35(45)42-39(43)46)26-50-40(29-12-9-8-10-13-29,30-14-18-32(47-5)19-15-30)31-16-20-33(48-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,46)/t34-,36-,37-,38-,54?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 2'-Deoxy-2'-O-Me-5'-O-DMT-Uridine-3'-CED Phosphoramidite; 2'-OMe-U-CEP; 5'-Dimethoxytrityl-Uridine, 2'-O-methyl, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-O-Methyl-3'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5'-O-(4,4'-dimethoxytrityl)uridine

5'-DMT-2'-O-TBDMS-rU Phosphoramidite (BRP-02155)

Description: 5'-DMT-2'O-TBDMS-rU Phosphoramidite is a classic 2-OTBDMS phosphoramidite used to incorporate U into synthetic oligonucleotides.

CAT: BRP-02155

CAS: 118362-03-1

Molecular Formula: C45H61N4O9PSi

Molecular Weight: 861.04

Purity: ≥97%

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Storage: Store at -20 °C, under nitrogen

InChIKey: SKNLXHRBXYGJOC-ZMHKPELYSA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C45H61N4O9PSi/c1-31(2)49(32(3)4)59(55-29-15-27-46)57-40-38(56-42(48-28-26-39(50)47-43(48)51)41(40)58-60(10,11)44(5,6)7)30-54-45(33-16-13-12-14-17-33,34-18-22-36(52-8)23-19-34)35-20-24-37(53-9)25-21-35/h12-14,16-26,28,31-32,38,40-42H,15,29-30H2,1-11H3,(H,47,50,51)/t38-,40-,41-,42-,59?/m1/s1

Synonyms: rU Phosphoramidite; (2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; DMT-2'-O-TBDMS-rU Phosphoramidite; 5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]uridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 3'-CE phosphoramidite; 5'-DMT-2'-O-TBDMS-Uridine Phosphoramidite; DMT-2'-O-TBDMS-U-CE-Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-uridine-3'-cyanoethyl Phosphoramidite

Ac-rC Phosphoramidite (BRP-02156)

Description: Ac-rC Phosphoramidite is a commonly used protected 2-OTBDMS phosphoramidite for incorporating cytidine nucleotides into synthetic oligonucleotides.

CAT: BRP-02156

CAS: 121058-88-6

Molecular Formula: C47H64N5O9PSi

Molecular Weight: 902.11

Purity: ≥98% by HPLC

Appearance: White to Off-white Powder

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Storage: Store at 2-8 °C

InChIKey: QKWKXYVKGFKODW-YOEDQOPESA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C47H64N5O9PSi/c1-32(2)52(33(3)4)62(58-30-16-28-48)60-42-40(59-44(43(42)61-63(11,12)46(6,7)8)51-29-27-41(49-34(5)53)50-45(51)54)31-57-47(35-17-14-13-15-18-35,36-19-23-38(55-9)24-20-36)37-21-25-39(56-10)26-22-37/h13-15,17-27,29,32-33,40,42-44H,16,30-31H2,1-12H3,(H,49,50,53,54)/t40-,42-,43-,44-,62?/m1/s1

Synonyms: N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]cytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 5'-O-DMT-2'-O-tert-butyldimethylsilyl-N4-Acetyl-cytidine 3'-CE phosphoramiditee; 5'-O-(4,4'-DiMethoxytrityl)-N4-acetyl-2'-O-t-butyldimethylsilylcytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 5'-O-DMTr-N4-Ac-2'-O-TBDMS-cytidine-3'-CED PhosphoraMidite; DMT-2'-O-TBDMS-rC(ac) Phosphoramidite; 2'-TBDMS-Ac-rC-CE-Phosphoramidite; 5'-DMT-2'-O-TBDMS-N4-Acetyl-Cytidine Phosphoramidite

Related CAS: 237060-94-5 (S-isomer)

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (BRP-02157)

Description: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is a modified phosphoramidite designed for use in the synthesis of stable and efficient RNA and DNA oligonucleotides. Its protective groups and modifications enhance the stability of the resulting nucleic acids and facilitate their incorporation into nucleic acid chains during solid-phase synthesis. This compound is crucial in the production of antisense oligonucleotides, siRNA, probes, and primers, providing enhanced resistance to enzymatic degradation and improved performance in various applications.

CAT: BRP-02157

CAS: 146954-75-8

Molecular Formula: C39H46FN4O8P

Molecular Weight: 748.78

Purity: ≥98%

Appearance: White to Off-white Powder

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Storage: Store at -20 °C

InChIKey: HQHQPAYRJJMYQX-DJTPZYMWSA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluorooxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C39H46FN4O8P/c1-26(2)44(27(3)4)53(50-24-10-22-41)52-36-33(51-37(35(36)40)43-23-21-34(45)42-38(43)46)25-49-39(28-11-8-7-9-12-28,29-13-17-31(47-5)18-14-29)30-15-19-32(48-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,42,45,46)/t33-,35-,36-,37-,53?/m1/s1

Synonyms: 2'-F-dU Phosphoramidite; DMT-2'Fluoro-dU Phosphoramidite; 5'-O-Dimethoxytrityl-2'-fluoro-2'-deoxyuridine 3'-CE phosphoramidite; 2'-Deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-fluorouridine 3-CE phosphoramidite; DMT-2'-Fluoro-dU amidite; 2'-Fluoro-2'-deoxy Uridine CED Phosphoramidite; 2'-Deoxy-5'-O-DMT-2'-fluorouridine 3-CE phosphoramidite; 5'-O-DMT-2'-F-dU 3'-CE phosphoramidite

5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine 3'-CE phosphoramidite (BRP-02158)

Description: 5'-O-DMT-2'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine 3'-CE phosphoramidite is a classic protected 2-OTBDMS phosphoramidite used for incorporating ribo-G into synthetic oligonucleotides.

CAT: BRP-02158

CAS: 147201-04-5

Molecular Formula: C50H68N7O9PSi

Molecular Weight: 970.18

Purity: ≥98% by HPLC

Appearance: White to yellow solid

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Storage: Store at -20 °C

InChIKey: PGJKESPHANLWME-FTZVBZPOSA-N

SMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)O[Si](C)(C)C(C)(C)C

InChI: InChI=1S/C50H68N7O9PSi/c1-32(2)45(58)54-48-53-44-41(46(59)55-48)52-31-56(44)47-43(66-68(12,13)49(7,8)9)42(65-67(63-29-17-28-51)57(33(3)4)34(5)6)40(64-47)30-62-50(35-18-15-14-16-19-35,36-20-24-38(60-10)25-21-36)37-22-26-39(61-11)27-23-37/h14-16,18-27,31-34,40,42-43,47H,17,29-30H2,1-13H3,(H2,53,54,55,58,59)/t40-,42-,43-,47-,67?/m1/s1

Synonyms: 5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; iBu-rG CE phosphoramidite; DMT-2'-O-TBDMS-rG(iBu) Phosphoramidite; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]-N-isobutyrylguanosine; 5'-O-DMT-2'-O-TBDMS-N2-Isobutyryl-Guanosine-CE Phosphoramidite; 2'-TBDMS-ibu-G-CE-Phosphoramidite; DMT-2'-O-TBDMS-G(iBu)-CE-Phosphoramidite; N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite

2'-OMe-G(iBu)-3'-phosphoramidite (BRP-02159)

Description: 2'-OMe-G(iBu)-3'-phosphoramidite is a modified phosphoramidite designed for the synthesis of stable and efficient RNA oligonucleotides. The protective groups and modifications, such as 5'-O-DMTr, N2-isobutyryl, and 2'-O-methyl, enhance the stability of the resulting nucleic acids and facilitate their incorporation into nucleic acid chains during solid-phase synthesis. This compound is crucial in producing antisense oligonucleotides, siRNA, probes, and primers, providing enhanced resistance to enzymatic degradation and improved performance in various applications.

CAT: BRP-02159

CAS: 150780-67-9

Molecular Formula: C45H56N7O9P

Molecular Weight: 869.94

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at -20 °C, under inert atmosphere

Melting Point: 138-140 °C

InChIKey: IRRDHRZUOZNWDJ-MLLDKZSOSA-N

Solubility: Soluble in Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly, Sonicated)

SMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C45H56N7O9P/c1-28(2)41(53)49-44-48-40-37(42(54)50-44)47-27-51(40)43-39(57-9)38(61-62(59-25-13-24-46)52(29(3)4)30(5)6)36(60-43)26-58-45(31-14-11-10-12-15-31,32-16-20-34(55-7)21-17-32)33-18-22-35(56-8)23-19-33/h10-12,14-23,27-30,36,38-39,43H,13,25-26H2,1-9H3,(H2,48,49,50,53,54)/t36-,38-,39-,43-,62?/m1/s1

Synonyms: 5'-O-DMTr-N2-iBu-2'-O-Me-guanosine-3'-CED phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyroyl-2'-O-methylguanosine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite; 5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine 3'-CE phosphoramidite; 2'-OMe-iBu-G CE phosphoramidite; 5'-O-DMT-2'-O-Me-G(iBu) phosporamidite; DMT-2'-O-Me-rG(iBu) amidite; N2-Isobutyryl-5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-Guanosine-3'-CE-Phosphoramidite

N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (BRP-02160)

Description: N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is used to incorporate 2-O-methyl modified nucleotides into oligonucleotides. It is a novel nucleoside analogue drug that inhibits tumor growth and activates RNA polymerase II promoter transcription.

CAT: BRP-02160

CAS: 199593-09-4

Molecular Formula: C42H52N5O9P

Molecular Weight: 801.86

Purity: ≥98% by HPLC

Appearance: Off-White to Light Yellow Solid

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Storage: Store at -20 °C, under inert atmosphere

Melting Point: 102-104 °C

InChIKey: WNWUMIPFLOKTEZ-UAQIPLLRSA-N

Solubility: Soluble in DMSO (Slightly), Methanol (Slightly)

SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C42H52N5O9P/c1-28(2)47(29(3)4)57(54-26-12-24-43)56-38-36(55-40(39(38)52-8)46-25-23-37(44-30(5)48)45-41(46)49)27-53-42(31-13-10-9-11-14-31,32-15-19-34(50-6)20-16-32)33-17-21-35(51-7)22-18-33/h9-11,13-23,25,28-29,36,38-40H,12,26-27H2,1-8H3,(H,44,45,48,49)/t36-,38-,39-,40-,57?/m1/s1

Synonyms: N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite; 2'-OMe-Ac-C CE phosphoramidite; N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-Cytidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; DMT-2'-O-methyl-rC(Ac) amidite; 5'-O-(4,4'-Dimethoxytrityl)-N4-Acetyl-2'-O-methylcytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DMT-2'-OMe-C(Ac)-CE-Phosphoramidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-CE-phosphoramidite

5'-O-DMT-N4-Benzoyl-5-Methy-2'-O-(2-methoxyethyl)cytidine 3'-CE phosphoramidite (BRP-02163)

Description: 5'-O-DMT-N4-Benzoyl-5-Methy-2'-O-(2-methoxyethyl)cytidine 3'-CE phosphoramidite is used to incorporate methyl-C modified with 2'-O-methoxyethyl into oligonucleotides, which is useful for anti-sense RNA.

CAT: BRP-02163

CAS: 163759-94-2

Molecular Formula: C50H60N5O10P

Molecular Weight: 922.01

Purity: ≥98% by HPLC

Appearance: White to Off-white Powder

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InChIKey: FLIGVMLIIDVDSN-GICDFOIUSA-N

SMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCCOC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(2-methoxyethoxy)oxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C50H60N5O10P/c1-34(2)55(35(3)4)66(63-29-15-28-51)65-44-43(33-62-50(38-18-13-10-14-19-38,39-20-24-41(59-7)25-21-39)40-22-26-42(60-8)27-23-40)64-48(45(44)61-31-30-58-6)54-32-36(5)46(53-49(54)57)52-47(56)37-16-11-9-12-17-37/h9-14,16-27,32,34-35,43-45,48H,15,29-31,33H2,1-8H3,(H,52,53,56,57)/t43-,44-,45-,48-,66?/m1/s1

Synonyms: N4-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine 3'-CE phosphoramidite; 2'-O-MOE-N4-Bz-5-Me-C Phosphoramidite; 5-Me-DMT-2'-O-MOE-C(Bz)-CEP; N4-Benzoyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-cyanoethyl phosphoramidite; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-(2-methoxyethyl)-5-methyl-3,4-dihydrocytidine; 5'-O-DMT-2'-O-MOE-MeC(Bz) 3'-CE phosphoramidite

5'-O-DMT-2'-O-(2-Methoxyethyl)-5-methyluridine 3'-CE phosphoramidite (BRP-02164)

Description: 5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine 3'-CE phosphoramidite can introduce uridine units into the building blocks of non-natural DNA and RNA chains.

CAT: BRP-02164

CAS: 163878-63-5

Molecular Formula: C43H55N4O10P

Molecular Weight: 818.89

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: YFRRKZDUDXHJNC-KZQAAKLLSA-N

SMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCCOC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C43H55N4O10P/c1-29(2)47(30(3)4)58(55-24-12-23-44)57-38-37(56-41(39(38)53-26-25-50-6)46-27-31(5)40(48)45-42(46)49)28-54-43(32-13-10-9-11-14-32,33-15-19-35(51-7)20-16-33)34-17-21-36(52-8)22-18-34/h9-11,13-22,27,29-30,37-39,41H,12,24-26,28H2,1-8H3,(H,45,48,49)/t37-,38-,39-,41-,58?/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-5-methyluridin-3'-yl]-2-cyanoethyl-N,N'-diisopropylphosphoramidite; 5'-O-DMT-2'-MOE-thymidine 3'-CE phosphoramidite; DMT-2'-O-MOE-T-CEP; 5-Me-DMT-2'-O-MOE-U-CE P; DMT-2'-O-MOE-T-CE-Phosphoramidite; 5-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-uridine-3'-cyanoethyl Phosphoramidite; 5'-O-DMT-2'-O-MOE-MeU 3'-CE phosphoramidite; 2'-O-MOE-5MeU-3'-phosphoramidite

Related CAS: 163759-51-1 (R-isomer)

5'-O-DMT-2'-O-methyl-5-methyluridine 3'-CE phosphoramidite (BRP-02165)

Description: 5'-O-DMT-2'-O-methyl-5-methyluridine 3'-CE phosphoramidite is a novel antiviral and anticancer agent.

CAT: BRP-02165

CAS: 153631-20-0

Molecular Formula: C41H51N4O9P

Molecular Weight: 774.86

Purity: ≥98% by HPLC

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Storage: Store at -20 °C

InChIKey: GMJRPRHRYILEOK-VNZAIEIISA-N

SMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C41H51N4O9P/c1-27(2)45(28(3)4)55(52-24-12-23-42)54-36-35(53-39(37(36)50-8)44-25-29(5)38(46)43-40(44)47)26-51-41(30-13-10-9-11-14-30,31-15-19-33(48-6)20-16-31)32-17-21-34(49-7)22-18-32/h9-11,13-22,25,27-28,35-37,39H,12,24,26H2,1-8H3,(H,43,46,47)/t35-,36-,37-,39-,55?/m1/s1

Synonyms: 5'-O-DMT-5-Methy-2'-O-methyluridine 3'-CE phosphoramidite; 5'-O-DMT-2'-O-methyl-5-methyl-D-uridine 3'-CE phosphoramidite; 2'-O-Methyl-5-methyl-U CEP; 5-O-(4,4'-dimethoxytrityl)-3-O-(diisopropylamino-2-cyanoethoxyphosphanyl)-1-deoxy-2-O-methyl-1-thymin-1-yl-beta-D-ribo-pentofuranose; 5-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-uridine-3'-cyanoethyl phosphoramidite

Related CAS: 168611-14-1 (R-isomer) ; 168611-18-5 (S-isomer)

5'-O-DMT-3'-O-TBDMS-N6-Benzoyl-Adenosine 2'-CE phosphoramidite (BRP-02168)

Description: 5'-O-DMT-3'-O-TBDMS-N6-Benzoyl-Adenosine 2'-CE phosphoramidite is an antiviral nucleoside phosphoramidite for DNA synthesis.

CAT: BRP-02168

CAS: 129451-75-8

Molecular Formula: C53H66N7O8PSi

Molecular Weight: 988.19

Purity: ≥95%

Appearance: White to off-white powder

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5 g	$599	In stock

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Storage: Store at 2-8 °C

InChIKey: HRYAQLIYKSXPET-RFMFGJHUSA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O[Si](C)(C)C(C)(C)C

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-47-46(68-70(10,11)52(5,6)7)44(66-51(47)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38)33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1

Synonyms: N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 2'-CE phosphoramidite; Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 3'-TBDMS-Bz-rA Phosphoramidite; N-Benzoyl-2'-O-[2-cyanoethoxy(diisopropylamino)phosphino]-3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)adenosine; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-adenosine-2'-cyanoethyl phosphoramidite; 5'-O-DMTr-3'-O-TBDMS-A(Bz)-2'-CE-Phosphoramidite; N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyl-dimethylsilyl)-adenosine-2'-cyanoethyl Phosphoramidite

N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine 3'-CE phosphoramidite (BRP-02170)

Description: N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine 3'-CE phosphoramidite can be used to incorporate 2-fluoro modified nucleotides into oligonucleotides, improving metabolic stability.

CAT: BRP-02170

CAS: 136834-22-5

Molecular Formula: C47H51FN7O7P

Molecular Weight: 875.95

Purity: ≥98% by HPLC

Appearance: White powder

Size	Price	Stock	Quantity
10 g	$1449	In stock

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Storage: Store at 2-8 °C

InChIKey: VCCMVPDSLHFCBB-MSIRFHFKSA-N

SMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1F)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C47H51FN7O7P/c1-31(2)55(32(3)4)63(60-27-13-26-49)62-42-39(61-46(40(42)48)54-30-52-41-43(50-29-51-44(41)54)53-45(56)33-14-9-7-10-15-33)28-59-47(34-16-11-8-12-17-34,35-18-22-37(57-5)23-19-35)36-20-24-38(58-6)25-21-36/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,50,51,53,56)/t39-,40-,42-,46-,63?/m1/s1

Synonyms: 2'-Fluoro-dA CEP; 2'-Fluoro-Bz-A-CEP; N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoro-D-adenosine 3'-CE phosphoramidite; N6-Benzoyl-5'-O-DMT-2'-fluoro-2'-deoxyadenosine 3'-CE phosphoramidite; DMT-2'-F-dA(Bz)-CE-Phosphoramidite; N6-Bz-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-CE-Phosphoramidite; N6-Benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoroadenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite