What are phosphoramidites used for?

Phosphoramidites are activated monomers used in solid-phase DNA and RNA oligonucleotide synthesis.

What is the difference between DNA and RNA phosphoramidites?

RNA phosphoramidites include additional 2′-hydroxyl protecting groups, making them more sensitive to moisture and handling conditions.

Why is moisture control important for phosphoramidites?

Moisture can cause premature hydrolysis of phosphoramidites, reducing coupling efficiency and synthesis yield.

Can phosphoramidites be used for long oligonucleotide synthesis?

Yes, high-quality phosphoramidites are essential for achieving good yields in long and complex oligonucleotide sequences.

Are modified phosphoramidites available for custom oligos?

Modified and specialty phosphoramidites are commonly used to introduce functional groups or labels into oligonucleotides.

Phosphoramidites - RNA / BOC Sciences

3'-O-DMT-O6-DPC-N2-Acetyl-Guanosine TNA 2'-CE phosphoramidite

Description: 3'-O-DMT-O6-DPC-N2-Acetyl-Guanosine TNA 2'-CE phosphoramidite is a highly complex chemical compound utilized in the biomedical industry to fabricate nucleic acid-based drugs that effectively combat a multitude of ailments, including but not limited to cancer, viral infections, and genetic disorders. The intricate nature of the molecule allows for the synthesis of oligonucleotides that specifically target variably expressed genes, culminating in an unparalleled approach towards achieving precision medication. Procuring this compound necessitates a specialized skill set and equipment, and can only be obtained from esteemed chemical outlets.

CAT: BRP-02367

CAS: 325683-97-4

Molecular Formula: C54H57N8O9P

Molecular Weight: 993.05

Purity: 98%

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InChIKey: QGLNDUMJEPXLMP-DMYMLFOFSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(COC1N2C=NC3=C2N=C(N=C3OC(=O)N(C4=CC=CC=C4)C5=CC=CC=C5)NC(=O)C)OC(C6=CC=CC=C6)(C7=CC=C(C=C7)OC)C8=CC=C(C=C8)OC

IUPAC Name: [2-acetamido-9-[(2R,3R,4S)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]聽N,N-diphenylcarbamate

InChI: InChI=1S/C54H57N8O9P/c1-36(2)62(37(3)4)72(68-33-17-32-55)71-48-46(70-54(39-18-11-8-12-19-39,40-24-28-44(65-6)29-25-40)41-26-30-45(66-7)31-27-41)34-67-51(48)60-35-56-47-49(60)58-52(57-38(5)63)59-50(47)69-53(64)61(42-20-13-9-14-21-42)43-22-15-10-16-23-43/h8-16,18-31,35-37,46,48,51H,17,33-34H2,1-7H3,(H,57,58,59,63)/t46-,48+,51+,72?/m0/s1

Synonyms: DMTr-TNA-G(O6-CONPh2)(N2Ac)-amidite; TNA-G(O-CONPh2)(N-Ac)CE-Phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, (2R,3R,4S)-2-[2-(acetylamino)-6-[[(diphenylamino)carbonyl]oxy]-9H-purin-9-yl]-4-[bis(4-methoxyphenyl)phenylmethoxy]tetrahydro-3-furanyl 2-cyanoethyl ester; 2-Acetamido-9-((2R,3R,4S)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-2-yl)-9H-purin-6-yl diphenylcarbamate

GalNAc-NAG-25 Phosphoramidite

Description: GalNAc-NAG-25 Phosphoramidite is a modified phosphoramidite that incorporates a N-acetylgalactosamine (GalNAc) moiety linked to the NAG component, specifically designed for the synthesis of oligonucleotides. This compound enhances the stability and bioactivity of nucleic acids, particularly in applications involving targeted delivery and therapeutic interventions. Its unique structural features allow for improved interactions with cellular receptors, making GalNAc-NAG-25 Phosphoramidite valuable in the development of glyco-engineered therapeutics and in the field of glycobiology, where carbohydrate-based modifications play a crucial role in biological processes.

CAT: BRP-02368

CAS: 2130036-52-9

Molecular Formula: C88H145N10O43P

Molecular Weight: 2062.13

Purity: ≥95%

Appearance: White to light yellow powder

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Storage: Store at -20 °C

Boiling Point: 1590.2±65.0 °C at 760 mmHg

InChIKey: GTRPVVVEZDWBLA-ODUHJEIDSA-N

CanonicalSMILES: O=C(C)O[C@@H]([C@H]1OC(C)=O)[C@H]([C@@H](O[C@@H]1COC(C)=O)OCCOCCNC(CC[C@@H](C(NCCOCCO[C@@H]([C@@H]([C@H]([C@H]2OC(C)=O)OC(C)=O)NC(C)=O)O[C@@H]2COC(C)=O)=O)NC(CC[C@@H](C(NCCOCCO[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)OC(C)=O)OC(C)=O)COC(C)=O)=O)NC(CCOCCOCCOCCOCCOCCOCCOP(N(C(C)C)C(C)C)OCCC#N)=O)=O)=O)NC(C)=O

InChI: InChI=1S/C88H145N10O43P/c1-53(2)98(54(3)4)142(131-27-17-23-89)132-49-45-124-41-40-123-39-38-122-37-36-121-35-34-120-33-32-116-28-22-74(113)97-68(85(115)92-26-31-119-44-48-127-88-77(95-57(7)101)83(138-66(16)110)80(135-63(13)107)71(141-88)52-130-60(10)104)19-21-73(112)96-67(84(114)91-25-30-118-43-47-126-87-76(94-56(6)100)82(137-65(15)109)79(134-62(12)106)70(140-87)51-129-59(9)103)18-20-72(111)90-24-29-117-42-46-125-86-75(93-55(5)99)81(136-64(14)108)78(133-61(11)105)69(139-86)50-128-58(8)102/h53-54,67-71,75-83,86-88H,17-22,24-52H2,1-16H3,(H,90,111)(H,91,114)(H,92,115)(H,93,99)(H,94,100)(H,95,101)(H,96,112)(H,97,113)/t67-,68-,69+,70+,71+,75+,76+,77+,78-,79-,80-,81+,82+,83+,86+,87+,88+,142?/m0/s1

Synonyms: NAG-25; NAG 25; NAG25; GalNAc NAG-25 Phosphoramidite; N2-[23-[Bis(1-methylethyl)amino]-26-cyano-1-oxo-4,7,10,13,16,19,22,24-octaoxa-23-phosphahexacos-1-yl]-N-[2-[2-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]-L-γ-glutamyl-N,N2-bis[2-[2-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]-L-glutamamide

3'-O-DMT-N6-Benzoyl-Adenosine TNA 2'-CE phosphoramidite

Description: 3'-O-DMT-N6-Benzoyl-Adenosine TNA 2'-CE phosphoramidite is a modified nucleotide used in the synthesis of Threose Nucleic Acid (TNA) molecules for biomedical research. TNA is a promising alternative to DNA and RNA for gene and drug delivery due to its chemical stability and resistance to nuclease degradation. This specific phosphoramidite derivative incorporates a benzoyl-adenosine moiety, making it ideal for designing TNA-based drugs for the treatment of viral infections, inflammatory diseases, and cancer.

CAT: BRP-02380

CAS: 325683-93-0

Molecular Formula: C46H50N7O7P

Molecular Weight: 843.92

Purity: 98%

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InChIKey: QDGHMYBPKHSPSZ-BZWOVQDPSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(COC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)OC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(2R,3R,4S)-4-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C46H50N7O7P/c1-31(2)53(32(3)4)61(58-27-13-26-47)60-41-39(28-57-45(41)52-30-50-40-42(48-29-49-43(40)52)51-44(54)33-14-9-7-10-15-33)59-46(34-16-11-8-12-17-34,35-18-22-37(55-5)23-19-35)36-20-24-38(56-6)25-21-36/h7-12,14-25,29-32,39,41,45H,13,27-28H2,1-6H3,(H,48,49,51,54)/t39-,41+,45+,61?/m0/s1

Synonyms: DMTr-TNA A(Bz)-amidite; TNA-A(Bz)-CE-Phosphoramidite; DMTr-TNA A(Bz)-Phosphoramidite; N-Benzoyl-9-[(2R)-3alpha-[(diisopropylamino)(2-cyanoethoxy)phosphinooxy]-4beta-(4,4'-dimethoxytrityloxy)tetrahydrofuran-2beta-yl]-9H-purine-6-amine; 1-{2'-O-[(2-Cyanoethoxy)(diisopropyl amino)phosphino]-3'-O-[(4,4'-dimethoxytriphenyl)methyl]-a-L-threofuranosyl}-N6-benzoyladenine; (2R,3R,4S)-2-[6-(Benzoylamino)-9H-purin-9-yl]-4-[bis(4-methoxyphenyl)phenylmethoxy]tetrahydro-3-furanyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, (2R,3R,4S)-2-[6-(benzoylamino)-9H-purin-9-yl]-4-[bis(4-methoxyphenyl)phenylmethoxy]tetrahydro-3-furanyl 2-cyanoethyl ester; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2R,3R,4S)-2-[6-(benzoylamino)-9H-purin-9-yl]-4-[bis(4-methoxyphenyl)phenylmethoxy]tetrahydro-3-furanyl 2-cyanoethyl ester

DMTr-LNA-C(Bz)-3-CED-phosphoramidite

Description: DMTr-LNA-C(Bz)-3-CED-phosphoramidite is a purine nucleoside analog which has broad antitumor activity targeting indolent lymphoid malignancies.

CAT: BRP-00015

CAS: 206055-78-9

Molecular Formula: C47H52N5O9P

Molecular Weight: 861.93

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InChIKey: SSGINSHBUWKRHC-XCHZTBEFSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=CC(=NC6=O)NC(=O)C7=CC=CC=C7

IUPAC Name: N-[1-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C47H52N5O9P/c1-32(2)52(33(3)4)62(59-29-13-27-48)61-42-41-44(51-28-26-40(50-45(51)54)49-43(53)34-14-9-7-10-15-34)60-46(42,30-57-41)31-58-47(35-16-11-8-12-17-35,36-18-22-38(55-5)23-19-36)37-20-24-39(56-6)25-21-37/h7-12,14-26,28,32-33,41-42,44H,13,29-31H2,1-6H3,(H,49,50,53,54)/t41-,42+,44-,46-,62?/m1/s1

Synonyms: LNA-C(Bz)-CE Phosphoramidite; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-LNA-cytidine-3'-cyanoethyl phosphoramidite; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methylene-cytidine 3'-O-[(2-cyanoethyl) (N,N-diisopropyl)]-phosphorramidite; 5'-O-DMTr-2'-O-4'-C-Locked-C(Bz) Phosphoramidite; DMT-locC(bz)Amidite; DMT-locC(bz) phosphoramidite; LNA-C(Bz)-3-CED-phosphoramidite; Bz-C-LA-CE Phosphoramidite

DMTr-LNA-G(iBu)-3'-CED-phosphoramidite

Description: DMTr-LNA-G(iBu)-3'-CED-phosphoramidite is a phosphoramidite used in the biomedical industry for the synthesis of modified nucleic acids. It contains DMTr-protected LNA-G(iBu)-3'-CED, which enables efficient and stable incorporation of modified bases during DNA/RNA synthesis.

CAT: BRP-00016

CAS: 206055-77-8

Molecular Formula: C45H54N7O9P

Molecular Weight: 867.94

Purity: ≥98% by HPLC

Appearance: Off-white to yellow powder

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InChIKey: UUBFSNDSLDOIDQ-NIQOLRRHSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C4C(C(O3)(CO4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)OP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: N-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C45H54N7O9P/c1-28(2)40(53)49-43-48-39-36(41(54)50-43)47-27-51(39)42-37-38(61-62(59-24-12-23-46)52(29(3)4)30(5)6)44(60-42,25-57-37)26-58-45(31-13-10-9-11-14-31,32-15-19-34(55-7)20-16-32)33-17-21-35(56-8)22-18-33/h9-11,13-22,27-30,37-38,42H,12,24-26H2,1-8H3,(H2,48,49,50,53,54)/t37-,38+,42-,44-,62?/m1/s1

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-LNA-guanosine-3'-cyanoethyl phosphoramidite; LNA-G(ibu) phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O,4'-C-methyleneguanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; LNA-G(iBu)-CE Phosphoramidite; DMTr-2'-O-4'-C-Locked-rG(iBu)-3'-CE-Phosphoramidite; DMT-2'-O-4'-C-Locked-G(iBu)-CE; N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-Guanosine-3'-cyanoethyl Phosphoramidite; N2-iBu-2'-O-4'-C-Locked-Gr-CE-Phosphoramidite

5'-DMT-2'-O-Me-PseudoUridine-CE-Phosphoramidite

Description: 5'-DMT-2'-O-Me-PseudoUridine-CE-Phosphoramidite is a phosphoramidite derivative used in the synthesis of modified oligonucleotides for biomedical research. It enables the incorporation of 2'-O-methyl-pseudouridine modifications into RNA sequences, enhancing stability and specific RNA-protein interactions.

CAT: BRP-00128

CAS: 199737-09-2

Molecular Formula: C40H49N4O9P

Molecular Weight: 760.81

Purity: ≥95% by HPLC

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InChIKey: QRORKJSFBIFPIM-ALEZOLFBSA-N

CanonicalSMILES: N#CCCOP(OC1C(OC(C2=CNC(=O)NC2=O)C1OC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)N(C(C)C)C(C)C

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C40H49N4O9P/c1-26(2)44(27(3)4)54(51-23-11-22-41)53-36-34(52-35(37(36)49-7)33-24-42-39(46)43-38(33)45)25-50-40(28-12-9-8-10-13-28,29-14-18-31(47-5)19-15-29)30-16-20-32(48-6)21-17-30/h8-10,12-21,24,26-27,34-37H,11,23,25H2,1-7H3,(H2,42,43,45,46)/t34-,35+,36-,37+,54?/m1/s1

Synonyms: 2'-O-Methyl-5'-O-DMT-pseudoUridine 3'-CE phosphoramidite; pseudoUridine (with 5'-DMT, 3'-phosphoramidite, and 2'-OMe); 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-methyl-β-D-ribofuranosyl]-; 5-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-methyl-β-D-ribofuranosyl]-2,4(1H,3H)-pyrimidinedione

5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite

Description: It is a modified ribonucleoside analogue suitable for incorporation into small interfering RNA (siRNA) to enhance RNA stability in biological applications such as gene silencing.

CAT: BRP-00130

CAS: 875302-45-7

Molecular Formula: C46H63N4O9PSi

Molecular Weight: 875.07

Purity: ≥98%

Appearance: White to off-white powder

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InChIKey: ZDZLHJPETUXZJT-NSASEYFNSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)C2=CN(C(=O)NC2=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: (2R,3R,4S,5S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1S/C46H63N4O9PSi/c1-31(2)50(32(3)4)60(56-28-16-27-47)58-41-39(57-40(38-29-49(8)44(52)48-43(38)51)42(41)59-61(11,12)45(5,6)7)30-55-46(33-17-14-13-15-18-33,34-19-23-36(53-9)24-20-34)35-21-25-37(54-10)26-22-35/h13-15,17-26,29,31-32,39-42H,16,28,30H2,1-12H3,(H,48,51,52)/t39-,40+,41-,42+,60?/m1/s1

Synonyms: 5'-Dimethoxytrityl-1-methyl-pseudouridine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 5-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-1-methyl-2,4(1H,3H)-pyrimidinedione; 2'-O-TBDMS-N1-Me-Pseudouridine CEP; 5'-O-DMTr-2'-O-TBDMS-N1-methylpseudouridine 3'-(cyanoethyl-N,N-diisopropyl)phosphoramidite; 5'-O-DMT-2'-O-TBDMS-N1-Me-pU Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-N1-methyl-Pseudouridine-3'-cyanoethyl Phosphoramidite

UNA-A(Bz)-CE Phosphoramidite

Description: UNA-A(Bz)-CE Phosphoramidite is an advanced biomedical compound used for the research of cancer, including breast and lung cancer. It acts by targeting specific cellular pathways involved in cancer progression, inhibiting tumor growth and promoting cell death.

CAT: BRP-00132

CAS: 1120329-52-3

Molecular Formula: C54H58N7O9P

Molecular Weight: 980.06

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: DETQAICZNNZAEM-OWWCMFKUSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OCC(COC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)OC(COC(=O)C4=CC=CC=C4)N5C=NC6=C(N=CN=C65)NC(=O)C7=CC=CC=C7

IUPAC Name: [(2R)-2-(6-benzamidopurin-9-yl)-2-[(2R)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropan-2-yl]oxyethyl] benzoate

InChI: InChI=1S/C54H58N7O9P/c1-38(2)61(39(3)4)71(68-32-16-31-55)69-34-47(33-67-54(42-21-14-9-15-22-42,43-23-27-45(64-5)28-24-43)44-25-29-46(65-6)30-26-44)70-48(35-66-53(63)41-19-12-8-13-20-41)60-37-58-49-50(56-36-57-51(49)60)59-52(62)40-17-10-7-11-18-40/h7-15,17-30,36-39,47-48H,16,32-35H2,1-6H3,(H,56,57,59,62)/t47-,48-,71?/m1/s1

Synonyms: N6-Benzoyl-(5'-(4,4'-dimethoxytrityl)-2'-benzoyl-2',3'-seco-adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)] phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2R)-2-[(1R)-1-[6-(benzoylamino)-9H-purin-9-yl]-2-(benzoyloxy)ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; (2R)-2-[(1R)-1-[6-(Benzoylamino)-9H-purin-9-yl]-2-(benzoyloxy)ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

UNA-G(iBu)-CE Phosphoramidite

Description: UNA-G(iBu)-CE Phosphoramidite is a uniquely intricate compound possessing potential applications in the realm of cancer therapeutics. Possessing potent antineoplastic capabilities, it demonstrates high efficacy in the research of obstruction in malignant cellular proliferation.

CAT: BRP-00133

CAS: 1120329-61-4

Molecular Formula: C51H60N7O10P

Molecular Weight: 962.04

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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InChIKey: PCZJDFIZVYBABW-WESQYFQMSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C(COC(=O)C3=CC=CC=C3)OC(COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)COP(N(C(C)C)C(C)C)OCCC#N

IUPAC Name: [(2R)-2-[(2R)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropan-2-yl]oxy-2-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]ethyl] benzoate

InChI: InChI=1S/C51H60N7O10P/c1-34(2)47(59)55-50-54-46-45(48(60)56-50)53-33-57(46)44(32-64-49(61)37-16-11-9-12-17-37)68-43(31-67-69(66-29-15-28-52)58(35(3)4)36(5)6)30-65-51(38-18-13-10-14-19-38,39-20-24-41(62-7)25-21-39)40-22-26-42(63-8)27-23-40/h9-14,16-27,33-36,43-44H,15,29-32H2,1-8H3,(H2,54,55,56,59,60)/t43-,44-,69?/m1/s1

Synonyms: N2-Isobutyryl-(5'-(4,4'-dimethoxytrityl)-2'-benzoyl-2',3'-seco-guanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)] phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2R)-2-[(1R)-2-(benzoyloxy)-1-[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; (2R)-2-[(1R)-2-(Benzoyloxy)-1-[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite

Yakima Yellow® Phosphoramidite

Description: Yakima Yellow® Phosphoramidite is a fluorescent phosphoramidite dye for 5’-end DNA labeling. It emits bright yellow fluorescence with excellent signal-to-noise performance.

CAT: BRP-00218

CAS: 502485-39-4

Molecular Formula: C49H60Cl4N3O10P

Molecular Weight: 1023.81

Appearance: Off-white solid

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InChIKey: POEPDWFKAYRZJK-UHFFFAOYSA-N

CanonicalSMILES: CC1=C2C(=CC(=C1OC(=O)C(C)(C)C)Cl)C3(C4=CC(=C(C=C4C(=O)O3)Cl)Cl)C5=C(O2)C(=C(C(=C5)CCC(=O)NCCCCCCOP(N(C(C)C)C(C)C)OCCC#N)OC(=O)C(C)(C)C)Cl

IUPAC Name: [2',5,5',6-tetrachloro-7'-[3-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylamino]-3-oxopropyl]-6'-(2,2-dimethylpropanoyloxy)-4'-methyl-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate

InChI: InChI=1S/C49H60Cl4N3O10P/c1-27(2)56(28(3)4)67(62-22-16-19-54)61-21-15-13-12-14-20-55-38(57)18-17-30-23-33-43(39(53)42(30)65-46(60)48(9,10)11)63-40-29(5)41(64-45(59)47(6,7)8)37(52)26-34(40)49(33)32-25-36(51)35(50)24-31(32)44(58)66-49/h23-28H,12-18,20-22H2,1-11H3,(H,55,57)

Synonyms: Y-Yellow Phosphoramidite; Yakima Yellow; 3-(5,6,4',7'-tetrachloro-5'-methyl-3',6'-dipivaloylfluorescein-2-yl)-propanamidohexyl-1-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; 1,1'-[2'-[12-[Bis(1-methylethyl)amino]-15-cyano-3-oxo-11,13-dioxa-4-aza-12-phosphapentadec-1-yl]-4',5,6,7'-tetrachloro-5'-methyl-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl] bis(2,2-dimethylpropanoate); Propanoic acid, 2,2-dimethyl-, 2'-[3-[[6-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]hexyl]amino]-3-oxopropyl]-4',5,6,7'-tetrachloro-5'-methyl-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3',6'-diyl ester; Epoch Yakima Yellow Phosphoramidite; Yakima Yellow Amidite; Yakima Yellow Phosphoramidite

DyLight 3 CEP

Description: DyLight 3 CEP is a fluorescent dye used for oligonucleotide labeling.

CAT: BRP-00220

CAS: 182873-76-3

Molecular Formula: C58H70CIN4O4P

Molecular Weight: 953.64

Purity: ≥90%

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InChIKey: DQXAVRZQYYKELZ-UHFFFAOYSA-M

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC[N+]1=C(C(C2=CC=CC=C21)(C)C)C=CC=C3C(C4=CC=CC=C4N3CCCOC(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=C(C=C7)OC)(C)C)OCCC#N.[Cl-]

IUPAC Name: 3-[[di(propan-2-yl)amino]-[3-[2-[3-[1-[3-[(4-methoxyphenyl)-diphenylmethoxy]propyl]-3,3-dimethylindol-2-ylidene]prop-1-enyl]-3,3-dimethylindol-1-ium-1-yl]propoxy]phosphanyl]oxypropanenitrile;chloride

InChI: InChI=1S/C58H70N4O4P.ClH/c1-44(2)62(45(3)4)67(65-42-21-38-59)66-43-23-40-61-53-31-19-17-29-51(53)57(7,8)55(61)33-20-32-54-56(5,6)50-28-16-18-30-52(50)60(54)39-22-41-64-58(46-24-12-10-13-25-46,47-26-14-11-15-27-47)48-34-36-49(63-9)37-35-48;/h10-20,24-37,44-45H,21-23,39-43H2,1-9H3;1H/q+1;/p-1

Synonyms: Cy3 MMTr CE Phosphoramidite; 1-[3-(4-monomethoxytrityloxy)propyl]-1'-[3-[(2-cyanoethyl)-(N,N-diisopropyl)phosphoramidityl]propyl]-3,3,3',3'-tetramethylindocarbocyanine chloride; Cyanine 3 Phosphoramidite

Related CAS: 718594-66-2 (free base)

Eclipse® Quencher Phosphoramidite

Description: Eclipse® Quencher Phosphoramidite is a paramount constituent employed in the fabrication of oligonucleotides, emerges as a pivotal ensemble. Its functions lie in its ability to dampen the fluorescence signal within nucleotide probes, consequently facilitating meticulous identification of distinctive DNA or RNA sequences. It substantiates its worth by contributing to the proficiency of diagnostic assays and molecular biology research, consequently augmenting the detection and scrutiny of assorted maladies and genetic irregularities.

CAT: BRP-00227

CAS: 916753-64-5

Molecular Formula: C52H61CIN7O8P

Molecular Weight: 978.51

Appearance: Black solid

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Boiling Point: 962.2±65.0 °C (Predicted)

InChIKey: CXNVOZCFZYENEQ-SOWLJRCBNA-N

CanonicalSMILES: N#CCCOP(OC1CN(C(=O)CCCN(C2=CC=C(N=NC3=CC=C(C=C3Cl)N(=O)=O)C=C2)C)C(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C1)N(C(C)C)C(C)C

IUPAC Name: rel-(3R,5S)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-1-(4-((4-((2-chloro-4-nitrophenyl)diazenyl)phenyl)(methyl)amino)butanoyl)pyrrolidin-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChI: InChI=1/C52H61ClN7O8P/c1-37(2)59(38(3)4)69(67-32-12-30-54)68-48-33-45(36-66-52(39-13-9-8-10-14-39,40-16-25-46(64-6)26-17-40)41-18-27-47(65-7)28-19-41)58(35-48)51(61)15-11-31-57(5)43-22-20-42(21-23-43)55-56-50-29-24-44(60(62)63)34-49(50)53/h8-10,13-14,16-29,34,37-38,45,48H,11-12,15,31-33,35-36H2,1-7H3/t45-,48+,69?/s2

Synonyms: EclipseQ Phosphoramidite; Eclipse Quencher Phosphoramidite; 4-N-methyl-N-(4'-nitro-2'-chloroazobenzen-4-yl)-aminobutanamido-1-(2-O-dimethoxytrityloxymethyl)-pyrrolidin-4-yl-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramdite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (3R,5S)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[4-[[4-[2-(2-chloro-4-nitrophenyl)diazenyl]phenyl]methylamino]-1-oxobutyl]-3-pyrrolidinyl 2-cyanoethyl ester, rel-; rel-(3R,5S)-5-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[4-[[4-[2-(2-chloro-4-nitrophenyl)diazenyl]phenyl]methylamino]-1-oxobutyl]-3-pyrrolidinyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; 5'-Eclipse Amidite

5'-Amino Modifier C3-TFA CE Phosphoramidite

Description: 5'-Amino Modifier C3-TFA CE Phosphoramidite is a valuable product used in the biomedical industry for the synthesis of modified nucleic acids. This phosphoramidite reagent allows for the introduction of an amino modifier group at the 5' position of nucleosides, enabling the creation of modified oligonucleotides with enhanced properties. It finds applications in various fields such as drug discovery, gene synthesis, and molecular diagnostics.

CAT: BRP-00229

CAS: 853955-89-2

Molecular Formula: C14H25F3N3O3P

Molecular Weight: 371.34

Appearance: Colorless Oil

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Boiling Point: 391.4±42.0 °C at 760 mmHg

InChIKey: AOAXRHUQUZSDAX-UHFFFAOYSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCCNC(=O)C(F)(F)F)OCCC#N

IUPAC Name: N-[3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropyl]-2,2,2-trifluoroacetamide

InChI: InChI=1S/C14H25F3N3O3P/c1-11(2)20(12(3)4)24(22-9-5-7-18)23-10-6-8-19-13(21)14(15,16)17/h11-12H,5-6,8-10H2,1-4H3,(H,19,21)

Synonyms: 5'-Amino Modifier C3 TFA CE Phosphoramidite; 5'-Amino-modifier-C 3-tfa cep; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 3-[(trifluoroacetyl)amino]propyl ester; 2-Cyanoethyl 3-[(trifluoroacetyl)amino]propyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 3-[(trifluoroacetyl)amino]propyl ester; 5'-Amino-Modifier C3-TFA

5'-BHQ-1 Phosphoramidite

Description: 5'-BHQ-1 Phosphoramidite, an indispensable reagent, is widely employed in synthesizing oligonucleotides with numerous biomedical potentialities. A notable function is creating luminous probes for detecting nucleic acid sequences in vivo and in vitro. Moreover, it has crucially contributed to the progress in crafting diagnostic devices for malignant neoplasms, viral infections and innate deficiencies.

CAT: BRP-00234

CAS: 1430816-77-5

Molecular Formula: C34H45N8O5P

Molecular Weight: 676.75

Purity: ≥98% by HPLC

Appearance: Dark red solid

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InChIKey: PYSPQPFQYWCYDV-UHFFFAOYSA-N

CanonicalSMILES: CCN(CCOP(N(C(C)C)C(C)C)OCCC#N)C1=CC=C(C=C1)N=NC2=C(C=C(C(=C2)C)N=NC3=C(C=C(C=C3)C)[N+](=O)[O-])OC

IUPAC Name: 3-[[di(propan-2-yl)amino]-[2-[N-ethyl-4-[[2-methoxy-5-methyl-4-[(4-methyl-2-nitrophenyl)diazenyl]phenyl]diazenyl]anilino]ethoxy]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C34H45N8O5P/c1-9-40(18-20-47-48(46-19-10-17-35)41(24(2)3)25(4)5)29-14-12-28(13-15-29)36-39-32-22-27(7)31(23-34(32)45-8)38-37-30-16-11-26(6)21-33(30)42(43)44/h11-16,21-25H,9-10,18-20H2,1-8H3

Synonyms: 4'-(2-Nitro-4-toluyldiazo)-2'-methoxy-5'-methyl-azobenzene-4''-(N-ethyl)-N-ethyl-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite; 5'-HDQ-1 Phosphoramidite; BHQ-1-Amidite; BHQ-1 Amidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[ethyl[4-[2-[2-methoxy-5-methyl-4-[2-(4-methyl-2-nitrophenyl)diazenyl]phenyl]diazenyl]phenyl]amino]ethyl ester; 2-Cyanoethyl 2-[ethyl[4-[2-[2-methoxy-5-methyl-4-[2-(4-methyl-2-nitrophenyl)diazenyl]phenyl]diazenyl]phenyl]amino]ethyl N,N-bis(1-methylethyl)phosphoramidite; DusQ1 amidite, 5'-terminal

5'-BHQ-2 Phosphoramidite

Description: 5'-BHQ-2 Phosphoramidite is integral in the synthesis of oligonucleotides for cutting-edge biomedical investigations and diagnostics, showcasing its prowess as a fluorescent quencher. It expedites the identification and evaluation of diverse DNA and RNA patterns. With unparalleled efficacy and unwavering consistency, it fulfills an optimal role in real-time PCR, next-generation sequencing is and hybridization assays.

CAT: BRP-00235

CAS: 1345959-73-0

Molecular Formula: C33H43N8O6P

Molecular Weight: 678.72

Purity: ≥98% by HPLC

Appearance: Dark purple solid

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InChIKey: OXESOGDAJXFPNE-UHFFFAOYSA-N

CanonicalSMILES: CCN(CCOP(N(C(C)C)C(C)C)OCCC#N)C1=CC=C(C=C1)N=NC2=CC(=C(C=C2OC)N=NC3=CC=C(C=C3)[N+](=O)[O-])OC

IUPAC Name: 3-[2-[4-[[2,5-dimethoxy-4-[(4-nitrophenyl)diazenyl]phenyl]diazenyl]-N-ethylanilino]ethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C33H43N8O6P/c1-8-39(19-21-47-48(46-20-9-18-34)40(24(2)3)25(4)5)28-14-10-26(11-15-28)35-37-30-22-33(45-7)31(23-32(30)44-6)38-36-27-12-16-29(17-13-27)41(42)43/h10-17,22-25H,8-9,19-21H2,1-7H3

Synonyms: 4'-(4-Nitro-phenyldiazo)-2'-methoxy-5'-methoxy-azobenzene-4''-(N-ethyl)-N-ethyl-2-cyanoethyl-(N,N-diisopropyl)-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[[4-[2-[2,5-dimethoxy-4-[2-(4-nitrophenyl)diazenyl]phenyl]diazenyl]phenyl]ethylamino]ethyl ester; 2-Cyanoethyl 2-[[4-[2-[2,5-dimethoxy-4-[2-(4-nitrophenyl)diazenyl]phenyl]diazenyl]phenyl]ethylamino]ethyl N,N-bis(1-methylethyl)phosphoramidite; BHQ-2-Amidite; BHQ-2 Amidite

5'-Aldehyde-Modifier C2 Phosphoramidite

Description: 5'-Aldehyde-Modifier C2 Phosphoramidite, an essential reagent for bioconjugation and labeling of oligonucleotides, is an attractive option for introducing aldehydes into DNA strands in a site-selective and efficient manner. With its potential applications in gene editing, diagnostics, and drug discovery, this product provides researchers with a versatile tool for developing advanced therapies. The wide range of possibilities provided by this reagent sets it apart from other options on the market, making it an essential component in any research lab dealing with DNA analyses.

CAT: BRP-00236

CAS: 433684-36-7

Molecular Formula: C25H41N2O5P

Molecular Weight: 480.58

Purity: ≥95%

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InChIKey: JCAVMJJPXGZACF-UHFFFAOYSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: N#CCCOP(OCCOC1=CC=C(C=C1)C2OCC(CO2)(CC)CC)N(C(C)C)C(C)C

InChI: InChI=1S/C25H41N2O5P/c1-7-25(8-2)18-29-24(30-19-25)22-10-12-23(13-11-22)28-16-17-32-33(31-15-9-14-26)27(20(3)4)21(5)6/h10-13,20-21,24H,7-9,15-19H2,1-6H3

Synonyms: 5'-Aldehyde-C2 Amidite; 2-[4-(5,5-Diethyl-1,3-dioxan-2-yl)phenoxy]ethan-1-yl-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl 2-[4-(5,5-diethyl-1,3-dioxan-2-yl)phenoxy]ethyl ester; 2-Cyanoethyl 2-[4-(5,5-diethyl-1,3-dioxan-2-yl)phenoxy]ethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, bis(1-methylethyl)-, 2-cyanoethyl 2-[4-(5,5-diethyl-1,3-dioxan-2-yl)phenoxy]ethyl ester

A(Ac)-TOM-CE Phosphoramidite

Description: 2'-O-TOM-A(Ac) Phosphoramidite is a specialized reagent used in oligonucleotide synthesis. It features a 2'-O-TOM (2'-O-tomc) modification attached to an adenosine (A) nucleotide, along with an acetyl (Ac) group. This modification enhances stability and protects against nuclease degradation. It is often employed in applications such as RNA interference, gene expression modulation, and therapeutic RNA-based treatments. The synthesis of RNA using monomers containing the 2'-O-Triisopropylsilyloxymethyl (TOM) group (TOM-Protecting-Group) has very high coupling efficiency along with fast, simple deprotection.

CAT: BRP-00239

CAS: 253586-13-9

Molecular Formula: C52H72N7O9PSi

Molecular Weight: 998.23

Purity: ≥95%

Appearance: White to Off-white Free-flowing Powder

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InChIKey: TWRRCYAUVCYCGL-UIRZPSOPSA-N

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCO[Si](C(C)C)(C(C)C)C(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-[tri(propan-2-yl)silyloxymethoxy]oxolan-2-yl]purin-6-yl]acetamide

InChI: InChI=1S/C52H72N7O9PSi/c1-34(2)59(35(3)4)69(65-29-17-28-53)68-47-45(30-64-52(40-18-15-14-16-19-40,41-20-24-43(61-12)25-21-41)42-22-26-44(62-13)27-23-42)67-51(48(47)63-33-66-70(36(5)6,37(7)8)38(9)10)58-32-56-46-49(57-39(11)60)54-31-55-50(46)58/h14-16,18-27,31-32,34-38,45,47-48,51H,17,29-30,33H2,1-13H3,(H,54,55,57,60)/t45-,47-,48-,51-,69?/m1/s1

Synonyms: 5'-Dimethoxytrityl-N-acetyl-Adenosine, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; N-Acetyl-2'-O-[(triisopropylsilyloxy)methyl]-3'-O-[diisopropylamino(2-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)adenosine; Adenosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; N-Acetyl-5'-O-DMT-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-adenosine 3'-CE phosphoramidite; 5'-O-DMTr-2'-O-TOM-A(Ac) Phosphoramidite; N6-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-triisopropylsilyloxymethyl-Phosphoramidite; 2'-TOM A(Ac) amidite; A-TOM-CE Phosphoramidite; 5'-DMT-2'-TOM-ribo Adenosine (n-acetyl) OP

Related CAS: 2659239-38-8 (Deleted CAS)

Zebularine 3'-CE phosphoramidite

Description: Zebularine 3'-CE phosphoramidite is a key compound widely used in biomedical field playing a crucial role in the synthesis of oligonucleotides and specifically designed for the modification of nucleic acids. It enables the research of various diseases, including cancer, by targeting specific gene sequences and regulating gene expression.

CAT: BRP-00240

CAS: 155831-90-6

Molecular Formula: C45H61N4O8PSi

Molecular Weight: 845.04

Purity: 95%

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InChIKey: UEUDLVPTCOPGMZ-MGVQLQBBSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=CC=NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-5-(2-oxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChI: InChI=1S/C45H61N4O8PSi/c1-32(2)49(33(3)4)58(54-30-15-27-46)56-40-39(55-42(48-29-16-28-47-43(48)50)41(40)57-59(10,11)44(5,6)7)31-53-45(34-17-13-12-14-18-34,35-19-23-37(51-8)24-20-35)36-21-25-38(52-9)26-22-36/h12-14,16-26,28-29,32-33,39-42H,15,30-31H2,1-11H3/t39-,40-,41-,42-,58?/m1/s1

Synonyms: 5'-Dimethoxytrityl-pyrimidin-2-one-riboside, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Zebularine-CE Phosphoramidite; 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-2(1H)-pyrimidinone; Zebularine CEP

N4-Acetyl-5'-O-DMT-2'-O-triisopropylsilyloxymethyl-5-methylcytidine 3'-CE phosphoramidite

Description: N4-Acetyl-5'-O-DMT-2'-O-triisopropylsilyloxymethyl-5-methylcytidine 3'-CE phosphoramidite is a crucial component used in the development of advanced biomedical therapies. This compound plays a pivotal role in the synthesis of modified nucleic acids utilized for treating various diseases like cancer, viral infections, and genetic disorders. Its unique structure enhances the stability and efficacy of therapeutic molecules, allowing targeted delivery and improved treatment outcomes.

CAT: BRP-00241

CAS: 872548-65-7

Molecular Formula: C52H74N5O10PSi

Molecular Weight: 988.23

Purity: 97%

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InChIKey: OBHVHGNMPRNNPM-RNGKMJNNSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCO[Si](C(C)C)(C(C)C)C(C)C

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-[tri(propan-2-yl)silyloxymethoxy]oxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C52H74N5O10PSi/c1-34(2)57(35(3)4)68(64-30-18-29-53)67-47-46(32-63-52(41-19-16-15-17-20-41,42-21-25-44(60-13)26-22-42)43-23-27-45(61-14)28-24-43)66-50(56-31-39(11)49(54-40(12)58)55-51(56)59)48(47)62-33-65-69(36(5)6,37(7)8)38(9)10/h15-17,19-28,31,34-38,46-48,50H,18,30,32-33H2,1-14H3,(H,54,55,58,59)/t46-,47-,48-,50-,68?/m1/s1

Synonyms: N4-Acetyl-5'-O-DMT-2'-O-TOM-5-methylcytidine 3'-CE phosphoramidite; 5-MeC-CE Phosphoramidite; 5-Me-C-TOM-CE Phosphoramidite; 5'-Dimethoxytrityl-N-acetyl-5-methyl-Cytidine, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5-methyl-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]cytidine

2-Aminopurine riboside CEP

Description: 2-Aminopurine riboside CEP, an indispensable chemical entity extensively utilized within the biomedical sector, serves as a nucleoside analog. Its application predominantly revolves around the investigation and advancement of antiviral therapeutics designed to combat RNA virus-induced infections.

CAT: BRP-00242

CAS: 151059-65-3

Molecular Formula: C50H68N7O8PSi

Molecular Weight: 954.18

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Storage: Store at -20 °C

InChIKey: NSNBXSIELVIXGV-SEHLHCIHSA-N

Solubility: Soluble in Anhydrous Acetonitrile

CanonicalSMILES: CC(C)C(=O)NC1=NC=C2C(=N1)N(C=N2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N)O[Si](C)(C)C(C)(C)C

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C50H68N7O8PSi/c1-33(2)46(58)55-48-52-30-41-45(54-48)56(32-53-41)47-44(65-67(12,13)49(7,8)9)43(64-66(62-29-17-28-51)57(34(3)4)35(5)6)42(63-47)31-61-50(36-18-15-14-16-19-36,37-20-24-39(59-10)25-21-37)38-22-26-40(60-11)27-23-38/h14-16,18-27,30,32-35,42-44,47H,17,29,31H2,1-13H3,(H,52,54,55,58)/t42-,43-,44-,47-,66?/m1/s1

Synonyms: N-[9-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]-2-methylpropanamide; Phosphoramidous acid, bis(1-methylethyl)-, mono(2-cyanoethyl) ester, ester with N-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribofuranosyl]-9H-purin-2-yl]-2-methylpropanamide; 2-Aminopurine-TBDMS-CE Phosphoramidite; 5'-Dimethoxytrityl-N2-isobutyryl-2-aminopurine riboside, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2-Amino Purine Riboside CED phosphoramidite